A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity. by Andrew P Holmes, Ting Y Yu, Samantha Tull, Fahima Syeda, Stefan M Kuhlmann, Sian-Marie O'Brien, Pushpa Patel, Keith L Brain, Davor Pavlovic, Nigel A Brown, Larissa Fabritz, Paulus Kirchhof

“…<h4>Methods</h4>We used high-resolution optical mapping and sharp microelectrode recordings to quantify regional differences in electrical activation and repolarisation within the intact, superfused murine left atrium and quantified regional ion channel mRNA expression by Taqman Low Density Array. We also performed selected cellular electrophysiology experiments to validate regional differences in ion channel function.…”
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Unveiling Theranostics: Nanocomplex-Assisted Photodynamic Eradication of Aggressive Cancer Cells and Modulation of Tumor-Associated Macrophages by Butkute A, Kazlauske E, Mlynska A, Peciukaityte E, Karabanovas V, Rotomskis R, Steponkiene S

“…Immunomodulatory effects were explored by exposing resident and recruited TAM models to a conditioned medium from PDT-treated CRC cells, followed by gene expression analysis.Results: Spectral characterization of the QDs-Ce6 nanocomplex demonstrated selective switching between diagnostic and therapeutic modes. …”
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Sensory integration research: priority scientific directions based on the analysis of Web of Science Core Collection resources by Olha Podrihalo, Wladyslaw Jagiello, Guo Xiaohong, Leonid Podrigalo, Tetiana Yermakova, Miroslawa Cieslicka

“…The bibliometric database Web of Science Core Collection (WoS) was analyzed. 388 sources that met the search criteria for 2013-2023 were selected for primary analysis. …”
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Epidemiology of Disability of Adult Population in the Russian Federation by S. N. Puzin, M. A. Shurgaya, N. V. Dmitrieva, G. E. Pogosyan, I. V. Lyalina, A. M. Mammaraeva, T. A. Ivanova, L. S. Idrisova

“…In one elderly patient older than 60 years, on average, four to five different chronic diseases are detected. The accumulation of impaired functions of organs and systems helps to reduce the adaptive capacity of the body and is associated with limited life, which entails an increase in the risks of disability in the elderly and the need for medical and social rehabilitation. …”
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Risk Analysis of Groundwater Contaminant in Rural Areas Using Spatial Distribution by Herawati Herawati, Maria Kanan, Anwar Mallongi, Ramli Bidullah, Sandy N. Sakati, Dwi Wahyu Balebu

“…Background: Water is a very important material for the life of creatures in nature and its function for life cannot be replaced by other compounds. …”
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Understanding Silent Eruptions of Depression among Youngsters and Adolescents by Yuan Rai, Ananya Bhattacharjee, Manodeep Chakraborty, Akanchya Rai, Ashika Bhattarai, Chetiz Sharma, Md Hasnat Jahan Ali, Rudra Acharya, Nihar Ranjan Bhuyan

“…It is marked by a depressed mood, diminished interests, and disinterest in routine tasks, feelings of loneliness, impaired cognitive function, and vegetative symptoms like disturbed sleep or appetite and a lack of desire. …”
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Influence of Pt nanoparticles modified by La and Ce oxides on catalytic dehydrocyclization of n-alkanes by A.H. Samia, M.S. Mohammed, S. Faramawy, S.A. Ahmed, H.B. Ahmed

“…In addition, reforming of hydrocarbon on the dual-function catalysts has been found to form fundamentally different products in hydrogen diluents. …”
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Social Confrontation with Menstruation: A Feminist Ethnography of Menstrual Experience among Female Instagram Users by Rana Mohammad Taghinejad Esfahani, Majid Movahed, Halimeh Enayat, Aliyar Ahmadi

“…This study examined women’s experiences of menstruation on Instagram and explored how menstruation taboos function as mechanisms for controlling women’s bodies within the existing power structures and daily life. …”
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Prognostic value and immunotherapy analysis of immune cell-related genes in laryngeal cancer by Sen Zhang, Jianrui Pan, Huina Guo, Xiaoya Guan, Chenxu Yan, Lingling Ji, Xiansha Wu, Hui Huangfu

“…Key genes were identified through the intersection of differentially expressed genes (DEGs) between normal and LC samples and module genes derived from weighted gene co-expression network analysis (WGCNA), followed by functional enrichment analysis. The prognostic risk model was constructed using univariate Cox and Least Absolute Shrinkage and Selection Operator (LASSO) analyses. …”
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How to reduce the risk of primary engraftment failure after haploidentical hematopoietic stem cell transplantation in patients with acute myeloid leukemia? by D. K. Zhogolev, S. N. Bondarenko, A. G. Smirnova, Yu. Yu. Vlasova, D. A. Chernyshova, I. S. Moiseev, A. D. Kulagin

“…Optimizing transplantation strategies, including the selection of the graft source and modification of conditioning regimens, may improve haplo‑HSCT outcomes.   …”
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Error Analysis and Compensation of 3‒PTT Parallel Robot by CHEN Mingfang, LIANG Hongjian, WEI Songpo, HE Chaoyin

“…Then, the improved particle swarm optimization algorithm is utilized to optimize the error correction objective function, where the slider compensation is obtained, and the servo driver is utilized to complete the error compensation. …”
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Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation by Jingyi Hou, Jingyi Hou, Jingyi Hou, Lihan Wang, Lihan Wang, Naiqiang Zhu, Xueli Li

“…This study aimed to clarify the roles of mitochondrial metabolism and immune infiltration in MI, using a combination of bioinformatics analyses and experimental validation.MethodsMI chip data (GSE96561, GSE181872, and GSE183272) were obtained from the Gene Expression Omnibus (GEO) database, and mitochondrial gene data were sourced from the MitoCarta3.0 database. Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analyses. …”
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Association of Omega-3 Index and Blood Cell Count-Derived Systemic Inflammatory Indexes among Testicular Germ Cell Tumor Survivors by Milica Zeković, Marko Živković, Marija Takić, Sanja Stanković, Nebojša Bojanić, Aleksandar Janičić, Uroš Bumbaširević

“…Background and objectives: Although testicular cancer is considered the paradigm of highly curable malignancy, treatment-induced adverse effects and potential impairment of gonadal function may cause non-negligible long-term health repercussions, including metabolic disturbances and cardiovascular sequelae. …”
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Research Progress on the Effect of Dissolved Organic Matter on the Environmental Behavior of Cadmium in Environmental Remediation by Jiabao MA, Siwen LIU, Bo WANG, Di WU, Jixin WEI, Qing SUN, Chenge MA, Yi HUANG, Taotao YAN

“…The various active functional groups contained in DOM, such as carboxyl, hydroxyl, and phenolic groups, are ligands and migration carriers for many heavy metals in the environment. …”
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WEB SERVICE OF WORKS PLANNING USING NETWORK GRAPH by Інна Грод, Надія Балик, Ярослав Василенко, Сергій Мартинюк, Василь Олексюк, Ольга Барна

“…During the study, a set of theoretical, empirical, and modeling methods were applied, in particular: systematic analysis of scientific and methodological sources, the results of domestic and foreign experience on the problem, review of existing software to determine the problem solution state and select development tools of web service, analysis of methods and technologies network graphs construction, generalization of information on the problem. …”
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A novel acidic laminarinase derived from Jermuk hot spring metagenome by Ani Paloyan, Tigran Soghomonyan, Mariam Karapetyan, Hasmik Grigoryan, Anna Krüger, Fiona Cuskin, Jon Marles-Wright, Christin Burkhardt, Garabed Antranikian

“…Abstract Laminarinase, an enzyme with a specific affinity for laminarin—a complex polysaccharide found in the cell walls of brown algae and select marine organisms—was investigated in this study. …”
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Exploring interactions between shading and view using visual difference prediction by Stephen Wasilewski, Marilyne Andersen

“…This paper is an exploration of how to approach the characterisation of view clarity through different facades as a function of both the facade and the view itself. While the findings are preliminary, there is already an indication that the type of view content matters to how well people will see through different systems, an important consideration when planning mock-ups and selecting shade fabrics, blinds or electrochromic glazing.…”
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Performance of the HAWC Observatory and TeV Gamma-Ray Measurements of the Crab Nebula with Improved Extensive Air Shower Reconstruction Algorithms by A. Albert, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, F. Carreón, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño de León, E. De la Fuente, C. de León, D. Depaoli, N. Di Lalla, R. Díaz Hernández, B. L. Dingus, M. A. DuVernois, K. Engel, T. Ergin, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, S. Fraija, J. A. García-González, F. Garfias, H. Goksu, M. M. González, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernández-Cadena, I. Herzog, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, S. Kaufmann, A. Lara, J. Lee, H. León Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, J. Martínez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, E. Moreno, M. Mostafá, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, M. Osorio-Archila, Y. Pérez Araujo, E. G. Pérez-Pérez, C. D. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, G. Schwefer, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Ureña-Mena, E. Varela, X. Wang, I. J. Watson, K. Whitaker, E. Willox, H. Wu, S. Yu, S. Yun-Cárcamo, H. Zhou, HAWC Collaboration

“…Thanks to these improvements, HAWC can now detect more sources, including the Galactic center.…”
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Case Report: Targeted treatment by fluoxetine/norfluoxetine of a KCNC2 variant causing developmental and epileptic encephalopathy by Ping Li, Alice Butler, Yu Zhou, Karl L. Magleby, Christina A. Gurnett, Lawrence Salkoff

“…The Kv3.2 subfamily of voltage activated potassium channels encoded by the KCNC2 gene is abundantly expressed in neurons that fire trains of fast action potentials that are a major source of cortical inhibition. Gain-of-function (GOF) de novo pathogenic variants in KCNC1 and KCNC2, encoding Kv3.1 and Kv3.2 respectively, cause several types of epilepsy including developmental and epileptic encephalopathy (DEE). …”
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PCI-DB: a novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development by Sven Nahnsen, Hans-Georg Rammensee, Cécile Gouttefangeas, Jonas S Heitmann, Juliane S Walz, Jens Bauer, Marcel Wacker, Annika Nelde, Jonas Scheid, Steffen Lemke, Marissa L Dubbelaar, Patrick Zimmermann, Naomi Hoenisch Gravel, Susanne Jung, Anna Dengler, Yacine Maringer, Sven Fillinger, Tatjana Bilich

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