HoloMoA: a holography and deep learning tool for the identification of antimicrobial mechanisms of action and the detection of novel MoA by Zohreh Sedaghat, Benoît Courbon, Héloïse Botrel, Hélène Dugua, Pawel Tulinski, Laethitia Alibaud, Lucia Pagani, Derry Mercer, Cyril Guyard, Christophe Védrine, Sophie Dixneuf

“…Secondly, we showed how our CRNN model combined with a Siamese Neural Network architecture can be used for the novelty assessment of the MoA of candidate antibiotics. We successfully evaluated our novelty detector on a test set containing three unseen molecules — two belonging to the conventional functional classes and one molecule from an additional class (Folate synthesis inhibitors, herein represented by trimethoprim-sulfamethoxazole). …”
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Synthesis, Evaluation, and Electrochemical Detection Application of Magnetic Molecularly Imprinted Polymers for 4,4′-Methylenedianiline from Food-Contact Materials by Lijing Lu, Haoyue Ning, Jipeng Guo, Chuang Guo, Liao Pan, Lixin Lu

“…Magnetic molecularly imprinted polymers (MIPs) capable of selectively recognizing and absorbing 4,4′-methylenedianiline (MDA) were successfully synthesized, using Fe3O4 coated with mesoporous silicon (Fe3O4@mSiO2) as the magnetic carrier, 4-vinyl pyridine (4-VP) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent, and MDA as the template molecule. …”
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A New Quinone Based Fluorescent Probe for High Sensitive and Selective Detection of Biothiols and Its Application in Living Cell Imaging by Yanju Liu, Manman Li, Keith Man-Chung Wong, Yan Tong, Huaixia Yang, Jinming Kong

“…In addition, the probe has been successfully applied to the detection of biothiols in Eca9706 cells by fluorescence confocal imaging technology.…”
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Sensitive and selective detection of Staphylococcus aureus via a dual-recognition colorimetric platform based on phenylboronic acid and IgY by Yun Zhang, Chunhui Huo, Xiaohong Yang, Yanjie Cui, Yiqing Hou, Qinghe Guo, Qiongzi Wang, Mingyong Wang, Yi Zhang

“…The optimized method can be performed within 120 min, with a detection limit of 9.4 × 102 CFU/mL. The proposed strategy was successfully applied to detection of S. aureus in spring water and apple juice samples. …”
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Fluorescent nanoprobe prepared from hyaluronic acid modified iron selenide nanoparticles for real-time detection of hyaluronidase as tumor marker by Chaoqun Zhang, Jie Song, Xin Shen, Qian Li, Feng Su, Suming Li

“…Analyses by FTIR, XRD, XPS, EDX, TEM, DLS, 1H NMR and TGA confirmed the successful synthesis of the nanoprobe, and fluorescence spectroscopy proved its good detection performance. …”
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Heart Rate Variability-Based Stress Detection and Fall Risk Monitoring During Daily Activities: A Machine Learning Approach by Ines Belhaj Messaoud, Ornwipa Thamsuwan

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Identification and Functional Testing of ERCC2 Mutations in a Multi-national Cohort of Patients with Familial Breast- and Ovarian Cancer. by Andreas Rump, Anna Benet-Pages, Steffen Schubert, Jan Dominik Kuhlmann, Ramūnas Janavičius, Eva Macháčková, Lenka Foretová, Zdenek Kleibl, Filip Lhota, Petra Zemankova, Elitza Betcheva-Krajcir, Luisa Mackenroth, Karl Hackmann, Janin Lehmann, Anke Nissen, Nataliya DiDonato, Romy Opitz, Holger Thiele, Karin Kast, Pauline Wimberger, Elke Holinski-Feder, Steffen Emmert, Evelin Schröck, Barbara Klink

“…Ten out of eleven mutations that were tested exemplarily in cell-based functional assays exert diminished excision repair efficiency and/or decreased transcriptional activation capability. …”
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Vibration-Based Damage Detection of a Steel-Concrete Composite Slab Using Non-Model-Based and Model-Based Methods by Liang Fang, Yun Zhou, Yunzhong Jiang, Yilin Pei, Weijian Yi

“…For the non-model-based method, modal flexibility and modal flexibility displacement (MFD) were used to detect the location and extent of the damage. The test results showed that the appearance and location of the damage in defect cases and loading conditions can be successfully identified by the MFD values. …”
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Rapid-Response and Highly Sensitive Boronate Derivative-Based Fluorescence Probe for Detecting H2O2 in Living Cells by Muthusamy Selvaraj, Kanagaraj Rajalakshmi, Yun-Sik Nam, Yeonhee Lee, Byoung Chan Kim, Sung Jin Pai, Sang Soo Han, Kang-Bong Lee

“…The probe was conjugated using the TPIOP functional group acting as an excellent fluorescent enhancer. …”
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Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas. by Irina Haecker, Lauren A Gay, Yajie Yang, Jianhong Hu, Alison M Morse, Lauren M McIntyre, Rolf Renne

“…In summary, we provide an extensive list of cellular and viral miRNA targets representing an important resource to decipher KSHV miRNA function.…”
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Secure ISAC MIMO systems: exploiting interference with Bayesian Cramér–Rao bound optimization by Nanchi Su, Fan Liu, Christos Masouros, George C. Alexandropoulos, Yifeng Xiong, Qinyu Zhang

“…Abstract In this paper, we present a signaling design for secure integrated sensing and communication (ISAC) systems comprising a dual-functional multi-input multi-output base station that simultaneously communicates with multiple users while detecting targets present in their vicinity, which are regarded as potential eavesdroppers. …”
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Discovery of candidate functional non-coding mutations in acute myeloid leukemia using single-cell chromatin accessibility sequencing by Ming Zhu, Jiali Zhu, Zhijuan Zhu, Yiding Yang, Jinxian Dai, Hua Li, Nainong Li, Jialiang Huang

“…Additionally, we develop eMut, an integrated computational pipeline for detecting, imputing, and functionally characterizing non-coding mutations in CREs at the single-cell level. …”
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Effect of melatonin, zinc sulfate, nano-melatonin, and nano-zinc oxide on mitochondria function and developmental competence of buffalo oocytes by Omaima Mohamed Kandil, Heba Elsaeed Elsehy, Nabil Mohamed Baker, Mohamed Asran Elbehiry, Sayed Ahmed Hattab

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High accuracy identification of maize seed varieties based on a lightweight improved YOLOv8 by Siqi Niu, Xiaolin Xu, Ao Liang, Yuliang Yun, Fengqi Hao, Jinqiang Bai, Wenyi Sheng, Dexin Ma

“…Lastly, the loss function was replaced with Inner_SIoU, which was more suitable for small-object detection tasks. …”
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Effect of Forest Species Canopy on the Accumulation of Toxic Metals in the Soil Within and Around Macedonia Airport, Northern Greece by Ioannis Mousios, Marianthi Tsakaldimi, Evangelia Gkini, Theocharis Chatzistathis, Petros Ganatsas

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PAMFPN: Position-Aware Multi-Kernel Feature Pyramid Network with Adaptive Sparse Attention for Robust Object Detection in Remote Sensing Imagery by Xiaofei Yang, Suihua Xue, Lin Li, Sihuan Li, Yudong Fang, Xiaofeng Zhang, Xiaohui Huang

“…Deep learning methods have achieved remarkable success in remote sensing object detection. Existing object detection methods focus on integrating convolutional neural networks (CNNs) and Transformer networks to explore local and global representations to improve performance. …”
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Highly sensitive live-cell imaging-based cytotoxicity assay enables functional validation of rare epitope-specific CTLs by Kathrin Wellach, Kathrin Wellach, Kathrin Wellach, Angelika B. Riemer, Angelika B. Riemer

“…Finally, the assay was successfully applied to functionally validate human papillomavirus (HPV)16 epitopes, by detecting epitope-specific killing of established patient-derived tumor cell lines by rare T-cell populations expanded from peripheral blood. …”
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CAZyme analysis and functional characterization of a new GH18 chitin hydrolase from Gelidibacter salicanalis PAMC21136 by Lakshan Paudel, Bashu Dev Pardhe, So-Ra Han, Jun Hyuck Lee, Tae-Jin Oh

“…The gene encoding chitinase (MBJ7879808.1) was successfully cloned and expressed in Escherichia coli BL21 cells. …”
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Improved Path Planning and Controller Design Based on PRM by Shengjin Chen, Guangyong Yang, Guanghai Cui, Shang Yi, Lihuang Wu

“…By dynamically adjusting the PRM sampling points, the success rate of path detection is improved. The Improved PRM (IPRM) algorithm demonstrates better performance in terms of shorter path generation compared to the original PRM, RRT* and Bi-RRT algorithms. …”
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An innovative and mass-sensitive quartz tuning fork (QTF) biosensor for GFAP detection: A novel approach for traumatic brain injury diagnosis by Burcu Özcan, İnci Uludağ Anıl, Mehmet Altay Ünal, Fikret Arı, Mustafa Kemal Sezgintürk, Sibel Ayşıl Özkan

“…This biosensor is designed to facilitate the highly sensitive and selective detection of GFAP in human serum. In contrast to conventional neuroimaging methods, which are resource-intensive and frequently inaccessible in emergency situations, this innovative biosensor offers a portable, cost-effective, and efficient alternative for rapid GFAP measurement. …”
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