Potent Antimicrobial Azoles: Synthesis, In Vitro and In Silico Study by Zeynep Özdemir, Yaren Nur Zenni, Arzu Karakurt, Suat Sari, Selma Saraç, Mevlüt Akdağ, İrem Bozbey Merde, Didem Kart, Roberto Venanzoni, Giancarlo Angeles Flores, Paola Angelini, Muzammil Kabier, Bijo Mathew, Simone Carradori

“…<b>Conclusions</b>: As a result, the title compounds emerged as promising entities with broad antifungal and antibacterial effects, highlighting the utility of oxime ether function in the azole scaffold.…”
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Directional hand movement can be classified from insular cortex SEEG signals using recurrent neural networks and high-gamma band features by Xiecheng Shao, Ryan S. Chung, Jonathon M. Cavaleri, Roberto Martin Del Campo-Vera, Miguel Parra, Shivani Sundaram, Selena Zhang, Ashwitha Surabhi, Ryan J. McGinn, Charles Y. Liu, Spencer S. Kellis, Brian Lee

“…Abstract Motor BCIs, with the help of Artificial Intelligence (AI) and machine learning, have shown promise in decoding neural signals for restoring motor function. Structures beyond motor cortex have provided additional sources for movement signals. …”
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Assessing the impact of diet formulation and age on targeted bacterial establishment in laboratory and mass-reared Mediterranean fruit fly using full-length 16S rRNA sequencing by Charles J. Mason, Rosalie C. Nelson, Mikinley Weaver, Tyler J. Simmonds, Scott M. Geib, Ikkei Shikano

“…In laboratory and mass-reared insects, gut microbiomes can differ in composition and function compared to wild conspecifics. For fruit flies, such as the Mediterranean fruit fly (medfly; Ceratitis capitata), these changes can influence male performance and behavior. …”
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Spatiotemporal Evolution Characteristics and Trade-offs/Synergies of Water Yield, Soil Conservation, and Carbon Storage Ecosystem Services in the Beiluo River Basin from 1970 to 20... by ZHANG Yujie, ZHANG Xiaoping, SUN Weinan, GENG Wenliang, AN Zefeng, CHEN Qingwei

“…［Objective］ This study aimed to investigate the spatiotemporal changes and trade-offs/synergies of ecosystem services within the Beiluo River basin to provide a scientific foundation for rational resource allocation and sustainable development. ［Methods］ Utilizing multi-source data and models, such as InVEST and CSLE, to quantitatively assess and analyze the spatiotemporal variations and trade-offs/synergies of three key ecosystem services-water yield, soil conservation, and carbon storage-across different periods. …”
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A Proposed Diagnostic and Treatment Algorithm for the Management of Lumbar Discogenic Pain by Lorio MP, Beall DP, Myers TJ, Naidu RK, McRoberts WP, Davis TT, Gage EG, Calodney AK, Verrills P, De Palma MJ, Amirdelfan K, Block JE

“…Morgan P Lorio,1 Douglas P Beall,2 Thomas J Myers,3 Ramana K Naidu,4 W Porter McRoberts,5 Timothy T Davis,6 Emmanuel G Gage,7 Aaron K Calodney,8 Paul Verrills,9 Michael J De Palma,10 Kasra Amirdelfan,11 Jon E Block12 1Orlando College of Osteopathic Medicine, Winter Garden, FL, USA; 2Comprehensive Specialty Care, Edmond, OK, USA; 3Paradigm Health System, Slidell, LA, USA; 4MarinHealth Spine Institute, Larkspur, CA, USA; 5Holy Cross Medical Group, Fort Lauderdale, FL, USA; 6Source Healthcare, Santa Monica, CA, USA; 7Centurion Spine &amp; Pain Centers, Waycross, GA, USA; 8Precision Spine Care, Tyler, TX, USA; 9MetroPain Group, Clayton, VIC, Australia; 10Virginia iSpine Physicians, Richmond, VA, USA; 11Boomerang Healthcare, Inc., Walnut Creek, CA, USA; 12Private Practice, San Francisco, CA, USACorrespondence: Jon E Block, Private Practice, 2210 Jackson Street, Ste. 401, San Francisco, CA, 94115, USA, Tel +1 415-775-7947, Email jb@drjonblock.comBackground: There is renewed interest in the intervertebral disc as a target for treatments aimed at ameliorating lumbar discogenic pain by restoring and preserving the natural structure and function of this component of the vertebral motion segment.Methods: Using a modified Delphi methodology involving a panel of 11 experts, we developed a simple, understandable clinical algorithm to serve as a foundation for objective decision making regarding the diagnosis and treatment of lumbar discogenic pain throughout the entire continuum of care. …”
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An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing by Jacob W. Fleming, Molly C. McCloskey, Kevin Gray, David R. Nash, Vincent Leung, Christos Michas, Shawn M. Luttrell, Christopher Cavanaugh, Julie Mathieu, Shawn Mcguire, Mark Bothwell, David L. Mack, Nicholas A. Geisse, Alec S.T. Smith

“…Engineered models have emerged as alternatives for studying NMJ functionality in response to genetic and/or pharmacological challenge. …”
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Recovery of coefficients of a heat equation by Ritz collocation method by Prof.Kamal Rashedi

“… In this work, we discuss a one dimensional inverse problem for the heat equation where the unknown functions are solely time-dependent lower order coefficient and multiplicative source term. …”
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TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation by Nihad Khiat, Julie Girouard, Emmanuelle Stella Kana Tsapi, Cathy Vaillancourt, Céline Van Themsche, Carlos Reyes-Moreno

“…Trophoblast cells predominantly utilize glucose as an energy source, metabolizing it through glycolysis in the cytoplasm and oxidative respiration in the mitochondria to produce ATP. …”
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Application of VGG16 in Automated Detection of Bone Fractures in X-Ray Images by Resky Adhyaksa, Bedy Purnama

“…The training and testing phases utilized an 80:20 split of the data, employing binary cross-entropy as the loss function and the Adam optimizer for efficient weight updates. …”
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High-performance nanostructured SiO2 from Ethiopian pumice: synthesis and characterization by Agraw Mulat Muhammud, Gemechu Deressa Edossa, Fedlu Kedir Sabir

“…The resulting 0D SiO2 outperforms conventional sources in both structural and functional properties, aligning with existing literature and industry standards and positioning it as an ideal and highly effective reinforcement filler for rubber composites. …”
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Intellectual Rooms based on AmI and IoT technologies by Radhakrishnan Delhibabu, Pham Tuan Anh, Nataly Zhukova, Alexey Subbotin

“…This study successfully demonstrated the core functionalities using simulated data; future work will involve deployment and evaluation in real-world clinical environments to confirm its practical utility.…”
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Design of a Novel Hybrid Concentrated Photovoltaic–Thermal System Equipped with Energy Storages, Optimized for Use in Residential Contexts by Carmine Cancro, Valeria Palladino, Aniello Borriello, Antonio Romano, Luigi Mongibello

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DETERMINATION OF CHEWING EFFICIENCY IN PATIENTS WITH RESTORED TOOTH CROWN PART by V.V. Nikolov, D M. Korol, D.D. Kindiy, M.D. Korol

“…In most cases preparation is confined to the ledge creation. Its function is to provide a smooth transition of orthopedic restoration to a tooth root and prevent the traumatization of marginal paradontium. …”
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Clinical efficacy and safety of sodium-glucose cotransporter protein-2 (SGLT-2) inhibitor, glucagon-like peptide-1 (GLP-1) receptor agonist, and Finerenone in type 2 diabetes melli... by Jingyi Guo, Maoying Wei, Wenhua Zhang, Yijia Jiang, Aijing Li, Churan Wang, Dan Yin, Anning Sun, Yanbing Gong

“…To assess the methodological quality and risk of bias in the included studies, we utilized the Cochrane Risk of Bias Assessment tool (RoB 2.0). …”
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Exploring the Therapeutic Potential, Ethnomedicinal Values, and Phytochemistry of <i>Helianthus tuberosus</i> L.: A Review by Ruvimbo Faith Tapera, Xavier Siwe-Noundou, Leshweni Jeremia Shai, Shoeshoe Mokhele

“…The Jerusalem artichoke has been utilized for various applications, including its use as a functional food source, a reservoir of bioactive compounds, and a raw material to produce biofuels. …”
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Exploring the ϕ-α interaction via femtoscopic study by Faisal Etminan

“…The numerical results show that the correlation functions at small source size (high density nuclear medium) depend on the employed potential model. …”
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Spacecraft Intelligent Fault Diagnosis under Variable Working Conditions via Wasserstein Distance-Based Deep Adversarial Transfer Learning by Gang Xiang, Kun Tian

“…Moreover, an improved one-dimensional convolutional neural network- (CNN-) based feature extractor which utilizes exponential linear units (ELU) as activation functions and wide kernels is designed to automatically extract the latent features of raw time-series input data. …”
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CHINESE YUAN EXCHANGE RATE AGAINST THE INDONESIAN RUPIAH PREDICTION USING SUPPORT VECTOR REGRESSION by Steven Soewignjo, Ni Wayan Widya Septia Sari, Andini Putri Mediani, M. Aqil Zaidan Kamil, Dita Amelia, Nur Chamidah

“…This study aims to forecast the exchange rate between the Chinese Yuan (CNY) and the Indonesian Rupiah (IDR) using Support Vector Regression (SVR), a machine-learning technique that can handle nonlinear and complex data. The authors utilize the monthly selling exchange rate of CNY against IDR from January 2012 to October 2023 sourced from the “investing” platform. …”
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Research on Pedestrians’ Visual Perception Characteristics Based on USGGS: A Case Study of the Six Inner-City Districts of Tianjin by Hanwen YANG, Shang’en TSOU, Yike HU

“…The core objective of the research is to propose strategies to optimize the greening structure of urban streets by analyzing the correlation between USGGS and visual perception of pedestrians, so as to enhance the quality of the visual environment of street pedestrians, improve the urban human settlement environment and promote the organic integration of the urban ecological and humanistic environments, thus providing a new way of thinking for urban planning and construction, and promoting the high-quality and sustainable development of urban street space.MethodsThe research selects the six inner-city districts of Tianjin City as the research area, utilizes Baidu street view image (SVI) as data source, and collect SVIs and their coordinates in the six districts in 2019 by calling Baidu API, with a total of 17,326 points selected and 13,281 valid samples obtained after screening. …”
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Impact of technology- and parent-based psychosocial interventions on family dynamics factors in children with cancer: A systematic review. by Yilin Zhang, Zitong Zhang, Yunyun Peng, Wanting Zhang, Guiyuan Ma, Sulan Lin, Carmen W H Chan, Ankie Tan Cheung, Jianhui Xie, Can Gu

“…<h4>Methods</h4>Data were sourced from ten databases (CNKI, Wanfang, VIP, Sinomed, the Cochrane Library, Embase, PubMed, Web of Science, Scopus, and CINAHL) up to August 2024. …”
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