Deciphering the structural and dynamic effects of SHP2-E76 mutations: mechanistic insights into oncogenic activation by Humaira Rafiq, Lu Han, Ashfaq Ur Rehman, Pei He, Ali Saber Abdelhameed, Eman S. G. Hassan, Hongxia Fu, Abdul Wadood, Junjian Hu

“…These mutations disrupt the closed conformation, which normally keeps SHP2 in an inactive, auto-inhibited state, thereby enhancing phosphatase activity and activating SHP2, leading to a gain-of-function effect. However, the structural and functional implications of these disease-related mutants are not well elucidated. …”
Get full text

RNA editing-induced structural and functional adaptations of NAD9 in Triticum aestivum under drought stress by Nermin G. Mohamed, Ahmed M. Ramadan, Ahmed M. Ramadan, Marwa Amer, Yasser Morsy, Yasser Morsy, Rasha A. Mohamed, Osama A. M. Said, Afnan A. Alnufaei, Mona I M. Ibrahim, Sameh E. Hassanein, Sameh E. Hassanein, Hala F. Eissa, Hala F. Eissa

Get full text

IL-17-neutralizing antibody mitigates functional and structural changes in cigarette smoke-induced COPD model by Alyne Riani Moreira, Camila Uchoa da Silva, Leticia de Paula Costa Mattos, Jussara Jesus Simão, Veronica Camargo Berti, Luan Henrique Vasconcelos Alves, Alex Ferreira da Silva, Franciele Jesus Lima, Suellen Karoline Moreira Bezerra, Cintia Nascimento Silva, Maria Isabel Cardoso Allonso- Vale, Iolanda de Fatima Lopes Calvo Tiberio, Francine Maria Almeida, Fernanda Degobbi Tenorio Quirino dos Santos Lopes, Fernanda Degobbi Tenorio Quirino dos Santos Lopes

Get full text

Chebfun approximation to structure of positive radial solutions for a class of supercritical semi-linear Dirichlet problems by Călin I. Gheorghiu

“… We use the Chebfun programming package to approximate numerically the structure of the set of positive radial solutions for a class of supercritical semilinear elliptic Dirichlet boundary value problems. …”
Get full text

PELATIHAN PENYELESAIAN SOAL-SOAL STRUCTURE AND WRITTEN EXPRESSION BEREKUIVALENSI TOEFL PADA SISWA SMK TELKOM PEKANBARU by Qori Islami Aris, Essy Syam

“…In this program, the community service team will provide strategies or tips in solving each problem in the Structure and Written Expression session. …”
Get full text

Syntactic Representation of predicational copular clauses in Persian Language by Maryam Khamse Ashari, Rezvan Motavallian

“…This article explores predicational copular sentences in Persian through the lens of the minimalist program. The analysis of these structures is approached from two key perspectives: symmetrical structure analysis and asymmetrical structure analysis. …”
Get full text

Consider the Multi-Objective Topology Optimization Design of a Space Structure Under Complex Working Conditions by Feng Jia, Pan Gao, Aodong Mo

“…Two sets of comparative experiments are used to verify the effectiveness of the simulation results and the rationality of using the multi-objective topology optimization design method for the lightweight design of space structures under complex working conditions. The conclusion can provide a theoretical reference for the lightweight design of supporting components for spacecraft and other systems.…”
Get full text

Identity Politics of Papuan Indigenous Ethnics in the Position Seizure Contestation: A Case Study of the OPD Structural Positions in the Governmental Bureaucracy in Papua by Ferinandus Leonardo Snanfi, Muhadjir Darwin, Setiadi Setiadi, Hakimul Ikhwan

“…The purpose of ethnics identity politics applied in the governmental bureaucracy include to dominate economic resources that are much such as:  Otsus Fund, APBD, PAD, DAK, DAU, governmental projects and programs for self ethnic interest and political groups in the governmental bureaucracy. (2) The filling of the OPD structural position of the governmental bureaucracy. …”
Get full text

Dynamic Response of a Bedding Rock Slope Reinforced by a Pile–Anchor Structure Under Earthquakes by Kaiyang Wang, Xianggui Yu, Zhuqiang Chu, Yanyan Li

“…This study explores the dynamic behavior of a bedding rock slope strengthened by pile–anchor structures in a seismic-prone region of China. We propose a method for the automatic application of viscoelastic boundaries and input of seismic waves in ABAQUS (version 2021) using MATLAB R2023a programming. …”
Get full text

The development of two Point of Care Ultrasound stations for Objective Structured Clinical Examinations in undergraduate medical education by Ryan Good, Juliana Wilson, Joshua C Kaine, Vijay J Daniels, Janeve Dessy, Joshua Lloyd, Gillian Sheppard, Linden Kolbenson, Irene WY Ma, Arthur Au, Paul Adam Olszynski

“…Validated assessment tools provide empirical evidence regarding trainee performance while also informing program-level evaluation. We developed two POCUS-specific stations for objective structured clinical examinations (OSCEs) to assess skill acquisition and inform best practices in undergraduate medical education. …”
Get full text

Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Carl Lawrence Arenos, Franessa Ysabel Dianne Chan Huan-Jacinto, Josephine Anne Lucero, Frederic Ivan Ting, Marvin Jonne Mendoza, Madelaine Amante, Danielle Benedict Sacdalan, John Paulo Vergara

“…Future studies must therefore be designed to account for confounders intrinsic to the underlying disease of study participants to better determine both the efficacy and the safety of structured, adjunctive exercise programs in this patient population.…”
Get full text

The Impact of a Hybrid Training Program on Point-of-Care Ultrasound (POCUS) Knowledge Acquisition & Skills among Non-ultrasound Trained Physicians by Maryam Alnuaimi, Hamid Shokoohi, Deborah Navedo, Roger Dias

Get full text

Vibration energy flow in welded connection of plates by J. Cieślik, W. Bochniak

“…The formulas were used in the program algorithm for structural intensity calculations. …”
Get full text

Building competence in systematic reviews and meta-analyses through structured mentorship: An IPS Karnataka chapter initiative by Vijaykumar Harbishettar, Lakshmi Shiva, Swarna B. Nayok, Ravindra Neelakanthappa Munoli

“…Hand-holding structured schedule with rigorous follow-up of the dedicated participating team members was distinct. …”
Get full text

An objective structured teaching exercise for faculty training and assessment of teaching ability in interprofessional collaborative practice and education by Hsiu-Chen Yeh, Sin-Yi Huang, Tsung-Ying Chen, Ming-Chen Hsieh

“…Materials and Methods: Health-care faculty members were studied; this study assessed a teacher education curriculum for interprofessional education (IPE) and applied an objective structured teaching exercise (OSTE) to evaluate IPE execution by clinical teachers. …”
Get full text

Structuring Corporate Governance in the Context of Crisis: Lessons from the COVID-19 Pandemic in a Nonprofit Organization by Raffaella Regueira de Oliveira, Osvaldo Luiz Gonçalves Quelhas, Níssia Carvalho Rosa Bergiante

Get full text

Investigation on Thrust Force Conversion Method of Oscillating Caudal Fin Based on Wake Vortex Field Structure by Hongjie Ling, Zhidong Wang

Get full text

Structure of rheumatic diseases among adult population of Russia according to data of an epidemiological study (preliminary results) by E A Galushko, T Y Bolshakova, I B Vinogradova, O N Ivanova, O M Lesnyak, L V Menshikova, T N Petrachkova, S F Erdes

“…Preliminary results of program diagnostic stage demonstrated significance of joint pathology problem and allowed to get the first data about structure of RD among adult inhabitants of Russia.…”
Get full text

Structured Teaching Programme on Knowledge Regarding Management of Obstructed Labor Among Final Year GNM Students by Noorjan K S, Preethi D’Souza

“…Objectives To assess the pre-existing knowledge prepare and administer the structured teaching program and to assess the effectiveness of structured teaching program by comparing the pre and post-test knowledge scores regarding the management of obstructed labour.Methods The study was conducted at a selected school of nursing and one group pre-test post-test experimental research design was used for the study. …”
Get full text

Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin by Grace Arhin, Sarah C. Keane

Get full text