Real-Time, Risk-Based Clinical Trial Quality Management in China: Development of a Digital Monitoring Platform by Min Jiang, Shuhua Zhao, Yun Mei, Zhiying Fu, Yannan Yuan, Jie Ai, Yuan Sheng, Ying Gong, Jingjing Chen

“…ConclusionsIn clinical practice, our tool would enable the automated monitoring and detection of risk points throughout all clinical trial stages; accurately identify the most relevant trial procedure and function line; and notify quality management personnel, in real time, to take prompt actions and dynamically prevent the recurrence of quality issues.…”
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Global Trends and Empirical Metrics in the Evaluation of Code Smells and Technical Debt: A Bibliometric Study by Ronald Henry Diaz Arrieta, Byron Leoncio Diaz Monroy, Luis Javier Castillo Heredia, Alexandra Gabriela Valenzuela Cobos

“…Among the critical factors that affect these attributes are code smells, indicators of structural deficiencies in the source code, which, although they do not directly affect functionality, significantly increase technical debt and maintenance costs. …”
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Exploring the Complexities of Seafood: From Benefits to Contaminants by Bettina Taylor, Kelvin Fynn Ofori, Ali Parsaeimehr, Gulsun Akdemir Evrendilek, Tahera Attarwala, Gulnihal Ozbay

“…Seafood plays a vital role in human diets worldwide, serving as an important source of high-quality protein, omega-3 fatty acids, and essential vitamins and minerals that promote health and prevent various chronic conditions. …”
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The impact of early massive galaxy formation on the cosmic microwave background by Eda Gjergo, Pavel Kroupa

“…A previously overlooked foreground component is the formation of massive early-type galaxies (ETGs), which can no longer be ignored, particularly in light of JWST's detection of massive, evolved systems at extreme redshifts (z>13). …”
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Predictive Capabilities and Limitations of Stream Interaction Region Observations at Different Solar Longitudes by R. C. Allen, G. C. Ho, L. K. Jian, G. M. Mason, S. K. Vines, D. Lario

“…Through comparing 10 years of SIRs/CIRs observed at L1 and at STEREO, we have investigated the probability of sequentially detecting SIRs/CIRs at two locations as a function of the difference in heliospheric longitude and latitudinal separation between the two spacecraft. …”
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Unsustainable anthropogenic mortality threatens the long-term viability of lion populations in Mozambique. by João Almeida, Willem D Briers-Louw, Agostinho Jorge, Colleen Begg, Marnus Roodbol, Hans Bauer, Andrew Loveridge, Matthew Wijers, Rob Slotow, Peter Lindsey, Kristoffer Everatt, Holly Rosier, Sean Nazerali, Lizanne Roxburgh, Hugo Pereira, Mercia da Conceicao, Armindo Araman, Osvaldo J Abrao, Alison J Leslie, Franziska Steinbruch, Vincent N Naude, Samantha K Nicholson

“…Our findings suggest that resilience to anthropogenic threats is largely a function of lion population size as well as resource and management capacity. …”
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Legality of bringing to administrative responsibility for an offense under Art. 130 Code of Ukraine on Administrative Offenses: retrospective analysis by K. O. Chyshko

“…It was stated that the clarification provided in this regard by the Committee on Law Enforcement of the Verkhovna Rada of Ukraine is neither a source of law nor a normative legal act and is not binding, but instead serves a recommendatory function, therefore, the involvement of persons for committing a specific criminal offense under the procedure of proceedings on administrative offenses has no legal grounds.…”
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The burden of intracerebral hemorrhage attributable to ambient particulate matter pollution in five Asian countries: a 32-year comparative analysis by Rui Yang, Xingke Wang, Panpan Hao

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Double-moment normalization of hail size number distributions over Switzerland by A. Ferrone, J. Kopp, M. Lainer, M. Gabella, U. Germann, A. Berne

“…These results highlight the invariance of the normalized distribution and the adaptability of the method to different data sources.</p>…”
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Machine learning models for clinical and structural knee osteoarthritis prediction: Recent advancements and future directions by Gabby B. Joseph, Charles E. McCulloch, Michael C. Nevitt, Nancy E. Lane, Sharmila Majumdar, Thomas M. Link

“…These evolving strategies underscore the growing potential of ML to improve the detection of early OA, individualized risk stratification, and personalized interventions in OA clinical care.…”
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Automated hypocenter determination of tectonic tremors in the Nankai subduction zone using convolutional neural networks combined with semblance analysis by Amane Sugii, Yoshihiro Hiramatsu, Takahiko Uchide, Kazutoshi Imanishi

“…The trained CNN model achieved high accuracy, with both precision and recall exceeding 97%, and correctly detected 96% of distant earthquakes. The probability of tectonic tremor as a function of the signal-to-noise ratio (SNR) increased steeply from 10 to 90% at an SNR of 4. …”
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Validation of the inadequate delivery of oxygen index in an adult cardiovascular intensive care unitCentral MessagePerspective by Heather Holman, BS, Dimitar Baronov, PhD, Jeff McMurray, MD, Arman Kilic, MD, Marc Katz, MD, Sanford Zeigler, MD

“…Conclusions: The IDO2 index is capable of detecting SvO2 ≤50% with good discriminatory function in non-MCS CVICU patients in a variety of monitoring situations. …”
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Complexity of immunobiology of tumor necrosis factor and novel anti-TNF therapy by S. А. Nedospasov

“…Systemic anti-cytokine therapy is known to be accompanied by undesirable side effects, which can hypothetically be explained by the neutralization of these protective functions. Thus, we developed prototypes of TNF blockers which limit the bioavailability of this cytokine only from its main “pathogenic” source – myeloid cells. …”
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scSEETV‐Net: Spatial and Channel Squeeze‐Excitation and Edge Attention Guidance V‐Shaped Network for Skin Lesion Segmentation by Hakan Ocal

“…The scSEETV‐Net is supported by fusing the binary cross‐entropy, which calculates the loss on a pixel‐based, and the focal Twersky loss function, which has significant success in class imbalances. …”
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Standard: human liver-on-a-chip by Haitao Liu, Xu Zhang, Yaqing Wang, Min Zhang, Peng Wang, Jing Shang, Zhongqiang Li, Likun Gong, Xin Xie, Dongyang Liu, Jingbo Pi, Xinghua Gao, Xianliang Li, Wei Ding, Dianbing Wang, Yun Long, Lan Wang, Song Li, Xingchao Geng, Pingkun Zhou, Wanjin Tang, Xian’en Zhang, Chunying Chen, Shengli Yang, Jianhua Qin

“…However, the lack of standardized definitions, structural designs, cell sources, model constructions, and functional validations has posed challenges to their widespread translational applications. …”
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High-Throughput Indirect Monitoring of TORC1 Activation Using the pTOMAN-G Plasmid in Yeast by Melissa Gómez, Guilherme Rocha, Diego Ruiz, Claudio Martínez, Francisco Salinas, Eduardo Kessi-Pérez

“…The target of rapamycin complex 1 (TORC1) is a highly conserved protein complex whose primary function is to link nutrient availability to cell growth in eukaryotes, particularly nitrogen sources. …”
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Spatial Pattern and Evolutionary Characteristics of Settlements in Dianchi River Basin from the Perspective of Toponymy by Ying’ao WANG, Weijian HU, Wen PENG, Yuliang YANG

“…By constructing a coupling analysis framework of toponym semantics and spatial attributes, this research confirms the “spatio-temporal code” function of toponym in the process reconstruction of human settlements, and the capability to analyze multi-source heterogeneous data based on the aforesaid function provides a new analytical methodology for the research on watershed human settlements. …”
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Safety and Probiotic Evaluation of Lactiplantibacillus plantarum CHEN1 and Its Metabolic Analysis of Soymilk Oligosaccharides by Zhina CHEN, Shiyi CAO, Linlin YIN, Mengyuan SHAO, Tao YE, Zhangrui XU, Xiaochen HUANG

“…The genetic characteristics of the strain were analyzed through genome sequencing and functional annotation. Phenotypic experiments, including hemolytic activity assays, detection of harmful metabolites, antibiotic susceptibility testing, tolerance experiments, hydrophobicity, and autoaggregation assays were conducted to evaluate its safety and probiotic potential. …”
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Real-World Efficacy of Explainable Artificial Intelligence using the SAGE Framework and Scenario-Based Design by Eleanor Mill, Wolfgang Garn, Chris Turner

“…The first of its kind, it leverages three distinct but complementary frameworks to support a user-centric and context-sensitive, post-hoc explanation for fraud detection. Using the principles of scenario-based design, it amalgamates two independent real-world sources to establish a realistic card fraud prediction scenario. …”
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The Intelligent Infectious Disease Active Surveillance and early warning system in China: An application of dengue prevention and control by Liangyu Kang, Jian Hu, Kangning Cai, Wenzhan Jing, Min Liu, Wannian Liang

“…The system comprises four functional modules including multi-channel active surveillance, intelligent early warning, data-driven risk assessment, and smart emergency response. …”
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