Kun–Qi birth cohort (KQBC) study for the incidence, aetiology and risk factors of chronic kidney disease in Chinese children: a cohort profile by Yan Ma, Xingdong Chen, Jie Wei, Li Guo, Jian Huang, Li Xie, Lei Chen, Ping Lu, Wei Sun, Wei Shi, Feng Ding, Liping Zhang, Yue Zhang, Linlin Zhang, Rui Song, Yi Huang, Jun Shen, Hong Xu, Zhigang Chen, Qian Shen, Ying Ma, Yiwen Zhang, Hongxia Li, Yihui Zhai, Biao Xu, Xian Zhou, Jun Sun, Bing Wu, Rui Su, Xiaoyan Yu, Jianhong Zhu, Yihong Huang, Ling Gong, Nana Wu, Jingjing Sun, Tianyi Liu, He Yuan, Yiwen Shen, Jiaojiao Liu, Xia Han, Juanjuan Wu, Yinghua Sun, Suxiang Xu, Qinyi Zhang, Na Xie, Jianfeng Ji, Weizhi Mo, Yuanxin Liu, Xinghua Shi, Wanshan Qiu, Jiapeng Mi, Juhua Yan, Minghui Zhu, Pei Feng, Wenqian Sheng, Mingqin Tai, Chunqin Zhou, Qian Jin, Chengyu Gu, Xiujuan Huang, Qinfang Qian, Yixin Cao, Haochen Shen, Ziwen Xue, Yucui Ma, Juan Tian, Yingdan Zhang, Weiyuan Zhuang, Kaiqun Yang, Xiaohui Shen, Yanwei Gu, Beibei Shi, Chenhong Pan, Hongmei Zhou, Xiuchen Zhang, Meihua Tang, Kaixuan Gu, Hongping Liu, Yuanxian Li

“…We aim to develop multimodal risk prediction models by integrating genomics and artificial intelligence algorithms. …”
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Machine learning applications in forecasting patient satisfaction and clinical outcomes after carpal tunnel release: a retrospective study by Zohreh Manoochehri, Sara Manoochehri, Seyed Reza Bagheri, Alireza Abdi, Ehsan Alimohammadi

“…This study aimed to develop a machine learning (ML) model to predict post-CTR patient satisfaction and outcomes, serving as a preoperative screening tool. …”
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Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology by Matteo P. Ferla, Rubén Sánchez-García, Rachael E. Skyner, Stefan Gahbauer, Jenny C. Taylor, Frank von Delft, Brian D. Marsden, Charlotte M. Deane

“…We show that an algorithmic approach (Fragmenstein) that ‘stitches’ the ligand atoms from this structural information together can provide more accurate and reliable predictions for protein–ligand complex conformation than general methods such as pharmacophore-constrained docking. …”
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Ambulatory Oxygen for Pulmonary Fibrosis (OxyPuF): a randomised controlled trial and acceptability study by Rachel L Adams, Alisha Maher, Nicola Gale, Anjali Crawshaw, David Thickett, Alice M Turner

“…Traditional qualitative analysis and arts-based coproduction analysis approaches were used to produce a short film. An economic model was planned but could not occur due to early termination. …”
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GLUcose COntrol Safety & Efficacy in type 2 DIabetes, a systematic review and NETwork meta-analysis. by Guillaume Grenet, Shams Ribault, Giao Bao Nguyen, Faustine Glais, Augustin Metge, Thomas Linet, Behrouz Kassai-Koupai, Catherine Cornu, Théodora Bejan-Angoulvant, Sylvie Erpeldinger, Rémy Boussageon, Aurore Gouraud, Fabrice Bonnet, Michel Cucherat, Philippe Moulin, François Gueyffier

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Exploring the role of neutrophil extracellular traps in neuroblastoma: identification of molecular subtypes and prognostic implications by Can Qi, Can Qi, Ziwei Zhao, Lin Chen, Le Wang, Yun Zhou, Guochen Duan, Guochen Duan

“…A total of five biomarkers,[Selenoprotein P1 (SEPP1), Fibrinogen-like protein 2 (FGL2), NK cell lectin-like receptor K1 (KLRK1), ATP-binding cassette transporters 6(ABCA6) and Galectins(GAL)], were screened, and a risk model based on the biomarkers was created. …”
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Prognostic Risk Signature and Comprehensive Analyses of Endoplasmic Reticulum Stress-Related Genes in Lung Adenocarcinoma by CaiZhen Yang, YuHui Wei, WenTao Li, JinMei Wei, GuoXing Chen, MingPeng Xu, GuangNan Liu

“…A total of 1034 samples from TCGA and GEO were used to screen differentially expressed genes. Further, Random Forest algorithm was utilized to screen characteristic genes related to prognosis. …”
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Joint analysis of single-cell RNA sequencing and bulk transcriptome reveals the heterogeneity of the urea cycle of astrocytes in glioblastoma by Minfeng Tong, Qi Tu, Lude Wang, Huahui Chen, Xing Wan, Zhijian Xu

“…For bulk RNA-seq, univariate Cox and LASSO analyses were undertaken to screen prognostic genes, while multivariate Cox regression analysis was applied to set up a prognostic model. …”
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Effect of miR-200c on inducing autophagy and apoptosis of HT22 cells from mouse hippocampal neurons via regulating PRDM1 protein: a bioinformatics analysis by W. Wu, J. Fu, Q. Liu, Q. Wang, S. Gao, X. Deng, C. Shen

“…The Support Vector Machine (SVM) algorithm in the Weka software was used to process, model, and screen the available miRNA data. …”
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Optimized Landing Site Selection at the Lunar South Pole: A Convolutional Neural Network Approach by Yongjiu Feng, Haoteng Li, Xiaohua Tong, Pengshuo Li, Rong Wang, Shurui Chen, Mengrong Xi, Jingbo Sun, Yuhao Wang, Huaiyu He, Chao Wang, Xiong Xu, Huan Xie, Yanmin Jin, Sicong Liu

“…The combined use of CNN and SHAP enables more effective potential site screening and a deeper understanding of the factors influencing selection. …”
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Immune Evasion Mechanism Mediated by ITPRIPL1 and Its Prognostic Implications in Glioma by Zou Xiaoyun, Ye Wenhao, Wu Huan, Yang Yuanyuan, Liu Changqing, Wen Hebao, Ma Caiyun

“…Ninety‐eight machine learning algorithm combinations were screened to identify the optimal predictive model. …”
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Case-control study combined with machine learning techniques to identify key genetic variations in GSK3B that affect susceptibility to diabetic kidney diseases by Jinfang Song, Yi Xu, Liu Xu, Tingting Yang, Ya Chen, Changjiang Ying, Qian Lu, Tao Wang, Xiaoxing Yin

“…On the other hand, the expression levels and kinase activity of GSK3β in exosomes differed significantly between patients with different genotypes of the GSK3B, suggesting that the effect of GSK3B gene polymorphisms on GSK3β expression and activity may be an important mechanism leading to individual differences in susceptibility to DKD. XG Boost algorithm model identified rs60393216 and rs1488766 as important biomarkers for clinical early warning of DKD.…”
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Identification and validation of endoplasmic reticulum stress-related diagnostic biomarkers for type 1 diabetic cardiomyopathy based on bioinformatics and machine learning by Qiao Tang, Yanwei Ji, Zhongyuan Xia, Yuxi Zhang, Chong Dong, Chong Dong, Qian Sun, Shaoqing Lei

“…The ERDEGs diagnostic model was developed based on a combination of LASSO and Random Forest approaches, and the diagnostic performance was evaluated by the area under the receiver operating characteristic curve (ROC-AUC) and validated against external datasets. …”
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Problems and perspectives of family doctors training on the undergraduate stage by Yu. M. Kolesnik, V. D. Syvolap, N. S. Mikhaylovskaya, T.O. Kulinich

“…For working on practical part of family doctors basic skills it is planned to organize educational and training center at the family ambulatory, and its equipment with the necessary visual means, phantoms, models, simulators, diagnostic, medical apparatus and instruments. …”
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Neutrophil- and Endothelial Cell-Derived Extracellular Microvesicles Are Promising Putative Biomarkers for Breast Cancer Diagnosis by Thayse Batista Moreira, Marina Malheiros Araújo Silvestrini, Ana Luiza de Freitas Magalhães Gomes, Kerstin Kapp Rangel, Álvaro Percínio Costa, Matheus Souza Gomes, Laurence Rodrigues do Amaral, Olindo Assis Martins-Filho, Paulo Guilherme de Oliveira Salles, Letícia Conceição Braga, Andréa Teixeira-Carvalho

“…Machine learning approaches were employed to determine the performance of MVs to identify BC and to propose BC classifier algorithms. <b>Results:</b> Patients with BC had more neutrophil- and endothelial cell-derived MVs than controls before treatment. …”
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Automated Detection of Reduced Ejection Fraction Using an ECG-Enabled Digital Stethoscope by Ling Guo, PhD, Gregg S. Pressman, MD, Spencer N. Kieu, BS, Scott B. Marrus, MD, PhD, George Mathew, PhD, John Prince, PhD, Emileigh Lastowski, MS, Rosalie V. McDonough, MD, MSc, Caroline Currie, BA, John N. Maidens, PhD, Hussein Al-Sudani, MD, Evan Friend, BA, Deepak Padmanabhan, MD, Preetham Kumar, MD, Edward Kersh, MD, Subramaniam Venkatraman, PhD, Salima Qamruddin, MD

“…Recently, electrocardiogram-based algorithms have shown promise in detecting ALVSD. Objectives: The authors developed and validated a convolutional neural network (CNN) model using single-lead electrocardiogram and phonocardiogram inputs captured by a digital stethoscope to assess its utility in detecting individuals with actionably low ejection fractions (EF) in a large cohort of patients. …”
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Multi-Target Mechanism of Compound Qingdai Capsule for Treatment of Psoriasis: Multi-Omics Analysis and Experimental Verification by Qiao Y, Li C, Chen C, Wu P, Yang Y, Xie M, Liu N, Gu J

“…CQC ingredients-targets network was constructed using these ingredients and their targets. Screening of CQC anti-psoriasis core targets using machine learning algorithm. …”
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Advancement of artificial intelligence based treatment strategy in type 2 diabetes: A critical update by Aniruddha Sen, Palani Selvam Mohanraj, Vijaya Laxmi, Sumel Ashique, Rajalakshimi Vasudevan, Afaf Aldahish, Anupriya Velu, Arani Das, Iman Ehsan, Anas Islam, Sabina Yasmin, Mohammad Yousuf Ansari

“…At the same time, the rapidly increasing role of AI in diabetes care is woven into the story, mainly targeting how insulin therapy can be modified and personalized through algorithms and predictive modelling. It leaves a deep review of their pre-existing synergies, which helps understand how collaborative opportunities will unlock the future of T2DM care. …”
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Unveiling diagnostic biomarkers and therapeutic targets in lung adenocarcinoma using bioinformatics and experimental validation by Sixuan Wu, Yuanbin Tang, Qihong Pan, Yaqin Zheng, Yeru Tan, Junfan Pan, Yuehua Li

“…In addition, a machine learning model constructed based on Stepglm[backward] with the random forest algorithm achieved the highest C-index (0.999) and screened eight core genes, among which ST14 was noted for its excellent predictive ability. …”
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Machine learning-based ultrasound radiomics for predicting risk of recurrence in breast cancer by Wei Fan, Hao Cui, Xiaoxue Liu, Xudong Zhang, Xinran Fang, Junjia Wang, Zihao Qin, Xiuhua Yang, Jiawei Tian, Lei Zhang

“…The receiver operating characteristic (ROC), calibration, and decision curve analysis (DCA) curves were used to evaluate the model’s clinical applicability and predictive performance.ResultsA total of 12 ultrasound radiomics features were screened, of which wavelet.LHL first order Mean features weighed more and tended to have a high risk of recurrence. …”
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