Unveiling Pharmacogenomics Insights into Circular RNAs: Toward Precision Medicine in Cancer Therapy by Saud Alqahtani, Taha Alqahtani, Krishnaraju Venkatesan, Durgaramani Sivadasan, Rehab Ahmed, Hassabelrasoul Elfadil, Premalatha Paulsamy, Kalaiselvi Periannan

“…Circular RNAs (circRNAs), a distinct subclass of endogenous non-coding RNAs, have recently emerged as key regulators of drug resistance, tumor progression, and therapeutic responses. …”
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Noncoding RNAs as regulators of FOSL1 in cancer by Xiaochang Wang, Li Wang, Shoushi Wang, Jinjie Zhang, Xueyang Wang, Ting Zhang, Linwei Li, Jin Wei, Yi Zhao, Zhixia Zhou

“…The AP-1 transcription factor FOSL1, also known as Fra-1, is a crucial oncoprotein that plays an important role in human tumor progression and metastasis and has thus emerged as a promising therapeutic target. FOSL1 regulates the expression of a large protein-coding gene network, and this molecular mechanism can promote the progression of tumors. …”
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Development of Liver-Targeting α_Vβ₅⁺ Exosomes as Anti-TGF-β Nanocarriers for the Treatment of the Pre-Metastatic Niche by Paloma Acosta Montaño, Eréndira Olvera Félix, Veronica Castro Flores, Arturo Hernández García, Ruben D. Cadena-Nava, Octavio Galindo Hernández, Patricia Juárez, Pierrick G. J. Fournier

“…Our findings suggest that α_Vβ₅⁺ exosomes could serve as nanocarriers for liver-targeted anti-TGF-β therapies.…”
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Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration by Lingqiu Zhang, Lingqiu Zhang, Lingqiu Zhang, Lingqiu Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Haimei Liang, Haimei Liang, Haimei Liang, Haimei Liang, Xiangling Qin, Xiangling Qin, Xiangling Qin, Xiangling Qin, Yuemi Mo, Yuemi Mo, Yuemi Mo, Yuemi Mo, Shiyi Chen, Shiyi Chen, Shiyi Chen, Shiyi Chen, Jinling Xie, Jinling Xie, Jinling Xie, Jinling Xie, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Jiagang Deng, Jiagang Deng, Jiagang Deng, Jiagang Deng, Jiagang Deng, Erwei Hao, Erwei Hao, Erwei Hao, Erwei Hao, Zhengcai Du, Zhengcai Du, Zhengcai Du, Zhengcai Du

“…Additionally, therapeutic strategies targeting the Hippo pathway—including clinical agents, molecular inhibitors, non-coding RNAs (ncRNAs), and natural products—were systematically evaluated to assess their clinical potential.ResultsHippo pathway dysregulation drives CRC progression through aberrant YAP activation, which promotes tumor proliferation, metastasis, metabolic reprogramming, and immune evasion. …”
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LncRNA regulation in ischemic stroke and their application prospects by Qianqian Chen, Xiangyi Xu, Shun Li, Tianqing Xiong

“…In recent years, research into regulatory long non-coding (lnc)RNAs, a diverse group of RNA molecules with regulatory functions, has emerged as a promising direction in the study of cerebral infarction. …”
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Identification and functional characterization of prognosis-related ferroptosis-associated lncRNAs in colorectal cancer by Xiaoxu Ge, Xiaoxu Ge, Xiaoxu Ge, Xiaoxu Ge, Xiaoxu Ge, Jiasheng Xu, Jiasheng Xu, Jinjie He, Jinjie He, Jinjie He, Jinjie He, Jinjie He, Jian Wang, Jian Wang, Jian Wang, Jian Wang, Jian Wang, Yucheng Qian, Yucheng Qian, Yucheng Qian, Yucheng Qian

“…These lncRNAs have potential as novel prognostic markers and therapeutic targets, providing valuable insights for personalized CRC treatment strategies.…”
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Challenges and enablers for scaling up interventions targeting non-communicable diseases: a qualitative study applying the Consolidated Framework for Implementation Research to 19... by Josefien van Olmen, Peter Delobelle, Meena Daivadanam, Hassan Haghparast-Bidgoli, Maria Lazo-Porras, J Jaime Miranda, Yuan Li, Rohina Joshi, Amanda G Thrift, Rajesh Vedanthan, Gina Agarwal, Mark D Huffman, Kerstin Klipstein-Grobusch, Naomi Levitt, Dike Ojji, Feng J He, Kamran Siddiqi, Pascal Geldsetzer, Puhong Zhang, Milena Soriano Marcolino, Lal B Rawal, Brian Oldenburg, Helena Teede, Josephine Birungi, Edwin Wouters, Abha Shrestha, Ari Probandari, Mayowa Owolabi, Vilma Irazola, Andrea Beratarrechea, Keiko Nakamura, Gindo Tampubolon, Zulma Ortiz, Violet Naanyu, Jaap Koot, Anusha Ramani-Chander, Stephen Sherwood, Monika Martens, Gade Waqa, Maria Eugenia Esandi, Sujarwoto Sujarwoto, Laura Antonietti, Jan-Walter De Neve, Sayoki G Mfinanga, Antonio Luiz Pinho Ribeiro

“…Introduction Scaling up interventions targeting non-communicable diseases (NCDs) is a global health priority, and implementation research can contribute to that effort. …”
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How well are implementation strategies and target healthcare professional behaviors reported? A secondary analysis of 204 implementation trials using the TIDieR checklist and AACTT... by Charlene Weight, Billy Vinette, Rachael Laritz, Meagan Mooney, Sonia A. Castiglione, Marc-André Maheu-Cadotte, Nikolas Argiropoulos, Kristin Konnyu, Christine E. Cassidy, Simonne E. Collins, Sonia Semenic, Nicola Straiton, Sandy Middleton, Natalie Taylor, Marie-Pierre Gagnon, Shuang Liang, Laura Crump, Olivia Di Lalla, Talia Meyers, Daniel N. Elakpa, Guillaume Fontaine

“…Abstract Background Clear specification and reporting of implementation strategies and their targeted healthcare professional behaviors are essential for replication, adaptation, and cumulative learning in implementation science. …”
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ITG turbulence in gyrokinetic simulations of high collisionality spherical tokamak plasmas by N. Kumar, G. Avdeeva, J. Candy, M. Reynolds, E. Belli, C.P. McNally

“…This paper presents a first detailed gyrokinetic analysis with the goal of understanding the dominant turbulent transport mechanisms and identifying the micro-instabilities present in small-aspect-ratio plasmas in the PI3 device, developed as magnetized target fusion targets. These plasmas are characterized by low temperatures and high collisionality compared to standard tokamaks. …”
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Evaluation of relative biological effectiveness of 225Ac and its decay daughters with Monte Carlo track structure simulations by Ziyi Hu, Shuiyin Qu, Hongming Liu, Yunhao Zhang, Shuchang Yan, Ankang Hu, Rui Qiu, Zhen Wu, Hui Zhang, Junli Li

“…Abstract Background 225Ac is a radionuclide that can be utilized in targeted alpha therapy (TAT). To accurately assess the absorbed dose and radiation effects in TAT, it is necessary to calculate the relative biological effectiveness (RBE). …”
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RELIABILITY OF THE DATA ON MORBIDITY AND MORTALITY FROM MUSCULOSKELETAL SYSTEM DISEASES IN RESIDENTS OF THE TULA REGION by David Sh Vaisman, V N Sorotskaya, Roland M Balabanova

“…The reliable statistics are important to analyze the situation and make necessary adjustments to the organization of medical care.Objective. …”
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Performance of M-QAM MIMO PNC Based on MRC and ZR Techniques by Alaa A. Yassin, Ebtihal H. G. Yousif, Rashid A. Saeed, Hashim Elshafie, Abdullah Alenizi, Hesham Alhumyani

“…Physical-layer Network Coding (PNC) combined with MIMO techniques is introduced to optimize performance metrics and provide increased data throughput and full diversity gain. …”
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Knockdown of LncRNA H19 inhibits vascularization and endochondral ossification via the MiRNA-21a-5p-Smad7/p-Smad2/3 pathway in fracture repair by Qiuyue Sun, Chen Zhang, Bowen Chen, Junyi Liao, Aowen Bao, Chen Zhao, Hong Chen, Dawei He, Wei Huang, Guangming Dai

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DEGNN: A Deep Learning-Based Method for Unmanned Aerial Vehicle Software Security Analysis by Jiang Du, Qiang Wei, Yisen Wang, Xingyu Bai

“…The binary code similarity analysis method offers a way to analyze drone firmware lacking source code. …”
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Newborn RSV immunization rates and reasons compared to family COVID-19 and influenza immunization status by Joshua Somers, Brittany Hansen, Julia Burger, Stephen Aronoff, Brian Tuohy

“…Grounded Theory methodology was applied for data analysis using iterative coding to identify themes related to immunization perceptions and acceptance. …”
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Deep Defense Against Mal-Doc: Utilizing Transformer and SeqGAN for Detecting and Classifying Document Type Malware by Gati Lother Martin, Sang-Min Lee, Jong-Hyun Kim, Young-Seob Jeong, Ah Reum Kang, Jiyoung Woo

“…Initially, we develop MalCode2Vec to learn associations between source codes and represent them as numeric vectors. …”
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Large Language Model-Driven Framework for Automated Constraint Model Generation in Configuration Problems by Roberto Penco, Damir Pintar, Mihaela Vranić, Marko Šoštarić

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Development of culture of departure from 'comply or explain' rules of corporate governance by Radović Vuk

“…They offer to companies the choice between application and non-application, and in later case com­panies are required to inform public by giving meaningful explanation for making that decision. The whole system is founded on the quality of reporting in case of departure, because if it is not working, corporate governance codes cannot achieve goals they were meant to accomplish. …”
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Self‐Powered, Soft and Breathable Human–Machine Interface Based on Piezoelectric Sensors by Zhipeng Jiang, Chi Zhang, Sun Hwa Kwon, Lin Dong

“…By successfully translating piezoelectric signals generated from bicep muscle movements into Morse Code, this HMI serves as an efficient communication device. …”
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Physicians’ opinion of patients’ CPR decision: Secondary analysis from a pilot RCT by Stephanie Ji, Alexa Pisciotti, Mitsu Patel, Catherine Chen, Michael B. Steinberg, Karthik J. Kota

“…Background: While patients in the United States generally have final say in their code status, discussion with their physician plays an important role in decision-making. …”
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