The role of circular RNA in immune response to tuberculosis and its potential as a biomarker and therapeutic target by Mingyang Hong, Xu Huang, Huiming Zhu, Jiahui Ma, Feng Li

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THE OFFENCE-CONSTITUTIONAL CHALLENGES OR CONTROVERSIES. ECONOMIC IMPLICATIONS by Elvira Mihaela PĂTRĂUȘ

“…The current Criminal Code defines the concept of offence differently from the previous regulation, abandoning social danger as an essential feature of the offence. …”
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REALITY THROUGH THE PRISM OF PAINTING: SIMULACRES BY MICHEL HOUELLEBECQ by Olga L. Kalashnikova.

“…The article examines the code of painting and the media codes of other sign systems that are inseparable from it, forming a peculiar picture of the modern information world as a world of simulacra in M. …”
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miR-590-3p and Its Downstream Target Genes in HCC Cell Lines by Mennatallah Elfar, Asma Amleh

“…In this study, we identified potential downstream target genes of hsa-miR-590-3p computationally. Several bioinformatics tools and more than one approach were used to identify potential downstream target genes of hsa-miR-590-3p. …”
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De Novo transcriptome assembly of Diaprepes abbreviatus: foundations for functional genomics and targeted pest management by Lamiaa M. Mahmoud, Tejbhan Saini, Nabil Killiny

“…Gene structure annotation predicted 75,895 coding sequences with an average length of 1,079 bp. …”
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MicroRNA155 in non-small cell lung cancer: a potential therapeutic target by Xiangju Wei, Xiangju Wei, Xianmin Xiong, Xianmin Xiong, Ze Chen, Bi Chen, Cantang Zhang, Wenhui Zhang

“…MicroRNAs (miRNAs), a large family of non-coding RNAs, play crucial roles in regulating several key biological processes, including cell proliferation, differentiation, inflammation, and apoptosis. …”
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Integrative Proteomics and Genomics Identify Novel Biomarkers and Therapeutic Targets in Vitiligo via Mendelian Randomization by Chenjue Yan, Ling Jiang, Yibo Hu, Ting You, Jing Chen, Songjiang Wu

“…Abstract Introduction Given that the proteome is a major source of therapeutic targets, we conducted a proteome-wide Mendelian randomization (MR) combined with transcriptome sequencing analysis to identify candidate protein markers and therapeutic targets for vitiligo. …”
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A targeted CRISPR screen identifies ETS1 as a regulator of HIV-1 latency. by Manickam Ashokkumar, Terry L Hafer, Abby Felton, Nancie M Archin, David M Margolis, Michael Emerman, Edward P Browne

“…To understand the complex relationship between the host cell and HIV-1 latency, we performed a lentiviral CRISPR screen that targeted a set of host cell genes whose expression or activity correlates with HIV-1 expression. …”
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Mitochondrial microRNAs (mitomiRs) as emerging biomarkers and therapeutic targets for chronic human diseases by Andrea Méndez-García, Marely Abigail García-Mendoza, Carmila Patricia Zárate-Peralta, Fernanda Valeria Flores-Perez, Luis Fernando Carmona-Ramirez, Surajit Pathak, Antara Banerjee, Asim K. Duttaroy, Sujay Paul

“…MicroRNAs, which are short, non-coding RNAs widely known for regulating gene expression at the post-transcriptional level, regulate many of these processes. …”
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Healthcare under siege: a qualitative study of health-worker responses to targeting and besiegement in Syria by Natasha Howard, Nasser Fardousi, Yazan Douedari

“…Objectives To explore health-worker perspectives on security, improving safety, managing constrained resources and handling mass casualties during besiegement in Syria.Design A qualitative study using semi-structured key informant interviews, conducted remotely over WhatsApp and Skype, and analysed thematically using inductive coding.Setting Secondary and tertiary health facilities affected by besiegement in Aleppo (from July to December 2016) and Rural Damascus (from August 2013 to February 2018).Participants Twenty-one male Syrian health-workers and service-users who had experienced besiegement and targeting of their health facilities.Results Participants described four related challenges of: (i) conflict-related responses, particularly responding to mass casualties; (ii) targeted attack responses, particularly preventing/surviving facility bombings; (iii) besiegement responses, particularly mitigating severe resource constraints; and (iv) chronic risk responses, particularly maintaining emotional resilience. …”
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Fostering Media Literacy: A Systematic Evidence Review of Intervention Effectiveness for Diverse Target Groups by Leen d'Haenens, Joyce Vissenberg, Marit Puusepp, Natalia Edisherashvili, Diego Martinez-Castro, Ellen Johanna Helsper, Łukasz Tomczyk, Tania Azadi, Sylwia Opozda-Suder, Erika Maksniemi, Guna Spurava, Katariina Salmela-Aro, Niina Sormanen, Sini Tiihonen, Terhi-Anna Wilska, Lauri Hietajärvi, Gemma Martínez, Nekane Larrañaga, Maialen Garmendia, Rubén Olveira-Araujo, Verónica Donoso, Margus Pedaste, Dominika Sepielak

“…This 2022 systematic evidence review, guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline, aimed to collect and synthesize scientific evidence on effective media literacy intervention programs across different target groups and the used frameworks. A comprehensive search across major scientific databases (Web of Science, Scopus, ProQuest, Communication & Mass Media Complete, and Education Resources Information Centre) and rigorous screening and coding processes identified 119 studies on media literacy intervention effectiveness and outcomes. …”
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Development of an alkaliptosis-related lncRNA risk model and immunotherapy target analysis in lung adenocarcinoma by Xiang Xiong, Wen Liu, Chuan Yao

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Nonsense‐mediated decay targets have multiple sequence‐related features that can inhibit translation by Zhenguo Zhang, Li Zhou, Landian Hu, Yufei Zhu, Heng Xu, Yang Liu, Xianfen Chen, Xianfu Yi, Xiangyin Kong, Laurence D Hurst

“…In this study, we show that mRNAs targeted by NMD are also suppressed at the translational level. …”
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Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment by Dae Hoon Lee, Jung Ki Yoo, Ki Hwan Um, Wootae Ha, Soo Min Lee, Junseong Park, Min Jeong Kye, Jungyo Suh, Jin Woo Choi

“…Considering the challenges of limited pharmaco-accessibility to the bladder due to its pathophysiological structure and the partially undruggable nature of target molecules, we designed a dual siRNA system targeting both mRNAs. …”
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Structural alterations of the EGFR gene in glioblastoma samples as a prognostic factor and molecular target for therapy by V. O.  Varachev, O. Yu. Susova, A. A. Mitrofanov, G. S. Krasnov, D. R. Naskhletashvili, Yu. I.  Ammour, S. D. Bezhanova, N. V. Sevyan, E. V. Prozorenko, A. Kh. Bekyashev, T. V. Nasedkina

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*Mechanisms of circular RNA in drug resistance of lung cancer: therapeutic targets, biomarkers, and future research directions by Xuanlin Tao, Xixian Ke, Gang Xu

“…Due to their closed-loop structure, circRNAs demonstrate high stability and resistance to degradation, making them promising diagnostic and therapeutic targets. …”
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Making a Home in the Taiga: Movements, Paths and Signs among Orochen-Evenki Hunters and Herders of Zabaikal Krai (South East Siberia) by Donatas Brandišauskas

“…In this article, I will explore interrelations between place making, movement, use of paths and signs among the Orochen of Zabaikal Krai (Province). …”
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Emotional, informational, and decision-making support needs among people seeking abortion in the US: perspectives from All-Options Talkline callers by Jane W. Seymour, Bria A. Goode, Paulina Guerrero, Angélica M. Campos, Kai Kyles, Poonam Dreyfus-Pai, Sarah E. Baum

“…We identified four key motivations for calling the Talkline, including the need for (1) decision-making support and validation, (2) a neutral perspective, (3) emotional support to discuss negative or complex feelings, and (4) information about the abortion process. …”
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Analysis of Universal Decoding Techniques for 6G Ultra-Reliable and Low-Latency Communication Scenario by Abhilasha Gautam, Prabhat Thakur, Ghanshyam Singh

“…Universal decoders work on a wide range of error-correcting codes, making them scalable for different communication protocols. …”
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PERTIMBANGAN PELANGGAN HOUSE OF PERCA DALAM KEPUTUSAN MEMBELI by Adelia Sagita Putri

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