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681
Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation
Published 2025-05-01“…This study aimed to clarify the roles of mitochondrial metabolism and immune infiltration in MI, using a combination of bioinformatics analyses and experimental validation.MethodsMI chip data (GSE96561, GSE181872, and GSE183272) were obtained from the Gene Expression Omnibus (GEO) database, and mitochondrial gene data were sourced from the MitoCarta3.0 database. Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analyses. …”
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682
Rossby Number Regime, Convection Suppression, and Dynamo-generated Magnetism in Inflated Hot Jupiters
Published 2025-01-01“…Specifically, we obtain the Rossby number Ro as a function of planetary depth and orbital period, after showing that tidal synchronization is likely valid for all HJs. …”
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683
Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma
Published 2025-05-01“…Obesity usually exacerbates the immunosuppressive tumor microenvironment (ITME), hindering CD8+ T cell infiltration and function, which further represents a significant barrier to the efficacy of immunotherapy. …”
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684
Unveiling the complex double-edged sword role of exosomes in nasopharyngeal carcinoma
Published 2025-01-01“…Exosomes are small membrane vesicles at the nanoscale that transport physiologically active compounds from their source cell and have a crucial function in signal transmission and intercellular message exchange. …”
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685
Face Recognition Door Security System and Contactless Bell
Published 2024-02-01“…Face recognition uses OpenCV based on an open source library to recognize faces in realtime using the Python programming language. …”
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686
Submillimeter and Mid-infrared Variability of Young Stellar Objects in the M17 H II Region
Published 2025-01-01“…This mid-IR fractional variability as a function of evolutionary stage result is similar to what has previously been found for YSO variability within the Gould Belt and the intermediate-mass star formation region M17 SWex, though overall less variability is detected in M17 in submillimeter and mid-IR. …”
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687
Gene Network Biological Validity Based on Gene-Gene Interaction Relevance
Published 2014-01-01“…Finally, the ability of GeneNetVal to detect biological functionality of the network is shown.…”
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688
Tumor-specific CD8+ T cells from the bone marrow resist exhaustion and exhibit increased persistence in tumor-bearing hosts as compared with tumor-infiltrating lymphocytes
Published 2025-02-01“…Importantly, in a competitive transfer experiment, BM T cells infiltrated the tumor more efficiently than TILs, displayed a higher polyfunctionality with interleukin-2, interferon-γ, tumor necrosis factor-α production and showed greater persistence compared with TILs.Conclusions T cells from the BM appear superior to TILs as a source of cells for cellular therapy. They possess a memory-enriched phenotype and exhibit improved effector function, greater persistence within a tumor-bearing host, and the capacity for increased tumor infiltration. …”
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689
Effects of moderate-protein and high-protein diets, including mealworm meal or poultry by-product meal, on immunological variables in healthy adult dogs
Published 2025-08-01“…An interaction effect between the dietary protein source and protein level could be detected for the phagocytic activity of blood granulocytes as well as for the plasma concentrations of IgA and IgE. …”
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690
Dietary compositions and their seasonal shifts in Japanese resident birds, estimated from the analysis of volunteer monitoring data.
Published 2015-01-01“…Determining the composition of a bird's diet and its seasonal shifts are fundamental for understanding the ecology and ecological functions of a species. Various methods have been used to estimate the dietary compositions of birds, which have their own advantages and disadvantages. …”
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691
Molecular mechanisms of leukemogenesis
Published 2022-11-01“…Such targets can be enzymes, proteins with other (non-enzymatic) functions, genomic DNA, mRNA, or, for example, certain lipid components of cell membranes. …”
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692
Whole blood RNA-seq analysis reveals the immunomodulatory effects of a supplemental multi-strain direct-fed microbial in the diet of newly weaned beef steers1
Published 2025-07-01“…Forty newly weaned Angus crossbred steers (12-h postweaning; 217 ± 4.6 kg of body weight [BW]; 202 ± 4 d of age) from three different sources were stratified by BW and randomly assigned to one of the two treatments: 1) basal diet with no additive (CON; n = 20), and 2) the basal diet supplemented with 9 g/steer/d of a multi-strain microbial additive (PRO; n = 20). …”
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693
Synthesis and Production of Sweet-Tasting Protein in E. coli and Purification by Amylose Resin
Published 2011-06-01“…However, the extraction of brazzein from its natural source is expensive and not applicable. In this study we used recombinant DNA technology to provide an alternative option for cheaper mass production of brazzein. …”
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694
Iodine deficiency as an environmental risk factor for thyroid gland diseases in animals
Published 2024-08-01“…The situation is complicated in the biogeochemical zones of Ukraine, where insufficient or excessive content of mobile forms of microelements in soils and water sources determines the biological reaction of local flora and fauna. …”
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695
Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review
Published 2025-05-01“…The main literature searches were then conducted using six databases: Applied Social Sciences Index and Abstracts (ProQuest), Cumulative Index to Nursing and Allied Health Literature (EBSCO), MEDLINE (Ovid), PsycInfo (Ovid), EMBASE (Ovid) and Web of Science Core Collection (Emerging Sources Citation Index). The search covered evidence from 1 January 2001 up to 21 July 2021 and yielded 16,775 hits, which were then reduced to 14,383, after using EndNote X9’s (2013) inbuilt duplication detection function and manual de-duplication. …”
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696
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697
Green Recovery and Identification of Antioxidant and Enzyme Inhibitor Molecules from Pisco Grape Pomace by Targeted Effects Analysis Using Thin-Layer Chromatography, Bioassay, and...
Published 2024-11-01“…The search and identification of inhibitory molecules from novel natural sources, such as pisco grape pomace extract obtained by green techniques, may help to develop agents with therapeutic potential that are beneficial to health with fewer adverse effects than drugs. …”
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698
Kajian Farmakoinformatika Senyawa Alkaloid Anggur Laut (Caulerpa racemose) Sebagai Inhibitor Collagenase Dalam Mekanisme Antiaging
Published 2022-11-01“…Sea grapes also well known as functional food source from marine, contains high protein, fibers and secondari metabolites. …”
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699
On path length, beam divergence, and retroreflector array size in open-path FTIR spectroscopy
Published 2025-06-01“…<p>Open-path Fourier transform infrared (OP-FTIR) spectroscopy is an established technique used to measure boundary layer trace gas concentrations, consisting (in this work) of a spectrometer with an active mid-IR source coupled to a single transmitting and receiving telescope, as well as a cube-corner retroreflector array separated from the spectrometer and telescope by an atmospheric path. …”
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700
Identification of Intracranial Germ Cell Tumors Based on Facial Photos: Exploratory Study on the Use of Deep Learning for Software Development
Published 2025-01-01“…Due to their insidious onset and impact on critical functional areas of the brain, these tumors often result in irreversible abnormalities in growth and development, as well as cognitive and motor impairments in affected children. …”
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