Advances and challenges in immunotherapy in head and neck cancer by Hazem Aboaid, Taimur Khalid, Abbas Hussain, Yin Mon Myat, Rishi Kumar Nanda, Ramaditya Srinivasmurthy, Kevin Nguyen, Daniel Thomas Jones, Jo–Lawrence Bigcas, Kyaw Zin Thein

“…Future research should focus on refining biomarker-driven treatment algorithms, developing rational immunotherapy combinations, and leveraging tumor microenvironment modifications to enhance therapeutic efficacy.…”
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Evaluating Maize Residue Cover Using Machine Learning and Remote Sensing in the Meadow Soil Region of Northeast China by Zhengwei Liang, Jia Du, Weilin Yu, Kaizeng Zhuo, Kewen Shao, Weijian Zhang, Cangming Zhang, Jie Qin, Yu Han, Bingrun Sui, Kaishan Song

“…The Google Earth Engine (GEE) and remote sensing images from 2019 to 2023 were used to obtain spectral characteristics before the maize seedling stage in Northeast China, followed by constructing the CRC estimation models using machine learning algorithms. To avoid the impact of multicollinearity among data, three machine learning algorithms—ridge regression (RR), partial least squares regression (PLSR), and least absolute shrinkage and selection operator (LASSO)—were employed. …”
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Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes by Liping Wang, Ran Zhou, Guanghui Li, Xiaodan Zhang, Yan Li, Yinchen Shen, Junwei Fang

“…Mechanistic pathways governing gene-metabolite-lipid interactions were inferred via random walk with restart algorithms and validated by gene set enrichment analysis (GSEA). …”
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Electrophysiological changes in the acute phase after deep brain stimulation surgery by Lucia K. Feldmann, Diogo Coutinho Soriano, Jeroen Habets, Valentina D'Onofrio, Jonathan Kaplan, Varvara Mathiopoulou, Katharina Faust, Gerd-Helge Schneider, Doreen Gruber, Georg Ebersbach, Hayriye Cagnan, Andrea A. Kühn

“…While beta band activity is confirmed as a reliable biomarker for bradykinesia using chronic recordings, little is known about the ideal time point for initial electrophysiology-based programming. …”
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Population-based colorectal cancer risk prediction using a SHAP-enhanced LightGBM model by Guinian Du, Hui Lv, Yishan Liang, Jingyue Zhang, Qiaoling Huang, Guiming Xie, Xian Wu, Hao Zeng, Lijuan Wu, Jianbo Ye, Wentan Xie, Xia Li, Yifan Sun

“…BackgroundColorectal cancer (CRC) is a highly frequent cancer worldwide, and early detection and risk stratification playing a critical role in reducing both incidence and mortality. we aimed to develop and validate a machine learning (ML) model using clinical data to improve CRC identification and prognostic evaluation.MethodsWe analyzed multicenter datasets comprising 676 CRC patients and 410 controls from Guigang City People’s Hospital (2020-2024) for model training/internal validation, with 463 patients from Laibin City People’s Hospital for external validation. Seven ML algorithms were systematically compared, with Light Gradient Boosting Machine (LightGBM) ultimately selected as the optimal framework. …”
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Non-Celiac Villous Atrophy—A Problem Still Underestimated by Katarzyna Napiórkowska-Baran, Paweł Treichel, Adam Wawrzeńczyk, Ewa Alska, Robert Zacniewski, Maciej Szota, Justyna Przybyszewska, Amanda Zoń, Zbigniew Bartuzi

“…Various immune pathways are involved, such as autoimmune deregulation and chronic inflammatory responses, while drug-induced and environmental factors further complicate its clinical picture. …”
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Machine learning-based diagnostic and prognostic models for breast cancer: a new frontier on the clinical application of natural killer cell-related gene signatures in precision me... by Yutong Fang, Rongji Zheng, Yefeng Xiao, Qunchen Zhang, Junpeng Liu, Jundong Wu

“…We constructed ML-based diagnostic models using 12 algorithms and evaluated their performance for identifying the optimal ML diagnostic model. …”
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Detecting schizophrenia, bipolar disorder, psychosis vulnerability and major depressive disorder from 5 minutes of online-collected speech by Julianna Olah, Win Lee Edwin Wong, Atta-ul Raheem Rana Chaudhry, Omar Mena, Sunny X. Tang

“…Linguistic and paralinguistic features were extracted and ensemble learning algorithms (e.g., XGBoost) were used to train models. …”
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Twice against thrice-weekly hemodialysis (TATH): a multicenter nonrandomized trial by Mabel Aoun, Serge Finianos, Chadia Beaini, Ghassan Sleilaty, Rita Ghaleb, Nicole Nourie, Sami Kais, Joseph El Hajal, Rachad Alameddine, Celine Boueri, Balsam El Ghoul, Sandy Zeidan, Hiba Azar, Antoine Dfouni, Jenny Hawi, Zeina Mechref, Valerie Hage, Dania Chelala

“…Abstract Background The optimal frequency of maintenance hemodialysis remains a subject of debate. …”
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Machine Learning and Deep Learning for Diagnosis of Lumbar Spinal Stenosis: Systematic Review and Meta-Analysis by Tianyi Wang, Ruiyuan Chen, Ning Fan, Lei Zang, Shuo Yuan, Peng Du, Qichao Wu, Aobo Wang, Jian Li, Xiaochuan Kong, Wenyi Zhu

“…Studies that evaluated DL or TML algorithms assessment value on diagnosing LSS were included, while those with duplicated or unavailable data were excluded. …”
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A novel biochemical analysis for ApoE4 quantification in plasma and discrimination of homozygous and heterozygous APOE ε4 carriers by Andrés Rodríguez, Olga Calero, Sergio Veiga, Miriam Menacho-Román, Ignacio Arribas, Lluís Cano, Guillermo García-Ribas, Miguel Calero

“…Conclusion The e4Quant assay is a novel alternative for genotyping to determine APOE ε4 carrier status, while also providing quantitative measurements of ApoE4 levels. …”
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Development of a postoperative recurrence prediction model for stage Ⅰ non-small cell lung cancer patients using multimodal data based on machine learning by ZHANG Di, WU Yi, XU Yu

“…Radiomic models were established based on extracted features from tumor-dominant regions of interest (ROI) on CT images, while clinical models were developed using demographic characteristics and preoperative laboratory examinations. …”
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Explainable machine learning for predicting distant metastases in renal cell carcinoma patients: a population-based retrospective study by Zhao Hou, Zhao Hou, Peipei Wang, Peipei Wang, Dingyang Lv, Dingyang Lv, Huiyu Zhou, Huiyu Zhou, Zhiwei Guo, Zhiwei Guo, Jinshuai Li, Jinshuai Li, Mohan Jia, Mohan Jia, Hongyang Du, Hongyang Du, Weibing Shuang, Weibing Shuang

“…Hyperparameters were optimized using grid search and tenfold cross-validation. …”
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Artificial intelligence-based prediction of second stage duration in labor: a multicenter retrospective cohort analysisResearch in context by Xiaoqing Huang, Xiaodan Di, Suiwen Lin, Minrong Yao, Suijin Zheng, Shuyi Liu, Wayan Lau, Zhixin Ye, Zilian Wang, Bin Liu

“…Since durations beyond 3 h were rare, we developed binary classification models with thresholds at 1 h and 2 h. After the optimal features selected by recursive feature elimination (RFE) method, four ML algorithms were employed to build the models. …”
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An IoT-enabled AI system for real-time crop prediction using soil and weather data in precision agriculture by MD Shaifullah Sharafat, Nilavro Das Kabya, Rahimul Islam Emu, Mehrab Uddin Ahmed, Jakaria Chowdhury Onik, Mohammad Aminul Islam, Riasat Khan

“…Several machine learning algorithms, including Random Forest, Gradient Boosting, and Stacking ensembles, as well as deep learning models such as TabNet, were evaluated for crop prediction. …”
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Cellular hierarchy framework based on single-cell and bulk RNA sequencing reveals fatty acid metabolic biomarker MYDGF as a therapeutic target for ccRCC by Ning Wang, Ziyu Xu, Lina Zhang, Lina Zhang, Yanfang Lu, Yanfang Lu, Yanliang Wang, Yanliang Wang, Lei Yan, Lei Yan, Huixia Cao, Huixia Cao, Limeng Wang, Limeng Wang, Fengmin Shao, Fengmin Shao

“…Functional enrichment algorithms, including AUCell, UCell, singscore, ssGSEA, and AddModuleScore, along with hdWGCNA analysis, were used to identify hub genes influencing high FAM of ccRCC. …”
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Comparison of Random Survival Forest Based‐Overall Survival With Deep Learning and Cox Proportional Hazard Models in HER‐2‐Positive HR‐Negative Breast Cancer by Wenqi Cai, Yan Qi, Linhui Zheng, Huachao Wu, Chunqian Yang, Runze Zhang, Chaoyan Wu, Haijun Yu

“…Predictive models were developed using five feature sets and three algorithms (Cox PH, RSF, DeepSurv), with feature selection optimized via Concordance index (C‐index). …”
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Identification and validation of diagnostic biomarkers and immune cell abundance characteristics in Staphylococcus aureus bloodstream infection by integrative bioinformatics analys... by Junhong Shi, Li Shen, Yanghua Xiao, Cailing Wan, Bingjie Wang, Peiyao Zhou, Jiao Zhang, Weihua Han, Rongrong Hu, Fangyou Yu, Hongxiu Wang

“…Gene expression dataset GSE33341 was optimized as the discovery dataset, which contained samples from human and mice. …”
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Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

“…Current precision medicine approaches lack robust molecular tools integrating transcriptomic signatures with immune dynamics for personalized treatment guidance.MethodsWe performed multi-omics analyses of GEO datasets using machine learning algorithms (LASSO/Random Forest) to derive a four-gene signature. …”
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Application of machine learning for the analysis of peripheral blood biomarkers in oral mucosal diseases: a cross-sectional study by Huiyu Yao, Zixin Cao, Liangfu Huang, Haojie Pan, Xiaomin Xu, Fucai Sun, Xi Ding, Wan Wu

“…Future research should focus on validating these findings in larger cohorts and exploring alternative machine-learning algorithms to improve diagnostic accuracy further.…”
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