Integrated analysis of single-cell and bulk transcriptomics reveals cellular subtypes and molecular features associated with osteosarcoma prognosis by Feng Liu, Tingting Zhang, Yongqiang Yang, Kailun Wang, Jinlan Wei, Ji-Hua Shi, Dong Zhang, Xia Sheng, Yi Zhang, Jing Zhou, Faming Zhao

“…Moreover, the study investigated the impact of ATF6α in OS aggressiveness through genetic and pharmacological loss of function analyses. Lastly, the CellChat algorithm was employed to investigate cell-cell communications. …”
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Characterization of a GH43 Bifunctional Glycosidase from Endophytic <i>Chaetomium globosum</i> and Its Potential Application in the Biotransformation of Ginsenosides by Yao Lu, Qiang Jiang, Yamin Dong, Runzhen Ji, Yiwen Xiao, Du Zhu, Boliang Gao

“…The GH43 family of glycosidases represents an important class of industrial enzymes that are widely utilized across the food, pharmaceutical, and various other sectors. …”
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Viewing Global Changes in the Heliosheath with IMAP’s Energetic Neutral Atom Imagers by E. J. Zirnstein, J. Heerikhuisen, D. J. McComas, J. Bower, G. Clark, M. A. Dayeh, H. O. Funsten, M. Gkioulidou, D. G. Mitchell, D. B. Reisenfeld, N. A. Schwadron

“…We aim to answer the following: (i) What are the time delays as a function of energy and direction; (ii) at what energies can we observe changes the soonest; and (iii) what might the ENA source distributions affecting the time delays look like? …”
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Effects of hydroxyproline-taurine-cholesterol supplementation on the liver health and lipid metabolisms of turbot Scophthalmus maximus fed Chlorella vulgaris by Daisong Ma, Nan Bai, Shihui Pan, Chuwen Chen, Min Gu

“…Seven experimental diets were formulated. The control diet utilized fishmeal as the exclusive protein source. …”
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BASE: a web service for providing compound-protein binding affinity prediction datasets with reduced similarity bias by Hyojin Son, Sechan Lee, Jaeuk Kim, Haangik Park, Myeong-Ha Hwang, Gwan-Su Yi

“…We developed the BASE web service to allow researchers to download and utilize these datasets. Feature importance analysis revealed that previous models heavily relied on protein features. …”
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Gaussian pulse shaping algorithm based on finite impulse response filters by HUANG Haixi, HONG Xu, LIU Junlong, SONG Xinru, LI Lin, ZHOU Chengzhuo

“…The truncated GPS algorithm has better energy resolution and saves more hardware resources, whilest the normal GPS algorithm owns better pulse pile-up rejection capability for the same peaking time.…”
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Examining the normative results of the Arab Spring on the legal status of religious minorities; Case study of Egypt by mohammad yosefzadeh, mohammad jalali

“…Therefore, examining the legal norms influenced by the Arab Spring on the legal status of religious minorities in Egypt, which took a more concrete form with the drafting of the 2012 and 2014 constitutions, is an issue worthy of attention.Methods: This paper, adopting a descriptive-analytical approach and utilizing the method of studying library resources, articles, etc., is written to analyze the research topic. …”
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Comparison of Per-Operative Outcomes between Simultaneous and Staged Bilateral Total Hip Arthroplasties by S Hiranya Kumar, N Vamshikrishna Chand, B A Pradeep, Thippeswamy Darshan, R V Chandan Kumar, D V Harish

“…Retrospective studies suggest simultaneous bilateral THA (sim-BTHA) utilizes fewer hospital resources, brings about a shorter length of stay, as well as fewer complications compared to traditional methods, but does seem to have a higher requirement for blood transfusions. …”
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Long-Term Snow Cover Change in the Qilian Mountains (1986–2024): A High-Resolution Landsat-Based Analysis by Enwei Huang, Guofeng Zhu, Yuhao Wang, Rui Li, Yuxin Miao, Xiaoyu Qi, Qingyang Wang, Yinying Jiao, Qinqin Wang, Ling Zhao

“…Snow cover, as a critical component of the cryosphere, serves as a vital water resource for arid regions in Northwest China. The Qilian Mountains (QLM), situated on the northeastern margin of the Tibetan Plateau, function as an important ecological barrier and water conservation area in western China. …”
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Integrative analysis of seed morphology, geographic origin, and genetic structure in Medicago with implications for breeding and conservation by Seunghyun Lim, Sunchung Park, Insuck Baek, Jacob Botkin, Jae Hee Jang, Seok Min Hong, Brian M. Irish, Moon S. Kim, Lyndel W. Meinhardt, Shaun J. Curtin, Ezekiel Ahn

“…The identified candidate genes associated with geographic origin provide a foundation for future investigations into the functional mechanisms of local adaptation. Furthermore, our imputation method offers a valuable data for maximizing the utility of genomic resources in Medicago and other species.…”
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Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs by Shuai Zhang, Xue Feng, Chong-Hui Li, Yuan-Ming Zheng, Meng-Ya Wang, Jun-Jie Li, Yun-Peng Dai, Naihe Jing, Jia-Wei Zhou, Gang Wang

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A Novel Signature Composed of Hypoxia, Glycolysis, Lactylation Related Genes to Predict Prognosis and Immunotherapy in Hepatocellular Carcinoma by Feng Yi, Shichao Long, Yuanbing Yao, Kai Fu

“…Subsequently, the single sample Gene Set Enrichment Analysis (ssGSEA), Tumor Immune Estimation Resource (TIMER) and Tumor Immune Dysfunction and Exclusion (TIDE) algorithms were utilized to assess immune infiltration and immune evasion. …”
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ESSegNeXt: A Novel Building Extraction Framework Based on Generalized SamGeo and SegNeXt Models Using High-Resolution Remote Sensing Images by Qi Lu, Wensong Liu, Lianpeng Zhang, Erzhu Li, Junlong Qiu, Lei Wang

“…Additionally, an edge-preserving loss function was introduced to enhance the boundary detection capability of the SegNeXt model using edge features extracted by SamGeo during cyclic validation. …”
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Ecological security driving mechanisms and optimization of zoning in Chinese urban agglomerations: A case study of the central plains urban agglomeration by Jinyuan Zhang, Xuning Qiao, Yongju Yang, Liang Liu, Yalong Li, Shengnan Zhao

“…Additionally, it combines the ’Three-dimensional Rubik’s Cube model with primary functional zoning to enhance the optimization of ecological security delineation. …”
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The Multifunctional Catalytic Hemoglobin from <i>Amphitrite ornata</i>: Protocols on Isolation, Taxonomic Identification, Protein Extraction, Purification, and Characterization by Anna L. Husted, Victoria R. Sutton, Lauren A. Presnar, R. Kevin Blackburn, Joseph L. Staton, Stephen A. Borgianini, Edward L. D’Antonio

“…The multifunctional catalytic hemoglobin from the terebellid polychaete <i>Amphitrite ornata</i>, also named dehaloperoxidase (<i>Ao</i>DHP), utilizes the typical oxygen transport function in addition to four observed activities involved in substrate oxidation. …”
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Unraveling the impact of blood RANKL and OPG levels on Alzheimer's disease: Independent of bone mineral density and inflammation by Xingzhi Guo, Wenzhi Shi, Juanjuan Lu, Peng Tang, Rui Li

“…Three distinct AD genome‐wide association study (GWAS) data sets from the International Genomics of Alzheimer's Project (IGAP), UK Biobank (UKB), and FinnGen were utilized. Summary‐level data on blood sRANKL and OPG were sourced from deCODE Genetics. …”
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Intrapleural tissue plasminogen activator and deoxyribonuclease in complex pleural effusion and empyema, clinical outcomes, and predictors by Yub Raj Sedhai, Priyanka Bhat, Roshan Acharya, Nada Qaisar Qureshi, Fawaz Mohammed, Irfan Waheed, Tahir Muhammad Abdullah Khan, Muhammad Altaf Ahmed, Nisarfathima Kazimuddin, Akinchan Kafle, Rodney T. Steff, Karan Singh

“…We have tested the clinical role RAPID score (Renal function measured as urea, Age, fluid Purulence, Infection source, Dietary status measured as albumin) to predict treatment success, and all-cause mortality at 6 months. …”
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Metagenomic and phylogenetic analyses reveal gene-level selection constrained by bacterial phylogeny, surrounding oxalate metabolism in the gut microbiota by Sromona D. Mukherjee, Mangesh Suryavanshi, John Knight, Dirk Lange, Aaron W. Miller

“…The frc gene was primarily allocated to the Pseudomonodota phylum, particularly the Bradyrhizobium genus, which is a species capable of utilizing oxalate as a sole carbon and energy source. …”
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Leveraging artificial intelligence for photo identification to aid CITES enforcement in combating illegal trade of the endangered humphead wrasse (Cheilinus undulatus) by C. Y. Hau, W. K. Ngan, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson

“…A Licence to Possess system for CITES is implemented in the city to regulate the quota of live wild-sourced CITES specimens, including humphead wrasse, held at each registered trading premise and ensure traceability through documentation. …”
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Constitutive overexpression of Qui-Quine Starch gene simultaneously improves starch and protein content in bioengineered cassava (Manihot esculenta Crantz) by Bertrand Bachaumond Hankoua, Marieme Diao, Ayalew Ligaba-Osena, Rafael A. Garcia, Sarahani Harun, Yogesh K. Ahlawat, Yogesh K. Ahlawat

“…Cassava is a crucial source of daily calorie intake for millions of people in sub-Saharan Africa (SSA) but has an inferior protein content. …”
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