Modeling autonomous shifts between focus state and mind-wandering using a predictive-coding-inspired variational recurrent neural network by Henrique Oyama, Takazumi Matsumoto, Jun Tani

“…To address this, we conduct model simulation experiments employing predictive coding as a theoretical framework of perception to investigate possible neural mechanisms underlying these autonomous shifts between the two states. …”
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Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. by Heather M Marshall, Keshet Ronen, Charles Berry, Manuel Llano, Heidi Sutherland, Dyana Saenz, Wendy Bickmore, Eric Poeschla, Frederic D Bushman

“…Lentiviral integration is favored in active transcription units, which allows efficient viral gene expression after integration, but the mechanisms directing integration targeting are incompletely understood. A cellular protein, PSIP1/LEDGF/p75, binds tightly to the lentiviral-encoded integrase protein (IN), and has been reported to be important for HIV infectivity and integration targeting.…”
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RNAi screening of uncharacterized genes identifies promising druggable targets in Schistosoma japonicum. by Yuxiang Xie, Xiaoling Wang, Shaoyun Cheng, Wanling Liu, Cun Yi, Yanmin You, Wei Zhang, Yuepeng Wang, Enlu Tang, Jipeng Wang, Wei Hu

“…Our work highlights the importance of UGs in schistosomes as promising targets for drug development in the treatment of the schistosomiasis.…”
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Alterations in expression of miRNA 497 and long non-coding RNAS (XIST–TSIX) and its significant role in colorectal cancer prediction by Mohamed Hassan Abd El-Magied, Amal Fawzy, Marwa Mohsen Mostafa, Ghada Nabil Elnaggar, Said Salama Moselhy, Mostafa Mohamed Elhady

“…Abstract Colorectal cancer (CRC) is a common type of malignancy in Western nations with high incidence related to different factors as genetic, foods and pollution. Long non-coding RNAs (LncRNAs) play a significant role in cellular processes, oncogensis and can be used as biomarkers for cancer progression. …”
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Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance by Jiawei Song, Ping Yang, Canting Chen, Weiqun Ding, Olivier Tillement, Hao Bai, Shuyu Zhang

“…Abstract Cancer remains one of the leading health threats globally, with therapeutic resistance being a long-standing challenge across chemotherapy, radiotherapy, targeted therapy, and immunotherapy. In recent years, the association between epigenetic modification abnormalities and therapeutic resistance in tumors has garnered widespread attention, spurring interest in the development of approaches to target epigenetic factors. …”
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A Sparse Variable Step-Size Least-Mean-Square Algorithm for Impulsive Noise in a Code-Division Multiple Access System by Mohammad Salman, Ahmed A. F. Youssef, Fahmi Elsayed, Mostafa Rashdan

“…In this work, we propose a sparse variable step-size LMS approach in a code-division multiple access (CDMA) system. The proposed algorithm makes use of an arctan constraint in the cost function of the algorithm. …”
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Proteome‐Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm by Ka Zhang, Yuan Liu, Aiqin Mao, Changzhu Li, Li Geng, Hao Kan

“…Background The proteome is a key source of therapeutic targets. We conducted a comprehensive Mendelian randomization analysis across the proteome to identify potential protein markers and therapeutic targets for abdominal aortic aneurysm (AAA). …”
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Intestinal current measurement and nasal potential difference to make a diagnosis of cases with inconclusive CFTR genetics and sweat test by Tobias Welte, Rebecca Minso, Angela Schulz, Christian Dopfer, Nadine Alfeis, Andrea van Barneveld, Lena Makartian-Gyulumyan, Gesine Hansen, Sibylle Junge, Carsten Müller, Felix C C Ringshausen, Annette Sauer-Heilborn, Frauke Stanke, Cornelia Stolpe, Stephanie Tamm, Anna-Maria Dittrich, Burkhard Tümmler

“…The disease-causing genetic lesions should reside in the non-coding region of CFTR or elsewhere in the genome, affecting the regulation of CFTR expression in a tissue-depending fashion which may explain the large within-group variability of CFTR activity in the respiratory and intestinal epithelium seen in this group.…”
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Targeting a pathogenic cryptic exon that drives HLRCC to induce exon skipping by Siddhardha S. Maligireddy, Mariana D. Mandler, Judith C. Lunger, Madeline Yuen, Sneha Kulkarni, Alexendar R. Perez, Christina M. Fitzsimmons, Daniel R. Crooks, Raj Chari, W. Marston Linehan, Pedro J. Batista

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Integrative Analysis of Plasma Proteomics and Transcriptomics Reveals Potential Therapeutic Targets for Psoriasis by Hesong Wang, Chenguang Wang, Ruihao Qin, Jia He, Xuan Zhang, Chenjing Ma, Shi Li, Lijun Fan, Liuying Wang, Lei Cao

“…Many patients experience relapse or inadequate responses, and PsO subtypes also lack effective therapies, highlighting the need for new therapeutic targets. <b>Methods:</b> We performed a proteome-wide Mendelian randomization (MR) to explore potential therapeutic targets for PsO. …”
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The student voice in quality assurance: what factors make for a great GP placement in the eyes of undergraduate medical students? by Simon Thornton, Trevor Thompson, Maria Gresham, Alice James

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Experiences of older adult Filipino-Americans surrounding eye surgery and factors in health decision-making: a qualitative study by Marycon C. Jiro, Michael Sigua, Migel Dio, Lauren Hennein, Jennifer Cocohoba

“…Despite this, Filipino-Americans are aggregated with the general “Asian-American” category, making it a challenge to obtain accurate population health data on social determinants of health. …”
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The lncRNA LOC100257036 and vvimiR156 modulate gibberellin signaling through AGAMOUS during cluster formation in Sistan Yaghooti grape by Shahla Sahraei, Nafiseh Mahdinezhad, Abbasali Emamjomeh, Kaveh Kavousi, Mahmood Solouki, Massimo Delledonne

“…Abstract The long non-coding RNAs (lncRNAs), despite lacking the ability to encode proteins, have become essential players in regulating gene expression in crops. …”
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Exploring the Gut Microbiota–Retina Axis: Implications for Health and Disease by Nicola Schiavone, Giulia Isoldi, Sara Calcagno, Elisabetta Rovida, Emiliano Antiga, Carolina Vieira De Almeida, Matteo Lulli

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High Fidelity Single-Pixel Imaging by Chao Deng, Xuemei Hu, Xiaoxu Li, Jinli Suo, Zhili Zhang, Qionghai Dai

“…Inspired by the fact that natural scenes exhibit unique degenerated structures in the low-dimensional subspace, we propose to take advantage of such local prior via convolutional sparse coding to implement high fidelity SPI. Specifically, we can represent the target scene via convolving with a set of statistically learned kernels, with the convolution coefficient matrix being sparse. …”
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Circular RNAs as disease modifiers of complex neurologic disorders by Veronica Galli, Sara Vinciguerra, Marta Biagioli, Jasmin Morandell

“…Circular RNAs are a large class of non-coding RNA molecules, conserved across species and produced by back-splicing. …”
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Compact classification using the biomimetic properties of ultrafast spiking microlaser neurons by Gibaek Kim, Matthieu Dubernard, Sami V El-Nakouzi, Amir-Hossein Masominia, Sylvain Barbay, Laurie E Calvet

“…Machine learning using spiking neurons offers high computational efficiency with minimal resources, enabling sparse coding and brain-inspired methods. Photonic systems potentially enable very fast classifications but, despite recent progress, demonstrations are still challenging to implement. …”
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Growth of the prefrontal cortical glioblastoma altered cognitive and emotional behaviors via mediating miRNAs and GABA-A receptor signaling pathways in rats by Sepide Nateghi, Ameneh Rezayof, Fatemeh Kouhkan, Ladan Delphi, Yavar Bagheri Davisaraei, Fatemeh Rostami, Fatemeh Tirgar, Houri Sepehri

“…Considering that the expression levels of targeted miRNAs could be influenced by the growth of the mPFC-GBM, both with or without muscimol treatment, these non-coding RNAs might serve as potential biomarkers for GBM.…”
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Scalable Hyperspectral Enhancement via Patch-Wise Sparse Residual Learning: Insights from Super-Resolved EnMAP Data by Parth Naik, Rupsa Chakraborty, Sam Thiele, Richard Gloaguen

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Circulating PIWI-interacting RNAs in Acute Ischemic Stroke patients by Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Abdelilah Arredouani, Ghulam Jeelani Pir, Sajitha V. Pananchikkal, Omar El-Agnaf, Ashfaq Shuaib, Nehad M. Alajez, Omar M.E. Albagha

“…In addition, we investigated the potential gene targets of the dysregulated piRNAs and their plausible involvement in pathophysiological processes affected in stroke. …”
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