Suggested Topics within your search.
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1661
LncRNAs and asymmetric cell division: The epigenetic mechanisms
Published 2025-04-01“…Emerging evidence suggests that long non-coding RNAs (lncRNAs) are key regulators of ACD, orchestrating the intricate molecular machinery that governs cell fate determination. …”
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1662
The role of macrophage polarization in ovarian cancer: from molecular mechanism to therapeutic potentials
Published 2025-04-01“…Therapeutic strategies targeting TAMs are extensively discussed, encompassing oncolytic viruses, engineered EVs, immunotherapies, nanoparticles, targeted therapies, and natural products. …”
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1663
Epithelial-mesenchymal transition in colorectal cancer metastasis and progression: molecular mechanisms and therapeutic strategies
Published 2025-07-01“…This review systematically examines the molecular mechanisms regulating EMT in CRC, including key transcription factors; post-translational and epigenetic modifications; non-coding RNAs; and pivotal signaling pathways. Additionally, we evaluate the clinical implications of EMT in CRC progression and metastasis and critically assess emerging therapeutic strategies targeting EMT. …”
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1664
The Pleiotropic Effect of ANRIL in Glaucoma and Cardiovascular Disease
Published 2025-07-01“…While SNPs within ANRIL provide valuable insights into disease mechanisms, these conditions remain complex, influenced by multiple genetic and environmental factors. Targeting ANRIL therapeutically poses challenges due to its non-coding nature, but emerging RNA-based therapies, including antisense oligonucleotides and small-molecule modulators, hold promise. …”
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1665
Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection
Published 2025-01-01“…Furthermore, in this review, we explore current therapeutic strategies targeting these epigenetic alterations and discuss future directions for research and treatment. …”
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1666
The informational “cosplay journey” of Star Wars cosplayers in the context of a Facebook group
Published 2023-09-01“…The researchers transcribed and jointly coded the collected data with an open coding scheme to identify themes that emerged from the data. …”
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1667
Construction of an lncRNA-mediated ceRNA network to investigate the inflammatory regulatory mechanisms of ischemic stroke.
Published 2025-01-01“…Long non-coding RNAs (lncRNAs) are among the most abundant types of non-coding RNAs in the genome and exhibit particularly high expression levels in the brain, where they play crucial roles in various neurophysiological and neuropathological processes. …”
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1668
Technique Comparative Analysis of OTT TV and IPTV
Published 2014-05-01“…Then the reasons of making these differences were found, accordingly the direction and trend of IP video service technique were predicted.…”
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1669
Antcin-H, a natural triterpene derived from Antrodia cinnamomea, ameliorates dextran sulfate sodium-induced colitis in mice by inhibiting the NLRP3 inflammasome
Published 2025-07-01“…Abnormal activation of the NLRP3 inflammasome is a crucial factor in the pathogenesis of IBD, making it an attractive therapeutic target. We discovered that Antcin-H, a triterpene isolated from the unique medicinal fungus Antrodia cinnamomea found in Taiwan, effectively inhibits the NLRP3 inflammasome in macrophages and alleviates dextran sulfate sodium (DSS)-induced colitis in a mouse model. …”
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1670
VACCIMEL, an allogeneic melanoma vaccine, efficiently triggers T cell immune responses against neoantigens and alloantigens, as well as against tumor-associated antigens
Published 2025-01-01“…Notably, effector T cells targeting the patient’s tumor antigens, comprising neoantigens and TAA, were found in higher frequencies than T cells targeting VACCIMEL-exclusive antigens. …”
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1671
Novel Clinical Insights into the Pathogenesis of Posttraumatic Elbow Stiffness: An Expression Profile Analysis of Contracted Joint Capsule in Human
Published 2025-01-01“…Differentially expressed genes (DEGs), microRNAs, and long non-coding RNAs (LncRNAs) were identified and analyzed. …”
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1672
Reasons for not Referral to health centers in Zahedan: a case study of 2022
Published 2025-05-01“…Finally, coding was done using the conventional content analysis method. …”
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1673
Insight Into the Nuclear and Mitochondrial Genome of the Caribbean King Crab Maguimithrax spinosissimus (Crustacea: Brachyura: Mithracidae) to Support Fisheries Management and Cons...
Published 2025-07-01“…The mitogenome of the Caribbean King Crab was 15,714 bp long and encoded for 13 protein‐coding genes, 22 transfer RNA genes, and two ribosomal RNA genes. …”
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1674
Circular RNAs in Cervical Cancer: What are the Prospects?
Published 2023-12-01“…Recent advances in non-coding RNAs have opened up new avenues for research, including circular RNAs (circRNAs) as molecules that play a multifaceted role in cellular processes. …”
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1675
Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma
Published 2025-07-01“…Functional experiments confirmed that NDUFB10 knockdown significantly enhanced ICIs therapy and increased GZMB+CD8+T cell infiltration, indicating NDUFB10’s crucial role in regulating tumor immune microenvironment and immunotherapy response.Conclusion The MitoPS scoring system reliably predicts prognosis and immunotherapy response in patients with LUAD, providing a novel reference for clinical decision-making. Furthermore, its core gene NDUFB10 regulates tumor immune microenvironment, offering a potential therapeutic target for improving immunotherapy outcomes.…”
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1676
Maternal health care services utilization and associated factors among pregnant women in Kersa district, Jimma zone, Southwest Ethiopia.
Published 2025-01-01“…<h4>Conclusion</h4>Maternal healthcare service utilization among pregnant women in the study area was lower than national targets and international recommendations. Therefore, increasing women's awareness of maternal healthcare services, addressing physical access to institutional delivery services, strengthening access to transportation such as making ambulance services more accessible, improving road conditions, and increasing household income would likely increase service utilization.…”
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1677
Time-Dependent Shortest Path Optimization in Urban Multimodal Transportation Networks with Integrated Timetables
Published 2025-05-01“…To address this NP-hard problem, we propose and implement two optimization algorithms: a variable-length coding genetic algorithm (V-GA) and a full permutation coding genetic algorithm (F-GA). …”
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1678
Visual impairment experience: empathy and spatial Inclusive Design system for urban rail transportation
Published 2025-07-01“…The findings revealed that: 1) This line is inclusive to passengers with mild visual impairments with positive emotional connotations being dominant; 2) The inclusivity of rail transit spaces is related to sensation, cognition, motion, and service layers; 3) There are significant differences in the number of coding in the thematic layer, the fewer number of coding in the service dimension reflects insufficient attention. …”
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1679
Financial Exploitation: A Qualitative Analysis from Türkiye
Published 2025-05-01“…The collected data were analyzed by creating themes according to the general framework coding method. The results of the study reveal that the participants receive help from their children in financial decision-making and that their children generally manage their budgets. …”
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1680
Traffic light nutrition labeling policy: a path to promoting healthier eating habits in Pakistan
Published 2024-06-01“…Green labels indicate healthier options, amber labels suggest moderate consumption and red labels highlight food that should be consumed sparingly4. The simple color-coding system empowers consumers to make healthier decisions and can contribute to a reduction in diet-related diseases4. …”
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