Targeting Amyloid Pathology in Early Alzheimer’s: The Promise of Donanemab-Azbt by Nadia Khartabil, Ayda Awaness

“…It specifically targets and reduces amyloid beta plaques, a hallmark of the disease, potentially slowing progression and preserving cognitive function. However, its administration requires careful patient selection, including genetic testing for ApoE ε4 status, to mitigate risks of ARIA. …”
Get full text

3D-MRI brain glioma intelligent segmentation based on improved 3D U-net network. by Tingting Wang, Tong Wu, Defu Yang, Ying Xu, Dongyang Lv, Tong Jiang, Hengjiao Wang, Qi Chen, Shengnan Xu, Ying Yan, Baoguang Lin

“…This method offers significant guidance for medical diagnosis, grading, and treatment strategy selection.<h4>Methods</h4>Glioma case data were sourced from the BraTS2023 public dataset. …”
Get full text

Regenerative Cartilage Treatment for Focal Chondral Defects in the Knee: Focus on Marrow-Stimulating and Cell-Based Scaffold Approaches by Filippo Migliorini, Francesco Simeone, Tommaso Bardazzi, Michael Kurt Memminger, Gennaro Pipino, Raju Vaishya, Nicola Maffulli

“…Given the limited regenerative capacity of hyaline cartilage, biologically based surgical strategies have emerged to promote tissue repair and restore joint function. This narrative review critically examines current treatment approaches that rely on autologous cell sources and scaffold-supported regeneration. …”
Get full text

Liver transplantation from 73-year-old cadaveric donor by M. N. Kornilov, M. G. Minina, I. A. Miloserdov, D. N. Kruglov, R. S. Chaikin, A. G. Malakhov, S. I. Zubenko, S. V. Gautier

“…Deceased donor organs are the prevailing source in most transplantation centers. However, there is an organ shortage because of the increasing number of patients in need of transplantation. …”
Get full text

Comparative Genomic and Transcriptomic Analysis Provides New Insights into the Aflatoxin B₁ Biodegradability by <i>Kocuria rosea</i> from Deep Sea by Jingying Wang, Jun Nan

“…AFB₁-producing fungi have been found in both terrestrial and marine sources. Over the last two years, the marine-derived bacteria <i>Kocuria rosea</i> has shown the ability to degrade AFB₁. …”
Get full text

Greenhouse gas emissions of global construction material production by Seth Kane, Josefine A Olsson, Sabbie A Miller

“…Both construction material production and emissions are primarily driven by structural materials, such as concrete and steel. Material selection can play a key role in reducing emissions in the context of the function, with variation in emissions of structural materials per unit strength between 0.001–0.1 kg CO _2 /kg/MPa and in insulation materials per R -value/thickness of 0.018–0.14 kg CO _2 /kg/(K⋅m ^2 W ^−1 ))). …”
Get full text

A new fluorescent probe based on BODIPY for testing NO2 released from propellants by Ying-cui Cui, De-bin Xia, Zhong-yu Cui, Yu-jing Li, Jian Zhang, Ping Wang, Ting Guo, Kai-feng Lin, Yu-lin Yang

Get full text

Harnessing polydiacetylene (PDA): A review of structural mechanics and infectious disease detection by Soumendu Patra, Harshita Shand, Sayan Ghosal, Suvankar Ghorai

“…These biosensors can also be functionalized with particular capture agents, such as antibodies or nucleic acid probes, to selectively bind and detect the target analytes. …”
Get full text

The therapeutic validity and effectiveness of physiotherapeutic exercise following total hip arthroplasty for osteoarthritis: A systematic review. by Annet Wijnen, Sjoukje E Bouma, Gesine H Seeber, Lucas H V van der Woude, Sjoerd K Bulstra, Djordje Lazovic, Martin Stevens, Inge van den Akker-Scheek

“…<h4>Objective</h4>To assess the therapeutic validity and effectiveness of physiotherapeutic exercise interventions following total hip arthroplasty (THA) for osteoarthritis.<h4>Data sources</h4>The databases Embase, MEDLINE, Cochrane Library, CINAHL and AMED were searched from inception up to February 2017.…”
Get full text

“Text of Culture” as a Category of Cultural Philosophy: from Semiotic Theory to Research Practice by E. N. Shatova

“…The article is of a theoretical and methodological character.Methodology and sources. The methodological basis of the research is the traditions of Russian cultural semiotics and the Tartu-Moscow semiotic school. …”
Get full text

SegTrackDetect: A window-based framework for tiny object detection via semantic segmentation and tracking by Aleksandra Kos, Karol Majek, Dominik Belter

“…This work introduces SegTrackDetect, an open-source, window-based framework for small and tiny object detection. …”
Get full text

The role of a tutor in teaching values by Anna Pekala

“…Commenting on the nowadays crisis of values, the author notes that the main source of problem is in men and their perception of the values and concludes that education of values is one of the most important tasks of modern education. …”
Get full text

The Effect of Different Levels of CLA and Omega-3 Supplements Along with Essential Oils of Fennel, Peppermint, and Eucalyptus Medicinal Plants on Production Performance, Blood Para... by Yadollah Chashnidel, Matin Movagharnezhad, Mehdi Jafary charati

“…Extended Abstract Background: Fats and fatty acids in the poultry diet have major physiological roles. A good source of oil or fat should have an ideal ratio of saturated and unsaturated fatty acids. …”
Get full text

Partner-Inflicted Brain Injury: Intentional, Concurrent, and Repeated Traumatic and Hypoxic Neurologic Insults by Julianna M. Nemeth, Clarice Decker, Rachel Ramirez, Luke Montgomery, Alice Hinton, Sharefa Duhaney, Raya Smith, Allison Glasser, Abigail (Abby) Bowman, Emily Kulow, Amy Wermert

“…Our aims were to 1. characterize the lifetime co-occurrence of strangulation and intentional head trauma exposures from all abuse sources to the same survivor and within select physical episodes of IPV and 2. establish the lifetime prevalence of PIBI. (2) Methods: Survivors seeking DV services in the state of Ohio in the United States of America (U.S.) completed interview-administered surveys in 2019 (<i>n</i> = 47). …”
Get full text

Exploration of crop germplasm resources knowledge mining in Chinese ancient books: a route toward sustainable agriculture by Wenjuan Zhao, Suoling Zhu, Yuan Cao

“…Using the local chronicles of Jiangsu Province, China (1251–1947) as the data source, we constructed a spatio-temporal ontology of rice species according to the writing paradigm of descriptive texts on rice, intelligently extracted the features of rice with entity word lists and rule templates, and compared them with existing rice germplasm resources to analyze the similarities and differences. …”
Get full text

Seq2scFv: a toolkit for the comprehensive analysis of display libraries from long-read sequencing platforms by Marianne Bachmann Salvy, Luca Santuari, Emanuel Schmid-Siegert, Nikolaos Lykoskoufis, Ioannis Xenarios, Bulak Arpat

“…To address this methodological gap, we introduce Seq2scFv, a novel open-source toolkit designed for analyzing in vitro display libraries from long-read sequencing platforms. …”
Get full text

Melatonin in the regulation of human life and its role in development pathology by A. V. Shilova, N. I. Ananyeva, N. Yu. Safonova, L. V. Lukina

“…For a detailed analysis, 42 literature sources were selected for the melatonin role in the development of neurological and mental disorders. …”
Get full text

Founders Can Increase Determinism of Community Assembly by Yi‐Ting Cheng, Wei Deng, Xiao‐Yan Yang, Kun Tan, Wen Xiao

“…This study used sterilized and nonsterilized paocai soup (a traditional Chinese fermented vegetable soup) from the same source to simulate initial environments with and without founders. …”
Get full text

Deep learning approach to the estimation of the ratio of reproductive modes in a partially clonal population by T. A. Nikolaeva, A. A. Poroshina, D. Yu. Sherbakov

“…Genetic diversity among biological entities, including populations, species, and communities, serves as a fundamental source of information for understanding their structure and functioning. …”
Get full text

Genetic Basis and Simulated Breeding Strategies for Enhancing Soybean Seed Protein Content Across Multiple Environments by Xu Sun, Bo Hu, Wen-Xia Li, Hai-Long Ning

“…Soybeans are a primary source of plant-based protein, with seeds containing approximately 40% protein—a key quality trait. …”
Get full text