Benchmark Investigation of SARS-CoV-2 Mutants’ Immune Escape with 2B04 Murine Antibody: A Step Towards Unraveling a Larger Picture by Karina Kapusta, Allyson McGowan, Santanu Banerjee, Jing Wang, Wojciech Kolodziejczyk, Jerzy Leszczynski

“…Three essentially different algorithms were employed: forced placement based on a template, followed by two steps of extended molecular dynamics simulations; protein–protein docking utilizing PIPER (an FFT-based method extended for use with pairwise interaction potentials); and the AlphaFold 3.0 model for complex structure prediction. …”
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Deep-Learning-Based Computer-Aided Grading of Cervical Spinal Stenosis from MR Images: Accuracy and Clinical Alignment by Zhiling Wang, Xinquan Chen, Bin Liu, Jinjin Hai, Kai Qiao, Zhen Yuan, Lianjun Yang, Bin Yan, Zhihai Su, Hai Lu

“…<b>Objective:</b> This study aims to apply different deep learning convolutional neural network algorithms to assess the grading of cervical spinal stenosis and to evaluate their consistency with clinician grading results as well as clinical manifestations of patients. …”
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Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision me... by Yutong Fang, Rongji Zheng, Yefeng Xiao, Qunchen Zhang, Junpeng Liu, Jundong Wu

“…We constructed ML-based diagnostic models using 12 algorithms and evaluated their performance for identifying the optimal ML diagnostic model. …”
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Constructing a tumor immune microenvironment-driven prognostic model in acute myeloid leukemia using bioinformatics and validation data by Amir Abbas Navidinia, Ali Keshavarz, Bentol Hoda Kuhestani Dehaghi, Reza Khayami, Najibe Karami, Vahid Amiri, Mehdi Allahbakhshian Farsani

“…ROC analysis demonstrated predictive accuracy (AUC: 63.38–68.5% for 1–5-year survival). …”
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Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective coh... by Damien Denimal, Maharajah Ponnaiah, Franck Phan, Anne-Caroline Jeannin, Alban Redheuil, Joe-Elie Salem, Samia Boussouar, Pauline Paulstephenraj, Suzanne Laroche, Chloé Amouyal, Agnès Hartemann, Fabienne Foufelle, Olivier Bourron

“…We also measured the serum biomarkers included in the FibroMax® panels (SteatoTest®, FibroTest®, NashTest®, ActiTest®). The predictive ability of these biomarkers of MASLD on LLACS progression was assessed through univariate and multivariate linear regression models, principal component regression analysis, as well as machine learning algorithms. …”
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Identifying Common Diagnostic Biomarkers and Therapeutic Targets between COPD and Sepsis: A Bioinformatics and Machine Learning Approach by Li X, Xiao Y, Yang M, Zhang X, Yuan Z, Zhang Z, Zhang H, Liu L, Zhao M

“…Immune cell infiltration was analyzed with CIBERSORT, while transcription factor (TF) and miRNA networks were constructed using NetworkAnalyst. Drug predictions were made using DSigDB, and molecular docking validated potential drugs.Results: Three immune cell types were identified as mediators between COPD and sepsis, with genetically predicted effects mediated by these cells at rates of 6.5%, 12.8%, and 3.9%. …”
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Age and Saving Lives in Crisis Standards of Care: A Multicenter Cohort Study of Triage Score Prognostic Accuracy by Michael Hermsen, MD, MS, Patrick G. Lyons, MD, MS, Govind Persad, JD, PhD, Alice F. Bewley, MS, Chengsheng Mao, PhD, Kaveri Chhikara, MS, Anoop Mayampurath, PhD, Matthew Churpek, MD, PhD, Monica E. Peek, MD, MPH, MSc, Yuan Luo, PhD, William F. Parker, MD, PhD

“…SOFA score substantially overpredicted mortality (13% predicted vs. 5% observed) for younger patients (< 40 yr) and underestimated mortality (14% predicted vs. 31% observed) for older patients (> 80 yr). …”
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Associations between age, red cell distribution width and 180-day and 1-year mortality in giant cell arteritis patients: mediation analyses and machine learning in a cohort study by Si Chen, Rui Nie, Xiaoran Shen, Yan Wang, Haixia Luan, Xiaoli Zeng, Yanhua Chen, Hui Yuan

“…Logistic and Cox regression analyses, Kaplan–Meier (KM) survival analysis, restricted cubic spline (RCS) analysis, and mediation effect analysis were employed to investigate the association between age, RDW levels, and 180-day and 1-year mortality in GCA patients hospitalized or admitted to the ICU. Predictive models were constructed using machine learning algorithms, and SHapley Additive exPlanations (SHAP) analysis was applied to evaluate the contributions of age and RDW levels to mortality in this patient population. …”
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New machine-learning models outperform conventional risk assessment tools in Gastrointestinal bleeding by Eszter Boros, József Pintér, Roland Molontay, Kristóf Gergely Prószéky, Nóra Vörhendi, Orsolya Anna Simon, Brigitta Teutsch, Dániel Pálinkás, Levente Frim, Edina Tari, Endre Botond Gagyi, Imre Szabó, Roland Hágendorn, Áron Vincze, Ferenc Izbéki, Zsolt Abonyi-Tóth, Andrea Szentesi, Vivien Vass, Péter Hegyi, Bálint Erőss

“…We analyzed the prospective, multicenter Hungarian GIB Registry’s data. The predictive performance of XGBoost and CatBoost machine-learning algorithms with the Glasgow-Blatchford (GBS), pre-endoscopic Rockall and ABC scores were compared. …”
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Prominent events in the development of a simultaneous multidiagnostic system with synthetic peptides by Oscar Noya, Henry Bermúdez, Diana Pachón, Belkisyolé Alarcón de Noya, Diana Ortiz-Princz, Flor Helene Pujol, Sandra Losada

“…Years of work have been required for this complex process, with the recent incorporation of new immunoinformatic predictive tools, methodologies, and cost advantages. …”
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Clinical-radiomics hybrid modeling outperforms conventional models: machine learning enhances stratification of adverse prognostic features in prostate cancer by Minghan Jiang, Minghan Jiang, Zeyang Miao, Run Xu, Mengyao Guo, Xuefeng Li, Guanwu Li, Peng Luo, Su Hu, Su Hu

“…LASSO regression selected optimal features, followed by model construction via five algorithms (logistic regression, decision tree, random forest, SVM, AdaBoost). …”
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Automated Lightweight Model for Asthma Detection Using Respiratory and Cough Sound Signals by Shuting Xu, Ravinesh C. Deo, Oliver Faust, Prabal D. Barua, Jeffrey Soar, Rajendra Acharya

“…Additionally, a majority voting ensemble technique was employed to aggregate the predictions of the various classifiers for improved diagnostic reliability. …”
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Atrial fibrillation and chronic kidney disease: main clinical characteristics of patients in selected subjects of the Russian Federation by M. A. Druzhilov, T. Yu. Kuznetsova, O. Yu. Druzhilova, U. D. Arustamova, D. V. Gavrilov, A. V. Gusev

“…The information was taken from the Webiomed predictive analytics platform, including 80775 patients with AF (men, 42,5%, mean age, 70,0±14,3 years) who underwent outpatient and/or inpatient treatment in medical organizations in 6 Russian subjects in 2016-2019 with data on blood creatinine levels. …”
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Unveiling the role of TGF-β signaling pathway in breast cancer prognosis and immunotherapy by Yifan Zheng, Yifan Zheng, Li Li, Wenqian Cai, Lin Li, Rongxin Zhang, Wenbin Huang, Wenbin Huang, Yulun Cao

“…To assess patient risk, we used 101 machine learning algorithms to develop an optimal TGF-β pathway-related prognostic signature (TSPRS). …”
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Investigating potential biomarkers associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis using Mendelian randomization and transcriptomic analysis by Yujia Wang, Zhimin Chen, Kaiqi Huang, Keng Ye, Shiwei He, Yanfang Xu, Hong Chen

“…Genes with a significant causal relationship were selected as candidate genes for further analysis. Machine learning algorithms, ROC curve analysis, and expression evaluation were employed to screen for biomarkers. …”
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Preoperative digital 6-minute walk test reveals risk of postoperative pulmonary complications in patients undergoing heart valve surgery: a pilot feasibility study by Lixuan Li, Yuqiang Wang, Zhengbo Zhang, Zeruxin Luo, Wenqing Wang, Jiachen Wang, Xiaoli Liu, Ying Shi, Tian Yuan, Yong Fan, Hong Liang, Yingqiang Guo, Buqing Wang, Jing Wang, Jiaoxue Deng

“…We extracted 94 physiological features across 6MWT phases (baseline, walking, recovery) and clinical variables, developing predictive models using five machine learning algorithms evaluated through rigorous five-fold cross-validation. …”
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Comprehensive Transcriptome Sequencing and Analysis of <i>Euspira gilva</i>: Insights into Aquaculture and Conservation by Zhixing Su, Jiayuan Xu, Xiaokang Lv, Xuefeng Song, Yanming Sui, Benjian Wang, Xiaoshan Wang, Bianbian Zhang, Baojun Tang, Liguo Yang

“…A total of 7929 simple sequence repeat (SSR) loci were identified, with single nucleotide repeats predominating at 85.0%. Predictive analysis of coding DNA sequences (CDS) resulted in 1340 BLAST comparisons, while ESTScan predicted 840. …”
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CTAB modified SnO₂ PEDOT PSS heterojunction humidity sensor with enhanced sensitivity stability and machine learning evaluation by Poundoss Chellamuthu, Kirubaveni Savarimuthu, M Gulam Nabi Alsath, R. Krishnamoorthy, Yuvaraj T, Feras Alnaimat, Mohammad Shabaz

“…Furthermore, to validate real-time application feasibility, machine learning (ML) algorithms were implemented to model and predict sensor behavior. …”
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Machine Learning-Based Interpretable Screening for Osteoporosis in Tuberculosis Spondylitis Patients Using Blood Test Data: Development and External Validation of a Novel Web-Based... by Yasin P, Ding L, Mamat M, Guo W, Song X

“…Multiple machine learning (ML) algorithms, including logistic regression, random forest, and XGBoost, were trained and optimized using nested cross-validation and hyperparameter tuning. …”
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Integrated bioinformatics analysis to develop diagnostic models for malignant transformation of chronic proliferative diseases by Hua Liu, Sheng Lin, Pei-Xuan Chen, Juan Min, Xia-Yang Liu, Ting Guan, Chao-Ying Yang, Xiao-Juan Xiao, De-Hui Xiong, Sheng-Jie Sun, Ling Nie, Han Gong, Xu-Sheng Wu, Xiao-Feng He, Jing Liu

“…Lactoferrin (LTF) and G protein-coupled receptor 65 (GPR65) were integrated into a nomogram with a robust predictive power. The predicted drug vemurafenib inhibited proliferation and increased apoptosis in PV and AML cells. …”
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