Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2 by Ahn G, Yoon HW, Jeong JH, Kim YH, Shin WR, Song MS, Ahn JY

“…Experiments in mice, Ag43β 700_RBD OMVs was successfully proven to be safe and effective; they produced a detectable level of nAbs with 39– 58% neutralisation and reduced viral titres in the lungs and brain without weight loss.Conclusion: The developed viral mimetic Ag43β 700_RBD OMVs may therefore be applied as a nanovesicle-theranostic platform for further emerging infectious disease-related diagnosis, vaccination, and treatment. …”
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A case-control genome-wide association study of estimated breeding values for resistance to gastrointestinal nematodes in two local dairy sheep breeds by C. Persichilli, S. Biffani, G. Senczuk, M. Di Civita, M.K. Bitew, A. Bosco, L. Rinaldi, S. Grande, G. Cringoli, F. Pilla

“…In this study, we took advantage of the use of EBVs as a metric for GIN resistance in a case-control genome-wide framework and successfully identified several genomic regions that might be involved in the trait. …”
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Oxidative Stress Markers and C-Reactive Protein Are Related to Severity of Heart Failure in Patients with Dilated Cardiomyopathy by Celina Wojciechowska, Ewa Romuk, Andrzej Tomasik, Bronisława Skrzep-Poloczek, Ewa Nowalany-Kozielska, Ewa Birkner, Wojciech Jacheć

“…Increased MnSOD activity indicates the mitochondrial source of ROS in patients with advanced heart failure.…”
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Antibiotic Resistance and Virulence Determinants of <i>Pseudomonas aeruginosa</i> Isolates Cultured from Hydrocarbon-Contaminated Environmental Samples by Chioma Lilian Ozoaduche, Balázs Libisch, Daniel Itoro, Iyore Blessing Idemudia, Katalin Posta, Ferenc Olasz

“…In some of these <i>P. aeruginosa</i> strains, loss-of-function mutations were detected in the regulatory genes <i>mexR</i>, <i>nalC</i>, or <i>nalD</i>, predicting an efflux-mediated acquired antibiotic-resistance mechanism. …”
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Optimization of Ultrasonic-Enzymatic-Assisted Extraction of Flavonoids from Sea Buckthorn (<i>Hippophae rhamnoides</i> L.) Pomace: Chemical Composition and Biological Activities by Wenyu Suo, Wenzhe Wang, Dajing Li, Haihong Wu, Haiyan Liu, Wuyang Huang, Yanhong Ma

“…Sea buckthorn pomace (SBP) is a rich source of flavonoid compounds with potential healthy properties. …”
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Enhancing Medium-Chain Fatty Acid Delivery Through Bigel Technology by Manuela Machado, Eduardo M. Costa, Sara Silva, Sérgio C. Sousa, Ana Maria Gomes, Manuela Pintado

“…This study presents the development and characterization of medium-chain fatty acid (MCFA)-loaded bigels, using coconut oil as the MCFA source. The bigels exhibited high oil binding capacity, ranging from 87% to 98%, effectively retaining MCFAs within the matrix, with lauric acid (C12) being the main component detected within the bigels at 178.32 ± 0.10 mg/g. …”
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In vitro fermentation of whole matrix, digested products and β-glucan enriched extract of Pleurotus eryngii mushrooms distinctively impact the fecal microbiota of healthy older adu... by Evangelia N. Kerezoudi, Marigoula Vlassopoulou, Evdokia K. Mitsou, Georgia Saxami, Georgios Koutrotsios, Ioanna Taflampa, Konstantinos C. Mountzouris, Ignacio Rangel, Robert J. Brummer, Georgios I. Zervakis, Vasiliki Pletsa, Panagiotis Georgiadis, Adamantini Kyriacou

“…The changes in bacterial communities upon fermentation at family, genera and species level were detected via 16S rRNA Next Generation Sequencing and Quantitative real-time PCR. …”
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Worlds Next Door: A Candidate Giant Planet Imaged in the Habitable Zone of α Centauri A. II. Binary Star Modeling, Planet and Exozodi Search, and Sensitivity Analysis by Aniket Sanghi, Charles Beichman, Dimitri Mawet, William O. Balmer, Nicolas Godoy, Laurent Pueyo, Anthony Boccaletti, Max Sommer, Alexis Bidot, Elodie Choquet, Pierre Kervella, Pierre-Olivier Lagage, Jarron Leisenring, Jorge Llop-Sayson, Michael Ressler, Kevin Wagner, Mark Wyatt

“…Additionally, postprocessing with the principal-component-analysis-based Karhunen–Loéve image processing algorithm reveals a point source, called S 1, in 2024 August, detected at signal-to-noise ratio of 4–6 (3.3–4.3 σ ), a projected separation of ≈1 $\mathop{.}…”
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Effect of yellow capsicum extract on the lipid metabolism in mice by CUI Xiaoman, YU Haining, XU Jielan, CHEN Zhongting, SHEN Shengrong

“…In the end, the mice were killed and dissected, body fat percentage, contents of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and leptin in serum, expression levels of TC, TG, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the liver, were all detected and analyzed. Besides, the pancrelipase (PL) level of pancreatic tissue was also detected through ELISA method, as it is an important lipase in lipids metabolism.The results showed that, after 40 days' treatment through hyperlipidic diet, the obesity model group was successfully built up, as they were overweighed (P&lt;0.01) and showed a higher mass of adipose tissue (P&lt;0.05), TC (P&lt;0.05), TG (P&lt;0.01) contents than the normal diet control group. …”
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GWAS and WGCNA analysis uncover candidate genes associated with drought in Brassica juncea L. by Yusong Zhang, Yusong Zhang, Xiaoyan Yuan, Xiaoyan Yuan, Yunyun Zhang, Yunyun Zhang, Yanqing Luo, Yanqing Luo, Kaiqin Zhao, Kaiqin Zhao, Feng Zu, Feng Zu, Zhengshu Tian, Zhengshu Tian, Jinfeng Li, Jinfeng Li, Lifan Zhang, Lifan Zhang, Xiaoying He, Xiaoying He, Jinxiang Gao, Jinxiang Gao, Minglian Fu, Minglian Fu, Genze Li, Genze Li, Feihu Liu

“…To screen drought-tolerant germplasm resources and key functional genes related to drought tolerance in Brassica juncea L.(193 accessions), three treatments were applied at the germination and seedling stages:control(CK), moderate drought stress (M), and severe drought stress (S). …”
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Effectiveness of Standalone Weight-bearing Radiographs in Guiding the Management of Supination External Rotation Type Isolated Lateral Malleolar Fractures in Indian Population: A P... by Singaravadivelu Vaidyanathan, Vignesh Murali, Aju Bosco

“…Periodic follow-up was done to assess radiological union and functional outcomes using the American Orthopaedic Foot and Ankle Society (AOFAS) score. …”
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Mechanism Analysis of Highly Effective Imidazole-Schiff Corrosion Inhibitor on P110 in HCl Solution by LIU Wenchao, WANG Pengjie, TANG Zijie, LI Hao, WANG Ming'an, LIU Wanying, LIN Yuanhua

“…In order to inhibit the corrosion of pipeline steel during oilfield acidification，an imidazole-Schiff corrosion inhibitor (IAP) was synthesized.The corrosion inhibition performance and mechanism of IAP corrosion inhibitor with different concentration on P110 steel in 15%HCl solution were studied through weight loss and electrochemical tests.Subsequently，Fourier infrared spectroscopy (FTIR)，scanning electron microscopy (SEM) ＋energy dispersive spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS) were used to further confirm the inhibition mechanism of IAP on P110 steel in 15%HCl.In addition， the rationality of inhibition mechanism was further clarified from the molecular level by theoretical calculation.Results showed that when IAP added concentration was 400.0 mg/L，the weight loss test corrosion inhibition efficiency of P110 steel in 15%HCl was 97.58%， the test results of AC impedance spectrum (EIS) and potentiodynamic polarization (Tafel)curve showed that the corrosion inhibition efficiencies were 97.32%and 96.76%， respectively.EIS test results proved that IAP played a role in corrosion inhibition by forming film on the surface of P110 steel， and Tafel curve test results proved that IAP was a mixed corrosion inhibitor mainly based on anode inhibition.Meanwhile， the adsorption of IAP on P110 steel followed Langmuir isothermal adsorption equation and could be spontaneously adsorbed on the surface of P110 steel.FTIR，SEM＋EDS，and XPS successfully detected the protective film formed by IAP on the surface of P110 steel.Density functional theory (DFT) and molecular dynamics (MD) proved that the active sites of IAP were benzene ring and imidazole ring.Specifically，the benzene ring could accept excess electrons on the surface of Fe，the lone electron pair of N on the imidazole ring formed a stable coordination bond with Fe， and MD could further proved that IAP were spontaneously adsorbed on the surface of Fe.Overall，IAP corrosion inhibitor could demonstrate excellent corrosion inhibition performance in 15%HCl corrosive medium，with its mechanism involving the formation of a stable protective film on the surface of P110 steel.…”
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Barriers to and facilitators of rehabilitation according to socio-economic status, after acute respiratory distress syndrome due to COVID-19: A qualitative study in the RECOVIDS co... by Mathilde Kléber, Nicolas Meunier-Beillard, Isabelle Fournel, Eléa Ksiazek, Marine Jacquier, Fiona Ecarnot, Jean-Philippe Rigaud, Pierre-Louis Declerq, Jean-Pierre Quenot, Marie Labruyère

“…<h4>Background</h4>The COVID-19 pandemic may have compounded social disparities in access to healthcare, with possible deleterious consequences on the functional prognosis of patients after a stay in the intensive care unit (ICU). …”
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Mortalin overexpression predicts poor prognosis in early stage of non–small cell lung cancer by Jie Sun, Shuan-Long Che, Jun-Jie Piao, Ming Xu, Li-Yan Chen, Zhen-Hua Lin

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Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy by Zhihe Chen, Zhongying Yang, Lifen Rao, Changgen Li, Na Zang, Enmei Liu

“…Results GSEA analysis showed significant enrichment of gene sets related to endothelial functions (barrier, defense, and regeneration) and ALI in the HAdV-7-infected group. …”
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Nanoprobe synchrotron X-ray fluorescence microscopy reveals selenium-rich spherical structure in mouse retinal pigment epithelium by Marta Ugarte, Kalotina Geraki, Elizabeth Bentley, Roger Cox

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The Effect of Hearing Aid Amplification on Gait Parameters: A Pilot Study Using Ear-Worn Motion Sensors by Ann-Kristin Seifer, Arne Küderle, Kaja Strobel, Ronny Hannemann, Björn M. Eskofier

“…Additionally, we showed the potential of ear-worn sensors for detecting relevant gait changes. To achieve this, we used a hearing-aid-integrated accelerometer and our open-source EarGait framework comprising gait-related algorithms specifically developed for ear-worn sensors. …”
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Interrelation of indicators of oxygen metabolism of neutrophils and antiendotoxin immune as a marker of the postoperative period in patients with acute colonic obstruction by A. V. Pikuza, A. M. Zakirov

“…The focus of purulent inflammation in the abdominal cavity serves as a source of concentration of antimicrobial mechanisms, among which the central role is played by neutrophilic granulocytes and factors cooperating with them. …”
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Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves&rsquo; Disease and Graves&rsquo; Ophthalmopathy by Ke C, Yu Y, Li J, Yu Y, Sun Y, Wang Y, Wang B, Lu Y, Tang M, Wang N, Chen Y

“…Then, downstream analyses were performed to detect protein interactions, gene function, cell type-specific expression and druggable information.Results: This study genetically predicted levels of 62 plasma proteins were associated with GD risk. …”
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Compact and Handheld SiPM-Based Gamma Camera for Radio-Guided Surgery and Medical Imaging by Fabio Acerbi, Aramis Raiola, Cyril Alispach, Hossein Arabi, Habib Zaidi, Alberto Gola, Domenico Della Volpe

“…We characterized the intrinsic position resolution (tested with pulsed light) as being ~200 µm, and the sensitivity and resolution when detecting gamma rays from Tc-99m source measured between 134 and 481 cps/MBq and as good as 1.4–1.9 mm, respectively.…”
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