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Genetic Comparison and Selection of Reproductive and Growth-Related Traits in Qinchuan Cattle and Two Belgian Cattle Breeds
Published 2025-02-01“…These findings provide valuable molecular markers for enhancing reproductive efficiency, growth, and meat production through genetic selection and selective breeding strategies.…”
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Candidate Anxiety‐Related Genes in the Hippocampus of Hatano Male Rats: Anxiolytic Action of Neuromedin U in the Hippocampus
Published 2025-06-01“…The present study focuses on the hippocampus, which is associated with anxiety‐like behavior, and used microarray analysis and RT‐qPCR to select genes with differential expression in the hippocampus between HAA and LAA (Experiment 1). …”
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GPC3 as a potential diagnostic and prognostic marker for lung adenocarcinoma
Published 2024-12-01“…Four gene expression profiles were downloaded from GEO and merged into a training cohort, and those genes that were differentially expressed between LUAD and normal samples were selected. We performed LASSO regression, SVM-RFE, and ROC curve analyses, and external validations were conducted using the GSE115002 dataset, TCGA + GTEx datasets, and tissue microarrays (TMAs) of 56 patients with LUAD from our hospital. …”
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Identification of intragenic variants in pediatric patients with intellectual disability in Peru
Published 2025-04-01Get full text
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The miRNA‐mRNA Regulatory Network in Human Hepatocellular Carcinoma by Transcriptomic Analysis From GEO
Published 2025-01-01Get full text
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Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.
Published 2012-01-01“…Our work therefore identifies CCT020312 as a novel small molecule chemical tool for the selective activation of EIF2A-mediated translation control with utility for proof-of-concept applications in EIF2A-centered therapeutic approaches, and as a chemical starting point for pathway selective agent development. …”
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QCanvas: An Advanced Tool for Data Clustering and Visualization of Genomics Data
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Improving machine learning detection of Alzheimer disease using enhanced manta ray gene selection of Alzheimer gene expression datasets
Published 2025-08-01“…However, the late enriched understanding of the genetic underpinnings of AD has been made possible due to recent advancements in data mining analysis methods, machine learning, and microarray technologies. However, the “curse of dimensionality” caused by the high-dimensional microarray datasets impacts the accurate prediction of the disease due to issues of overfitting, bias, and high computational demands. …”
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Tissue‐based quantitative proteomics to screen and identify the potential biomarkers for early recurrence/metastasis of esophageal squamous cell carcinoma
Published 2018-06-01“…Thirteen proteins were selected by cutoff value of 0.67 fold for underexpression and 1.5‐fold for overexpression. …”
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Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.
Published 2010-07-01“…<h4>Background</h4>Thymocyte expressed molecule involved in selection 1 (Themis1, SwissProt accession number Q8BGW0) is the recently characterised founder member of a novel family of proteins. …”
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Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma
Published 2025-01-01“…Identified AAbs were validated in silico using public immunohistochemistry datasets and experimentally using a custom PDAC protein microarray comprising the 11 optimal AAb biomarker panel. …”
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LIMA1-alpha staining predicts curative intent surgery response in HPV negative head and neck cancer
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Differential gene expression analysis in patients with primary hyperhidrosis
Published 2025-02-01“…Based on the highest expression of ITPR2 in hyperhidrosis, it was selected for PCR amplification as well as sequencing. …”
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Identification of three small nucleolar RNAs (snoRNAs) as potential prognostic markers in diffuse large B‐cell lymphoma
Published 2023-02-01“…Results Twelve prognosis‐correlated snoRNAs were selected from the DLBCL patient cohort of microarray profiles, and a three‐snoRNA signature consisting of SNORD1A, SNORA60, and SNORA66 was constructed. …”
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Protein-specific immune response elicited by the Shigella sonnei 1790GAHB GMMA-based candidate vaccine in adults with varying exposure to Shigella
Published 2025-05-01“…An ideal vaccine would provide protection against the most prevalent species, Shigella flexneri and Shigella sonnei; therefore, it could be relevant to identify common antigens. We developed a microarray containing 3,150 full-length or fragmented proteins selected across Shigella species. …”
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