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O-GlcNAcylation of glutaminase isoform KGA inhibits ferroptosis through activation of glutaminolysis in hepatoblastoma
Published 2025-04-01“…Metabolism reprogramming represents a pivotal hallmark in the oncogenic transformation process, with glutamine emerging as a critical energy source for neoplastic cells, rivaling glucose. However, the mechanism by which glutamine is involved in the development of HB remains unclear. …”
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942
Hydro- and deutero-deamination of primary amines using O-diphenylphosphinylhydroxylamine
Published 2024-11-01“…By synergizing with site-selective C–H functionalization of primary aliphatic amines, our method reveals synthetic strategies utilizing nitrogen atom as a traceless directing group, encompassing deaminative alkylation, 1,1-deuteroalkylation, 1,1-dialkylation, 1,1,1-deuterodialkylation, C–H arylation, and 1,3-deuteroarylation. …”
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943
Inferring regulatory networks by combining perturbation screens and steady state gene expression profiles.
Published 2014-01-01“…We develop a computational approach to appropriately utilize both data sources for estimating a regulatory network. …”
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944
Wild ActionFormer: Enhancing wildlife action recognition for 11 endangered species in Wolong
Published 2025-11-01“…Experimental results on our released LoTE-Animal open-source dataset show that the proposed action recognition network achieves a Top-1 accuracy of 95.09%, approximately 4 percentage points higher than the baseline. …”
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945
Fast detection method for radionuclides based on Sequential Bayesian approach
Published 2025-01-01“…Finally, experimental verifications were conducted on the feasibility, detection performance, and universality of the method by placing a set of standard point sources at different distances from the front of a LaBr3(Ce) detection system in both low and natural radiation background environments. …”
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946
Application of Anionic Hydrogels from Date Palm Waste for Dye Adsorption in Wastewater Treatment
Published 2024-09-01“…The study reveals that CNF adsorbents derived from renewable natural waste sources such as date palm leaves can be effective in removing cationic contaminants such as methylene blue dye.…”
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947
The Multifunctional Catalytic Hemoglobin from <i>Amphitrite ornata</i>: Protocols on Isolation, Taxonomic Identification, Protein Extraction, Purification, and Characterization
Published 2024-12-01“…The multifunctional catalytic hemoglobin from the terebellid polychaete <i>Amphitrite ornata</i>, also named dehaloperoxidase (<i>Ao</i>DHP), utilizes the typical oxygen transport function in addition to four observed activities involved in substrate oxidation. …”
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948
Intrapleural tissue plasminogen activator and deoxyribonuclease in complex pleural effusion and empyema, clinical outcomes, and predictors
Published 2025-05-01“…We have tested the clinical role RAPID score (Renal function measured as urea, Age, fluid Purulence, Infection source, Dietary status measured as albumin) to predict treatment success, and all-cause mortality at 6 months. …”
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949
Metagenomic and phylogenetic analyses reveal gene-level selection constrained by bacterial phylogeny, surrounding oxalate metabolism in the gut microbiota
Published 2025-06-01“…The frc gene was primarily allocated to the Pseudomonodota phylum, particularly the Bradyrhizobium genus, which is a species capable of utilizing oxalate as a sole carbon and energy source. …”
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950
Control over biopower in cognitive and surveillance capitalism
Published 2023-01-01“…Power can achieve an effective command over the entire life of the population only when it becomes an integral, vital function that every individual embraces and reactivates of his or her own accord. …”
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951
Gut dysbiosis narrative in psoriasis: matched-pair approach identifies only subtle shifts correlated with elevated fecal calprotectin
Published 2025-01-01“…We next showed that these enriched species were correlated with elevated biomarkers of intestinal and systemic inflammation and liver function. Functionally, one of the top species, Megasphaera elsdenii, is a potent lactate utilizer in the context of intestinal lactic acidosis and inflammation. …”
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952
Cost-Effective Photoacoustic Imaging Using High-Power Light-Emitting Diodes Driven by an Avalanche Oscillator
Published 2025-03-01“…While lasers have traditionally been the light source for PAI, their high cost and complexity drive interest towards alternative sources like light-emitting diodes (LEDs). …”
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953
Microwave-assisted Deep Eutectic Solvent Extraction of Xinjiang Wild Prunus cerasifera Ehrh. Polysaccharides and Analysis of Its Antioxidant and Antibacterial Activities
Published 2025-05-01“…These findings indicate the promising in vitro antioxidant and antibacterial properties of cherry plum polysaccharides and provide a theoretical foundation for their development and utilization as functional products.…”
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954
MDPNet: a dual-path parallel fusion network for multi-modal MRI glioma genotyping
Published 2025-05-01“…Magnetic Resonance Imaging (MRI) has been widely utilized for glioma diagnosis and research due to its non-invasive nature and clinical accessibility. …”
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955
Constitutive overexpression of Qui-Quine Starch gene simultaneously improves starch and protein content in bioengineered cassava (Manihot esculenta Crantz)
Published 2025-02-01“…Cassava is a crucial source of daily calorie intake for millions of people in sub-Saharan Africa (SSA) but has an inferior protein content. …”
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956
Refined prognostication of pathological complete response in breast cancer using radiomic features and optimized InceptionV3 with DCE-MRI
Published 2025-07-01“…To optimize the model’s performance, we experimented with different combinations of loss functions, optimizer functions, and activation functions. …”
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957
Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma
Published 2025-05-01“…Obesity usually exacerbates the immunosuppressive tumor microenvironment (ITME), hindering CD8+ T cell infiltration and function, which further represents a significant barrier to the efficacy of immunotherapy. …”
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958
Structural Basis and Mechanism of a Unique Haemophore in the Haem‐Iron Acquisition by Riemerella anatipestifer
Published 2025-04-01“…Abstract Several bacterial pathogens employ haemophores to scavenge haem from host haemoprotein to obtain an iron source. However, no homologues of well‐characterized haemophores are found in Riemerella anatipestifer, a bacterium belonging to the order Flavobacteriales that encodes haem uptake systems. …”
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959
ATClean: A Novel Method for Detecting Low-luminosity Transients and Application to Pre-explosion Counterparts from SN 2023ixf
Published 2025-01-01“…Our method “ATLAS Clean,” or ATClean, utilizes the reported fluxes, uncertainties, and fits to the point-spread function (PSF) from difference images to quantify the statistical significance of individual measurements. …”
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960
Early Bearing Fault Diagnosis in PMSMs Based on HO-VMD and Weighted Evidence Fusion of Current–Vibration Signals
Published 2025-07-01“…The reliability of these features is utilized to adaptively weight the basic probability assignment (BPA) functions. …”
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