Genomic landscape of diffuse glioma revealed by whole genome sequencing by Ben Kinnersley, Josephine Jung, Alex J. Cornish, Daniel Chubb, Ross Laxton, Anna Frangou, Andreas J. Gruber, Amit Sud, Giulio Caravagna, Andrea Sottoriva, David C. Wedge, Thomas Booth, Safa Al-Sarraj, Samuel E. D. Lawrence, Erminia Albanese, Giulio Anichini, David Baxter, Alexandros Boukas, Yasir A. Chowdhury, Pietro D’Urso, Robert Corns, Andrew Dapaah, Ellie Edlmann, Fay Greenway, Paul Grundy, Ciaran S. Hill, Michael D. Jenkinson, Sandhya Trichinopoly Krishna, Stuart Smith, Susruta Manivannan, Andrew J. Martin, Samir Matloob, Soumya Mukherjee, Kevin O’Neill, Puneet Plaha, Jonathan Pollock, Stephen Price, Ola Rominiyi, Bobby Sachdev, Fozia Saeed, Saurabh Sinha, Lewis Thorne, Ismail Ughratdar, Peter Whitfield, Amir Saam Youshani, Helen Bulbeck, Prabhu Arumugam, Richard Houlston, Keyoumars Ashkan

“…As well as identifying drug targets for treatment of glioma our findings offer the prospect of improving treatment allocation with established targeted therapies.…”
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Dynamic pre-structuration of lipid nanodomain-segregating remorin proteins by Zeren Xu, Adrien Schahl, Marie-Dominique Jolivet, Anthony Legrand, Axelle Grélard, Mélanie Berbon, Estelle Morvan, Louis Lagardere, Jean-Philip Piquemal, Antoine Loquet, Véronique Germain, Matthieu Chavent, Sébastien Mongrand, Birgit Habenstein

“…We here combined molecular imaging, NMR spectroscopy, protein structure calculations and advanced molecular dynamics simulation to unveil a stable pre-structuration of coiled-coil dimers as nanodomain-targeting units, containing a tunable fuzzy coat and a bar code-like positive surface charge before membrane association. …”
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Women’s wellbeing as an empty declaration? A qualitative exploration of challenges in accessing termination of pregnancy due to fetal anomaly in Germany by Tamar Nov-Klaiman, Hilary Bowman-Smart, Ruth Horn

“…This includes decision-making around termination of pregnancy (TOP), including where it is due to a diagnosis of fetal anomaly (TOPFA). …”
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LazyAct: Lazy actor with dynamic state skip based on constrained MDP. by Hongjie Zhang, Zhenyu Chen, Hourui Deng, Chaosheng Feng

“…Inspired by human decision-making patterns, which involve reasoning only on critical states in continuous decision-making tasks without considering all states, we introduce the LazyAct algorithm. …”
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Designing model of place branding based on brand attachment (Kish Island case study) by khadigeh Ghaemmaghami Tabrizi, Asghar Moshabaki Esfahaniَ, Abdolah Naami, Naser Azad

“…According to the systematic approach (GTM), theorizing has been done in three main steps: open coding, axial coding and selective coding. All the steps of this part were analyzed by "MAXQDA" software. …”
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Criminal law protection of critical infrastructure objects against subversive encroachments by О. V. Shamsutdinov, D. S. Melnyk

“…On the objective side, the composition of sabotage, defined in Art. 113 of the Criminal Code of Ukraine, does not criminalize illegal inaction, as well as actions aimed at disorganization, slowing down or making impossible the operation of such facilities important to the state. …”
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Categorizing E-cigarette-related tweets using BERT topic modeling by D. Murthy, S. Keshari, S. Arora, Q. Yang, A. Loukas, S.J. Schwartz, M.B. Harrell, E.T. Hébert, A.V. Wilkinson

“…Background: Social media platforms are critical channels for promoting e-cigarettes, particularly among youth, making analysis of their vast and diverse content essential for public health interventions. …”
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Towards a universal implementation of labor companionship: a synthesis of the policy and facility environment of eight low-and-middle income countries by Soha El-Halabi, Andrea Barnabas Pembe, Alexandre Dumont, Ana Pilar Betrán, Charles Kaboré, Effie Chipeta, Guillermo Carroli, Helle Mölsted Alvesson, Hussein Kidanto, Jean-Paul Dossou, Kristi Sidney Annerstedt, Lenka Beňová, Mechthild M. Gross, Peter Waiswa, Pisake Lumbiganon, Quoc Nhu Hung Mac, Meghan A. Bohren, Claudia Hanson, Claudia Hanson

“…This study aimed to understand the maturity of labor companionship implementation in eight low-and-middle income countries with focus on the policy and facility environment.MethodsThis was a multi-country study nested in two hospital-based implementation research studies: Action Leveraging Evidence to Reduce perinatal mortality and morbidity in Sub-Saharan Africa (ALERT) study and the QUALIty DECision-making by women and providers for appropriate use of caesarean section (QUALI-DEC) study. …”
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Genome Editing of the <i>NF-YA8</i> Gene Modifies Tomato Plant Architecture and Fruit Traits by Nestor Petrou, Nikoleta Tsigarida, Zoe Hilioti

“…Through the transient expression of custom-engineered zinc finger nucleases (ZFNs) in tomato seeds, mutations were successfully introduced in the target gene. The recovered mutant <i>NF-YA8</i> coding sequences showed a significant level of similarity to the wild type, with a range of 86.9% to 98.21%. …”
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MicroRNA-499a in heart diseases: prospects for use in diagnostics. A review by Maria V. Pisklova, Natalia M. Baulina, Ivan S. Kiselev, Olga O. Favorova

“…Cardiac-specific (or myomiR) miRNA-499a (miR-499a) is a small (21–22 bp) non-coding RNA that is involved in the regulation of cardiac function both under normal and in various pathological conditions. …”
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Roles of extracellular microRNAs in central nervous system by Liang Li, Jin Wang

“…Abstract MicroRNAs are small non-coding RNAs containing about 18–25 nucleotides which modulate gene expression post-transcriptionally. …”
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Mechanistic insights into the therapeutic effects on liver fibrosis in Wilson's disease: a transcriptomic and network pharmacology-based approach by Ying Ma, Yue Pu, Hong Chen, Lei Zhou, Bo Yang, Xiaofeng Huang, Juan Zhang

“…Furthermore, the target genes of DELncRNAs were identified, followed by GO functional enrichment and KEGG pathway analyses. …”
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The emerging roles of aberrant alternative splicing in glioma by Reda Ben Mrid, Sara El Guendouzi, Marco Mineo, Rachid El Fatimy

“…Despite successful advances in understanding glioma, several genetic, epigenetic, and post-transcriptional alterations leave various targeted therapies ineffective, leading to a poor prognosis for high-grade glioma. …”
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Circular RNAs in endometriosis analyzed through RNA sequencing and bioinformatics for expression profile by Yan Yue, Jing Qian, Dandan Gui, Bin Lu

“…Background Endometriosis severely affects women’s physical and mental health; it is particularly important to find targets for the treatment and diagnosis of endometriosis. …”
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New insights into microRNA in dermatological diseases by Mengting Xu, Jiadong Yan, Xin Wang, Yue Zhang, Shengju Yang

“…MicroRNAs (miRs) are a class of non-coding RNA molecules that regulate gene expression post-transcriptionally. …”
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CUT&Tag reveals unconventional G-quadruplex landscape in Mycobacterium tuberculosis in response to oxidative stress by Ilaria Maurizio, Emanuela Ruggiero, Irene Zanin, Marta Conflitti, Giulia Nicoletto, Roberta Provvedi, Sara N. Richter

“…To combat tuberculosis effectively, novel therapeutic targets are urgently needed. G-quadruplexes (G4s) represent promising candidates for this purpose. …”
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Gamma-Retrovirus Integration Marks Cell Type-Specific Cancer Genes: A Novel Profiling Tool in Cancer Genomics. by Kathryn L Gilroy, Anne Terry, Asif Naseer, Jeroen de Ridder, Amin Allahyar, Weiwei Wang, Eric Carpenter, Andrew Mason, Gane K-S Wong, Ewan R Cameron, Anna Kilbey, James C Neil

“…A meta-analysis based on several gamma-retrovirus integration profiling (GRIP) studies in human cells (CD34+, K562, HepG2) revealed a similar cancer gene bias but also remarkable cell-type specificity, with prominent exceptions including a universal integration hotspot at the long non-coding RNA MALAT1. Comparison of GRIP targets with databases of super-enhancers from the same cell lines showed that these have only limited overlap and that GRIP provides unique insights into the upstream drivers of cell growth. …”
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A chromosome-level genome assembly of skipjack tuna, Katsuwonus pelamis (Perciformes: Scombridae) by Xuanguang Liang, Junrou Huang, Bilin Liu, Feng Wu, Jian Liu, Jianguo Lu

“…A total of 32,001 protein-coding genes were predicted with 31,993 genes (99.98%) annotated. …”
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MicroRNAs and vascular damage in chronic kidney disease: advances and clinical implications by Regiane Stafim da Cunha, Carolina Amaral Bueno Azevedo, Guilherme Miniskiskosky, Paulo Cézar Gregório, Andréa Emilia Marques Stinghen

“…MicroRNAs (miRNAs) are a group of non-coding RNAs that regulate gene expression and other cellular processes. …”
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Modulating gene expression as a strategy to investigate thyroid cancer biology by Diego Claro de Mello, Joice Moraes Menezes, Antonio Tarelo Freitas de Oliveira, Marcella Maringolo Cristovão, Edna Teruko Kimura, Cesar Seigi Fuziwara

“…ABSTRACT Modulating the expression of a coding or noncoding gene is a key tool in scientific research. …”
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