Clinical approbation today: analysis of current problems and solutions by V. V. Omelyanovskiy, D. V. Lukyantseva, T. I. Alekseeva, Yu. V. Voropaeva, T. A. Tomilina, R. A. Teryan, A. O. Gadzhieva

“…Objective: description of the current problems concerning the development and conducting of a protocol of clinical approbation (CA) of methods of prevention, diagnosis, treatment and rehabilitation to optimize the implementation of innovative medical technologies in practical health care through CA.Material and methods. …”
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Biopolymer encapsulation for improved probiotic delivery: Advancements and challenges by Srirengaraj Vijayaram, Reshma Sinha, Caterina Faggio, Einar Ringø, Chi-Chung Chou

“…Through detailed comparative analysis of the effectiveness of various encapsulation methods, we identify key strategies for optimizing probiotic deployment in challenging conditions such as high-temperature processing, acidic environments, and gastrointestinal transit. …”
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Assessing developability early in the discovery process for novel biologics by Monica L. Fernández-Quintero, Anne Ljungars, Franz Waibl, Victor Greiff, Jan Terje Andersen, Torleif T. Gjølberg, Timothy P. Jenkins, Bjørn Gunnar Voldborg, Lise Marie Grav, Sandeep Kumar, Guy Georges, Hubert Kettenberger, Klaus R. Liedl, Peter M. Tessier, John McCafferty, Andreas H. Laustsen

“…We furthermore present in silico, in vitro, and in vivo methods and techniques that can be exploited at different stages of the discovery process to identify molecules with liabilities and thereby facilitate the selection of the most optimal drug leads. …”
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A Review of Oscillators in Hydrokinetic Energy Harnessing Through Vortex-Induced Vibrations by Deping Cao, Jie He, Hanqi Zeng, Yijia Zhu, Sean Zixuan Chan, Mark Ravinpal Williams, Ivan Zhi Liang Khor, Omkar Venkata Yalla, Mohammed R. Sunny, Ritwik Ghoshal, Anirban Bhattacharyya, Swapnadip De Chowdhury, Zaibin Lin, Cheng Siong Chin, Hao Chen

“…VIVs serve as a novel energy source, converting the kinetic energy of fluid flows into mechanical or electrical power. …”
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IoT-based green-smart photovoltaic system under extreme climatic conditions for sustainable energy development by Yufei Wang, Jia-Wei Zhang, Kaiji Qiang, Runze Han, Xing Zhou, Chen Song, Bin Zhang, Chatchai Putson, Fouad Belhora, Hajjaji Abdelowahed

“…This review also offers new perspectives for optimizing the current international standards for green energy systems using big data from IoT-based smart sensors.…”
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Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization by Mengmeng Liu, Hongli Wang, Yizhuang Yang, Jianhua Wang, Zhen Sun, Shiyuan Zhao, Weihua Kong, Wenxue Sun, Cuiyun Wang, Lei Feng

“…Future research should focus on clarifying their mechanisms of action, optimizing preparation methods, and validating their long-term safety to facilitate the clinical translation of PDELNs.KEY MESSAGESPDELNs are derived from abundant plant sources, exhibit favorable physicochemical properties.PDELNs offer new possibilities for CNS therapies owing to their low immunogenicity, high biocompatibility, and ability to cross the BBB.…”
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Functional Dehydrated Foods for Health Preservation by R. M. S. C. Morais, A. M. M. B. Morais, I. Dammak, J. Bonilla, P. J. A. Sobral, J.-C. Laguerre, M. J. Afonso, E. C. D. Ramalhosa

“…The microorganisms used, impregnation procedures, drying methods, and evaluated parameters are presented and discussed. …”
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A novel data-driven NLMPC strategy for techno-economic microgrid management with battery energy storage under uncertainty by Elnaz Yaghoubi, Elaheh Yaghoubi, Mehdi Zareian Jahromi, Mohammad Reza Maghami, Ali Paşaoğlu, Harold R. Chamorro

“…Abstract As renewable energy sources become more widespread and energy consumption continues to grow, there is an urgent requirement for smarter, more flexible control methods to manage microgrids (MGs) effectively. …”
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Synergistic effects of GGBFS addition and oven drying on the physical and mechanical properties of fly ash-based geopolymer aggregates by T. Muralidhara Rao, B. Naga Malleswara Rao, Bypaneni Krishna Chaitanya, Mukkala Priyanka, Venkatesh Chava, Chereddy Sonali Sri Durga

“…Furthermore, two aggregate drying methods, oven drying, and ambient air drying, are adopted to evaluate their optimal performance through physical and mechanical tests. …”
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Mapping and interpretability of aftershock hazards using hybrid machine learning algorithms by Bo Liu, Haijia Wen, Mingrui Di, Junhao Huang, Mingyong Liao, Jingyuan Yu, Yutao Xiang

“…This research provides new tools and methods for enhancing aftershock warning and response.…”
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Enzymatic Hydrolysis of Pretreated Miscanthus Biomass by Olga B. Kalashnikova, Ekaterina A. Budenkova, Elena V. Ulrikh, Evgeny G. Chupakhin, Olga V. Kriger, Yakov A. Masiutin, Maria A. Smaga, Yulia S. Basova

“…The article introduces the optimal enzymatic hydrolysis parameters for pretreating Miscanthus sinensis Strictus biomass as a source of carbohydrate-containing substrates and describes their subsequent use for bacterial cellulose biosynthesis. …”
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A Low-Cost Arduino-Based I–V Curve Tracer with Automated Load Switching for PV Panel Characterization by Pedro Leineker Ochoski Machado, Luis V. Gulineli Fachini, Erich T. Tiuman, Tathiana M. Barchi, Sergio L. Stevan, Hugo V. Siqueira, Romeu M. Szmoski, Thiago Antonini Alves

“…Accurate photovoltaic (PV) panel characterization is critical for optimizing renewable energy systems, but it is often hindered by the high cost of commercial tracers or the slow, error-prone nature of manual methods. …”
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La biodiversidad y los servicios ecosistémicos en sistemas agroecológicos. Una revisión by Wendy Mercedes Ramírez-Suárez, Jorge Carlos López-Chouza, María de los Ángeles Flores-Acosta, Saray Sánchez-Cárdenas, Pedro Lázaro Rodríguez-Morejón

“…Objective: To analyze the relationships between biodiversity and ecosystem services in an agroecological context. Materials and Methods: Different sources of information (114) were consulted and analyzed, referring to the available literature in the fields of biology, agricultural sciences and agroecology, with the purpose of deepening the state of knowledge related to biodiversity and ecosystem services provided by agroecological systems. …”
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Biotechnology of Lactulose Production: Progress, Challenges, and Prospects by Svetlana A. Ryabtseva, Andrey G. Khramtsov, Maria A. Shpak, Alexey D. Lodygin, Georgy S. Anisimov, Serafima N. Sazanova, Yulia A. Tabakova

“…Commercial lactulose is usually synthesized by isomerization in alkaline media at high temperatures. Enzymatic methods offer a more sustainable alternative and require more moderate processing conditions. …”
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Modern problems of diagnosis and prevention of obesity in children by Yu.V. Marushko, S.P. Kryvopustov, O.V. Khomych, O.A. Dmytryshyn, А.О. Pysariev

“…An increase in the number of cases of obesity in the child population is a global trend that requires effective methods of diagnosis, prevention and treatment. The purpose of this article was to summarize current scientific data presented in publications from PubMed, Scopus, and Web of Science databases, as well as in international and national clinical guidelines in order to optimize approaches to the diagnosis and prevention of obesity in children. …”
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A systematic review of home-based records in maternal and child health for improving informational continuity, health outcomes, and perceived usefulness in low and middle-income co... by Linju Joseph, Anna Lavis, Sheila Greenfield, Dona Boban, Prinu Jose, Panniyammakal Jeemon, Semira Manaseki-Holland

“…Current HBRs from LMICs are sub-optimally documented leading to poor informational availability that defeats the point of them as a source of information for future providers.…”
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Predictive Value of Hepatitis B Core-Related Antigen for Multiple Recurrence Outcomes After Treatment Cessation in Chronic Hepatitis B: A Meta-Analysis Study by Guoyang Yu, Meiqi Cheng, Yuxin Duan, Minrong Kang, Ning Jiang, Wei Yan, Jianhua Yin

“…Meta-regression established that HBcrAg’s predictive value was unaffected by age, sex, hepatitis B e antigen status, or detection methods (<i>p</i> > 0.05). Conclusions: HBcrAg is validated as a robust non-invasive biomarker to optimize treatment cessation strategies, with high sensitivity providing strong negative predictive value in CHB populations. …”
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AI-augmented pathology: the experience of transfer learning and intra-domain data diversity in breast cancer metastasis detection by Manuel Cossio, Nina Wiedemann, Esther Sanfeliu Torres, Esther Barnadas Sole, Laura Igual

“…Our experiments demonstrated that integrating an external dataset (Camelyon16) during training significantly improved model performance, surpassing the benefits of data augmentation alone. The optimal model, trained on both external and local data, achieved an accuracy and F1-score of 0.98, outperforming existing state-of-the-art methods.ConclusionsThis study demonstrates that transfer learning architectures, when enhanced with multi-source data integration and interpretability frameworks, can significantly improve metastatic detection in whole slide imaging. …”
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Knowledge and self-care practice among patients with hypertension in tertiary public hospitals of Addis Ababa, Ethiopia: A multicenter cross-sectional study by Freweini Gebremeskel Gebresilase, Yohannes Ayalew Bekele, Ketema Bizuwork Gebremedhin, Boka Dugassa Tolera

“…This study aimed to evaluate the level of knowledge and self-care practice among hypertensive patients in Addis Ababa, Ethiopia. Methods: A facility-based cross-sectional study was conducted among 413 hypertensive patients using simple random sampling methods. …”
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Successful desensitization of donor-specific antibodies in a single cord blood transplant recipient by Mégane Tanguay, Sandra Cohen, Isabelle Ménard, Marie-Christine Meunier, Jean-Sébastien Delisle, Jean Roy, Olivier Veilleux, Imran Ahmad

“…Existing literature on HLA desensitization has primarily focused on haploidentical transplants, and there is a lack of experience regarding the optimal strategy in UCB transplantation.Methods: We report our successful desensitization strategy in a 42-year-old woman with acute lymphoblastic leukemia receiving a single UCB unit. …”
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