The role of major and minor structural proteins of porcine reproductive and respiratory syndrome virus in induction of protective immunity by Dan Li, Dan Li, Laixu Zhu, Laixu Zhu, Chenchen Cui, Chenchen Cui, Zhenchun Wu, Zhenchun Wu, Pengkai Qing, Pengkai Qing, Qiongqiong Zhou, Qiongqiong Zhou, Peng Gao, Peng Gao, Yongning Zhang, Yongning Zhang, Lei Zhou, Lei Zhou, Xinna Ge, Xinna Ge, Xin Guo, Xin Guo, Jun Han, Jun Han, Hanchun Yang, Hanchun Yang

“…IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV), an economically significant threat to the world pork production, is notoriously known for its heterogeneity, and therefore the current vaccines often fail to provide efficient cross-protection against diverse PRRSV strains.MethodsBy making chimeric viruses using HP-PRRSV-2 lineage 8 (JXwn06) and lineage 1 NADC30-like strains (CHsx1401) as model organisms, the recently results have shown that the viral structural protein-coding region is critical for induction of homologous immunity. …”
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Websites: The Good and the Bad by Ricky W. Telg, Laura M. Gorham, Tracy Irani

“…This 2-page publication on understanding what makes a good and bad website is the second of the Writing and Designing for the Web series. …”
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Translational framework for implementation evaluation and research: implementation strategies derived from normalization process theory by Carl R. May, Alyson Hillis, Bianca Albers, Laura Desveaux, Anthony Gilbert, Melissa Girling, Roman Kislov, Anne MacFarlane, Frances S. Mair, Sebastian Potthoff, Tim Rapley, Tracy L. Finch

“…These strategies support practical decision-making across the planning, delivery, and sustainment phases of implementation, and offer context-sensitive guidance for adapting interventions to diverse settings. …”
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Supporting Muslim undergraduate medical students through medical school: lessons from a novel, student-led case-based learning intervention by Zain Mohammed, Zain Mohammed, Hafsah Ba, Linta Nasim, Emily Roisin Reid

“…The in-session discussions evidenced that participants had increased their cultural literacy and awareness of Muslim students' needs and identified practical solutions, including inclusive scheduling, making appropriate prayer facilities available to enable equitable educational attainment, providing clear clinical attire guidelines, and providing robust reporting mechanisms. …”
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Characteristics of Land Use Change and Evaluation of Ecological Sensitivity in Chongqing by XIE Xianjian, GOU Qiantao, WU Han

“…Specifically, the Coupled Spatial Distance Index Model, Spatial Autocorrelation Analysis, Geodetector Model, and Grid Coding techniques were applied to evaluate the ecological sensitivity comprehensively. …”
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CENTER-ing Black voices: incorporating lived experience across the research process to advance equity in drug treatment and outcomes by Devin E. Banks, Maria E. Paschke, Kaytryn D. Campbell, Daje D. Bradshaw-Glenn, Rashmi Ghonasgi, Burton Barr, Arial Collins, Gerald Dennis, Keith Lofton, Alfred Long, Harriet Montgomery, Andreas Prince, Rachel P. Winograd

“…Academic staff dedicated to liaising with the CAB encouraged establishing structure and bylaws toward a self-governing CAB with decision-making power independent of agency partner and research teams. …”
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Patients’ Experiences of Digital Health Interventions for the Self-Management of Chronic Pain: Systematic Review and Thematic Synthesis by Ashleigh Main, Haruno McCartney, Maryam Ibrar, Fiona Muirhead, Alexandra Mavroeidi, Harleen Kaur Rai, Roma Maguire

“…Following a 3-step inductive thematic synthesis approach, the researcher performed line-by-line coding of each eligible article to identify descriptive themes. …”
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Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients in the UK: A cohort study. by Annie Herbert, Meena Rafiq, Tra My Pham, Cristina Renzi, Gary A Abel, Sarah Price, Willie Hamilton, Irene Petersen, Georgios Lyratzopoulos

“…Jointly assessing the risk of cancer or IBD can better support decision-making and prompt diagnosis of both conditions, optimising specialist referrals or investigations, particularly in women.…”
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Illuminating the “black box” of complex suicide prevention interventions: towards a theory of implementation using the normalisation process theory by Sadhvi Krishnamoorthy, Gregory Armstrong, Sharna Mathieu, Victoria Ross, Kairi Kõlves

“…The Normalisation Process Theory translational coding manual was used to map data related to the primary and secondary constructs defined in the theory and its extensions.ResultsThree domains pertaining to implementation context, mechanisms, and outcomes (CMO) were explored. …”
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Secondary use of routinely collected administrative health data for epidemiologic research: Answering research questions using data collected for a different purpose by Scott D. Emerson, Taylor McLinden, Paul Sereda, Amanda M. Yonkman, Jason Trigg, Sandra Peterson, Robert S. Hogg, Kate A. Salters, Viviane D. Lima, Rolando Barrios

“…Key considerations were organized around four themes: 1) Know the data and their primary use (understand their scope and limitations); 2) Understand classification and coding systems (appreciate the nuances regarding classification systems, versions, how they are employed in the primary uses of the data, and querying the values); 3) Transform data into meaningful forms (process data and apply identification algorithms, when necessary); 4) Recognize the importance of validity when defining analytic variables (make meaningful inferences based on data/algorithms). …”
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SaaS sRNA promotes the interfering effect of Salmonella on hepatic iron metabolism via modulating ferroportin 1 by Linlin Cai, Yunting Xie, Haijing Hu, Chongyang Lv, Liangting Shao, Huhu Wang, Xinglian Xu, Guanghong Zhou

“…The mechanisms by which Salmonella antagonizes nutritional immunity, particularly those regulated by small non-coding RNAs (sRNAs), remain incompletely understood. …”
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Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by Campylobacter jejuni by Brandon Ruddell, Alan Hassall, Orhan Sahin, Paul J. Plummer, Qijing Zhang, Amanda J. Kreuder

“…ABSTRACT Post-transcriptional gene regulation by non-coding small RNAs (sRNAs) is critical for colonization and survival of enteric pathogens, including the zoonotic pathogen Campylobacter jejuni. …”
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Deciphering the oncogenic network: how C1QTNF1-AS1 modulates osteosarcoma through miR-34a-5p and glycolytic pathways by Yu Zhang, Hailong Lun, Naiqiang Zhu, Naiqiang Zhu, Ning Yang, Kaikai Ding, Bin Chen, Chengbing Chang, Haipeng Gu, Yanqi Liu

“…IntroductionOsteosarcoma (OS), a prevalent metastatic cancer among young individuals, is associated with a grim prognosis. Long non-coding RNAs (lncRNAs), including C1QTNF1-AS1, are pivotal regulators of cancer cell proliferation and motility. …”
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Unraveling the mitochondrial genome of the medicinal Chinese motherwort (Leonurus japonicus, Lamiaceae): structural dynamics, organelle-to-nuclear gene transfer, and evolutionary i... by Xinyu Bai, Xinyu Bai, Tingting Zhu, Huiru Chen, Xiaoqun Wang, Jing Liu, Yuqing Feng, Yuqing Feng, Yanbo Huang, Joongku Lee, Goro Kokubugata, Zhechen Qi, Xiaoling Yan

“…These findings enrich genomic resources for Leonurus, support phylogenetic and evolutionary studies in Lamiaceae, and lay groundwork for molecular breeding and conservation strategies targeting mitochondrial traits. …”
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Analysis of Proteins and Piwi-Interacting RNA Cargo of Extracellular Vesicles (EVs) Isolated from Human Nose Organoids and Nasopharyngeal Secretions of Children with RSV Infections by Tiziana Corsello, Nicholas Dillman, Yingxin Zhao, Teodora Ivanciuc, Tianshuang Liu, Antonella Casola, Roberto P. Garofalo

“…Extracellular vesicles (EVs), released by airway epithelial cells, contain proteins and different families of non-coding RNAs (EV cargo) that can modulate the responses of target cells to viral infection. …”
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LncRNA UCA1 promotes renal cell carcinoma proliferation through epigenetically repressing p21 expression and negatively regulating miR-495 by Yun Lu, Wei-Gang Liu, Jia-Hui Lu, Zhi Jun Liu, Hai-Bin Li, Gui-Jing Liu, Hong-Yan She, Gui-Ying Li, Xin-Hua Shi

“…Long non-coding RNAs have recently emerged as important regulators in the pathogenesis and progression of cancers. …”
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Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines by Nandita Barnabas, Dalia Cohen

“…The major signaling pathways that give rise to the phenotype of these cells may serve as a good resource of information when researchers in drug discovery and development use these cells to identify novel targets and biomarkers. Major signaling pathways and mutations affecting the coding sequence are also described providing important information when using these cells as a model in a variety of studies.…”
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Automatic speech signal segmentation with chosen parametrization method by Cz. BASZTURA, T. SAWCZYN

“…It is based on calculations of the phonetic function at speech, which makes it possible to find the boundaries of these phonetic segments. …”
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Mechanisms of pulmonary fibrosis and lung cancer induced by chronic PM2.5 exposure: Focus on the airway epithelial barrier and epithelial-mesenchymal transition by Yuyu Shi, Qi Shao, Zilin Ren, Guojiao Shang, Jinhua Han, Jialin Cheng, Yuxiao Zheng, Fafeng Cheng, Changxiang Li, Qingguo Wang, Xueqian Wang

“…Emphasizing the translational prospects from basic research to clinical applications, and we proposed new ideas for treating PM2.5-related lung diseases from four aspects-anti-inflammatory and antioxidant drugs, signaling pathway inhibitors, non-coding RNA-targeted therapies, and gene editing and cell therapies-by focusing on the two key links of the airway epithelial barrier and EMT.…”
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HDAC3 inhibition mitigates acute kidney injury by alleviating RIPK1-mediated programmed necrosis by Manman Xie, Manman Xie, Rui Hou, Runrun Shan, Xinyu Cheng, Pengcheng Wu, Xiufeng Luo, Yangyang Wei, Li Gao, Xiaoying Liu, Xiaoying Liu, Qi Chen

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