Biological and prognostic insights into the prostaglandin D2 signaling axis in lung adenocarcinoma by Qiang Liu, Huiguo Chen, Dongfang Tang, Huibiao Zhang, Shaogeng Chen, Yiran Meng, Boying Zheng, Fei Liu, Jing Zhou, Wen Zhang

“…Furthermore, we found that a risk model developed based on this signaling axis could predict responses to immune therapy in hot and cold tumors, suggesting potential drugs that may benefit low-risk patients. …”
Get full text

Identifying bellwether sewershed sites for sustainable disease surveillance in Bengaluru, India: a longitudinal studyResearch in context by Rebecca Fern Daniel, Subash K. Kannan, Namrta Daroch, Sutharsan Ganesan, Farhina Mozaffer, Vishwanath Srikantaiah, Lingadahalli Subrahmanya Shashidhara, Rakesh Mishra, Farah Ishtiaq

“…This was achieved by integrating established metrics for wastewater analysis, calculating sample-to-sample percentage rate of change, and applying algorithms to differentiate signal from noise, thereby validating factors contributing to the precision and reliability of outbreak predictions. …”
Get full text

MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3 by Lou Zhong, Siyuan Sun, Jiahai Shi, Fei Cao, Xiao Han, Zhong Chen

“…The downregulation of miR-125a-5p provided very contrasting results. Computational algorithms predicted that the STAT3 is a target of miR-125a-5p. …”
Get full text

Role of ARRB1 in prognosis and immunotherapy: A Pan-Cancer analysis by Yingquan Ye, Yingquan Ye, Haili Jiang, Haili Jiang, Yue Wu, Yue Wu, Gaoxiang Wang, Gaoxiang Wang, Yi Huang, Yi Huang, Weijie Sun, Mei Zhang, Mei Zhang

“…ESTIMATE and CIBERSORT algorithms were performed to assess immune infiltration. …”
Get full text

Graph cut-based segmentation for intervertebral disc in human MRI by Leena Silvoster, R. Mathusoothan S. Kumar

Get full text

Generalized third-kind Chebyshev tau approach for treating the time fractional cable problem by Waleed Mohamed Abd-Elhameed, Omar Mazen Alqubori, Abdulrahman Khalid Al-Harbi, Mohammed H. Alharbi, Ahmed Gamal Atta

Get full text

Method of Entry Layout under Synergistic Effects of Abutment Stress and Dynamic Stress by Wenlong Shen, Guocang Shi, Meng Wang, Tenglong Rong, Yungang Wang, Ruifeng Zhang, Xiangyu Wang, Jianbiao Bai

Get full text

Construction and validation of renal cell carcinoma tumor cell differentiation-related prognostic classification (RCC-TCDC): an integrated bioinformatic analysis and clinical study by Yifan Liu, Keqin Dong, Yuntao Yao, Bingnan Lu, Lei Wang, Guo Ji, Haoyu Zhang, Zihui Zhao, Xinyue Yang, Runzhi Huang, Wang Zhou, Xiuwu Pan, Xingang Cui

“…In addition, we performed correlation analysis and Cmap algorithm for regulatory network establishment and candidate inhibitor prediction. …”
Get full text

Adaptive surge control of variable-mass unmanned surface vehicle based on super-twisting sliding mode observation by Zhaokun YAN, Guanyu YANG, Hongdong WANG

Get full text

Addressing Spatial Variability in Estimating Cover Management Factor of Soil Erosion Models using Geoinformatics: A Case Study of Netravati Catchment, Karnataka, India by Waleed Makhdumi, Shwetha H. R., G. S. Dwarakish, Jagadeesha B. Pai

“…This study presents a region-specific approach for estimating the C factor, serving as a reliable tool for improving soil erosion predictions in the Western Ghats and Coastal Plains of India. …”
Get full text

Identification and validation of key biomarkers associated with immune and oxidative stress for preeclampsia by WGCNA and machine learning by Tiantian Yu, Tiantian Yu, Tiantian Yu, Guiying Wang, Guiying Wang, Guiying Wang, Xia Xu, Xia Xu, Xia Xu, Jianying Yan, Jianying Yan, Jianying Yan

“…Additionally, we constructed a miRNA - gene regulatory network for the identified diagnostic genes and predicted potential candidate drugs. In the final step, we validated the significant hub gene using independent external datasets, the hypoxia model of the HTR-8/SVneo cell line, and human placental tissue samples.ResultsAt last, leptin (LEP) was identified as a core gene through screening and was found to be upregulated. …”
Get full text

Improving early epidemiological assessment of emerging Aedes-transmitted epidemics using historical data. by Julien Riou, Chiara Poletto, Pierre-Yves Boëlle

Get full text

Improving accessibility to radiotherapy services in Cali, Colombia: cross-sectional equity analyses using open data and big data travel times from 2020 by Luis Gabriel Cuervo, Carmen Juliana Villamizar, Daniel Cuervo, Pablo Zapata, Maria B. Ospina, Sara Marcela Valencia, Alfredo Polo, Ángela Suárez, Maria O. Bula, J. Jaime Miranda, Gynna Millan, Diana Elizabeth Cuervo, Nancy J. Owens, Felipe Piquero, Janet Hatcher-Roberts, Gabriel Dario Paredes, María Fernanda Navarro, Ingrid Liliana Minotta, Carmen Palta, Eliana Martínez-Herrera, Ciro Jaramillo, on behalf of the AMORE Project Collaboration

“…We predicted accessibility cumulative opportunities (ACO) for traffic ranging from peak congestion to free-flow conditions with hourly assessments for 6–12 July 2020 and 23–29 November 2020. …”
Get full text

Primary health care data-based early warning system for dengue outbreaks: a nationwide case study in BrazilResearch in context by Rejane Santos-Silva, Pilar Tavares Veras Florentino, Thiago Cerqueira-Silva, Vinicius de Araújo Oliveira, Juracy Bertoldo Junior, George C.G. Barbosa, Gerson O. Penna, Viviane S. Boaventura, Pablo I. Pereira Ramos, Manoel Barral-Netto, Izabel Marcilio

“…We assessed EWS timeliness, sensitivity, and positive predictive value (PPV) against fixed-incidence dengue outbreak thresholds. …”
Get full text

A prognostic model of 8-T/B cell receptor-related signatures for hepatocellular carcinoma by Xuan Zuo, Hui Li, Shi Xie, Mengfen Shi, Yujuan Guan, Huiyuan Liu, Rong Yan, Anqi Zheng, Xueying Li, Jiabang Liu, Yifan Gan, Haiyan Shi, Keng Chen, Shijie Jia, Guanmei Chen, Min Liao, Zhanhui Wang, Yanyan Han, Baolin Liao

“…Conclusions Together, our study screened a TCR/BCR-related signature prognostic model, which might turn into a beneficial and practical tool to solve the perplexities of the treatment, prognosis prediction and management for HCC patients.…”
Get full text

Artificial intelligence in psychiatry: A systematic review and meta-analysis of diagnostic and therapeutic efficacy by Moustaq Karim Khan Rony, Dipak Chandra Das, Most. Tahmina Khatun, Silvia Ferdousi, Mosammat Ruma Akter, Mst. Amena Khatun, Most. Hasina Begum, Md Ibrahim Khalil, Mst. Rina Parvin, Daifallah M Alrazeeni, Fazila Akter

Get full text

Knowledge Graph Reasoning Based on Tensor Decomposition and MHRP-Learning by Tangsen Huang, Xiaowu Li, Sheping Zhai, Juanli Wei

Get full text

Circulating biomarkers associated with pediatric sickle cell disease by Cecilia Elorm Lekpor, Cecilia Elorm Lekpor, Cecilia Elorm Lekpor, Felix Abekah Botchway, Adel Driss, Alaijah Bashi, Afua D. Abrahams, Kwadwo Asamoah Kusi, Godfred Futagbi, Ernest Alema-Mensah, William Agbozo, Wesley Solomon, Adriana Harbuzariu, Andrew A. Adjei, Jonathan K. Stiles

“…We conclude that a predictive algorithm based on these biomarkers could be developed and validated through longitudinal assessment of within-genotype differences and correlation of the data with disease severity or outcomes. …”
Get full text

Computational Reconstruction of the Volatility Term Structure in the General Hull–White Model by Slavi G. Georgiev, Lubin G. Vulkov

Get full text

Insight into public sentiment and demand in China’s public health emergency response: a weibo data analysis by Yanping Wang, Min Wei, Peng Wang, Yiran Gao, Tian Yu, Nan Meng, Huan Liu, Xin Zhang, Kexin Wang, Qunhong Wu

“…A total of 50,249 valid comments on 100 blog posts were collected from December 2019 to October 2023 in China. The SnowNLP algorithm was employed for sentiment analysis, Latent Dirichlet Allocation was used for topic clustering, and sampling coding was applied to further explore public demands by condensing the comment texts. …”
Get full text