Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR. by Benjamin G Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan, Pierre Boivin, Vihasi Jani, Aaron J Cantor, Akshay Tambe, Mary Haak-Frendscho, Mary J Janatpour, Spencer C Wei

“…We determine that knockout of ADAR using these guide RNAs induces pharmacodynamic responses primarily consisting of immunological responses such as a type I interferon response, consistent with the known function of ADAR as a key regulator of dsRNA sensing. …”
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Advanced Monte Carlo for Acquisition Sampling in Bayesian Optimization by Javier Garcia-Barcos, Ruben Martinez-Cantin

“…Optimizing complex systems usually involves costly and time-consuming experiments, where selecting the experiments to perform is fundamental. …”
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The Interface Between Innovation and Entrepreneurship with Strategic Risks and the Budget in a Brazilian Agribusiness Company by Thiago Bruno de Jesus Silva, Carlos Eduardo Facin Lavarda

“… In the context of Resource-based Theory (rbt), management control components such as budgeting play a crucial role in organizing and maximizing the potential of resources and capabilities. …”
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Distance Conversion Factors for In Situ H-Field Emissions Tests by Jordi Sole-Lloveras, Yasutoshi Yoshioka, Manuel Anon-Cancela, Thilo Kootz, Ferran Silva, Marco A. Azpurua

“…An algorithm is developed to extract the H-field strengths normalized to the reference distance and then, through methods for optimal detection of changepoints, such a normalized curve is fitted to a piece-wise linear function that becomes the generalized distance conversion factor, presented in the form of simplified equations. …”
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Rapid and Accurate Prediction of the Melting Point for Imidazolium-Based Ionic Liquids by Artificial Neural Network by Xinyu Liu, Jie Yin, Xinmiao Zhang, Wenxiang Qiu, Wei Jiang, Ming Zhang, Linhua Zhu, Hongping Li, Huaming Li

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Rock Mechanical Properties and Breakdown Pressure of High-Temperature and High-Pressure Reservoirs in the Southern Margin of Junggar Basin by Mingwei Kong, Zhaopeng Zhang, Chunyan Zhao, Huasheng Chen, Xinfang Ma, Yushi Zou

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MGSurvE: A framework to optimize trap placement for genetic surveillance of mosquito populations. by Héctor M Sánchez C, David L Smith, John M Marshall

“…For these projects, monitoring will be required to detect unintended spread of gene drive mosquitoes beyond field sites, and the emergence of alternative alleles, such as drive-resistant alleles or non-functional effector genes, within intervention sites. …”
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Prokaryotic microbial compositions and physicochemical characteristics of Huangshui, a by-product of Baijiu fermentation by TANG Yanping, GAO Xiubing, NI Jie, ZHANG Fengqin

“…In this study, the similarities and differences in physicochemical properties and prokaryotic microbial structures among different sources of Huangshui were comprehensively analyzed by physicochemical detection methods and high-throughput sequencing technology. …”
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From Lab to Life: Self‐Powered Sweat Sensors and Their Future in Personal Health Monitoring by Nan Gao, Guodong Xu, Gang Chang, Yuxiang Wu

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Are Supernovae Responsible for the Gamma Ray Spectrum from the Galactic Center? by Todor Stanev

“…We discuss the supernova remnants distribution as a function of the galactic longitude and compare their positions to that of the detected TeV gamma ray sources. …”
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Inoculant Formulation for <i>Bradyrhizobium</i> spp.: Optimizing CMC/Starch Blends for Improved Performance by Jaqueline Carvalho de Almeida, Vinício Oliosi Favero, Janaina Ribeiro Costa Rouws, Carla de Sant’Anna Freitas, Érica Barbosa de Sousa, Jéssica Feitoza da Rocha, Nainicelle Cibelle Sousa Chantre, Gustavo Ribeiro Xavier, Paulo Jansen de Oliveira, Norma Gouvêa Rumjanek

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The Transjugular Intrahepatic Portosystemic Shunt in the Treatment of Portal Hypertension: Current Status by Gilles Pomier-Layrargues, Louis Bouchard, Michel Lafortune, Julien Bissonnette, Dave Guérette, Pierre Perreault

“…The role of TIPS to treat refractory ascites is probably more justified to improve the quality of life rather than to improve survival, except for patients with preserved liver function. It can be helpful for hepatic hydrothorax and can reverse hepatorenal syndrome in selected cases. …”
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A Comprehensive Review of Detection Methods for <i>Staphylococcus aureus</i> and Its Enterotoxins in Food: From Traditional to Emerging Technologies by Assia Mairi, Nasir Adam Ibrahim, Takfarinas Idres, Abdelaziz Touati

“…The review underscores the necessity of context-driven method selection, balancing speed, sensitivity, and resource availability. …”
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Hybrid modeling approaches for predicting COVID-19 mortality: A comparative study across USA, France, and India by B. Uppalaiah, D. Mallikarjuna Reddy, K. Rajalakshmi, P. Vignesh, V. Govindan, Siriluk Donganont

“…The models combine the adaptability of Gaussian Processes with the deep learning functionalities of RBM, LSTM, and CNN to improve prediction precision and uncertainty assessment. …”
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Optimal Dispatch of Power System with P2G-Wind-Thermal-Nuclear-Carbon Capture Units by Wenhao CHAO, Zhi YUAN, Ji LI

“…Finally, the minimization of system comprehensive operation costs is selected as the overall objective function. At the same time, the carbon trading mechanism is considered to build the simulation model on the Matlab platform to verify the effectiveness of the proposed model. …”
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Evaluating Sleep in Pediatric Cancer: A Scoping Review of Assessment Tools for Quality and Care by Elena Rostagno, Veronica Rivi, Pierfrancesco Sarti, Pietro Guastella, Dorella Scarponi, Johanna Maria Catharina Blom

“…Conclusion A wide range of tools exists for assessing sleep in pediatric oncology, each with distinct strengths and limitations. Selection of the most appropriate tool should consider the specific sleep concern, patient age, clinical context, and resource availability. …”
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TRENDS IN HIGHER VOCATIONAL EDUCATION: PROFESSIONALIZATION OR DEPROFESSIONALIZATION? by Yu. R. Vishnevsky, D. Yu. Narkhov, Ya. V. Didkovskaya

“…Student population is the most important social resource of development of post-industrial information society. …”
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Pharmacological Mechanisms of Cryptotanshinone: Recent Advances in Cardiovascular, Cancer, and Neurological Disease Applications by Zheng Z, Ke L, Ye S, Shi P, Yao H

“…Ziyao Zheng,1 Liyuan Ke,1 Shumin Ye,1 Peiying Shi,2 Hong Yao1,3 1Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, People’s Republic of China; 2Department of Traditional Chinese Medicine Resource and Bee Products, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, 350002, People’s Republic of China; 3Fujian Key Laboratory of Drug Target Discovery and Structural and Functional Research, Fujian Medical University, Fuzhou, 350122, People’s Republic of ChinaCorrespondence: Peiying Shi; Hong Yao, Email peiyshi@126.com; yauhung@126.com, hongyao@mail.fjmu.edu.cnAbstract: Cryptotanshinone (CTS) is an important active ingredient of Salvia miltiorrhiza Bge. …”
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Principles for determining effective parameters for organizing train traffic in suburban-urban traffic, taking into account the differentiation of service classes by A. F. Borodin, I. F. Mustafin, K. Yu. Nikolaev

“…Relevant constraints for the task, due to the resources of the railway infrastructure and rolling stock, have been determined. …”
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Therapeutic Strategies for Dry Mouth Management with Emphasis on Electrostimulation as a Treatment Option by Amela Tulek, Aida Mulic, Martine Hogset, Tor Paaske Utheim, Amer Sehic

“…The aim of this study was to give an overview of the latest and most relevant data related to treatment modalities for the management of dry mouth conditions. Data Resources and Study Selection. The present review was prepared by searching the National Library of Medicine database using the relevant medical terms and their combinations. …”
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