A telemedicine tool for acute stroke management in Malaysia: a smartphone application by Hong Chuan Loh, Teck Long King, Irene Looi, Wan Chung Law

Get full text

Competing endogenous RNA networks in ovarian cancer by Roghaiyeh Derogar, Fatemeh Nejadi Orang, Mahdi Abdoli Shadbad

“…Aside from providing ample opportunities for targeted therapies, circRNA- and lncRNA-mediated ceRNA network components provide invaluable biomarkers. …”
Get full text

Circular RNA expression in ALS is progressively deregulated and tissue-dependent by Leticia Moreno-García, Laura Moreno-Martínez, Miriam de la Torre, Sofía Macías-Redondo, Alberto García-Redondo, Rosario Osta, Janne Markus Toivonen, Ana Cristina Calvo

Get full text

<i>CTC-537E7.3</i> as a Liver-Specific Biomarker for Hepatocellular Carcinoma: Diagnostic and Prognostic Implications by Hyung Seok Kim, Se Ha Jang, Geum Ok Baek, Moon Gyeong Yoon, Jaewon Shim, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun

“…By mining the TCGA_LIHC and two GEO cohorts, we identified the liver-specific long non-coding RNA <i>CTC-537E7.3</i> as the most consistently down-regulated transcript in tumors. …”
Get full text

How the HBRC contributes to the Sustainability in Egypt by Khaled El Zahaby

“…</p><p>HBRC is the sole entity nationwide responsible for issuing the Egyptian Codes (30) as well as technical specifications (21), in addition to providing periodical training for these codes and specifications. …”
Get full text

Astilbin Alleviates Radiation-Induced Pulmonary Fibrosis via <i>circ</i>PRKCE Targeting the TGF-β/Smad7 Pathway to Inhibit Epithelial–Mesenchymal Transition by Zhiling Shi, Jing Liu, Jing Qin, Xian Liang, Xue Ou, Tingting Zhang, Xueting Yan, Qianxin Hu, Weimei Huang, Kai Hu

“…High-throughput sequencing revealed that AST upregulated <i>circPRKCE</i>, a non-coding RNA that functions through a ceRNA mechanism by binding to miR-15b-5p, thereby promoting Smad7 expression and suppressing the TGF-β/Smad7 pathway. …”
Get full text

POTENTIAL POSSIBILITIES OF SPATIAL DEVELOPMENT OF CITIES AND REGIONS FROM IMPLEMENTATION NON-CONTACT PAYMENT TECHNOLOGIES by O.V. Kolomytseva, І.В. Shevchuk

“…The high le vel of security of the population by smartphones makes it possible to use NFC technology to make contactless payment for goods and services. …”
Get full text

Control-flow integrity technology based on the combination of software and hardware by LIANG Hao, HE Benwei, WANG Qingfeng, CHENG Guozhen, MA Hailong

“…At runtime, legitimacy checks were applied to these target addresses, thereby reducing performance overhead. …”
Get full text

Penggunaan Clickbait Headline pada Situs Berita dan Gaya Hidup Muslim dream.co.id by M Rizky Kertanegara

“…The rapid flows of information in the digital age makes online site producers create news that attracted the attention of netizen not only on their main sites but also for social media platforms. …”
Get full text

Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities by Roberta Veglia Tranchese, Sabrina Battista, Laura Cerchia, Monica Fedele

“…This review delves into the epigenetic mechanisms that modulate ferroptosis in cancer cells, focusing on how DNA methylation, histone modifications, and non-coding RNAs influence the expression and function of essential genes involved in this process. …”
Get full text

microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements. by Alexander Schwickert, Esther Weghake, Kathrin Brüggemann, Annika Engbers, Benjamin F Brinkmann, Björn Kemper, Jochen Seggewiß, Christian Stock, Klaus Ebnet, Ludwig Kiesel, Christoph Riethmüller, Martin Götte

“…These endogenous small non-coding RNAs play significant roles in tumorigenesis and tumor progression. miR-142-3p expression is dysregulated in several breast cancer subtypes. …”
Get full text

HNF4α-Mediated LINC02560 Promotes Papillary Thyroid Carcinoma Progression by Targeting the miR-505-5p/PDE4C Axis by Yongcheng Su, Beibei Xu, Chunyi Gao, Wenbin Pei, Miaomiao Ma, Wenqing Zhang, Tianhui Hu, Fuxing Zhang, Shaoliang Zhang

“…In conclusion, our findings elucidate the critical HNF4α/<i>LINC02560</i>/<i>miR-505-5p</i>/PDE4C axis in PTC pathology, presenting this regulatory network as a promising biomarker combination and potential therapeutic target to improve patient outcomes and survival rates, warranting further clinical investigation to validate these insights and support the development of targeted therapies in PTC management.…”
Get full text

LncRNA BACE1-AS delays the propagation of Cryptosporidium parvum through regulating cell apoptosis by targeting the miR-6805-5p/IRF3 axis by Shuang Huang, Xin Yang, Ting-Li Liu, Gui-Rong Hu, Qian Yao, Jun-Ke Song, Ying-Ying Fan, Guang-Hui Zhao

“…Increasing evidence has indicated that long non-coding RNAs (lncRNAs) play significant roles in various physiological and pathological processes. …”
Get full text

Identification and expression profiling of microRNAs in leaf tissues of Foeniculum vulgare Mill. under salinity stress by Luis Alberto Bravo-Vázquez, Mariana García-Ortega, Sara Medina-Feria, Aashish Srivastava, Sujay Paul

“…Subsequently, employing the psRNATarget tool, a total of 67 different candidate target transcripts for the characterized fennel miRNAs were predicted. …”
Get full text

Male attitudes towards family planning in the Limpopo province of South Africa by Ndifelani D. Radzuma, Gert J.O. Marincowitz, Clara Marincowitz

Get full text

The crane radar: Development and deployment of an operational eco-digital twin by K. De Koning

“…This paper therefore aims to outline the main concept and the steps involved in building digital twins for ecological decision making. By showing an example of the crane radar, a real-time digital twin of the common crane (Grus grus) migration, this paper illustrates what digital twins could look like in ecology, and which challenges modellers face towards actual deployment of their digital twin in an operational environment.The most important challenges identified here are: ex ante quality and error control of the input data; accounting for time lags between observations and data availability; harmonising the updating frequencies and temporal resolutions of models and data; developing robust model/software code to keep digital twins alive; the necessity of learning new skills for ecological modellers; and effectively communicating digital twin outputs to stakeholders. …”
Get full text

Low-dose extracorporeal shock wave attenuates sepsis-related acute lung injury by targeting mitochondrial dysfunction and pyroptosis crosstalk in type II alveolar epithelial cells by Jianning Guo, Xiaoxuan Qu, Ruidong Ge, Die Liu, Jing Liu, Qin Hui, Fang Ye, Yuanmei Chen, Chao Wang, Di Lv, Di Lv, Lijuan Tang, Lijuan Tang, Meihong Xia, Meihong Xia, Qi Zhang

“…The mechanism study shows that SW can enhance mitochondrial membrane potential and ATP production, inhibit mtDNA migration and p65 nuclear translocation, and down-regulate the expression of mitochondrial coding genes (MT-ND2, MT-ND4) and iNOS. At the same time, SW inhibited the NLRP3/ASC/Caspase-1 signaling axis, thereby disrupting pyroptosis cascades.ConclusionThis study reveals that SW attenuates septic ALI by targeting mitochondrial-pyroptosis crosstalk, offering a novel non-invasive therapeutic strategy for clinical applications.…”
Get full text

Advance care planning for older adults with advanced dementia living at old age homes- perspective of the surrogates by Faye Chan, Jenny Lee, Derek Lai, Connie Tong, Christopher Lum, Jean Woo

“…The interviews were transcribed and coded using a thematic content analysis framework. …”
Get full text

Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility by Jemar R. Bather, Melody S. Goodman, Adrian Harris, Guilherme Del Fiol, Rachel Hess, David W. Wetter, Daniel Chavez-Yenter, Lingzi Zhong, Lauren Kaiser-Jackson, Rachelle Chambers, Richard Bradshaw, Wendy Kohlmann, Sarah Colonna, Whitney Espinel, Rachel Monahan, Saundra S. Buys, Ophira Ginsburg, Kensaku Kawamoto, Kimberly A. Kaphingst, on behalf of the BRIDGE research team

Get full text

Challenges in achieving the UNAIDS 95-95-95 targets: evaluation of the antiretroviral therapy program among adult HIV/AIDS patients at Woldia General Hospital, Northeast Ethiopia by Seada Seid, Mezgebu Yitayal, Lake Yazachew, Abdurahman Arega, Tilahun Dessie, Hassen Ahmed Yesuf, Jemila Seid Hassen, Abdulaziz Kebede Kassaw, Ali Yimer

“…The qualitative data underwent transcription, translation into English, coding, thematic analysis, and manual interpretation. …”
Get full text