Applying bioinformatic analysis for prognostic assessment of the <i>HS3ST6</i> missense mutations clinical significance in the development of hereditary angioedema by N. A. Pechnikova, Yu. V. Ostankova, M. A. Saitgalina, A. M. Bebyakov, A. R. Denisova, N. S. Podchernyaeva, A. A. Totolian

“…Currently, mutations in the HS3ST6 gene remain poorly understood; only one missense mutation (p.Thr144Ser, rs746467957) associated with the development of HAE has been described.The aim of our work was to study new mutations in the HS3ST6 gene and analyze in silico their prognostic nature and clinical significance for the development of hereditary angioedema.The material was whole blood samples obtained from 13 patients with symptoms of hereditary angioedema without reduced levels and function of C1-INH.Whole exome sequencing of patients, bioinformatic analysis of HS3ST6 gene mutations using a number of databases and Web resources to predict the effect of mutations on the protein and assess the conservatism of the positions of the mutations detected was involved in study methods.Mutations in the HS3ST6 gene were identified in four patients, including two cases with two mutations simultaneously. …”
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Worlds Next Door: A Candidate Giant Planet Imaged in the Habitable Zone of α Centauri A. II. Binary Star Modeling, Planet and Exozodi Search, and Sensitivity Analysis by Aniket Sanghi, Charles Beichman, Dimitri Mawet, William O. Balmer, Nicolas Godoy, Laurent Pueyo, Anthony Boccaletti, Max Sommer, Alexis Bidot, Elodie Choquet, Pierre Kervella, Pierre-Olivier Lagage, Jarron Leisenring, Jorge Llop-Sayson, Michael Ressler, Kevin Wagner, Mark Wyatt

“…Additionally, postprocessing with the principal-component-analysis-based Karhunen–Loéve image processing algorithm reveals a point source, called S 1, in 2024 August, detected at signal-to-noise ratio of 4–6 (3.3–4.3 σ ), a projected separation of ≈1 $\mathop{.}…”
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GWAS and WGCNA analysis uncover candidate genes associated with drought in Brassica juncea L. by Yusong Zhang, Yusong Zhang, Xiaoyan Yuan, Xiaoyan Yuan, Yunyun Zhang, Yunyun Zhang, Yanqing Luo, Yanqing Luo, Kaiqin Zhao, Kaiqin Zhao, Feng Zu, Feng Zu, Zhengshu Tian, Zhengshu Tian, Jinfeng Li, Jinfeng Li, Lifan Zhang, Lifan Zhang, Xiaoying He, Xiaoying He, Jinxiang Gao, Jinxiang Gao, Minglian Fu, Minglian Fu, Genze Li, Genze Li, Feihu Liu

“…To screen drought-tolerant germplasm resources and key functional genes related to drought tolerance in Brassica juncea L.(193 accessions), three treatments were applied at the germination and seedling stages:control(CK), moderate drought stress (M), and severe drought stress (S). …”
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A Comprehensive Study on the Nutritional Profile and Shelf Life of a Custom-Formulated Protein Bar Versus a Market-Standard Product by Corina Duda-Seiman, Liliana Mititelu-Tartau, Simona Biriescu, Alexandra-Loredana Almășan, Bianca-Oana Bitu, Adina-Ioana Bucur, Andrei Luca, Bogdan Hoinoiu, Teodora Hoinoiu

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Enhancing yield and quality: research and practice of agro-forest waste for Lentinus edodes (shiitake mushroom) cultivation by Hongyan Xu, Hongyan Xu, Guocai Han, Yanyan Li, Qing Meng, Qing Meng, Yang Zhang, Yayi Wang, Songling Li

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Barriers to and facilitators of rehabilitation according to socio-economic status, after acute respiratory distress syndrome due to COVID-19: A qualitative study in the RECOVIDS co... by Mathilde Kléber, Nicolas Meunier-Beillard, Isabelle Fournel, Eléa Ksiazek, Marine Jacquier, Fiona Ecarnot, Jean-Philippe Rigaud, Pierre-Louis Declerq, Jean-Pierre Quenot, Marie Labruyère

“…<h4>Background</h4>The COVID-19 pandemic may have compounded social disparities in access to healthcare, with possible deleterious consequences on the functional prognosis of patients after a stay in the intensive care unit (ICU). …”
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Mortalin overexpression predicts poor prognosis in early stage of non–small cell lung cancer by Jie Sun, Shuan-Long Che, Jun-Jie Piao, Ming Xu, Li-Yan Chen, Zhen-Hua Lin

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Fate and risks of potentially toxic elements associated with lacustrine groundwater discharge: quantification, modeling, and biogeochemistry by Shen Qu, Juliang Wang, Keyi Zhang, Mengyu Fan, Yuanzhen Zhao, Xu Yang, Zhongli Wang, Helena I. Gomes, Rachel L. Gomes, Limin Duan, Shaogang Dong, Ruihong Yu

“…Thus, self-organizing maps (SOM) and positive matrix factorization (PMF) were employed in present work to decipher source of selected PTE (Li, V, Mn, Cr, Co, Ni, Cu, Zn, Ba, Pb, U, Sr) in Ulansuhai Lake basin (Inner Mongolia, China). …”
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Comparative study of nosZI and nosZII clade isolates: insights into their responses to environmental variables and soil fertilization types by Haoran Li, Qishi Luo, Lichao Sun, Huicui Xu, Xiaodong Hao, Kai Zhu, Ming Li, Bao Li, Wei Jiao, Jibiao Geng, Zhiqun Chen, Lihua Huang, Zongwei Xia

“…In contrast, the nosZI strain tended to increase emissions, except under the mixed fertilization regime.DiscussionThese findings highlight the importance of selecting N2O-reducing microbial strains based on their functional capacity and environmental tolerance. …”
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Nanoprobe synchrotron X-ray fluorescence microscopy reveals selenium-rich spherical structure in mouse retinal pigment epithelium by Marta Ugarte, Kalotina Geraki, Elizabeth Bentley, Roger Cox

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The Effect of Hearing Aid Amplification on Gait Parameters: A Pilot Study Using Ear-Worn Motion Sensors by Ann-Kristin Seifer, Arne Küderle, Kaja Strobel, Ronny Hannemann, Björn M. Eskofier

“…Additionally, we showed the potential of ear-worn sensors for detecting relevant gait changes. To achieve this, we used a hearing-aid-integrated accelerometer and our open-source EarGait framework comprising gait-related algorithms specifically developed for ear-worn sensors. …”
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Interrelation of indicators of oxygen metabolism of neutrophils and antiendotoxin immune as a marker of the postoperative period in patients with acute colonic obstruction by A. V. Pikuza, A. M. Zakirov

“…The focus of purulent inflammation in the abdominal cavity serves as a source of concentration of antimicrobial mechanisms, among which the central role is played by neutrophilic granulocytes and factors cooperating with them. …”
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Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves&rsquo; Disease and Graves&rsquo; Ophthalmopathy by Ke C, Yu Y, Li J, Yu Y, Sun Y, Wang Y, Wang B, Lu Y, Tang M, Wang N, Chen Y

“…Then, downstream analyses were performed to detect protein interactions, gene function, cell type-specific expression and druggable information.Results: This study genetically predicted levels of 62 plasma proteins were associated with GD risk. …”
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Compact and Handheld SiPM-Based Gamma Camera for Radio-Guided Surgery and Medical Imaging by Fabio Acerbi, Aramis Raiola, Cyril Alispach, Hossein Arabi, Habib Zaidi, Alberto Gola, Domenico Della Volpe

“…We characterized the intrinsic position resolution (tested with pulsed light) as being ~200 µm, and the sensitivity and resolution when detecting gamma rays from Tc-99m source measured between 134 and 481 cps/MBq and as good as 1.4–1.9 mm, respectively.…”
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Identification of Soybean E1-E4 Gene Orthologs in the Guar Genome Using Comprehensive Transcriptome Assembly and Annotation by Luisa Criollo Delgado, Aleksei Zamalutdinov, Elena Potokina

“…Taub.), a well-known source of guar gum (food additive E 412). At high latitudes, e.g., in Russia, the main challenge for guar cultivation is the long photoperiod during summer, which delays flowering and maturation of guar plants. …”
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Impact of probiotic supplementation on serum levels of brain-derived neurotrophic factor: GRADE-based dose-response meta-analysis by Reza Hashemi, Mohammad M. Hussein M. Raouf, Tanya S. Salih, Marzieh Feyzpour, Maryam Eskandarioun, Najmeh Nezamabadipour, Hossein Gandomkar

“…Abstract Background Brain-derived neurotrophic factor (BDNF) is a key neurotrophin involved in neuroplasticity and cognitive function, with its dysregulation linked to neurodegenerative and psychiatric disorders. …”
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Vitamin C, Sugar Content, Color Intensity and Some Physicochemical Properties of Watermelon and Orange Peels by Selvican Gökçe, İsa Arslan Karakütük, Memnune Şengül

“…Therefore, orange peel can be used as a natural antioxidant and color source in the food, pharmaceutical, and cosmetic industries.…”
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Personality and Personality Disorders in Medication-Overuse Headache: A Controlled Study by SWAP-200 by Federica Galli, Annalisa Tanzilli, Alessandra Simonelli, Cristina Tassorelli, Grazia Sances, Micol Parolin, Patrizia Cristofalo, Ivan Gualco, Vittorio Lingiardi

“…At levels of specific PDs, MOH patients showed higher obsessive and dysphoric traits and better overall psychological functioning than SUD and PD patients. Conclusion. Although MOH, SUD, and PD populations have been evaluated in multiple sites with different levels of expertise, the study supported the presence of a specific constellation of personality in MOH patients including obsessive (perfectionist) and dysphoric characteristics, as well as good enough psychological resources. …”
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Prevalence and contributing factors of depression among women with infertility in low-resource settings: a systematic review and meta-analysis by Shimelis Tadesse, Henok Kumsa, Gemeda Wakgari Kitil, Alex Ayenew Chereka, Getnet Gedefaw, Fiker Chane, Esuyawkal Mislu

“…Good functioning family, good husband support, primary infertility, history of divorce, and duration of infertility lasting more than 10 years were statistically associated. …”
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Research note: Harnessing the potential of chicken blastodermal cells as a new frontier in poultry science and biotechnology – Establishment of embryonic stem cells and their diffe... by Małgorzata Duda, Patrycja Maciak, Grzegorz Tylko, Kamil Wartalski, Monika Trzcińska, Marek Romek, Marcin Samiec

“…Further research exploring the functional attributes of B-ESC-derived SC-LCs is required to elucidate their therapeutic potential in nerve reconstruction/repair.…”
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