Exploring pesticide risk in autism via integrative machine learning and network toxicology by Ling Qi, Jingran Yang, Qiao Niu, Jianan Li

“…Each combination of 1–23 targets was used to construct predictive models using eight different machine learning algorithms. …”
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Machine learning-derived prognostic signature integrating programmed cell death and mitochondrial function in renal clear cell carcinoma: identification of PIF1 as a novel target by Guangyang Cheng, Zhaokai Zhou, Shiqi Li, Fu Peng, Shuai Yang, Chuanchuan Ren

“…Finally, a novel RCC prognostic marker PIF1 was identified in model genes. The knockdown of PIF1 in vitro inhibited the progression of renal carcinoma cells. …”
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Identification and validation of the diagnostic biomarker MFAP5 for CAVD with type 2 diabetes by bioinformatics analysis by Qiang Shen, Lin Fan, Chen Jiang, Dingyi Yao, Xingyu Qian, Fuqiang Tong, Zhengfeng Fan, Zongtao Liu, Nianguo Dong, Chao Zhang, Jiawei Shi

“…Machine learning (ML) algorithms were employed to screen potential biomarkers. …”
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Signatures of Six Autophagy‐Related Genes as Diagnostic Markers of Thyroid‐Associated Ophthalmopathy and Their Correlation With Immune Infiltration by Qintao Ma, Yuanping Hai, Jie Shen

“…The combined six‐gene model also showed good diagnostic efficacy (AUC = 0.948). …”
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Identifying and Validating an Acidosis-Related Signature Associated with Prognosis and Tumor Immune Infiltration Characteristics in Pancreatic Carcinoma by Pingfei Tang, Weiming Qu, Dajun Wu, Shihua Chen, Minji Liu, Weishun Chen, Qiongjia Ai, Haijuan Tang, Hongbing Zhou

“…Univariate Cox regression and the Kaplan–Meier method were applied to screen for prognostic genes. The least absolute shrinkage and selection operator (LASSO) Cox regression was used to establish the optimal model. …”
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Novel insights into the molecular mechanisms of sepsis-associated acute kidney injury: an integrative study of GBP2, PSMB8, PSMB9 genes and immune microenvironment characteristics by Haiting Ye, Xiang Zhang, Pengyan Li, Mei Wang, Ruolan Liu, Dingping Yang

“…Immune cell infiltration was analyzed using the CIBERSORT algorithm, and potential associations between the hub genes and clinicopathological features were explored based on the Nephroseq database. …”
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Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data by Jialiang Lin, Linjuan Huang, Weiming Li, Haijun Xiao, Mingmang Pan

“…Furthermore, in vitro experiments successfully established a DFU oxidative stress model of fibroblasts, revealing reduced migration ability in the absence of cell death. …”
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Association between pace of biological aging and cancer and the modulating role of physical activity: a national cross-sectional study by Jingying Nong, Yu Wang, Yi Zhang

“…Epigenetic clocks, derived from sets of DNA methylation CpGs and mathematical algorithms, have demonstrated a remarkable ability to indicate biological aging and age-related health risks. …”
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Identification and validation of efferocytosis-related biomarkers for the diagnosis of metabolic dysfunction-associated steatohepatitis based on bioinformatics analysis and machine... by Chenghui Cao, Chenghui Cao, Wenwu Liu, Xin Guo, Shuwei Weng, Yang Chen, Yonghong Luo, Shuai Wang, Botao Zhu, Botao Zhu, Yuxuan Liu, Yuxuan Liu, Daoquan Peng

“…This analysis was followed by a series of in-depth investigations, including protein–protein interaction (PPI), correlation analysis, and functional enrichment analysis, to uncover the molecular interactions and pathways at play. To screen for biomarkers for diagnosis, we applied machine learning algorithm to identify hub genes and constructed a clinical predictive model. …”
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Estimation of potato leaf area index based on spectral information and Haralick textures from UAV hyperspectral images by Jiejie Fan, Jiejie Fan, Yang Liu, Yang Liu, Yiguang Fan, Yihan Yao, Riqiang Chen, Mingbo Bian, Yanpeng Ma, Huifang Wang, Haikuan Feng, Haikuan Feng, Haikuan Feng

“…Three types of spectral data—original spectral reflectance (OSR), first-order differential spectral reflectance (FDSR), and vegetation indices (VIs)—along with three types of Haralick textures—simple, advanced, and higher-order—were analyzed for their correlation with LAI across multiple growth stages. A model for LAI estimation in potato at multiple growth stages based on spectral and textural features screened by the successive projection algorithm (SPA) was constructed using partial least squares regression (PLSR), random forest regression (RFR) and gaussian process regression (GPR) machine learning methods. …”
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Integrating bioinformatics and machine learning for comprehensive analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric septic... by Peng Lyu, Na Xie, Xu-peng Shao, Shuai Xing, Xiao-yue Wang, Li-yun Duan, Xue Zhao, Jia-min Lu, Rong-fei Liu, Duo Zhang, Wei Lu, Kai-liang Fan

“…Abstract This study aims to predict and diagnose pediatric septic shock through the screening of immune infiltration-related biomarkers. …”
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Geographic variation in secondary metabolites contents and their relationship with soil mineral elements in Pleuropterus multiflorum Thunb. from different regions by Yaling Yang, Siman Wang, Ruibin Bai, Feng Xiong, Yan Jin, Hanwei Liu, Ziyi Wang, Chengyuan Yang, Yi Yu, Apu Chowdhury, Chuanzhi Kang, Jian Yang, Lanping Guo

“…Conversely, a positive correlation was found between the contents of elements Na, Ce, Ti, and physcion and THSG-5, 2 components that exhibited higher levels in Deqing. Furthermore, an RF algorithm was employed to establish an interrelationship model, effectively forecasting the abundance of the majority of differential metabolites in HSW samples based on the content data of soil mineral elements. …”
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Poor Nutritional Status Increases Risk of Postoperative Adverse Events after Surgical Management of Traumatic Ankle Fracture by Sanket Mehta MD, Nicholas Danford MD

“…Patients with poor nutritional status were older (56 vs. 51 years), more likely to present in shock (7.5% vs. 2.3%) and due to motor vehicle collision mechanism (all P< 0.001). …”
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Generative and predictive neural networks for the design of functional RNA molecules by Aidan T. Riley, James M. Robson, Aiganysh Ulanova, Alexander A. Green

“…We pair these predictive models with generative adversarial RNA design networks (GARDN), allowing the generative modelling of a diverse range of functional RNA molecules with targeted experimental attributes. …”
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Evaluation of the shielding initiative in Wales (EVITE Immunity): protocol for a quasiexperimental study by Stephen Jolles, Ashley Akbari, Andrew Carson-Stevens, Helen Snooks, Alan Watkins, Adrian Edwards, Ann John, Alison Porter, Victoria Williams, Bridie Angela Evans, Ronan Lyons, Bernadette Sewell, Mark Rhys Kingston, Tony Whiffen, Jane Lyons, Rowena Bailey, Catherine A Thornton, Lesley Bethell, Samantha Bufton, Lucy Dixon

“…Clinically extremely vulnerable people identified through algorithms and screening of routine National Health Service (NHS) data were individually and strongly advised to stay at home and strictly self-isolate even from others in their household. …”
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Review of applications of deep learning in veterinary diagnostics and animal health by Sam Xiao, Navneet K. Dhand, Zhiyong Wang, Kun Hu, Kun Hu, Peter C. Thomson, John K. House, Mehar S. Khatkar, Mehar S. Khatkar

“…Deep learning (DL), a subfield of artificial intelligence (AI), involves the development of algorithms and models that simulate the problem-solving capabilities of the human mind. …”
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Research trends among new investigators at ISOQOL: a bibliometric analysis from 2019 to 2023 by Jae-Yung Kwon, Manraj N. Kaur, Ellen B. M. Elsman, Ava Mehdipour, Lori Suet Hang Lo, Ahmed M. Y. Osman, Sandrine Herbelet, Carrie-Anne Ng, Lotte van der Weijst, on behalf of the New Investigators Special Interest Group Members

“…Methodology Data on publications authored by 56 NI-SIG members between 2019 and 2023 were extracted from Web of Science and Scopus. A two-step screening process, guided by the Wilson and Cleary model of QoL, identified 561 unique documents for analysis. …”
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ATP6V0A4 as a novel prognostic biomarker and potential therapeutic target in oral squamous cell carcinoma by Xiaopu Gao, Jiamin Zhou, Yu Qiao, Chuyin Lin, Guanxiong Zhang, Qiuyu Wu, Zhikang Su, Qianji Zhang, Songkai Huang

“…Methods This study initially integrated TCGA and GEO databases for cross-platform differential gene screening. A prognostic model was constructed using univariate Cox regression and LASSO regression, complemented by random forest algorithms to identify core genes. …”
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Impact of ITH on PRAD patients and feasibility analysis of the positive correlation gene MYLK2 applied to PRAD treatment by Chuanyu Ma, Chuanyu Ma, Guandu Li, Xiaohan Song, Xiaochen Qi, Tao Jiang

“…GO and KEGG pathway enrichment analyses were performed on these 103 positively correlated differentially expressed genes, and the proportion and type of tumour-infiltrating immune cells were assessed by TIMER, CIBERSORT, CIBERSORT-ABS, QUANTISEQ, MCPCOUNTER, XCELL and EPIC algorithms in patients. In addition, we calculated the relevance of immunotherapy and predicted various drugs that might be used for treatment and evaluated the predictive power of survival models under multiple machine learning algorithms through the training set TCGA-PRAD versus the validation set PRAD-FR cohort. …”
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Artificial intelligence in breast oncology by Alexander Mundinger

“…Abstract Artificial intelligence (AI) is based on complex artificial neural networks, characterized by layered network architecture, parallel processing of large data sets and iterative algorithms for processing large data sets. AI-assisted screening studies have demonstrated non-inferior diagnostic performance, reduced human workload by up to 70%, and reduced recall rates by 25% compared to human double reading. …”
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