Product Development of High-Dose Ambroxol HCl Capsules for an n-of-1 Clinical Trial Involving Dutch Patients with Gaucher Disease Type 3 by Hoang Lan Le, Natalja Bouwhuis, Carla E. M. Hollak, Abraham J. Wilhelm, Anne-Loes E. Gerards, Yuma A. Bijleveld, Eleonora L. Swart

“…As an adequate commercial AMB formulation is unavailable for this high target dosage, we aimed to develop high-dose AMB capsules and assess the formulated capsule’s quality. <b>Methods</b>: AMB API was sourced and tested according to the requirements of the European Pharmacopoeia. …”
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Harmonization trial on ESR1 testing strategies in ER+/HER2- breast cancer patients: an Italian experience by Francesco Pepe, Gianluca Russo, Konstantinos Venetis, Claudia Scimone, Lucia Palumbo, Mariantonia Nacchio, Domenica di Giovanni, Claudia Sarracino, Ilaria Tomaiuolo, Elisabetta Zulato, Matteo Fassan, Daniela Righi, Giuseppe Perrone, Dario de Biase, Gabriele Casati, Fabio Pagni, Lucia Gullotti, Antonio Rizzo, Alessandro Perez, Antonio Russo, Katia Zavaglia, Gianluca Gragnano, Domenico Cozzolino, Sabrina Alfano, Cristian Scatena, Sara D’andrea, Monica Schiappacassi, Giuseppina Roscigno, Alessia Paganotti, Renzo Boldorini, Francesco Esposito, Pierlorenzo Pallante, Daniela Furlan, Marta Sbaraglia, Angelo Paolo Dei Tos, Giancarlo Troncone, Nicola Fusco, Umberto Malapelle

“…Harmonized ring trials are key weapons to standardize analytical and post-analytical procedures optimizing clinical stratification of BC patients…”
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Machine learning-based brain magnetic resonance imaging radiomics for identifying rapid eye movement sleep behavior disorder in Parkinson’s disease patients by Yandong lian, Yibin Xu, Linlin Hu, Yuguo Wei, Zhaoge Wang

“…This study aims to develop and validate an magnetic resonance imaging (MRI) radiomics-based machine learning classifier to accurately detect RBD patients with Parkinson’s disease (PD). Methods Data from 183 subjects, including 63 PD patients with RBD, sourced from the PPMI database were utilized in this study. …”
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Multi-machine learning model based on radiomics features to predict prognosis of muscle-invasive bladder cancer by Bin Wang, Zijian Gong, Peide Su, Guanghao Zhen, Tao Zeng, Yinquan Ye

“…Abstract Objective This study aims to construct a survival prognosis prediction model for muscle-invasive bladder cancer based on CT imaging features. Materials and methods A total of 91 patients with muscle-invasive bladder cancer were sourced from the TCGA and TCIA dataset and were divided into a training group (64 cases) and a validation group (27 cases). …”
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Evaluating Freshwater, Desalinated Water, and Treated Brine as Water Feed for Hydrogen Production in Arid Regions by Hamad Ahmed Al-Ali, Koji Tokimatsu

“…This study highlights the trade-offs between water sourcing, brine treatment, and freshwater purification for hydrogen production, offering insights for optimizing sustainable hydrogen systems in water-stressed regions.…”
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Energy Hub Operation Under Uncertainty: Monte Carlo Risk Assessment Using Gaussian and KDE-Based Data by Spyros Giannelos, Danny Pudjianto, Tai Zhang, Goran Strbac

“…Energy hubs integrating onsite renewable generation and battery storage provide cost-efficient solutions for meeting building electricity requirements. This study presents methods for modeling uncertainties in load demand and solar generation, ranging from normal distribution assumptions to distributions sourced from CityLearn 2.3.0. …”
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Design and Simulation of an Irish Potato Peeling machine. by Namuri, Gift Evelyn

“…Prototype testing was conducted using Irish potatoes with an Irish potato sourced locally. Results demonstrate the machine can peel potatoes with an average efficiency of 90% and can reduce peeling time by 70% compared to manual methods. …”
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Optimising colorectal cancer screening strategies and target populations in budget-constrained regions through cost-effectiveness analysis: a case from eastern China by Hao Li, Peng Zhang, Yun Fu, Weibing Wang, Ao Xu

“…Objectives The primary aim of this study was to optimise colorectal cancer (CRC) screening strategies and target populations in resource-limited areas through cost-effectiveness analysis, evaluating the best screening methods and appropriate screening ages.Design A prospective microsimulation model was used for cost-effectiveness analysis, calibrated with real-world data.Setting The study was conducted in Huzhou City, Zhejiang Province, China, focusing on primary and secondary healthcare levels. …”
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From Fibroadenoma to Phyllodes Tumor: Case Analysis of Borderline and Giant Breast Tumors with Literature Review by Justė Kazlauskaitė, Iryna Schmeil

“…Differential diagnosis between phyllodes tumors and fibroadenomas by using imaging techniques such as ultrasound or mammography, as well as histological methods, can be challenging due to overlapping features. …”
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Penentuan Musim Penangkapan Ikan Ekor Kuning (Blonch, 1791): Studi Perairan Karimunjawa, Indonesia by Pranata Candra Perdana Putra, Setyo Tri Wahyudi, Abu Bakar Sambah, Aida Sartimbul

“…This study aims to determine the optimal yellowtail fishing season index using the moving average method based on time series analysis to optimize fishing sustainably. …”
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Psycho-Theological Learning Model to Improve Mental Resilience in Muslim Adolescents by Muhammad Zamzam, Winsidi Winsidi

“…To ensure data richness, the study employed triangulated collection methods including in-depth semi-structured interviews, participatory classroom observations, and document analysis comprising lesson plans, student portfolios, and reflective teacher notes. …”
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Effect of transcranial direct current stimulation combined with speech and language therapy in post ischemic stroke aphasia: A systematic review by Isna Imroah Husna, Putri Ma'rifatul Mardiyah, Yanuareza Totti Adyanata, Zahra Roidah Amalia Hasna, Faris Khairuddin Syah, Muhana Fawwazy Ilyas

“…Data were sourced from the PubMed, Scopus, and ScienceDirect databases. …”
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Patient Participation in Healthcare Safety Practices: A Scoping Review by Shabnam Ghasemyani, Kobra Movalled, Shafi Habibi, Rahim Khodayari Zarnaq

“…Materials and Methods: A scoping review of the English-language literature published from 2000 to 2021 was performed. …”
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Supercritical carbon dioxide extraction of astaxanthin from Corynebacterium glutamicum by Jan Seeger, Maximilian Zäh, Volker F. Wendisch, Christoph Brandenbusch, Nadja A. Henke

“…As astaxanthin integrates into the cellular membrane, effective extraction methods are essential to access this valuable compound. …”
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Analyzing the Reproductive Characteristics of the Naked Carp Gymnocypris Przewalskii (Kessler) Based on the Oxygen Isotopes of Otolith Core Using SHRIMP by Ling ZHOU, Linbo QIAN, Sumei ZHAO, Xiulan ZHANG, Yinglie LIU, Qiaoling TANG, Jie YUAN

“…Otolith δ18O provides a method for fish population identification, migration and environment exploration of spawning ground. …”
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Enhancing Concrete Sustainability: A Critical Review of the Performance of Recycled Concrete Aggregates (RCAs) in Structural Concrete by Alireza Alibeigibeni, Flavio Stochino, Marco Zucca, Fernando López Gayarre

“…However, pretreatment methods—mechanical, chemical, and thermal—along with optimized mix designs and the use of supplementary cementitious materials (SCMs) have shown to significantly improve the concrete properties of RCAs. …”
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Stem Cell Perspective for Regenerative Wound Healing: from Biology toward Future Clinical Directions: A Review by Nahid Nasiri, Fatemeh Haghdoost, Masoud Habibi, Mohsen Fateh, Shaghayegh Gholami, Seyed Mehdi Tabaie

“…Despite the therapeutic progress, key issues, such as optimal cell sourcing, cell dosage, delivery modalities, andlong-term safety profiles, there are a number of unresolved issues which need to be dealt with. …”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…The key findings in this research stage were: Regarding housing survivability, the housing stock in the Netherlands evolved to be characterized by single-family private houses, apparently larger, built under non-traditional methods and better sound constructed compared to the recent post-war period. …”
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Mononuclear cell therapy of neonatal hypoxic‐ischemic encephalopathy in preclinical versus clinical studies: A systematic analysis of therapeutic efficacy and study design by Alexander M. Scrutton, Francesca Ollis, Johannes Boltze

“…Cell‐based treatments using mononuclear cells (MNCs), which can be sourced from umbilical cord blood, are currently being investigated. …”
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An adaptive filter for anemia screening using deep convolutional neural network by Jose B. Lazaro, Jr., Jennifer C. Dela Cruz, Jocelyn F. Villaverde

“…Early and efficient detection is crucial for timely intervention, yet conventional diagnostic methods often require laboratory access, limiting widespread screening capabilities, especially in resource-limited settings. …”
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