The potential for gene-editing to increase muscle growth in pigs: experiences with editing myostatin by A. C. Dilger, X. Chen, L. T. Honegger, B. M. Marron, J. E. Beever

“…The vast majority of gene-editing projects have focused on a single gene, myostatin (MSTN), with several reports of successful editing events. These attempts have been limited by the low efficiency of successful edits and issues of viability. …”
Get full text

Retinal vein occlusion risk prediction without fundus examination using a no-code machine learning tool for tabular data: a nationwide cross-sectional study from South Korea by Na Hyeon Yu, Daeun Shin, Ik Hee Ryu, Tae Keun Yoo, Kyungmin Koh

“…An easy-to-use oversampling function was employed to address class imbalance, enhancing the usability of the workflow. …”
Get full text

Cognitive bias modification for social anxiety: protocol for a living systematic review of human studies and meta-analysis [version 2; peer review: 2 approved, 1 approved with rese... by Paulina Schenk, Virginia Chiocchia, Hossein Dehdarirad, Janna Hastings, Claire Stansfield, Toshi Furukawa, Simon E. Blackwell, Ava Homiar, Thomy Tonia, Per Carlbring, Kelvin Opiepie, Claire Friedrich, Simonne Wright, Susan Michie, Georgia Salanti, Richardson Mojica, James Thomas, Jaycee Kennett, Andrea Cipriani, Jennifer Potts

“…Cases of elevated distress and impaired functioning can lead to a clinical diagnosis of social anxiety disorder. …”
Get full text

Oligosaccharide production using β-galactosidase from Lactobacillus bulgaricus and Kluyveromyces lactis in sweetened reconstituted nonfat dry milk by Giselle K.P. Guron, Arland T. Hotchkiss, Jr., Brittany H. Bodnar, Andrew Harron, John A. Renye, Jr., Michael J. McAnulty

Get full text

Effective disinfecting of negative pressure pipelines of DCUs reduces the risk of cross infection in dental care by Xuerong Lv, Ke Yan, Xiang Han, Feiyang Wang, Yuzhuo Ma, Shougang Zhang, Xiaoqian Wang

“…Objectives Microbial contamination of various accessory parts of the dental chair units (DCUs) is an essential source of cross infection, while the accessories of the crucial suction function are usually overlooked. …”
Get full text

and as prognostic biomarkers for prognosis and palindromia of human hepatocellular carcinoma by Xin Zhang, Jin-Xiang Wan, Zun-Ping Ke, Feng Wang, Hai-Xia Chai, Jia-Qiang Liu

“…TMEM88, CCL14 , and CLEC3B were selected as driver genes which clustered high-/low-risk patients successfully (generally, p = 0.0005124445). …”
Get full text

Recent achievements in synthesis of anthracene scaffolds catalyzed transition metals by Fadhil Faez Sead, Fadhil Faez Sead, Fadhil Faez Sead, Vicky Jain, R. Roopashree, Aditya Kashyap, Suman Saini, Girish Chandra Sharma, Pushpa Negi Bhakuni, Pushpa Negi Bhakuni, Mosstafa Kazemi, Ramin Javahershenas

“…The function of ligands, including phosphines and N-heterocyclic carbenes, in improving reaction efficiency and selectivity is also examined. …”
Get full text

CURRENT STATE AND PROSPECTS OF COMPUTER TERMINOLOGY ONLINE LEXICOGRAPHY by Iryna B. Mentynska

“…It was established that the analyzed modern popular online lexicographic sources, which record the terms of the computer terminology, according to the basic principles of lexicography, have an effective toolkit with a variety of functionality. …”
Get full text

Prevalence and contributing factors of depression among women with infertility in low-resource settings: a systematic review and meta-analysis by Shimelis Tadesse, Henok Kumsa, Gemeda Wakgari Kitil, Alex Ayenew Chereka, Getnet Gedefaw, Fiker Chane, Esuyawkal Mislu

“…Good functioning family, good husband support, primary infertility, history of divorce, and duration of infertility lasting more than 10 years were statistically associated. …”
Get full text

Social Confrontation with Menstruation: A Feminist Ethnography of Menstrual Experience among Female Instagram Users by Rana Mohammad Taghinejad Esfahani, Majid Movahed, Halimeh Enayat, Aliyar Ahmadi

“…This study examined women’s experiences of menstruation on Instagram and explored how menstruation taboos function as mechanisms for controlling women’s bodies within the existing power structures and daily life. …”
Get full text

Characterization of two novel chia (Salvia hispanica L.) white and black genotypes via DNA barcoding, physiological, and agronomic traits by Clara R. Azzam, Mokhtar Said Rizk, Soha Sayed Mohammad Mostafa, Ramadan A. Arafa, Mohamed Samy Al-Nabawi, Nahid Abdelaty Ali Morsi, Marwa Mahmoud Nasr El-Din, Enass Hassan Taher, Khaled Adly Khaled

“…Results: DNA barcoding using five markers (trnH-psbA, matK, rpoC1, rbcL, and ITS) successfully amplified sequences of 930 bp, 1520 bp, 2295 bp, 1910 bp, and 1630 bp, respectively. …”
Get full text

Much More Than the Malady: The Promise of a Web-Based Digital Platform Incorporating Self-Report for Research and Clinical Care in Mild Cognitive Impairment by Andrew McGarry, MD, Oliver Roesler, PhD, Jackson Liscombe, PhD, Michael Neumann, PhD, Hardik Kothare, PhD, Abhishek Hosamath, MBM, Lakshmi Arbatti, MS, Anusha Badathala, MD, Stephen Ruhmel, BS, MPH, Bryan J. Hansen, PhD, Madeline Quall, BA, Sandrine Istas, MBio, Arthur Wallace, MD, PhD, David Suendermann-Oeft, PhD, Vikram Ramanarayanan, PhD, Ira Shoulson, MD

“…A complementary approach using digital biomarkers to surpass exam-based limitations for detecting physical change coupled with a direct report from participants on what their sources of suffering are could be a useful advance in reporting beneficial effects of interventions, particularly if changes track together. …”
Get full text

„Looduse universaal-biblioteek“: raamatusarja juhtumiuuring / Universal Library by Loodus (1927–1931): a case study of the book series by Piret Pärgma

“…The series was given out by publishing house Loodus (Nature; 1920–1940), the company that became the biggest and most successful publisher in the interwar period Estonia. …”
Get full text

Harnessing greylag goose optimization for efficient MPPT and seven-level inverter in renewable energy systems by K. Rajaram, R. Kannan

“…The inverter THD output voltage was used as the objective function, and the proposed method is particularly beneficial in agricultural settings. …”
Get full text

Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis by Ricardo Félix Morais, José Maria Sousa, Cemal Koba, Leon Andres, Tiago Jesus, Inês Baldeiras, Tiago Gil Oliveira, Isabel Santana

“…In MCI, early serotonergic dysregulation involving SERT occurs before detectable atrophy.…”
Get full text

Exploration of the interaction between antimicrobial peptides and gamma radiation for biosensor development. by Fabiane Modenese Garbim, Marcela Rabelo De Lima, Giulianna Santos Pereira, João Nilton Conceição Bandeira, Álvaro José Mendes-Boareto, Fernando Manuel Araújo-Moreira, N.F.G. Serrano

“…These findings indicate that, although AMPs demonstrate changes in activity as a function of dose and could be explored for biosensing, their functional stability is limited at higher radiation doses. …”
Get full text

Prognostic value and immunotherapy analysis of immune cell-related genes in laryngeal cancer by Sen Zhang, Jianrui Pan, Huina Guo, Xiaoya Guan, Chenxu Yan, Lingling Ji, Xiansha Wu, Hui Huangfu

“…Key genes were identified through the intersection of differentially expressed genes (DEGs) between normal and LC samples and module genes derived from weighted gene co-expression network analysis (WGCNA), followed by functional enrichment analysis. The prognostic risk model was constructed using univariate Cox and Least Absolute Shrinkage and Selection Operator (LASSO) analyses. …”
Get full text

Introducing the dataset for measuring centrality for sustainability—A case study of Pecinci municipality, SerbiaMendeley DataMendeley Data by Tatjana Mrđenović

“…The current theories and practices of planning central activities in Serbia primarily rely on functional factors of network flow. However, this approach aims to enhance the current practice of data utilisation for the sustainable development of central activities and integrative central places. …”
Get full text

The SIRT1 activator SRT2104 exerts exercise mimetic effects and promotes Duchenne muscular dystrophy recovery by Matteo Giovarelli, Silvia Zecchini, Silvia Rosanna Casati, Laura Lociuro, Oriola Gjana, Luca Mollica, Elena Pisanu, Harcel Djaya Mbissam, Ornella Cappellari, Chiara De Santis, Alessandro Arcari, Anne Bigot, Giuditta Clerici, Elisabetta Catalani, Simona Del Quondam, Annapaola Andolfo, Clarissa Braccia, Maria Grazia Cattaneo, Cristina Banfi, Dario Brunetti, Emanuele Mocciaro, Annamaria De Luca, Emilio Clementi, Davide Cervia, Cristiana Perrotta, Clara De Palma

Get full text

Low dose Adenoviral Vammin gene transfer induces myocardial angiogenesis and increases left ventricular ejection fraction in ischemic porcine heart by Niko Järveläinen, Paavo J. Halonen, Jussi Nurro, Antti Kuivanen, Juho Pajula, Miikka Tarkia, Maria Grönman, Antti Saraste, Johanna Laakkonen, Pyry Toivanen, Tiina Nieminen, Tuomas T. Rissanen, Juhani Knuuti, Seppo Ylä-Herttuala

“…In addition, we demonstrated successful in vivo imaging of enhanced angiogenesis using [68Ga]NODAGA-RGD peptide. …”
Get full text