Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells by Eui-Hwan Choi, Keun P. Kim

“…Cohesin maintains the cohesion of replicated sister chromatids until their separation at anaphase, whereas condensin facilitates the reorganization of chromosomes into a highly compact structure characteristic of mitosis. First, we found via ChIP-seq analysis that cohesins (SMC3, RAD21, and REC8) and condensin (SMC4) share DNA binding sites in close proximity and directly interact with the insulator protein CTCF. …”
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Building Professional Skills and Reducing Student Stress with Competency-based Education: An Exploratory Case Study by Ajay Rampersad, Noah Gentner

“…The results revealed five principal themes: (1) balancing flexibility with structure, (2) enhancing practical skills for career preparedness, (3) supportive learning through instructor and peer engagement, (4) navigating challenges in course design and workload, and (5) positive impact of mastery-based assessment. …”
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A Study of Prosocial Trends of Mothers with Children with Down Syndrome by Mambetalina Gaukhar, Aubakirova Zhanat, Medetbekova Anar, Burganova Roza

“…The results highlight a complex structure of prosociality, emphasizing individual differences in how these mothers respond to various social contexts. …”
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Crisis of the EU Eastern Policy by I. V. Bolgova

“…The article analyses key misperceptions of the actors involved in the complex of interactions in the region. The structure is complicated by the deepening and widening of Russia-lead Eurasian integration project. …”
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Aspects of the socio‐economic situation of disabled people in Russia by D.V. Nekipelova

“…The key aspects are reflected, including the legal basis for support, accessibility of the environment, education, employment, income level and structure of expenses of households consisting of disabled people. …”
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Order fulfillment planning with crowdsourcing integration by Xuejing Cao, Zhongmin Da, Xuefei Wang

“…To tackle the computational complexity, we develop an adaptive large neighborhood search algorithm tailored to exploit the problem structure and handle large-scale instances efficiently. …”
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Reliability analysis of passive residual heat removal system for large advanced pressurized water reactors by Tianrui Li, Xinkun Xiao, Guoqing Lu, Shikang Chen, Ronghua Chen, Wenxi Tian

“…Such comprehensive analysis contributes to ensuring the safe operation and advancement of nuclear power plants. The best-estimate program VITARS is used to analyze and calculate accident scenarios, with sensitivity analysis conducted based on preliminary thermal-hydraulic calculations to optimize parameter selection and simplify the response surface model structure, thereby streamlining the analysis process. …”
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Methodical foundations of the use of project-based technologies in teaching physics to students of technical specialties of higher education institutions by А.Б. Искакова, А.К. Каирбаева

“…The paper also proposes a general structure of the educational project for one semester. …”
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THE PROBLEMS OF PERFORMANCE MONITORING TO TAKLE THE TASKS OF THE AIRCRAFT CONTINUED AIRWORTHINESS by Yu. M. Chinyuchin

“…Not least important among the issues of resource and age structure monitoring to be considered is the need to improve the design of aircraft, taking into account preliminary technical and economic feasibility assessment of its modifications in the interests of the operator. …”
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Modelled impact of Tiny Targets on the distribution and abundance of riverine tsetse. by Glyn A Vale, John W Hargrove, Andrew Hope, Steve J Torr

“…Particular attention was given to demonstrating that the model could explain three matters of interest: (i) good control can be achieved despite the degradation of targets, (ii) local elimination of tsetse is impossible if invasion sources are not tackled, and (iii) with invasion and target degradation it is difficult to detect any effect of control on the age structure of the tsetse population.<h4>Conclusions</h4>Despite its simplifications, the model can assist planning and teaching, but allowance should be made for any complications due to seasonality and management challenges associated with greater scale.…”
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Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale. by André Golldack, Björn Henke, Bärbel Bergmann, Marie Wiechert, Holger Erler, Alexandra Blancke Soares, Tobias Spielmann, Eric Beitz

“…Resistance selection of cultured P. falciparum parasites with sub-lethal concentrations of MMV007839 produced a single nucleotide exchange in the PfFNT gene; this, and functional characterization of the resulting PfFNT G107S validated PfFNT as a novel antimalarial target. From quantitative structure function relations we established the compound binding mode and the pharmacophore. …”
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Novel mTORC2/HSPB4 Interaction: Role and Regulation of HSPB4 T148 Phosphorylation by Zachary B. Sluzala, Yang Shan, Lynda Elghazi, Emilio L. Cárdenas, Angelina Hamati, Amanda L. Garner, Patrice E. Fort

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The intervening role of the image of green brands in increasing green brands’ purchasing intention of personal care product by Sutisna, Elisiyah, Umalihayati, Syamsul Hidayat, Theresia Gunawan

“…The data analysis employed a structural equation model utilizing SMART-partial least square.The study’s findings suggest that green marketing (β = 0.665, p = 0.000) and corporate social responsibility (β = 0.205, p = 0.000) are essential for establishing an image of a green brand. …”
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Toroidal distribution of heat load on castellated plasma facing components for lower divertor target in EAST by Wenxue Fu, Dahuan Zhu, Binfu Gao, Zongxiao Guo, Bin Zhang, Mehdi Firdaouss, Chuannan Xuan, Rong Yan, Yang Wang, Chunyu He, Yi Li, Baoguo Wang, Rui Ding, Junling Chen

“…The lower divertor of EAST adopts an ITER-like cassette modules (CMs) structure. However, regular distribution of damage along the toroidal direction have been observed on the divertor target plates, which not only affects the lifespan of PFCs but also limits the long-pulse and high-performance plasma operations. …”
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Fine-grained forecasting of COVID-19 trends at the county level in the United States by Tzu-Hsi Song, Leonardo Clemente, Xiang Pan, Junbong Jang, Mauricio Santillana, Kwonmoo Lee

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TRANSFORMATION OF ETHYL-P-METHOXYCINNAMATE TO P –METHOXYCINNAMIC ACID FROM KENCUR (Kaempheria galanga L.) AND THEIR ANTIBACTERIAL ACTIVITY by Muhamad Salman Fareza, Rehana Rehana, Nuryanti Nuryanti, Didin Mujahidin

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Computational Model and Constructal Design Applied to Thin Stiffened Plates Subjected to Elastoplastic Buckling Due to Combined Loading Conditions by Raí Lima Vieira, Guilherme Ribeiro Baumgardt, Elizaldo Domingues dos Santos, Luiz Alberto Oliveira Rocha, Thiago da Silveira, João Paulo Silva Lima, Liércio André Isoldi

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Gender differences and factors affecting opinions on condom use and sexual experiences among adolescents in a high teenage pregnancy setting in the Volta Region, Ghana by Desmond Klu, Percival Delali Agordoh, Charles Azagba, Evelyn Acquah, Phidelia Doegah, Alfred Kwesi Manyeh, Evelyn Korkor Ansah, Margaret Gyapong

“…Methods Data for this study were extracted from a larger primary baseline cross-sectional study among 188 adolescents (109 girls and 79 boys) aged 10–19 years in 30 communities. Data from a semi-structured questionnaire were analyzed using a bivariate analysis and binary logistic regression. …”
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The effect of prenatal education on exclusive breastfeeding among women in Quito: prospective cohort study by Betzabé Tello, Herminio Hernández, Iván Dueñas-Espín, Eduardo Tejera

“…Data collection included a structured survey, with baseline clinical information obtained through face-to-face interviews before hospital discharge and follow-up telephone interviews at one, four, and six months postpartum. …”
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HIV risk perception and associated factors among pregnant and breastfeeding women in Zambia: implications for PrEP uptake in antenatal and postnatal settings by Twaambo Euphemia Hamoonga, Wilbroad Mutale, Karen Hampanda, Benjamin H. Chi

“…Study team members administered a structured questionnaire to pregnant and breastfeeding women at the hospital's maternal and child health clinic to get information on socio-demographics, obstetrics and pregnancy history, sexual behavior and HIV risk perception. …”
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