Construction and validation of acetylation-related gene signatures for immune landscape analysis and prognostication risk prediction in luminal breast cancer by Mengdi Zhu, Jinna Lin, Haohan Liu, Jingru Wang, Nianqiu Liu, Yudong Li, Hongna Lai, Qianfeng Shi

“…Conclusions In this study, we successfully constructed a 6-gene acetylation-associated risk model for luminal breast cancer, providing a new direction and evidence for personalized treatment. …”
Get full text

Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Work package 4: Development and refinement of a care transitions intervention Intervention development Functional resonance analysis method was used to model the transition process. …”
Get full text

Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised... by John Norrie, Stephen Morris, Daniel Francis McAuley, Bronagh Blackwood, Paul Dark, Matt P Wise, Anthony C Gordon, Kalliopi Kydonaki, Timothy Simon Walsh, David Hope, Christopher Weir, Gavin Perkins, Nazir I Lone, Benedict Creagh-Brown, Julia Boyd, Michael Reade, Richard Anthony Parker, Leanne M Aitken, Valerie J Page, Alasdair MacLullich, Cathrine A McKenzie, Alix Macdonald, Annabel Giddings, Lydia Emerson, Robert Glen

“…Post-ICU outcomes include mortality, anxiety and depression, post-traumatic stress, cognitive function and health-related quality of life at 6-month follow-up. …”
Get full text

Narva noorte väärtused ja identiteet by Andu Rämmer, Maria Žuravljova, Anne Kivimäe, Maria Anderson

“…Among them are aspirations towards a successful career, independence from parents and good looks. …”
Get full text

How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study by Joshua Dissemond, Tim Havers, Steffen Held, Stephan Geisler, Tihomir Kostov, Patrick Diel, Svea Türschmann, Maria K. Parr, Eduard Isenmann

“…M. vastus lateralis and M. vastus intermedius). Liver and kidney function, along with endocrine parameters, were measured via blood samples pre- and post-intervention. …”
Get full text

Lung cancer intravasation-on-a-chip: Visualization and machine learning-assisted automatic quantification by Christy Wing Tung Wong, Joyce Zhi Xuen Lee, Anna Jaeschke, Sammi Sze Ying Ng, Kwok Keung Lit, Ho-Ying Wan, Caroline Kniebs, Dai Fei Elmer Ker, Rocky S. Tuan, Anna Blocki

“…When introduced into microvascular networks (MVNs) in microfluidic devices, EMT-IC did not affect MVN stability and physiologically relevant barrier functions.To model lung cancer intravasation on-a-chip, EMT-IC was supplemented into co-cultures of lung tumor micromasses and MVNs. …”
Get full text

Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway by Qiuhong Jiao, Xiufeng Xu, Longwu Xu, Yuying Wang, Shulan Pang, Jie Hao, Xiaohong Liu, Yudan Zhao, Wanpeng Qi, Limin Qin, Tao Huang, Jingtian Li, Tao Wang

“…Double-labeled immunofluorescence showed eIF3a was mostly co-localized with CD31, this result indicated that the development of MCT-induced PAH was related to the regulation of PAECs function (most likely associated with the change of EndMT in endothelial cells). …”
Get full text

Molecular organization of the nanoscale surface structures of the dragonfly Hemianax papuensis wing epicuticle. by Elena P Ivanova, Song Ha Nguyen, Hayden K Webb, Jafar Hasan, Vi Khanh Truong, Robert N Lamb, Xiaofei Duan, Mark J Tobin, Peter J Mahon, Russell J Crawford

“…The molecular organization of the epicuticle (the outermost layer) of insect wings is vital in the formation of the nanoscale surface patterns that are responsible for bestowing remarkable functional properties. Using a combination of spectroscopic and chromatographic techniques, including Synchrotron-sourced Fourier-transform infrared microspectroscopy (FTIR), x-ray photoelectron spectroscopy (XPS) depth profiling and gas chromatography-mass spectrometry (GCMS), we have identified the chemical components that constitute the nanoscale structures on the surface of the wings of the dragonfly, Hemianax papuensis. …”
Get full text

LH Gene Cloning, Sequence Feature Analysis and Prokaryotic Expression in Conger myriaster by Yan CHEN, Bao SHI, Chenggang WANG, Wanjun BO, Kewen YAN, Meijun TAO, Xinyu ZHAO, Xiaodong MA

“…Western blot analysis revealed that histidine tagged LH protein reacted with anti-His antibody, LH protein yielded clear bands of 26.5 kDa were detected. The observed size is in accordance with the anticipated molecular weight expression, indicating successful expression of the fusion protein carrying 6×His tag. …”
Get full text

Elevated heterotrophic activity in Guaymas Basin hydrothermal plumes influences deep-sea carbon cycling by Andrew Montgomery, Guang-Chao Zhuang, Zhichao Zhou, Marguerite V. Langwig, María del Carmen Millán-Motolinía, Hannah Y. L. Choi, Kimberley S. Hunter, Carlos A. Mortera-Gutiérrez, Christelle Hyacinthe, Zachary Marinelli, Karthik Anantharaman, Andreas Teske, Samantha B. Joye

“…Metatranscriptomic analysis of functional genes for heterotrophic metabolisms implicates Gammaproteobacteria and diverse heterotrophs in hydrothermally-sourced organic carbon degradation. …”
Get full text

Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Main outcome measures The primary outcome was diagnostic model sensitivity and specificity for detecting bladder outlet obstruction, detrusor underactivity and detrusor overactivity, with 75.0% considered minimum clinically useful performance. …”
Get full text

Development and validation of liquid–liquid phase separation-associated prognostic biomarkers in gastric cancer by Donghui Liu, Mingzhu Liu, Juan Du

“…Abstract Objective Liquid–liquid phase separation (LLPS) is the membrane-less formation of functional assemblies from specific molecules. It plays a key role in tumor growth by governing gene expression. …”
Get full text

Fish Diversity Patterns in Rivers Receiving Ecological Water Supplement Driven by Riparian Land Use by LIU Han, LI Lu-dan, GUO Wei-jie, QIAO Qiang-long, GONG Dan-dan, DU Qi, LI Hang, ZHAO Wei-hua

“…Functional dispersion (FDis) and taxonomic diversity (Delta) correlating significantly with all diversity dimensions (r=0.36-0.90; p<0.05) and outperforming species richness in detecting environmental responses. …”
Get full text

Neonatal Microcephaly and Central Nervous System Abnormalities During the Zika Outbreak in Rio de Janeiro by Marlos Melo Martins, Roberto de Andrade Medronho, Carlos Eduardo Raymundo, Arnaldo Prata-Barbosa, Antonio José Ledo Alves da Cunha

“…This retrospective cohort study analyzed 7870 pregnant women, including 2269 with confirmed Zika virus (ZIKV) infection and 5601 without Zika infection, along with their fetuses and newborns. Data were sourced from multiple databases in the state of Rio de Janeiro, Brazil. …”
Get full text

Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…Phase 2 – realist synthesis: Empirical and grey literature, together with online discussion boards, social media sources and blogs were used to create initial programme theories regarding service architecture. …”
Get full text

Implementasi Steganografi Gambar Menggunakan Algoritma Generative Adversarial Network by Khairunnisak Khairunnisak, Gilang Miftakhul Fahmi, Didit Suhartono

“…In addition, the results of testing the Generative Adversarial Network algorithm were successfully applied to image steganography which functions to prevent steganalysis techniques from trying to detect messages in images. …”
Get full text

A methodology for quantitatively managing the bug fixing process using Mahalanobis Taguchi system by Boby John, R. S. Kadadevarmath

“…The controlling of bug fixing process during the system testing phase of software development life cycle is very important for fixing all the detected bugs within the scheduled time. The presence of open bugs often delays the release of the software or result in releasing the software with compromised functionalities. …”
Get full text

Interpretable correlator Transformer for image-like quantum matter data by Abhinav Suresh, Henning Schlömer, Baran Hashemi, Annabelle Bohrdt

“…Here, we introduce the correlator Transformer (CoTra), which classifies different phases of matter while at the same time yielding full interpretability in terms of physical correlation functions. The network’s underlying structure is a tailored attention mechanism, which learns efficient ways to weigh local and non-local correlations for a successful classification. …”
Get full text

Dual-Level Fault-Tolerant FPGA-Based Flexible Manufacturing System by Gehad I. Alkady, Ramez M. Daoud, Hassanein H. Amer, Yves Sallez, Hani F. Ragai

“…Reconfigurable duplication was used as the first level of fault tolerance at the workcell level. It was shown how to detect and recover from FPGA faults such as Single Event Upsets (SEUs), hard faults, and Single Event Functional Interrupts (SEFIs). …”
Get full text

Irreducible traumatic pure hip dislocation by the entrapment of the lateral rotator muscle group of the hip: A case report by Zied Mansi, Saibi Firas, Ben Mahmoud Aymen, Tounsi Abdelkader, Islem Chneti, Hedi Rbai, Wajdi Chermiti, Ali Haggui, Bacem Zaidi, Wael Gazzah

“…The posterior-lateral approach provides excellent exposure of the posterior hip structures, but it carries the risk of injury to the medial circumflex artery. After successfully reducing the dislocation, it is essential to perform a computed tomography (CT) scan to detect any osteochondral lesions, including femoral head impaction. …”
Get full text