Exploring the role of mitochondrial metabolism and immune infiltration in myocardial infarction: novel insights from bioinformatics and experimental validation by Jingyi Hou, Jingyi Hou, Jingyi Hou, Lihan Wang, Lihan Wang, Naiqiang Zhu, Xueli Li

“…This study aimed to clarify the roles of mitochondrial metabolism and immune infiltration in MI, using a combination of bioinformatics analyses and experimental validation.MethodsMI chip data (GSE96561, GSE181872, and GSE183272) were obtained from the Gene Expression Omnibus (GEO) database, and mitochondrial gene data were sourced from the MitoCarta3.0 database. Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analyses. …”
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Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model by Samuel Martinez-Meza, Thomas A. Premeaux, Stefano M. Cirigliano, Courtney M. Friday, Stephanie Michael, Sonia Mediouni, Susana T. Valente, Lishomwa C. Ndhlovu, Howard A. Fine, Robert L. Furler O’Brien, Douglas F. Nixon

“…Abstract Background HIV-1-associated neurocognitive impairment (HIV-1-NCI) is marked by ongoing and chronic neuroinflammation with loss and decline in neuronal function even when antiretroviral drug therapy (ART) successfully suppresses viral replication. …”
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Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study by Muhammad Suleman, Abrar Mohammad Sayaf, Sohail Aftab, Mohammed Alissa, Abdullah Alghamdi, Suad A. Alghamdi, Mohammed A. Alshehri, Kar Kheng Yeoh, Sergio Crovella, Abdullah A. Shaito

“…<b>Background:</b> Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional coactivator p300, a critical step for promoting cancer cell survival and adaptation in hypoxic environments. …”
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Cacao Agroforestry in Mahakam Ulu: Transformation Strategy from Traditional to Good Agricultural Practices and Smart Agroforestry System by Catur Budi Wiati, Eddy Mangopo Angi, Karmilasanti Karmilasanti, Murniati Murniati, Sri Suharti, Indra A.S.L.P. Putri, Aris Pudji Hadi, Muhammad Furkan, Belasius Anyeq, Krista Tala, Veronica Carolina, Awaluddin Aziz, Ria Andiana, Yuliara Limbong, Yosua Naibaho, Mukrimin Mukrimin

“…The implementation of cacao SAF is anticipated to enhance cacao productivity, improve the welfare of local communities, and preserve the forest’s function as a crucial life support system for the Dayak Community in Mahakam Ulu (Mahulu) District. …”
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Path to Heritagization in Landscape Architecture: A Review of the Regeneration Design of Beijing Changchunyuan Park by Yufan ZHU

“…Undoubtedly, Changchunyuan Park adjacent to Changchun Temple is inherently bearing the same responsibility for cultural transmission. 2) Style and form selection: The traditional Beijing garden style is taken as the tone of “named composition” to regain the contemporary significance of traditional classic space. …”
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Subtype cluster analysis unveiled the correlation between m6A- and cuproptosis-related lncRNAs and the prognosis, immune microenvironment, and treatment sensitivity of esophageal c... by Ming Zhang, Yani Su, Pengfei Wen, Xiaolong Shao, Peng Yang, Peng An, Wensen Jing, Lin Liu, Zhi Yang, Mingyi Yang

“…Data on 23 m6A regulators and 25 cuproptosis-related genes were sourced from the latest literature. The m6aCRLncs linked to EC were identified through co-expression analysis. …”
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Rapid parameter estimation for merging massive black hole binaries using continuous normalizing flows by Bo Liang, Minghui Du, He Wang, Yuxiang Xu, Chang Liu, Xiaotong Wei, Peng Xu, Li-e Qiang, Ziren Luo

“…Detecting the coalescences of massive black hole binaries (MBHBs) is one of the primary targets for space-based gravitational wave observatories such as laser interferometer space antenna, Taiji, and Tianqin. …”
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SentemQC - A novel and cost-efficient method for quality assurance and quality control of high-resolution frequency sensor data in fresh waters [version 1; peer review: 1 approved,... by Sofie Gyritia Madsen van't Veen, Joachim Audet, Eti Ester Levi, Brian Kronvang, Søren Erik Larsen, Erik Jeppesen, Esben Astrup Kristensen, Anders Nielsen, Thomas Alexander Davidson, Jane Rosenstand Laugesen, Peter Mejlhede Andersen

“…The SentemQC method is computationally efficient and features a six-step user-friendly setup for anomaly detection. The method marks anomalies in data using five moving windows. …”
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Direct-fed microbials optimize ruminal fermentation, microbial ecosystem and milk quality to enhance the lactation performance of Sanhe dairy cows by Aoyu Jiang, Zixin Liu, Ziyan Yang, Shizhe Zhang, Jian Wu, Chuanshe Zhou, Zhiliang Tan

“…Dairy cows are the most important source of milk production, with billions of microorganisms present in the rumen. …”
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Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response by Alistair Perry, Laura E. Hughes, Natalie E. Adams, Michelle Naessens, Niels A. Kloosterman, Matthew A. Rouse, Alexander G. Murley, Duncan Street, P. Simon Jones, James B. Rowe

“…Across bvFTD and PSP groups, the beta response to deviant stimuli (relative to standard stimuli) correlated with clinical severity, but not with atrophy of the prefrontal source region. These findings confirm the proposed importance of higher-order cortical regions, and their beta-power generators, in sensory change detection and context-updating during oddball paradigms. …”
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The BoRG-JWST Survey: Abundance and Mass-to-light Ratio of Luminous z = 7–9 Galaxies from Independent Sight Lines with NIRSpec by Sofía Rojas-Ruiz, Micaela Bagley, Guido Roberts-Borsani, Tommaso Treu, Steven L. Finkelstein, Takahiro Morishita, Nicha Leethochawalit, Charlotte Mason, Eduardo Bañados, Michele Trenti, Massimo Stiavelli, L. Y. Aaron Yung, Pablo Arrabal Haro, Rachel S. Somerville, Christian Soto

“…We present new results on the rest-frame UV luminosity function (UVLF) and stellar mass-to-light ( M / L ) ratio of bright ( M _UV  ≲ −20 mag) spectroscopically confirmed galaxies at z  = 7–9 derived from the BoRG-JWST survey, a unique data set of NIRSpec prism follow-up of Hubble Space Telescope (HST)–selected sources from random-pointing imaging. …”
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TSLP pretreatment inhibits M1 macrophage polarization and attenuates LPS-induced iNKT cell-dependent acute lung injury by Ting Zhou, Ziyao Zhang, Yawen Zhan, Meiying Wang, Meiying Wang, Meiying Wang, Mi Wu, Xiufang Weng, Xiufang Weng, Xiufang Weng, Xiufang Weng, Younian Xu, Younian Xu, Younian Xu

“…The ratio, number, phenotype, and function of immune cells and cytokine levels were measured. …”
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تقييم تأثير وسائل الاعلام والدعاية على إدراک المستخدمين للعمارة والعمران "دراسة حالة مشروعات الاسکان في مصر"... by محمود سليمان, ولاء زقدان

“…The objectives of the research can be summedup as follows:- Demonstrating how mass media can affect the definition of the essence and concepts of architecture and construction in general, and housing in particular.- Evaluating the role played by mass media, in terms of positivity and negativity, through running an analysis of the messages conveyed by media and advertising, whichare often influenced by the vision of the investing developers, in quest for marketing their housing products.- Detecting the criteria upon which the mass media rely in order to market an architectural product, to see if such mass media adopt honesty in presenting the characteristicsof the product, and to see whether such presentation provides the user with the informed knowledge of what he/she is going to possess or not.- Outline controls system to regulate the methods of promotion and marketing, in connection with the information to be provided by the mass media about the architecturalproducts available at the housing market, to enable residence seekers to select the most suitable product, among the available residential models, in accordance wi th theirdiverse and versatile characteristics and needs.…”
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Knowledge management: the tool of the conceptual map in the evaluation of a seminar on safety and security by Fernando Barcellos Razuck, FRANCISCO CESAR DA SILVA

“…The course is free and has been designed to meet the needs of professionals with higher education equivalent to the university degree in physics, chemistry, health and earth sciences or engineering and have been selected to work in the field of radiation protection and safety of sources of radiation in their countries. …”
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Performance of the HAWC Observatory and TeV Gamma-Ray Measurements of the Crab Nebula with Improved Extensive Air Shower Reconstruction Algorithms by A. Albert, R. Alfaro, C. Alvarez, A. Andrés, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, A. Bernal, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, F. Carreón, S. Casanova, U. Cotti, J. Cotzomi, S. Coutiño de León, E. De la Fuente, C. de León, D. Depaoli, N. Di Lalla, R. Díaz Hernández, B. L. Dingus, M. A. DuVernois, K. Engel, T. Ergin, C. Espinoza, K. L. Fan, K. Fang, N. Fraija, S. Fraija, J. A. García-González, F. Garfias, H. Goksu, M. M. González, J. A. Goodman, S. Groetsch, J. P. Harding, S. Hernández-Cadena, I. Herzog, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, S. Kaufmann, A. Lara, J. Lee, H. León Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, J. Martínez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Montes, E. Moreno, M. Mostafá, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, M. Osorio-Archila, Y. Pérez Araujo, E. G. Pérez-Pérez, C. D. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, D. Salazar-Gallegos, A. Sandoval, M. Schneider, G. Schwefer, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Ureña-Mena, E. Varela, X. Wang, I. J. Watson, K. Whitaker, E. Willox, H. Wu, S. Yu, S. Yun-Cárcamo, H. Zhou, HAWC Collaboration

“…Thanks to these improvements, HAWC can now detect more sources, including the Galactic center.…”
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Effects of exercise with music in frail older adults: a systematic review and meta-analysis by NamHee Kim, Gwang Suk Kim, Min Kyung Park, Layoung Kim, Jae Jun Lee, Seungbum Yang

“…This study evaluated the impact of exercise with music on the physical and emotional health of frail, community-dwelling older adults.Design A systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines.Data sources MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Embase, Cochrane Library, PsycINFO, Google Scholar and the Virginia Henderson International Nursing Library were last searched on 14 March 2025.Eligibility criteria for selecting studies We included randomised controlled trials (RCTs) and non-RCTs that applied exercise with music to community-dwelling frail older adults.Data extraction and synthesis Five independent reviewers used standardised methods to search, screen and code included studies. …”
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Understanding the political economy of reforming global health initiatives – insights from global and country levels by Sophie Witter, Natasha Palmer, Rosemary Jouhaud, Shehla Zaidi, Severine Carillon, Rene English, Giulia Loffreda, Emilie Venables, Shifa Salman Habib, Jeff Tan, Fatouma Hane, Maria Paola Bertone, Seyed-Moeen Hosseinalipour, Valery Ridde, Asad Shoaib, Adama Faye, Lilian Dudley, Karen Daniels, Karl Blanchet

“…Funders have not collaborated to enable reforms, despite concerns amongst a number of them, because of the helpful functional role of GHIs, which serves funder interests. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…Adolescent adaptive functioning was predicted not only by early childhood autistic symptoms and IQ and ADHD symptoms. …”
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Intranasal administration of stem cell derivatives for the treatment of AD animal models: a systematic review and meta-analysis by Zilin Hua, Nan Zhou, Zijing Zhou, Zewei Fu, Ruiyun Guo, Herman Yao Akogo, Jiayin Yang, Meixuan Yu, Yujie Jiang, Siyi Lan, Haixia Chang, Jun Ma, Huixian Cui

“…Subgroup analyses indicated that stem cell source, stem cell derivative types and Aβ detection method were not primary drivers of heterogeneity. …”
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Targeting hyperlipidemia: A polarity-driven ternary extraction of Apium graveolens bioactives—A coupled in-vivo, in-vitro and in-silico investigation by Nargis Sultana Chowdhury, Tasnuva Sharmin Zaman, Rifah Noor Chowdhury, Md Abdur Rahman, Sheikh Rakibul Alam, Romana Akter, Md. Nazmus Samdani, Syeda Sadia Afrin, Md. Rafat Tahsin, Fahima Aktar, Ishrat Jahan, Nasiba Binte Bahar, Salehuddin Ayubee, Umme Habiba Ria, Md Zakir Sultan, Mohammad Borhan Uddin, Jakir Ahmed Chowdhury, Md. Selim Reza, Abu Asad Chowdhury, Shaila Kabir, Md. Shah Amran

“…Moreover, rats treated with the plant extract exhibited a significant reduction in their serum levels of the hepatic damage biomarkers and renal function biomarkers compared to the disease control group. …”
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