MSC-Derived Extracellular Vesicles Activate Mitophagy to Alleviate Renal Ischemia/Reperfusion Injury via the miR-223-3p/NLRP3 Axis by Zejia Sun, Zihao Gao, Jiyue Wu, Xiang Zheng, Shizhao Jing, Wei Wang

“…MSC-derived extracellular vehicles (EVs) exhibit a protective functional role in renal ischemia/reperfusion injury (RIRI). …”
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Optimization in High-pressure Microfluidics Preparation of Black Pepper Essential Oil Nanoemulsion by Response Surface Methodology and Its Component Analysis by Yaxin TAN, Song WU, Hanyue YANG, Xiaoya YUAN, Yonggui PAN

“…The particle size of BPEO nanoemulsion prepared under these conditions was 126.64 nm and the polymer dispersity index (PDI) was 0.238. Most of the functional groups of Tween 80 and BPEO exist in the BPEO nanoemulsion, and the wavenumber changes of the characteristic absorption peaks were slightly small, which proved that BPEO was successfully wrapped in the droplet. …”
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Multimorbidity and associated outcomes among older adult inpatients with neurological disorders by Aroldo BACELLAR, Telma ASSIS, Bruno Bacellar PEDREIRA, Luan CÔRTES, Silas SANTANA, Osvaldo José Moreira do NASCIMENTO

“…Methods: We enrolled patients aged ≥60 years successively admitted to a tertiary medical center with NDs between January 1, 2009, and December 31, 2010. …”
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Novel resistance to Cydia pomonella granulovirus (CpGV) in codling moth shows autosomal and dominant inheritance and confers cross-resistance to different CpGV genome groups. by Annette J Sauer, Eva Fritsch, Karin Undorf-Spahn, Petr Nguyen, Frantisek Marec, David G Heckel, Johannes A Jehle

“…Commercial Cydia pomonella granulovirus (CpGV) products have been successfully applied to control codling moth (CM) in organic and integrated fruit production for more than 30 years. …”
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Reduced representation sequencing reveals genetic diversity and adaptive genetic divergence in Calamus rhabdocladus by Rui Gu, Ruijing Xu, Songpo Wei, Pär K. Ingvarsson, Shaohui Fan, Guanglu Liu

“…The Latent Factor Mixed Model (LFMM) identified 955 loci significantly associated with environmental adaptation and successfully aligned 469 genes from related species, which were enriched in functional categories involving cell structure, carbohydrate metabolism, and protein degradation. …”
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Early life microbiome disbalance impacts neuroendocrine outcomes in pre-pubertal mice in a sexually dimorphic manner by Bistra B. Nankova, Bistra B. Nankova, Furong Hu, Edmund F. LaGamma, Edmund F. LaGamma, Edmund F. LaGamma

“…Maternal antibiotics during nursing caused: (1) microbial dysbiosis in the offspring as evident by markedly enlarged ceca, no detectable by-products of bacterial fermentation (sp. …”
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Integrating parental genomes to reduce reference bias and identify intramuscular fat genes in Qinchuan Black pigs by Guangquan Lv, Peiyu Yang, Ao Guo, Minghao Cao, Dong Li, Zhe Liu, Mingyu Wang, Jingchun Sun, Rongrong Ding, Taiyong Yu

“…Selection signal analysis based on the integrated parental genomic strategy successfully identified more differentiated windows and positively selected genes. …”
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Enhanced intestinal epithelial co-culture model with orbital mechanical stimulation: a proof-of-concept application in food nanotoxicology by Mattia Santoni, Giovanni Piccinini, Giovanni Piccinini, Giovanni Liguori, Maria Roberta Randi, Massimo Baroncini, Liliana Milani, Francesca Danesi

“…The optimized model successfully detected concentration-dependent oxidative stress responses to TiO₂ exposure, revealing cellular dysfunction preceding membrane damage.DiscussionThis improved co-culture system provides a better physiological platform for nanotoxicology studies. …”
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Environmental DNA as a tool for soil health monitoring and unveiling new ecological frontiers by Yuan Zhang, Weijun Lu, Kaihang Xing, Fen Guo, Qingping Du, Xinfei Zhang, Fan Zhang, Zongyao Qian, Feilong Li

“…We observed a rapid increase in the use of eDNA for soil health, with more than 700 publications on soil eDNA methods since 2001, and an annual growth rate of over 20% since 2017. eDNA has been successfully applied to detect a wide range of taxa in soil, including bacteria, fungi, and metazoans, with bacteria being the most frequently studied group, accounting for 43% of total publications. …”
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Foamy Melamine Resin–Silica Aerogel Composite-Derived Thermal Insulation Coating by Dongfang Wang, Yabin Ma, Yingjie Ma, Baolei Liu, Dewen Sun, Qianping Ran

“…The results of foamy structure analyses via scanning electron microscopy, micro-CT, and N₂ adsorption–desorption isotherms validate the successful generation of a micro-scale porous structure with the enhancement of the aerogel nano-scale solid particles at the wall as a stabilizer. …”
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Experience of extended transtriceps approach in osteosynthesis of complex fractures of the distal metaepiphysis of the humerus by A. Yu. Sergyeev, A. M. Fain, A. Yu. Vasa, S. F. Gnetetsky, V. B. Bondarev

“…Evaluation of treatment results confirms that osteosynthesis using this access allows to reduce the time and trauma of the operation, to avoid complications associated with osteotomy of the olecranon, and to carry out successful postoperative rehabilitation, achieving good functional results.…”
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A Review: The Beauty of Serendipity Between Integrated Circuit Security and Artificial Intelligence by Chen Dong, Decheng Qiu, Bolun Li, Yang Yang, Chenxi Lyu, Dong Cheng, Hao Zhang, Zhenyi Chen

“…Integrated circuits are the core of a cyber-physical system, where tens of billions of components are integrated into a tiny silicon chip to conduct complex functions. To maximize utilities, the design and manufacturing life cycle of integrated circuits rely on numerous untrustworthy third parties, forming a global supply chain model. …”
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Indocyanine green fluorescence to ensure perfusion in middle segment-preserving pancreatectomy: a case report by Tomohiro Iguchi, Norifumi Iseda, Kosuke Hirose, Mizuki Ninomiya, Takuya Honboh, Takashi Maeda, Fumi Sawada, Yu-ichi Tachibana, Tetsuro Akashi, Naotaka Sekiguchi, Noriaki Sadanaga, Hiroshi Matsuura

“…Abstract Background Middle segment-preserving pancreatectomy (MSPP) is an alternative to total pancreatectomy that allows for the preservation of the endocrine and exocrine functions of the pancreas. However, maintaining perfusion to the pancreatic remnant is of critical importance. …”
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High-resolution genetic and physical mapping reveals a peanut spotted wilt disease resistance locus, PSWDR-1, to Tomato spotted wilt virus (TSWV), within a recombination cold-spot... by Dongliang Wu, Chuanzhi Zhao, Walid Korani, Ethan A. Thompson, Hui Wang, Gaurav Agarwal, Jake C. Fountain, Albert Culbreath, C. Corley Holbrook, Xingjun Wang, Josh P. Clevenger, Baozhu Guo

“…Sequencing of these two recombinants confirmed the cold spot with only five SNPs detected within this region. Conclusions This study successfully identified a peanut spotted wilt disease resistance locus, PSWDR-1, on chromosome A01 within a recombination “cold spot”. …”
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Experience with artificial intelligence algorithms for the diagnosis of vertebral compression fractures based on computed tomography: from testing to practical evaluation by Zlata R. Artyukova, Alexey V. Petraikin, Nikita D. Kudryavtsev, Fedor A. Petryaykin, Dmitry S. Semenov, Daria E. Sharova, Zhanna E. Belaya, Anton V. Vladzimirskyy, Yuriy A. Vasilev

“…RESULTS: From June 2021 to June 2022, two artificial intelligence algorithms (Nos. 1 and 2) with different methods of detecting compression fractures were tested. Both artificial intelligence algorithms successfully passed the self-testing (6 tests), functional (5 tests), and calibration (100 tests) stages. …”
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A Validation Tool (VaPCE) for Postcoordinated SNOMED CT Expressions: Development and Usability Study by Tessa Ohlsen, Viola Hofer, Josef Ingenerf

“…Additionally, 868 OncoTree codes were evaluated, resulting in 161 (20.9%) PCEs containing inactive concepts, which were successfully replaced with valid alternatives. A user survey reflects a favorable evaluation of the tool’s functionality. …”
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Predictive model for coronavirus disease 2019 severity based on blood biomarkers: a retrospective study by Liu Xiaoyan, Bao Zhongying, Duan Shuhong, Sun Jing, Zhang Yijie, Zhang Jie, Liu Jingxin

“…Emergency department data functioned as an independent external validation set to test the model’s generalizability.ResultsThe study included 1,007 patients, with 778 in the training set and 229 in the validation set. …”
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Relevance of TNF-α, IL-6 and IRAK1 gene expression for assessing disease severity and therapy effects in tuberculosis patients by Ivana Buha, Vesna Škodrić-Trifunović, Tatjana Adžić-Vukičević, Aleksandra Ilić, Ana Blanka-Protić, Mihailo Stjepanovic, Marina Anđelković, Miša Vreća, Jelena Milin-Lazović, Vesna Spasovski, Sonja Pavlović

“… Introduction: Tuberculosis (TBC) is a contagious chronic respiratory disease which despite the known cause, Mycobacterium tuberculosis (Mtb), and many decades of successful therapy, remains one of the leading global health problems. …”
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Coenzyme Q10 protects keratinocytes against oxidation-induced energy stress as revealed by spatiotemporal analysis of cell energetics by Roland Abi Nahed, Ali Hussein, Cécile Cottet-Rousselle, Alexandra Vogelsang, Francesco Aulicino, Imre Berger, Thomas Blatt, Julia M. Weise, Uwe Schlattner

“…We successfully established HaCaT cells stably expressing AMPfret, validated their functionality by inducing energy stress with 2-deoxy-D-glucose, and demonstrated that Q10, together with high glucose conditions in culture, can enhance cellular energetics compared to low glucose controls. …”
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Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…Experiments in mice, Ag43β 700_RBD OMVs was successfully proven to be safe and effective; they produced a detectable level of nAbs with 39– 58% neutralisation and reduced viral titres in the lungs and brain without weight loss.Conclusion: The developed viral mimetic Ag43β 700_RBD OMVs may therefore be applied as a nanovesicle-theranostic platform for further emerging infectious disease-related diagnosis, vaccination, and treatment. …”
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