Tumor-specific CD8+ T cells from the bone marrow resist exhaustion and exhibit increased persistence in tumor-bearing hosts as compared with tumor-infiltrating lymphocytes by Ivan Borrello, Amy Thomas, Luca Biavati, Robert Leone, Elizabeth M Zawidzka, Claudio Zanettini, Luigi Marchionni

“…Importantly, in a competitive transfer experiment, BM T cells infiltrated the tumor more efficiently than TILs, displayed a higher polyfunctionality with interleukin-2, interferon-γ, tumor necrosis factor-α production and showed greater persistence compared with TILs.Conclusions T cells from the BM appear superior to TILs as a source of cells for cellular therapy. They possess a memory-enriched phenotype and exhibit improved effector function, greater persistence within a tumor-bearing host, and the capacity for increased tumor infiltration. …”
Get full text

Research and practice of SASE cloud security by Chaoyang YE, Xin WANG, Shicong ZHANG, Zhiyong ZHAN, Yisha LIU

“…With the development of the Internet today, earth shaking changes have taken place compared with the traditional network.In today's network reform, ＆quot;cloud＆quot; has become the mainstream direction of the evolution of enterprise IT architecture, so the requirements for cloud security are becoming higher and higher.The practical deployment scheme of SASE cloud security architecture was introduced to solve the problem of cloud security for customers.A unique and complete SASE solution was proposed, which combined security functions with SD-WAN functions, and realized real-time monitoring, intelligent analysis and automatic interception of malware or malicious activities by building a unified management and control platform and centralized deployment of core security resource pool.Practice has proved that the scheme achieves the expected results in unified management and control, intrusion detection and defense, fine access control and so on, and can fully ensure the cloud security of enterprises.…”
Get full text

Research and practice of SASE cloud security by Chaoyang YE, Xin WANG, Shicong ZHANG, Zhiyong ZHAN, Yisha LIU

“…With the development of the Internet today, earth shaking changes have taken place compared with the traditional network.In today's network reform, ＆quot;cloud＆quot; has become the mainstream direction of the evolution of enterprise IT architecture, so the requirements for cloud security are becoming higher and higher.The practical deployment scheme of SASE cloud security architecture was introduced to solve the problem of cloud security for customers.A unique and complete SASE solution was proposed, which combined security functions with SD-WAN functions, and realized real-time monitoring, intelligent analysis and automatic interception of malware or malicious activities by building a unified management and control platform and centralized deployment of core security resource pool.Practice has proved that the scheme achieves the expected results in unified management and control, intrusion detection and defense, fine access control and so on, and can fully ensure the cloud security of enterprises.…”
Get full text

Identification of Intracranial Germ Cell Tumors Based on Facial Photos: Exploratory Study on the Use of Deep Learning for Software Development by Yanong Li, Yixuan He, Yawei Liu, Bingchen Wang, Bo Li, Xiaoguang Qiu

“…Due to their insidious onset and impact on critical functional areas of the brain, these tumors often result in irreversible abnormalities in growth and development, as well as cognitive and motor impairments in affected children. …”
Get full text

Synthesis and Production of Sweet-Tasting Protein in E. coli and Purification by Amylose Resin by F. Mansouri

“…MBP-brazzein system permits large-scale functional expression and purification of recombinant soluble proteins, providing a basis for the future study of structure and function of brazzein.…”
Get full text

Renal Biopsy Pathological Tissue Segmentation: A Comprehensive Review and Experimental Analysis by Yan Liu, Taiping Wang, Xinxin He, Wei Wang, Qiang He, Juan Jin

“…This study provides a novel technical framework for precise renal pathological tissue segmentation and lays the foundation for future lesion detection and intelligent diagnostic applications.…”
Get full text

Research on a traffic flow statistical algorithm based on YBOVDT and SAM2 by Yuanyuan Wang, Zheng Ding, Jiange Liu, Kexiao Wu, Md Sharid Kayes Dipu, Tingmei Ma, Yonghao Ma, Haiyan Zhang

“…To address these challenges, this paper proposes a traffic flow statistical method based on YBOVDT(YOLO-World and BOT-SORT-Open Vocabulary Detection and Tracking)and SAM2.Specifically, in the method, this paper proposes a “Traffic Flow Data Processing and Analysis” module, aiming to optimize and supplement the five core functions required for traffic flow statistics tasks, thereby making the functions of the entire solution more comprehensive.In addition, this paper combines the latest open set object detection and tracking algorithms to enhance the recognition ability and tracking stability of traffic objects. …”
Get full text

Kajian Farmakoinformatika Senyawa Alkaloid Anggur Laut (Caulerpa racemose) Sebagai Inhibitor Collagenase Dalam Mekanisme Antiaging by Dewi Ratih Tirto Sari, M.Eko Pranoto, Siti Zamilatul Azkiyah

“…Sea grapes also well known as functional food source from marine, contains high protein, fibers and secondari metabolites. …”
Get full text

Fine-grained access control method for private data in android system by Gang Liu, Guofang Zhang, Quan Wang, Shaomin Ji, Lizhi Zhang

“…In order to facilitate users to manage policies, the proposed framework implements automatic policy generation and policy conflict detection functions. The framework is implemented in TaintDroid and experiments indicate that the improvement is effective in achieving fine-grained access control to sensitive information and does not adversely affect the system overhead costs.…”
Get full text

PPI-GA: A Novel Clustering Algorithm to Identify Protein Complexes within Protein-Protein Interaction Networks Using Genetic Algorithm by Naeem Shirmohammady, Habib Izadkhah, Ayaz Isazadeh

“…Any disturbance in proteins interactive network can act as a source for biological disorders and various diseases such as Alzheimer and cancer. …”
Get full text

Presepsin as a sepsis biomarker by K. A. Trunova

“…The review includes 42 Russian-language and English-language  sources. Particular attention was paid to comparative studies on the role of presepsin and other bio-markers in the diagnosis of sepsis.Results. …”
Get full text

The role of internal auditors in preventing financial fraud in the Republic of Serbia by Jeremić Nebojša, Jakovljević Nemanja

“…By exploring the practices and challenges faced by internal auditors, this paper aims to provide valuable insights and recommendations to strengthen the effectiveness of internal audit functions in detecting and preventing financial fraud. …”
Get full text

Retracted: Study on Modeling Method of Forest Tree Image Recognition Based on CCD and Theodolite by Yeqiong Shi, Sainan Wang, Shuna Zhou, M. M. Kamruzzaman

“…Forest vegetation is the main body that constitutes forest resources. Accurate identification of the types of forest trees can lay the foundation for the research and utilization of forest resources. …”
Get full text

FREQ‐NESS Reveals the Dynamic Reconfiguration of Frequency‐Resolved Brain Networks During Auditory Stimulation by Mattia Rosso, Gemma Fernández‐Rubio, Peter Erik Keller, Elvira Brattico, Peter Vuust, Morten L Kringelbach, Leonardo Bonetti

“…In this study, FREQ‐NESS is applied to source‐reconstructed magnetoencephalography (MEG) data during resting state and isochronous auditory stimulation. …”
Get full text

Trends and advances in Leptospira, a bibliometric analysis by Wei Wang, Wei Wang, Wei Wang, Yamin Gao, Yamin Gao, Yamin Gao, Jianyu Ji, Jianyu Ji, Jianyu Ji, Zhai Huang, Zhai Huang, Bin Xiong, Bin Xiong, Shulin Xiang, Shulin Xiang

“…Prominent research areas included restriction endonucleases, monoclonal antibodies, outer membrane proteins, water environments, detection methods, and antimicrobial agents. Research focus has shifted from early genomic and antigenic studies to investigations into outer membrane protein functions and environmental persistence, culminating in recent advances in molecular mechanisms and diagnostic technology development.ConclusionThis bibliometric analysis provides a comprehensive snapshot of leptospirosis research, emphasizing collaborations and impact among authors, countries, institutions, and journals. …”
Get full text

Multiphysics Coupling Model of Rock Mass considering Damage and Disturbance and Its Application by Wei Wang, Zhouquan Luo, Yaguang Qin, Jun Xiang, Lei Wen, Shaowei Ma

Get full text

Conditions for the emergence of circumnutations in plant roots. by Ilya Loshchilov, Emanuela Del Dottore, Barbara Mazzolai, Dario Floreano

“…Here we describe a model capable of replicating root growth behaviors, which we used to analyze the role of circumnuntations, revealing their emergence I) under gravitropic stress, as a combination of signal propagation and sensitivity to the signal carriers; II) as a result of the interplay between gravitropic and thigmotropic responses; and III) as a behavioral strategy to detect and react to resource gradients. The latter function requires the presence of a hypothetical internal oscillator whose parameters are regulated by the perception of environmental resources.…”
Get full text

Recombinant Tissue Plasminogen Activator Induces Neurological Side Effects Independent on Thrombolysis in Mechanical Animal Models of Focal Cerebral Infarction: A Systematic Review... by Mei-Xue Dong, Qing-Chuan Hu, Peng Shen, Jun-Xi Pan, You-Dong Wei, Yi-Yun Liu, Yi-Fei Ren, Zi-Hong Liang, Hai-Yang Wang, Li-Bo Zhao, Peng Xie

“…Subgroup analysis, meta-regression and sensitivity analysis were performed to explore sources of heterogeneity. Funnel plot, Trim and Fill method and Egger's test were obtained to detect publication bias.…”
Get full text

HMG Box-containing Protein 1 (HBP1) Protects Against Pancreatic Injury in Acute Pancreatitis but Promotes Neoplastic ProgressionSummary by Seung-Won Lee, Taelor Ekstrom, Elise C. Manalo, Shangyuan Ye, Mark Berry, Dmytro Grygoryev, Malwina Szczepaniak, Jinho Lee, Carlos Origel Marmolejo, Syber Haverlack, Juyoung Lee, Vidhi M. Shah, Dove Keith, John L. Muschler, Koei Chin, Rosalie C. Sears, Stuart P. Weisberg, Terry Morgan, Jungsun Kim

Get full text

Viewing Global Changes in the Heliosheath with IMAP’s Energetic Neutral Atom Imagers by E. J. Zirnstein, J. Heerikhuisen, D. J. McComas, J. Bower, G. Clark, M. A. Dayeh, H. O. Funsten, M. Gkioulidou, D. G. Mitchell, D. B. Reisenfeld, N. A. Schwadron

“…We aim to answer the following: (i) What are the time delays as a function of energy and direction; (ii) at what energies can we observe changes the soonest; and (iii) what might the ENA source distributions affecting the time delays look like? …”
Get full text