Complexity of immunobiology of tumor necrosis factor and novel anti-TNF therapy by S. А. Nedospasov

“…Systemic anti-cytokine therapy is known to be accompanied by undesirable side effects, which can hypothetically be explained by the neutralization of these protective functions. Thus, we developed prototypes of TNF blockers which limit the bioavailability of this cytokine only from its main “pathogenic” source – myeloid cells. …”
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Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii by Francesca L. Short, Ram Maharjan, Liping Li, Nusrat Afrin, Natasha Delgado, Christine J. Boinett, Julian Parkhill, Amy K. Cain, Ian T. Paulsen

“…ABSTRACT Mutation rates in bacteria are an important determinant of adaptation to new environments and success in different niches. In some bacterial pathogens, “hypermutator” variants—most often associated with mutations in components of the DNA mismatch repair system—are associated with increased antibiotic resistance and poorer patient outcomes. …”
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Human sensory-like neuron surfaceome analysis. by Maximilian Breyer, Stephanie Lamer, Andreas Schlosser, Nurcan Üçeyler

“…Samples from three independent cell differentiations were analyzed via liquid chromatography tandem mass spectrometry. Detected proteins were categorized by cellular location and function, followed by generating an interaction network for deregulated surface proteins. …”
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Additive Manufacturing for Automotive Radar Sensors Using Copper Inks and Pastes by Nihesh Mohan, Fabian Steinberger, Sonja Wächter, Hüseyin Erdogan, Gordon Elger

“…Radar sensors are critical for obstacle detection and navigation, especially for automated driving. …”
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Simulation of Vertical Movements of Seawater in Stratified Reservoirs by N. V. Kudinov, A. A. Filina, A. V. Nikitina, D. V. Bondarenko, I. F. Razveeva

“…A software module for numerical simulation of hydrophysical processes of water movement with different salinity and density was developed. This is open-source software that provides not only the redefinition of empirical dependences (as algebraic functions), but also the connection of external simulating modules to display dependences algorithmically.Discussion and Conclusion. …”
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Feasibility and case studies on converting small hydropower stations to pumped storage by Yangqing Dan, Qingyue Chen, Daren Li, Wenhuan Bai, Weiming Zhou, Anyu Yang, Jia Yang

“…Abstract Hydropower, as a controllable energy source, plays a crucial role in supporting essential functions such as peak shaving, frequency regulation, and load reserve within modern power systems, thereby enhancing the overall economic efficiency and safety of these systems. …”
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A bibliometric and visual analysis of Jak1 to explore trends and frontiers by Cong Yu, Jiamin Cao, Xiaodong Xie, Wenguang Chen, Ensi Hong, Ensi Hong

“…CiteSpace is used to analyze references and keywords of authors, institutions, countries, and commonly cited, and applies co-current and clustering functions to generate visual knowledge maps.ResultsA total of 3,686 articles were incorporated. …”
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Establishing a national biosafety and biosecurity agency for the United States by David R. Gillum, David R. Gillum, David R. Gillum, Rebecca Moritz, Rebecca Moritz, Gregory D. Koblentz

“…The NBBA would consolidate various regulatory functions, streamline processes, and enhance oversight. …”
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Sex assessment from the proximal femur in a Spanish population based on three-dimensional computed tomography metric analysis by Đorojević Mirjana, Roldán Concepción, Botella Miguel, Alemán Inmaculada

“…The univariate and multivariate discriminant functions (DFs) were formulated for assessing sex. …”
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An Empirical Framework Characterizing the Metallicity and Star-formation History Dependence of X-Ray Binary Population Formation and Emission in Galaxies by Bret D. Lehmer, Erik B. Monson, Rafael T. Eufrasio, Amirnezam Amiri, Keith Doore, Antara Basu-Zych, Kristen Garofali, Lidia Oskinova, Jeff J. Andrews, Vallia Antoniou, Robel Geda, Jenny E. Greene, Konstantinos Kovlakas, Margaret Lazzarini, Chris T. Richardson

“…We present a new empirical framework modeling the metallicity and star formation history (SFH) dependence of X-ray luminous ( L ≳ 10 ^36 erg s ^−1 ) point-source population X-ray luminosity functions (XLFs) in normal galaxies. …”
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Pretreatment HIV‐1 Drug Resistance Among Newly Diagnosed People in Eastern Ethiopia by Abdella Gemechu, Adane Mihret, Mesfin Mengesha, Dawit Hailu Alemayehu, Eleni Kidane, Abraham Aseffa, Rawleigh Howe, Berhanu Seyoum, Andargachew Mulu

“…Results Among newly diagnosed individuals with baseline viral load (≥ 1000 copies/mL) and amplifications were successful, the genotyping success rate was 78.4%. Among the isolates successfully sequenced, three HIV‐1 strains were detected, of which 97.1% had HIV‐1 subtype C, 1.4% A1C, and 1.4% CF1 recombinant. …”
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Loading Patterns of the Posterior Cruciate Ligament in the Healthy Knee: A Systematic Review. by S H Hosseini Nasab, Renate List, Katja Oberhofer, Sandro F Fucentese, Jess G Snedeker, William R Taylor

“…<h4>Data sources</h4>MEDLINE, EMBASE and CENTRAL.<h4>Eligibility criteria for selecting studies</h4>Databases were searched for articles containing any numerical strain or force data on the healthy PCL and its functional bundles. …”
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CYP2D6 genotype and tamoxifen response for breast cancer: a systematic review and meta-analysis. by Danny W K Lum, Pablo Perel, Aroon D Hingorani, Michael V Holmes

“…Heterogeneity, publication bias, subgroup, and meta-regression analyses were performed.<h4>Data sources</h4>PubMed (inception-2012) and EMBASE (inception-2012).…”
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A systematic literature review of the impact and measurement of mobility impairment in rare bone diseases by Inês Alves, Ingunn Westerheim, Edward C. Hsiao, Jaymin Upadhyay, Luca Sangiorgi, Alexander Artyomenko, Kim Croskery, Juliet Johns, Emma Warnants, Gabor Barton

“…There were 34 functional assessments, 22 questionnaires, and 5 technologies described. …”
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Diagnosis and non-surgical management of traumatic type II dens invaginatus: A case report by Sanjeev Kunhappan, Pallav Patni, Shruti Sial, Swadhin Raghuwanshi, Voshishma Aleti, Shubham Tripathi

“…Treatment included endodontic access, drainage, copious irrigation, ultrasonic activation, calcium hydroxide dressing, and obturation with mineral trioxide aggregate.Discussion: Nonsurgical endodontic management of type II DI with a periapical abscess resulted in successful long-term healing and functional restoration.…”
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Biochar-based contaminant removal: A tutorial on analytical quality assurance and best practices in batch sorption by Tellulah A. Fernando, Dinushi N. Fernando, Sameera R. Gunatilake, Chanaka Navarathna, Xuefeng Zhang

“…The accuracy and the reliability of laboratory scale biochar-based batch sorption experiments are essential for a successful transition to pilot scale applications. The accuracy in preparation of solutions, proper storage conditions, and selection of the most appropriate instrumental method and its corresponding sensitivity, selectivity, detection limits and repeatability should be assessed to ensure analytical quality assurance (QA) during the quantification of analytes. …”
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Algorithm for Key Transparency with Transparent Logs [version 2; peer review: 2 approved, 1 approved with reservations, 1 not approved] by Shasivar Rexhepi, Ikechukwu John Chukwu, Ridvan Bunjaku, Hasan Dag, Elissa Mollakuqe

“…Security evaluations demonstrate the algorithm's robustness against tampering, with approximately 95% of keys verified successfully and effective detection of unauthorized modifications. …”
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Partial Analysis of the Capsid Protein (VP1) of Human Sapovirus Isolated from Children with Diarrhoea in Rural Communities of South Africa by Mpho Magwalivha, Jean-Pierre Kabue Ngandu, Afsatou Ndama Traore, Natasha Potgieter

“…Twenty-five samples were randomly selected from 40 sapovirus-positive samples previously detected and analyzed for the VP1 region using the One-Step RT-PCR assay. …”
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Signal Quality Index Estimator for Complex-Lead type ECG beat detectors by Hintermüller Christoph, Blessberger Hermann, Steinwender Clemens

“…The Electro Cardio Gram is a very valuable clinical tool to access the electric function of the heart. It provides insight into the different phases of the heart beat and various kinds of disorders which may affect them. …”
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Free radial forearm flap for reconstruction of postoperative defects in combined and complex treatment of patients with locally-advanced squamous cell carcinoma of the oral cavity by H. Chen, A. M. Mudunov, R. I. Azizian, I. N. Pustynskiy, O. A. Saprina, M. V. Bolotin

“…It allows restoring vital functions of the oral cavity and achieving good aesthetic and functional results.…”
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