<i>MiR-34b</i> Regulates Muscle Growth and Development by Targeting <i>SYISL</i> by Yuting Wu, Xiao Liu, Yonghui Fan, Hao Zuo, Xiaoyu Niu, Bo Zuo, Zaiyan Xu

“…Non-coding genes, such as microRNA and lncRNA, which have been widely studied, play an important role in the regulatory network of skeletal muscle development. …”
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Recommendation‐making in the emergency department: A qualitative study of how Canadian emergency physicians guide treatment decisions about resuscitation in critically ill patients... by Henry Ajzenberg, Katie N. Dainty, Erin O'Connor

“…Abstract Study Objective Emergency physicians are frequently responsible for making time‐sensitive decisions around the provision of life‐sustaining treatment. …”
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Multi-Faceted Role of Histone Methyltransferase Enhancer of Zeste 2 (EZH2) in Neuroinflammation and Emerging Targeting Options by Sotirios Moraitis, Christina Piperi

“…The Enhancer of Zeste 2 (EZH2) histone lysine methyltransferase is a multi-faceted and context-dependent regulator of immune response and neural cell function, significantly involved in the underlying mechanisms of neuroinflammation, such as inflammatory gene expression, astrocyte function, microglial activation, BBB integrity, and interactions with non-coding RNAs. Herein, we explore the intricate implication of EZH2 activity in the onset of neuroinflammation and associated pathological conditions, and discuss its potential as a therapeutic target. …”
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RETRACTED ARTICLE: Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis by Zheng Ren, Xiaochun Liu, Yaoran Si, Desheng Yang

“…., & Yang, D. (2020). Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis. …”
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Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia. by Md Arif Hossen, Umme Mim Sad Jahan, Md Arju Hossain, Khalid Hossain Asif, Ahona Rahman, Sabbir Ahmed, Md Moin Uddin, Md Faisal Amin, Muhammad Abdul Barik, Mohammod Johirul Islam, Mohammad Kamruzzaman, Soharth Hasnat, Mohammad Nasir Uddin, Tofazzal Islam, M Nazmul Hoque

“…Out of the 12,191 mapped SNPs, 132 were nsSNPs located in the coding region. Among these, 18 nsSNPs were identified as detrimental including 12 destabilizing and 6 stabilizing nsSNPs. …”
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Nanomaterial-Based Drug Delivery Systems Targeting Functional Cells for Osteoarthritis Treatment: Mechanisms, Challenges and Future Prospects by Kong H, He Q, Han J, Zhang XA

“…In this review, the related references on the treatment of osteoarthritis with nanomaterial-based DDSs targeting functional cells have been included, and how a variety of functional cells can be engineered into nanomaterial-based DDSs serving as targets or arrows to treat OA has been summarised for the first time, providing a new idea and method for the targeted treatment of OA. …”
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Selective targeting of genes regulated by zinc finger proteins in endometriosis and endometrioid adenocarcinoma by zinc niflumato complex with neocuproine by Ivana Špaková, Lukáš Smolko, Gabriela Sabolová, Zuzana Badovská, Katarína Kalinová, Corina Madreiter-Sokolowski, Wolfgang F. Graier, Mária Mareková, Janka Vašková, Miroslava Rabajdová

“…The NSAID-metal complex [Zn(neo)(nif)2] shows an ability to intercalate into ZNF3-7 target DNA sequence at a higher rate, which could explain its effect on genes regulated by this transcription factor. …”
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Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP by Zhuoyi Song, Bongmin Bae, Simon Schnabl, Fei Yuan, Thareendra De Zoysa, Maureen V. Akinyi, Charlotte A. Le Roux, Karine Choquet, Amanda J. Whipple, Eric L. Van Nostrand

“…However, many orphan snoRNAs remain uncharacterized, with unidentified or unvalidated targets, and studies on additional snoRNA-associated proteins are limited. …”
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Creating an adolescent intensive health behavior and lifestyle treatment for type 1 diabetes: Feedback from the target population by Jennifer L. Warnick, Katherine E. Darling, Smriti Maskey, Lisa Swartz Topor, Katelyn Fox, KayLoni Olson, Elissa Jelalian

“…All data were analyzed by two independent coders who met to discuss divergence in coding and came to 100 % agreement. Codes were iteratively reduced and organized into themes. …”
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Unraveling the causal role of TGF-βRII in osteoporosis and the potential of its associated differential genes as novel targets by Xinyu Zhu, Yueyang Fan, Wenyu Wang, Rui Wu, Chen Zhang, Ziquan Yang

“…In addition, analysis of immune infiltration showed the involvement of these genes in various immune cells, and potential non-coding RNA targeting ID2, ID4, and LRRC32 were investigated using ceRNA networks. …”
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Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma by Kelly Gaudelot, Jean-Baptiste Gibier, Nicolas Pottier, Brigitte Hémon, Isabelle Van Seuningen, François Glowacki, Xavier Leroy, Christelle Cauffiez, Viviane Gnemmi, Sébastien Aubert, Michaël Perrais

“…MicroRNAs are a class of small non-coding RNAs, which have been previously shown to promote malignant initiation and progression. …”
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Other and Alien: Faces of Medea in Dramatic and Stage Interpretations of 20th-21st Centuries by T. A. Sharypina

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Feature, specification and evidence framework for communicating design rationale by Yakira Mirabito, Megane Annaelle Tchatchouang Kayo, Kosa Goucher-Lambert

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Experiences of internship nursing students in confronting ethical issues: a qualitative study by Tahereh Heidari, Leila Jouybari, Fariba Borhani, Zahra Sabzi

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On being and having: a qualitative study of self-perceptions in bipolar disorder by Matthew N. Ponticiello, Alexis L. Chang, Rebecca J. Chang, Salahudeen Mirza, Andrés Martin

“…We conducted individual, semi-structured interviews with 20 adults with clinically stable BD to explore their perceptions of the condition, their construction of meaning of their illness, and their view of BD in relation to their sense of self. We coded the transcripts according to the principles of thematic analysis and analyzed the data using an interpretative phenomenological analysis approach.ResultsWe identified three overarching domains: (1) Benefit or burden: a dialectic through which participants weighed the valence of their illness over time; (2) Self or other: the internal or external locus through which they experienced BD; and (3) From ineffability to meaning making: the process of naming, understanding, and incorporating BD into their life’s whole. …”
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Revisiting the effects of helper intentions on gratitude and indebtedness: Replication and extensions Registered Report of Tsang (2006) by Chi Fung Chan, Hiu Ching Lim, Fung Yee Lau, Wing Ip, Chak Fong Shannon Lui, Katy Yuen Yan Tam, Gilad Feldman

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Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues by Yufan Sheng, Sen Niu, Da Li, Chunyuan Meng, Tong Wang

“…This suggests that SH3BP1 may promote tumor proliferation and migration in colorectal cancer and offers the opportunity to be used as a therapeutic target.ConclusionThe large differences between single nucleotide mutations and insertion-deletion mutations in somatic cells and germ line cells indicate the large changes in the genome, especially in the non-coding region genome, during the transformation of normal tissue adjacent to cancer into cancerous tissue. …”
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Recent advances in the development and clinical application of miRNAs in infectious diseases by Sara Nunes, Rana Bastos, Ananda Isis Marinho, Raissa Vieira, Ingra Benício, Maria Alícia de Noronha, Sofia Lírio, Cláudia Brodskyn, Natalia Machado Tavares

“…In the search for new biomarkers and therapeutic targets for infectious diseases, several molecules have been investigated. …”
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Long non-coding RNA CCAT2 promotes cell proliferation and invasion through regulating Wnt/β-catenin signaling pathway in clear cell renal cell carcinoma by Jian-lin Huang, Yong Liao, Ming-xing Qiu, Jun Li, Yu An

“…Clear cell renal cell carcinoma (ccRCC) is a common urologic malignancy. Long non-coding RNA colon cancer–associated transcript 2 (CCAT2) has been suggested as serving pivotal roles in tumorigenesis. …”
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MiR-200b-3p elevates 5-FU sensitivity in cholangiocarcinoma cells via autophagy inhibition by targeting KLF4 by Feng Peng, Ruizhi He, Yuhui Liu, Yu Xie, Guangbing Xiong, Xu Li, Min Wang, Chunle Zhao, Hang Zhang, Simiao Xu, Renyi Qin

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