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A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancer
Published 2025-08-01“…With the explosion of clinical NGS data and the concurrent availability of protein structures through the Protein Data Bank and protein models through programs such as AlphaFold, there exists an unprecedented opportunity to use structural information to help standardize NGS analysis with the overall goal of advancing personalized cancer therapy.MethodsUsing the Catalogue of Somatic Mutations in Cancer (COSMIC), the largest curated database of clinical cancer mutations, we mapped thousands of missense mutations in the kinase and juxtamembrane (JM) domains of 48 receptor tyrosine kinases (RTKs) onto structurally aligned kinase structures, then clustered known activating mutations along with VUSs based on proximity in three-dimensional structure. …”
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Exploring the genetic diversity and population structure of little-pod false flax (Camelina microcarpa: Brassicaceae) in Ukraine
Published 2025-04-01“…The observed high heterozygosity and complex population structure highlight the potential of C. microcarpa (especially the Southern Ukrainian population) to be used as a germplasm donor for C. sativa breeding programs. …”
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Variability of the structure of correlations between the morphological and commercial traits of soybeans with different growth habit and branching characters
Published 2019-10-01“…A comparison of the level (R2, coefficient of determination) and structure of correlations in different years has shown that the deterioration of external conditions is followed by an increase in the strength of relationships (R2) between the traits and in the difference between correlation matrices’ structure. …”
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Surgical thyroid pathology in Crimea and Sevastopol: the way COVID-19 pandemic altered the frequency and structure of diseases
Published 2025-06-01“…To evaluate the impact of the COVID-19 pandemic on the structure of surgical thyroid pathology among the population of the Republic of Crimea and Sevastopol City in 2019–2024 through a retrospective data analysis.Patients and methods. …”
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Comparison of two methods in determining hearing loss type and hearing loss degree: mobile application coded with artificial neural networks and conditional structures
Published 2025-07-01“…Eclipse IDE for Java Developers-2021–03 program in Java programming language was used for the codes written with conditional structures. …”
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Struktur Mikroanatomi Insang Ikan Bandeng di Tambak Wilayah Tapak Kelurahan Tugurejo Kecamatan Tugu Semarang
Published 2013-03-01“…In observations milkfish gill structure mikroanatomi showed that tissue damage caused by damage structure it’s self.…”
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Active Vibration Control of Cantilever Structures by Integrating the Closed Loop Control Action into Transient Solution of Finite Element Model and an Application to Aircraft Wing
Published 2025-04-01“…It is observed that the AVC of real engineering structures can be simulated by integrating control action into transient solution in ANSYS.…”
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Approaches to Developing New Complex Meat Products with Preset Qualitiy
Published 2023-12-01Subjects: Get full text
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Resolution on the results of the First All-Russian Forum "Therapeutic Education in Endocrinology"
Published 2022-07-01Subjects: Get full text
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A Generalized Composition Approach in Network Data Envelopment Analysis for Complex Structures: An Application of Higher Education Institutions in Poland
Published 2025-01-01“…To overcome these issues, we build a general composition approach that can be applied to units with any type of structure. Our approach relies on Multi-Objective Programming and, unlike existing methods in the literature, we identify the divisional efficiency scores in a min-max and max-min sense simultaneously. …”
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