Clinical and cost-effectiveness of first contact physiotherapy for musculoskeletal disorders in primary care: the FRONTIER, mixed method realist evaluation by Nicola E Walsh, Alice Berry, Serena Halls, Rachel Thomas, Hannah Stott, Cathy Liddiard, Zoe Anchors, Fiona Cramp, Margaret E Cupples, Peter Williams, Heather Gage, Dan Jackson, Paula Kersten, Dave Foster, Justin Jagosh

“…Outcome measures were recorded at baseline, 3 and 6 months (primary end point) to track changes in pain and functioning using the Short Form questionnaire-36 items physical component summary (SF-36-PCS) primary outcome measure, and were compared across the care models. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…Secondary outcomes included patient self-reported measures of BMI and eating psychopathology, visual analogue scale measuring motivation and ability to recover; psychosocial functioning (assessed using the Work and Social Adjustment Scale). …”
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Growth Performance, Feed Intake and vegf121 Gene Expression Feature of Dwarf Cyprinus carpio rubrofuscus by Shuozhen CHEN, Dongmei MA, Zaixuan ZHONG, Jiajia FAN, Huaping ZHU, Huanhuan SU

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Chromosome-level genome assembly of Phortica okadai, a vector of Thelazia callipaeda by Lingjun Wang, Hongsong Yu, Bo Luo, Rong Yan, Juan Zhou, Hui Liu, Ze Zhang, Wei Sun

“…Additionally, 302 rRNAs, 377 tRNAs, 52 miRNAs, 40 snRNAs and 21 snoRNAs were detected. In conclusion, this high-quality chromosome level reference genome will be a valuable resource for furthering the fields of ecology, genetics, evolution and functional genomics of P. okadai.…”
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Assembly and comparative analysis of the complete mitochondrial of Spodiopogon sagittifolius, an endemic and protective species from Yunnan, China by Chao Xu, Wei Bi, Ren-yi Ma, Pin-rong Li, Feng Liu, Zhen-wen Liu

“…Abstract Background Spodiopogon sagittifolius, a C4 plant closely related to cultivated crops, is an edible resource and a Class II nationally protected species in China. …”
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Predicting protein synergistic effect in Arabidopsis using epigenome profiling by Chih-Hung Hsieh, Ya-Ting Sabrina Chang, Ming-Ren Yen, Jo-Wei Allison Hsieh, Pao-Yang Chen

“…QHistone accurately identifies histone modifications associated with specific known proteins, and allows users to computationally validate their results using gene expression data from various plant tissues. These functions demonstrate an useful approach to utilizing epigenome data for gene regulation analysis, making QHistone a valuable resource for the scientific community ( https://qhistone.paoyang.ipmb.sinica.edu.tw ).…”
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Positioning, navigation, and timing on the Moon and Mars with galactic cosmic rays by G. Leone, H.K.M. Tanaka, M. Holma, S. Krishnan, A.R. Duffy, T. Enqvist, P. Kuusiniemi, J. Joutsenvaara, G. Cerretto, E. Cantoni, M. Sellone, J. Marteau, D. Lo Presti, J.G. Szűcs, D. Varga

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Comparative Analysis of Transcriptomes from Secondary Reproductives of Three Reticulitermes Termite Species. by Franck Dedeine, Lucy A Weinert, Diane Bigot, Thibaut Josse, Marion Ballenghien, Vincent Cahais, Nicolas Galtier, Philippe Gayral

“…A total of 18,323 orthologous gene clusters were detected. Functional annotation and taxonomic assignment were performed on a total of 41,287 predicted contigs in the three termite species. …”
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Identification and Analysis of Phenolic Compounds in <i>Vaccinium uliginosum</i> L. and Its Lipid-Lowering Activity In Vitro by Ying Zhang, Wenjiang Dong, Manjun Zhao, Jiyue Zhang, Li Li, Yan Ma, Xianjun Meng, Yuehua Wang

“…(VU), rich in polyphenols, is an important wild berry resource primarily distributed in extremely cold regions. …”
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From ancient practices to contemporary green building: Analyzing organic additives in Pitalkhora earthen plasters for sustainable construction by Bhushan Dighe, Manager Rajdeo Singh

“…Further research is necessary to explore their functional properties and assess their viability in contemporary applications.…”
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Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases by András Zeke, Tomas Bastys, Anita Alexa, Ágnes Garai, Bálint Mészáros, Klára Kirsch, Zsuzsanna Dosztányi, Olga V Kalinina, Attila Reményi

“…We used a structurally consistent model on kinase‐docking motif interactions to facilitate the discovery of short functional sites in the structurally flexible and functionally under‐explored part of the human proteome and applied experimental tools specifically tailored to detect low‐affinity protein–protein interactions for their validation in vitro and in cell‐based assays. …”
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Identification of Genomic Variants and Candidate Genes for Reproductive Traits and Growth Traits in Pishan Red Sheep Using Whole-Genome Resequencing by Maimaitijiang Muhetapa, Mengting Zhu, Aladaer Qi, Sulaiman Yiming

“…Through selective sweep analysis, 92 genomic regions under selection were detected, containing 90 positional candidate genes significantly associated with growth, reproduction, and immune functions. …”
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Near telomere-to-telomere genome assembly of the blackspot tuskfish (Choerodon schoenleinii) by Zhongdian Dong, Jiahao Gao, Yanfei Zhao, Jin Gao, Yusong Guo, Zhongduo Wang, Ning Zhang

“…Notably, telomeres were identified at both ends of 23 chromosomes, with 14 being completely gapless and only 12 gaps detected across the remaining nine. A total of 24,524 protein-coding genes were annotated, with 96.25% assigned functional annotations. …”
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Explainable artificial intelligence of DNA methylation-based brain tumor diagnostics by Salvatore Benfatto, Martin Sill, David T. W. Jones, Stefan M. Pfister, Felix Sahm, Andreas von Deimling, David Capper, Volker Hovestadt

“…Here, we describe an interpretable framework to explain the classifier’s decisions. We show that functional genomic regions of various sizes are predominantly employed to distinguish between different tumor classes, ranging from enhancers and CpG islands to large-scale heterochromatic domains. …”
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Accumulation and effect of contaminants in soil biota following waste stream application in agriculture: A European perspective by Iris L. Schaap, Marjolein Derks, Peter W.G. Groot Koerkamp, Nico W. van den Brink

“…In particular, behavioural changes in soil organisms, which significantly influence soil functionality and ecosystem processes, remain underexplored. …”
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Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes. by Dave T Gerrard, Claudia Fricke, Dominic A Edward, Dylan R Edwards, Tracey Chapman

“…However, the subtle nature of those effects suggests substantial functional redundancy or parallelism in this gene network, which could buffer females against excessive responses. …”
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Diversity and composition of sponge-associated microbiomes from Korean sponges revealed by full-length 16S rRNA analysis by Myoung-Sook Shin, Inho Yang, Weihong Wang, Hiyoung Kim

“…Our integrative, high-resolution approach not only uncovers remarkable taxonomic and functional diversity, but also provides a valuable genetic resource for future marine natural-product discovery and advances ecological restoration efforts.…”
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The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging by Hong-Fei Li, Bao Dong, Yuan-Yuan Peng, Hao-Yue Luo, Xiao-Lan Ou, Zheng-Lin Ren, Yoonseong Park, Jin-Jun Wang, Hong-Bo Jiang

“…Further analysis of the mutant flies revealed that sets of odorant receptor (OR) genes were differentially expressed. Functional characterization of the differentially expressed ORs suggested that sulfakinin directly suppresses the expression of ORs that respond to opposite-sex hormones while enhancing the expression of ORs that detect food volatiles. …”
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Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting arsenic accumulation in plants. by Dai-Yin Chao, Yi Chen, Jiugeng Chen, Shulin Shi, Ziru Chen, Chengcheng Wang, John M Danku, Fang-Jie Zhao, David E Salt

“…Complementation verified the identity of HAC1, and expression in Escherichia coli lacking a functional arsenate reductase confirmed the arsenate reductase activity of HAC1. …”
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A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro by Paolo Petazzi, Telma Ventura, Francesca Paola Luongo, Heather McClafferty, Alisha May, Helen Alice Taylor, Michael J Shipston, Nicola Romanò, Lesley M Forrester, Pablo Menendez, Antonella Fidanza

“…A major challenge in the stem cell biology field is the ability to produce fully functional cells from induced pluripotent stem cells (iPSCs) that are a valuable resource for cell therapy, drug screening, and disease modelling. …”
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