Multi-locus CRISPRi targeting with a single truncated guide RNA by Molly M. Moore, Siddarth Wekhande, Robbyn Issner, Alejandro Collins, Anna J. Cruz, Yanjing V. Liu, Nauman Javed, Salvador Casaní-Galdón, Jason D. Buenrostro, Charles B. Epstein, Eugenio Mattei, John G. Doench, Bradley E. Bernstein, Noam Shoresh, Fadi J. Najm

“…Abstract A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. …”
Get full text

A Multi-Input Neural Network Model for Accurate MicroRNA Target Site Detection by Mohammad Mohebbi, Amirhossein Manzourolajdad, Ethan Bennett, Phillip Williams

“…(1) Background: MicroRNAs are non-coding RNA sequences that regulate cellular functions by targeting messenger RNAs and inhibiting protein synthesis. …”
Get full text

SPAT inhibits LUAD metastasis by targeting SF1-mediated splicing by Yun Ma, Xiaoxu Zhou, Mengqian Yu, Xiang Cheng, Juze Yang, Jiayi Ren, Chengcai Zheng, Jia Li, Xinyi Qian, Jiani Yi, Honghe Zhang, Yan Lu, Pengyuan Liu

“…Here, we present a functional characterization of a novel long non-coding RNA (lncRNA), SPAT (splice associated transcript). …”
Get full text

Mettre en scène les codes du genre : artifice et théâtralité dans la comédie musicale hollywoodienne classique by Anne Martina

“…Based on highly artificial dramatic and formal codes, the musical is the most hybrid, heterogeneous and unnaturalistic genre in Hollywood. …”
Get full text

Codes d’éthique et travail éthique dans la recherche et le partage des données génétiques transnationales by Klaus Hoeyer, Aaro Tupasela, Malene Bøgehus Rasmussen

Get full text

Who amends the International Code of Nomenclature for algae, fungi, and plants, the participation that the Latin American Herbaria have and how it can be increased? by María de Lourdes Rico-Arce

“…How the Code is amended? The “decision” to conserve the name Acacia with a new type from Australia, one of the most heated and polarized debates over botanical nomenclature, casting doubt over the legitimacy of the procedure and botanical decision-making is taken as example. …”
Get full text

Evaluation of Compliance with the Fundamentals of Preference of Certainty over Severity of Punishment in Sentencing Criminal code of Afghanistan - with an Emphasis on Administrativ... by Mohammad Iqbal Haqyar, Syed Baqer Mohammadi

“…Despite the fact that with the implementation of the penal code, the country's criminal policy went down in terms of quantity and quality; There is basically no relationship between the severity of the punishment and the achievement of the goal.in specific crimes such as crimes against internal and external security or crimes of administrative corruption, the country's criminal policy is different and in this context, the scope of crime is wider and the punishments are more severe.The purposeful penalization model means policy making in the field of punishment, both in terms of type and amount, based on a predictable and systematic logic, and penological and criminological scientific teachings play a prominent role in it.This model is proposed in the direction of organizing punishments and moving away from stereotyped punishments, which has its own fundamentals, and its executive measures should be planned according to these fundamentals that one of them is "improving certainty over the severity of punishment".This work has evaluated how to comply with the fundamental of preference of certainty over severity of punishment in the penal code of Afghanistan from the perspective of the mentioned model with emphasis on administrative corruption crimes and found that the fundamental of preference of certainty over severity of punishment in 14 discourses which includes 5 discourses of general sentences and 9 discourses of crimes and punishments (administrative corruption) has not been observed.…”
Get full text

Behavioural components and delivery features of early childhood obesity prevention interventions: intervention coding of studies in the TOPCHILD Collaboration systematic review by Brittany J. Johnson, Paul M. Chadwick, Samantha Pryde, Anna Lene Seidler, Kylie E. Hunter, Mason Aberoumand, Jonathan G. Williams, Hei In Lau, Sol Libesman, Jannik Aagerup, Angie Barba, Louise A. Baur, Samantha Morgillo, Lee Sanders, Sarah Taki, Kylie D. Hesketh, Karen Campbell, Alexandra Manson, Alison Hayes, Angela Webster, Charles Wood, Denise A. O’Connor, Karen Matvienko-Sikar, Kristy Robledo, Lisa Askie, Luke Wolfenden, Rachael Taylor, H. Shonna Yin, Vicki Brown, Alexander Fiks, Alison Ventura, Ata Ghaderi, Barry J. Taylor, Cathleen Stough, Christine Helle, Cristina Palacios, Eliana M. Perrin, Elizabeth Reifsnider, Finn Rasmussen, Ian M. Paul, Jennifer S. Savage, Jessica Thomson, Jinan Banna, Junilla Larsen, Kaumudi Joshipura, Ken K. Ong, Levie Karssen, Li Ming Wen, Márcia Vitolo, Margrethe Røed, Maria Bryant, Maribel Campos Rivera, Mary Jo Messito, Natalia Golova, Nina Cecilie Øverby, Rachel Gross, Rajalakshmi Lakshman, Rebecca Byrne, Russell L. Rothman, Sharleen O’Reilly, Stephanie Anzman-Frasca, Vera Verbestel, Claudio Maffeis, Kayla de la Haye, Sarah-Jeanne Salvy, Seema Mihrshahi, Janani Ramachandran, Paola Seffrin Baratto, Rebecca K. Golley, on behalf of the TOPCHILD Collaboration

“…Standardised approaches were used to code target behaviours, delivery features and BCTs in both published and unpublished intervention materials. …”
Get full text

Applied sport science and medicine of women’s rugby codes: a systematic-scoping review and consensus on future research priorities protocol by Ben Jones, Stacey Emmonds, Gregory Roe, Keith Stokes, Omar Heyward, Sean Scantlebury

Get full text

Application of Open-Source, Low-Code Machine-Learning Library in Python to Diagnose Parkinson's Disease Using Voice Signal Features by Daniel Hilário da Silva, Caio Tonus Ribeiro, Leandro Rodrigues da Silva Souza, Adriano Alves Pereira

Get full text

An Analysis of WhatsApp Interactions Among Youth: A Case of Language Attrition by Shubhra Shubhra, Devina Krishna

“…This results in a unique linguistic landscape where expressions from different languages coexist, sometimes making it challenging to distinguish between them. …”
Get full text

Employing a low-code machine learning approach to predict in-hospital mortality and length of stay in patients with community-acquired pneumonia by Hao Chen, Shurui Zhang, Hiromi Matsumoto, Nanami Tsuchiya, Chihiro Yamada, Shunsuke Okasaki, Atsushi Miyasaka, Kentaro Yumoto, Daiki Kanou, Fumihiro Kashizaki, Harumi Koizumi, Kenichi Takahashi, Masato Shimizu, Nobuyuki Horita, Takeshi Kaneko

“…For the LOS, the CCI score, activities of daily living, and social support were significant predictors. The low-code approach enables medical professionals with limited technical expertise to effectively employ data science in their clinical decision-making process. …”
Get full text

Decision‐making for pediatric cervical spine imaging after blunt trauma: Investigating team dynamics in the emergency department by Megan E. Gregory, Annie Truelove, Fahd Ahmad, Daniel Corwin, Leah Tzimenatos, Scott J. Oglesbee, Martin J. Herman, Julie C. Leonard

“…Methods We interviewed (pediatric and general emergency physicians, trauma surgeons, neurosurgeons, orthopedic surgeons and ED nurses at 21 hospitals to ascertain how team dynamics affect the pediatric cervical spine imaging decision‐making process. Data were coded following a framework‐driven deductive coding process and thematic analysis was used. …”
Get full text

Target Localization in Wireless Sensor Networks for Industrial Control with Selected Sensors by Zhenxing Luo, Paul S. Min, Shu-Jun Liu

“…This paper presents a novel energy-based target localization method in wireless sensor networks with selected sensors. …”
Get full text

Proton acceleration from a pair of laser pulses target interaction by Obaydur Rahman, Zheng-Mao Sheng

“…The two-dimensional particle-in-cell simulation code Opic has been used for this investigation. In this scheme, the pre-target is highly dense while the rear-target is critically dense. …”
Get full text

Suppression of Repeat-Intensive False Targets Based on Temporal Pulse Diversity by Gang Lu, Yongqiang Chen, Yu Lei, Guan Gui

“…A multipeak matched-filtering output is then produced other than the merely expected true target. An electronic protection (EP) algorithm based on the space time block code (STBC) is proposed to suppress the adverse effects of this jammer. …”
Get full text

Towards national risk-targeted seismic hazard maps for mainland China by Meng Zhang, Hua Pan, Yaohu Zhang

“…The global adoption of risk-targeted hazard models as the basis for seismic design has significantly increased over the past decade. …”
Get full text

Assessing fidelity of design and training of Making Every Contact Count (MECC) in a mental health inpatient setting by Emma Kemp, Maria Raisa Jessica Aquino, Rob Wilson, Milica Vasiljevic, Kate McBride, Craig Robson, Sally Faulkner, Mish Loraine, Jill Harland, Catherine Haighton, Angela Rodrigues

“…Abstract Background Making Every Contact Count (MECC) is a public health strategy which strives to enable brief interventions to be implemented through opportunistic healthy lifestyle conversations. …”
Get full text

Exploring microRNA targeting as a promising approach for solid tumor treatment by Behrouz Shademan, Vahidreza Karamad, Alireza Nourazarian, Cigir Biray Avci

“…Dysregulation of specific miRNAs can initiate, progress, and metastasize tumors, making them appealing targets in cancer therapy. This article explores recent studies on identifying specific miRNAs associated with solid tumors and their influence on crucial signaling pathways. …”
Get full text

Using self-generated identification codes to match anonymous longitudinal data in a sexual health study of secondary school students: a cohort study by Edmond Pui Hang Choi, Ellie Bostwick Andres, Heidi Sze Lok Fan, Lai Ming Ho, Alice Wai Chi Fung, Kevin Wing Chung Lau, Neda Hei Tung Ng, Monique Yeung, Janice Mary Johnston

Get full text