Nucleic acid therapeutics: Past, present, and future by Sajid Naeem, Ju Zhang, Yang Zhang, Yu Wang

“…Nucleic acid therapeutics have become increasingly recognized in recent years for their capability to target both coding and non-coding sequences. Several types of nucleic acid modalities, including siRNA, mRNA, aptamer, along with antisense oligo, have been approved by regulatory bodies for therapeutic use. …”
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The Problem of Knowledge-Based Development by Karim Hanafi Niri, Robabeh Pourjabali, Mahboube Babaei

“…The sample size was selected using judgmental (targeted) sampling of 84 people. After collecting the data, they were coded and analyzed by using the "Strauss and Corbin" method. …”
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Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer by Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou

“…These findings also provide a novel strategy for improving chemotherapy in HGSOC by targeting CATED.…”
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Small extracellular vesicles: messengers at the service of breast cancer agenda in the primary and distant microenvironments by Angela Galardi, Valentina Fogazzi, Claudia Tottone, Marta Giussani, Serenella M. Pupa, Giulia Cosentino, Marilena V. Iorio

“…These vesicles carry a diverse cargo of proteins, lipids, DNA, and various non-coding RNAs—such as miR-21, miR-155, and miR-1246—mirroring the molecular status of their originating cells. …”
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A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy by Yingying Wu, Shaojie Cheng, Ting Zhang, Leilei Wang, Ting Li, Yongbo Zheng, Guo Yang, Xiaohou Wu, Chunli Luo, Tingmei Chen, Liping Ou

“…Abstract Background Progression to castration resistance is the leading cause of death in prostate cancer patients. Long non-coding RNAs (lncRNAs) have recently become a focal point in the regulation of cancer development. …”
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Exploring the roles of snoRNA-induced ribosome heterogeneity in equine osteoarthritis by Alzbeta Chabronova, Marie Walters, Sara Regårdh, Stine Jacobsen, Louise Bundgaard, James R. Anderson, Mandy J. Peffers

“…Altogether, our novel data show that snoRNAs are regulated in equine OA, highlighting their potential as early molecular biomarkers and therapeutic targets. Targeting snoRNA to modulate protein synthesis in OA joints could ultimately improve outcomes for OA-affected horses.…”
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Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies? by Manoj Kumar, Manoj Kumar, Linda Yip, Fangyuan Wang, Saci-Elodie Marty, C. Garrison Fathman

“…The majority of disease-associated variants lie in non-coding regulatory elements, suggesting that transcriptional dysregulation plays a central role in disease susceptibility. …”
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LINC01559 drives osimertinib resistance in NSCLC through a ceRNA network regulating miR-320a/IGF2BP3 axis by Leidi Xu, Yibo Zhang, Liangliang Xing, Ying Zhou, Ning Chang, Hangtian Xi, Xiangrui Xu, Jian Zhang, Jian Zhang

“…Targeting the LINC01559/miR-320a/IGF2BP3 axis may provide a therapeutic strategy to overcome osimertinib resistance.…”
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Kinetics of pIgR and IgM immune responses in snakehead (Channa argus) to inactivated Aeromonas hydrophila via immersion and intraperitoneal injection by Guojing Xu, Lili Cao, Xiuli Chen, Fangfang Guo, Yan Jiang, Xiangyue Li, Haiqiang Xu, Jinliang Zang, Junpeng Wang, Yuguang Qin

“…Furthermore, a polyclonal antibody targeting the snakehead recombinant ChpIgR was constructed. …”
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Comparative chloroplast genomics of wild-type Panicum miliaceum cv. ATL1 and its M4 mutant line: insights for molecular breeding applications by Ayushi Kumar, Ravikesavan Rajasekaran, Iyanar Krishnamoorthy, Senthil Alagarswamy, K. Chandrakumar, Sowmya Pulapet, Kesavan Markkandan, Selvaraju Kanagarajan, Manikanda Boopathi Narayanan

“…The mutant-derived SSRs and structural variants offer actionable targets for enhancing yield stability under variable photoperiods, a priority for climate-resilient proso millet breeding in marginal agroecosystems.…”
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Loss of MNX1 Sensitizes Tumors to Cytotoxic T Cells by Degradation of PD‐L1 mRNA by Zhengzheng Li, Lei Chen, Ge Zhang, Shuang Wang, Enhang Xu, Jinglei Teng, Jiancheng Xu, Fang Peng, Qingjie Min, Zhuoya Wang, Shujuan Shao, Lianmei Zhao, Baoen Shan, Yang Wang, Qimin Zhan, Xuefeng Liu

“…In addition, MNX1 is upregulated by its adjacent long non‐coding RNA MNX1‐AS1 via HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HERC2). …”
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IGFN1_v1 is required for myoblast fusion and differentiation. by Xiang Li, Jane Baker, Tobias Cracknell, Andrew R Haynes, Gonzalo Blanco

“…Igfn1 is a complex locus that codes for multiple splicing variants of Immunoglobulin- and Fibronectin-like domain containing proteins predominantly expressed in skeletal muscle. …”
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Design of the CRISPR/Cas9-based <i>OsNRAMP2</i> editing construct in TBR225 rice (<i>Oryza sativa</i> L.) variety by Duy Phuong Nguyen, Tran Tuyet Mai Le, Thi Thu Huong Phung, Anh Minh Nguyen, Phuong Ngoc Pham, Xuan Hoi Pham, Quynh Mai Le

“…In rice, several protein-coding genes of the NRAMP (Natural resistance-associated macrophage protein) family have been identified as being involved in metal accumulation. …”
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Seasonal transcriptome profile across three different tissues of the Andean Killifish Orestias ascotanensis by Rodrigo Maldonado-Agurto, Elvis Acevedo, Vinicius Maracaja-Coutinho, Martin Montecino

“…Compared to protein-coding genes, lncRNAs exhibited higher tissue specificity, with a predominance of monoexonic structures and shorter exon lengths. …”
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Polyploidization-driven transcriptomic dynamics in Medicago sativa neotetraploids: mRNA, smRNA and allele-specific gene expression by D. F. Santoro, G. Marconi, S. Capomaccio, M. Bocchini, A. W. Anderson, A. Finotti, M. Confalonieri, E. Albertini, D. Rosellini

“…A large majority of the genes whose expression level changed due to WGD presented increased expression, indicating that the 4x state requires the upregulation of approximately 2.66% of the protein-coding genes. Overall, we estimated that 3.63% of the protein-coding genes were transcriptionally affected by WGD and may contribute to the phenotypic novelty of the neotetraploid plants. …”
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Neurophysiological Basis of Electroacupuncture Stimulation in the Treatment of Cardiovascular‐Related Diseases: Vagal Interoceptive Loops by Yun Liu, Tiancheng Xu, Zhi Yu, Bin Xu

“…Additionally, we clarified the multidimensional coding pattern in the VSNs, revealing that the targeted control of multimodal interoceptive is the functional basis of the synchronization of cardiovascular system. …”
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Designing a Suitable and Local Model for The Evaluation of Teachers Performance in Qom Province and its Validation by Fatemeh Janaghli, Jafar Rahmani, Hossein Karimian

“…Content analysis (interviews) and coding (open, axial, and selective coding) were employed for qualitative data analysis, while the quantitative analysis utilized exploratory and confirmatory factor analysis. …”
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Validation of the MIRACLE2 Score for Prognostication After Out-of-hospital Cardiac Arrest by Nicholas Sunderland, Francine Cheese, Zoe Leadbetter, Nikhil V Joshi, Mark Mariathas, Ioannis Felekos, Sinjini Biswas, Geoff Dalton, Amardeep Dastidar, Shahid Aziz, Dan McKenzie, Raveen Kandan, Ali Khavandi, Hazim Rahbi, Christopher Bourdeaux, Kieron Rooney, Matt Govier, Matthew Thomas, Stephen Dorman, Julian Strange, Thomas W Johnson

“…Prognostic scoring may assist decision-making regarding early angiographic assessment.…”
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Designing a Policy Model Based on the Development of Human Capabilities of the Ministry of Education of the Kurdistan Region of Iraq by Rahman Rasul Fatah, Mojtaba Amiri, Seyed Reza Seyed Javadin, Rasool Norouzi Seyed Hosseini

“…The aim of this research is to design a policy-making model based on the development of human capabilities in the Kurdistan Region's Ministry of Education. …”
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MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839 by Ben-gang Wang, Jun-shuai Li, Yong-feng Liu, Qian Xu

“…MicroRNAs could mediate the targeted coding gene and the targeted non-coding RNA to form endogenous competition, which have an important regulatory role in tumorigenesis of many types of cancer, including hepatocellular carcinoma. …”
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