The Challenges of Local Intra-Articular Therapy by Gailute Kirdaite, Jaroslav Denkovskij, Diana Mieliauskaite, Jolita Pachaleva, Eiva Bernotiene

“…As pain is an essential symptom, caused by both inflammation and cartilage damage, various molecules acting on pain receptors are being investigated in clinical trials as potential targets for local intra-articular treatment. We also overview the new targets for local treatment, including surface markers and intracellular proteins, non-coding ribonucleic acids (RNAs), etc.…”
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Decoding bronchopulmonary dysplasia in premature infants through an epigenetic lens by Seyed Alireza Dastgheib, Reza Bahrami, Mohammad Golshan-Tafti, Mahsa Danaei, Sepideh Azizi, Amirhossein Shahbazi, Maryam Yeganegi, Amirmasoud Shiri, Ali Masoudi, Hossein Neamatzadeh

“…Additionally, specific histones and microRNAs, particularly from the miR-17∼92 cluster, are implicated in pulmonary development and vascular regulation. Long non-coding RNAs (lncRNAs), such as MALAT1, also play a role in gene regulation via competitive endogenous RNA networks, indicating their potential as biomarkers and therapeutic targets. …”
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Perceptual Uncertainty and Its Monitoring in Visual Snow Syndrome: A Multimodal Framework by Sophie De Beukelaer, Antonia Klein, Christoph J. Schankin

“…By clarifying these mechanisms, we aim to inform targeted interventions that could address this currently untreatable condition.…”
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Targeting LINC02320 prevents colorectal cancer growth via GRB7-dependent inhibition of MAPK signaling pathway by Lingwei Zhang, Hong Chen, Yangmei Yang, Liangbo Zhao, Huimin Xie, Peixian Li, Xinrui Lv, Luyun He, Nian Liu, Benyu Liu

“…Nevertheless, the functions of the vast majority of non-coding RNAs are yet to be clearly elucidated. Methods Long non-coding RNA (lncRNA) LINC02320 was screened out by RNA-sequencing using paired CRC samples. …”
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Uncertainty and hope in people with metastatic uveal melanoma in the era of immunotherapy and targeted treatments: a theory-based qualitative study by Tim Luckett, Carrie-Anne Ng, Julia Lai-Kwon, Damien Kee, Brendan Mulhern, Anthony M. Joshua

“…Analysis involved inductive coding followed by deductive coding against Mishel’s (1988) theoretical framework of uncertainty in illness. …”
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Epigenetic mechanisms in stem cell therapies for achilles tendinopathy by Zheyang Yuan, Zheyu Yao, Xufeng Mao, Xiang Gao, Sengyi Wu, Haijiao Mao

“…We focused on gene regulatory mechanisms controlled by DNA methylation, histones and non-coding RNAs including microRNAs, circRNAs and long non-coding RNAs. …”
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Profiling the expression and functional roles of mRNAs and lncRNAs associated with post-stroke aphasia by Yanling Xi, Hui Chang, Mei Qu

“…Functional enrichment analyses of these targets demonstrated the strong enrichment of co-expressed DElncRNAs and DEGs in immune system processes and the inflammatory response. …”
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Sorbitol induces flavonoid accumulation as a secondary signal via the nanoencapsulated SPc/lncRNA809-MmNAC17 module against Alternaria alternata in Malus micromalus by Tingting Du, Dong Meng, Hongyan Cao, Yi Lian, Rui Wu, Tengyue Liu, Tianyi Wang, Cai Qin, Zhihua Song, Biying Dong, Yujie Fu, Qing Yang

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Competing endogenous RNAs network dysregulation in oral cancer: a multifaceted perspective on crosstalk and competition by Jiajun Wu, Chanjuan Zhang, Hongfang Li, Shuo Zhang, Jingxin Chen, Li Qin

“…Networks of ceRNAs establish connections between the functions of protein-coding mRNAs and non-coding RNAs, including microRNA, long non-coding RNA, pseudogenic RNA, and circular RNA, piwi-RNA, snoRNA. …”
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Exploring potent miRNA combinations for detecting early-stage breast cancer by Barbara N. Borsos, Zoltán G. Páhi, Tibor Pankotai

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Interaction between the liver transcriptome and gut microbiota in mice during Toxoplasma gondii infection as identified by integrated transcriptomic and microbiome analysis by Yang Zou, He Ma, Xing Yang, Xin-Yu Wei, Chao Chen, Jing Jiang, Tao Jiang

“…Liver transcriptome analysis identified numerous differentially expressed (DE) non-coding RNAs and mRNAs potentially potentially involved in mediating liver immune responses and inflammation induced by T. gondii. …”
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Long Non-Coding RNA lncTAF15:1-1 Promotes CCL5 Secretion and Cell Migration of Monocyte-Derived Dendritic Cells via PI3K/AKT/mTOR Pathway in Systemic Lupus Erythematosus by Xiang M, Sun Z, Ge Y, Zhang Z, Zheng C, Gao Z, Wang J, Xu J, Liang J, Wang Y

“…The rescue experiments demonstrated that the effects of lncTAF15:1– 1 on multiple functions of moDCs were attenuated when the PI3K/AKT/mTOR pathway was disrupted.Conclusion: This study elucidated the role of lncTAF15:1– 1 in orchestrating DC migration and the recruitment of CD4+ T cells by enhancing CCL5 secretion through activating PI3K/AKT/mTOR pathway, which provides insights into potential molecular targets for SLE diagnosis and treatment. Keywords: systemic lupus erythematosus, monocyte-derived dendritic cells, CCL5, long non-coding RNA…”
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Genetic clustering algorithm by M. A. Anfyorov

“…Firstly, the decimal chromosomes coding is used instead of the traditional binary coding. …”
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Insights into the regulatory role of the lncRNA H19 and miRNA-152 and their cross-talk with their target genes in glioblastoma by M. A. Abdelsamed, N. A. Hasona, A. Lotfy, H. Y. Abdallah

“…This study aimed to identify new potential biomarkers for early diagnosis and novel therapeutic targets. Methods In a descriptive cross-sectional study, we employed quantitative real-time PCR for expression of lncRNA H19, miRNA-152, and their target genes in 84 glioblastoma specimens compared to 35 control samples (low-grade glioma, astrocytic astrocytoma, normal brain tissues). …”
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Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria. by Aziz El Hage, Shaun Webb, Alastair Kerr, David Tollervey

“…Here we employ ChIP-seq in strains expressing or lacking RNase H to map targets of RNase H activity throughout the budding yeast genome. …”
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Mitochondrial ribosomal protein L3 (MRPL3): An early diagnostic biomarker and potential molecular target in pancreatic cancer by Mudassier Ahmad, Sahir Sultan Alvi, Anupam Dhasmana, Jasmine Benavidez, Murali M Yallapu, Dae Joon Kim, Subhash C Chauhan, Bilal Bin Hafeez

“…This highlights the need to discover new biomarkers and targets for the treatment of PanCa. Dysregulated mitochondrial ribosome biogenesis occurs in PanCa and can be utilized as a potential biomarker and molecular target for its management. …”
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Efficacy and Autopoiesis of the System of Science, Education, Law and Politics by Ksenija Grubišić

“…The paper examines whether and in what way the interpretation of the efficacy of the legal system by means of the reduced principle of imputation differs, or is insufficient, in relation to the reduction of complexity of the legal system by means of codes and operations that make it autopoietic. I shall explain the most significant theoretical implications on the example of a legal norm of one section of public law - university law and the law of scientific organisations - by determining the criteria for assessing legal and societal efficacy with respect to the feature of autopoiesis of the pertaining systems - law, science, education and politics in the way they are determined in Luhmann’s systems theory.…”
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Traces et espaces de consommation by Franck Cochoy, Jan Smolinski

“…From the analysis of these traces recorded during the visit of the QR-codes affixed on three food products (a packet of salt, a chocolate bar and a bottle of water), our investigation endeavours to make explicit the theoretical, methodological and analytical stakes involved in the process of digitising the space for physical retail mobility.…”
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Dynamics of Neutron Transfer in the Reaction ³He + ⁹Be by Aidos K. Azhibekov, Englik K. Almanbetova, Mikhail A. Naumenko, Kairat O. Mendibayev, Sergey M. Lukyanov, Talgat G. Issatayev, Bakhytzhan A. Urazbekov, Asset M. Kabyshev, Kuralay Dyussebayeva, Timur K. Zholdybayev

“…The paper presents the results of experiments on measuring cross-sections for the neutron transfer channels ⁹Be(³He, α)⁸Be_gs,3.03 in the reaction of the ³He (30 MeV) ions with the ⁹Be target. To describe the angular distributions, we use the Distorted Wave Born Approximation (DWBA) applying the FRESCO code. …”
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Use of lightweight FFT-based algorithms for remote measurements using DIC by Slávek Zbirovský, Václav Nežerka

“…The unit is fully autonomous, capable of localizing QR code targets and extracting encoded information. …”
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