ML-Based Screening of miRNA Inhibitors and Intervention of lncRNA/miRNA/mRNA Axis in Oncogenic KRAS-Associated Colorectal Cancer by Prasanna Srinivasan Ramalingam, Deepak B. Thimiri Govinda Raj, Murugan Subramanian, Sivakumar Arumugam

“…Although the role and function of the lncRNA axis are not clearly understood, various studies have recently focussed on the evaluation of the lncRNA axis role in various cancers. …”
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FAM3C Regulates Glioma Cell Proliferation, Invasion, Apoptosis, and Epithelial Mesenchymal Transition via the Notch Pathway by Xiaochao Xia, Zihao Wang, Lvmeng Song, Yinchuan Cheng, Ping Xiong, Shun Li

“…Herein, we aimed to further investigate the oncological mechanism of FAM3C, specifically in glioma. Methods We utilized open‐source bioinformatics tools and platforms to analyze the transcriptional expression levels, prognosis, and correlation with clinical variables of FAM3C in gliomas, and subsequently, to hypothesize its potential molecular functions and possibly associated signaling pathways. …”
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Development of empirical correlations for sustainable breakup characterization of water and high-viscous oil sheets under acoustic perturbations using high-speed imaging by Aman Singh, Devesh T, Subhash K, Preetam Polavarapu, Jayakrishnan Rahul, Karthick S, Balaji K

“…The key innovation of this study is the design and fabrication of a compact liquid sheet acoustic atomizer that efficiently utilizes acoustic energy to produce high-quality sprays. …”
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Impulse Shaping Method Based on Bayesian Deconvolution by JIA Tonghui, LIU Yi, WANG Ming, MA Yingjie, WANG Bo

“…The initial step of this method entailed expressing the measured pulse signal as the convolution of the current impulse pulse signal and the detection system response function. Then, the measured signal was expressed in the continuous time domain and decomposed into the form of an impulse signal and a double exponential kernel convolution by derivation. …”
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A two-stage model of the fuzzy analytic hierarchy process and the fuzzy synthetic evaluation technique to prioritize sustainable sanitation services under uncertainty by Shaher Zyoud, Siwar M. Omair, Susan A. Jarrad

“…Environmental risks account for 12.40%, utilities’ competency (11.5%), and industrial wastes risks (8.72%). …”
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Ultrasonic-assisted extraction of polysaccharides from Albizia julibrissin Durazz. leaf and pod: process optimization, physicochemical properties and anticomplementary activity by Yuanqi Duan, Yuxin Jiang, Jiayu Gu, Chenxi Sun, Boshi Sun, Yue Xu, Long Jin, Mei Jin, Mei Jin, Jinfeng Sun, Wei Zhou, Zhengyu Hu, Gao Li

“…This study established a foundation for developing and utilizing polysaccharide resources from A. julibrissin agro-byproducts, while providing a theoretical basis for their application in complement system overactivation.…”
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Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke by Ahmet Alptekin, Mohammad B. Khan, Mahrima Parvin, Hasanul Chowdhury, Sawaiz Kashif, Fowzia A. Selina, Anika Bushra, Justin Kelleher, Santu Ghosh, Dylan Williams, Emily Blumling, Roxan Ara, Asamoah Bosomtwi, Joseph A. Frank, Krishnan M. Dhandapani, Ali S. Arbab

“…The objectives of the proposed studies were to determine whether LIPFUS-mediated increased delivery of EPC-derived exosomes enhances stroke recovery and functional improvement in mice with transient middle cerebral artery occlusion (tMCAo) stroke.MethodsTo enhance exosome delivery to the stroke area, we utilized LIPFUS. …”
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Enhancing hepatopathy clinical trial efficiency: a secure, large language model-powered pre-screening pipeline by Xiongbin Gui, Hanlin Lv, Xiao Wang, Longting Lv, Yi Xiao, Lei Wang

“…And its capability to function in resource-constrained environments further enhances its utility in clinical settings.…”
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Integrated multi-omics identify key signalling pathways for notochord lumenogenesis in ascidian Ciona savignyi by Jin Zhang, Zicheng Tan, Qishu Qin, Hongzhe Peng, Wenjie Shi, Haiyan Yu, Bo Dong

“…Meanwhile, we identified that CDC42 was a potential downstream target factor of the Ras-Rap1-MAPK signalling axis, playing crucial functions in notochord lumenogenesis. Overall, we systematically revealed the key regulatory signalling pathways for notochord lumen formation and verified a lumenogenesis-related signalling axis, providing a foundational data resource for exploring the mechanisms of lumenogenesis.…”
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Fuzzy volume fraction model representation of blood-based sisko tri-hybrid nanofluid flow via a stretching cylinder by N. Deepa, P. Kavya, N. Thamaraikannan, S. Madhanraj, P. Asaigeethan, K. Loganathan

“…The triangular membership function (TMF) is utilized to analyze the variability of uncertainty, while the α− cut is responsible for controlling the TFNs. …”
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(Cost-)effectiveness of lower extremity nerve decompression surgery in subjects with diabetes: the DeCompression (DECO) trial—study protocol for a randomised controlled trial by Manuel Castro Cabezas, Erwin Birnie, Willem D Rinkel, Tirzah M Fakkel, J Henk Coert

“…Surgical treatment of compression neuropathies in the lower extremities (lower extremity nerve decompression (LEND)) results in relief of symptoms and gain in peripheral nerve function, which may lead to less sensory loss (short term) and less associated detrimental effects including foot ulceration and amputations, and lower costs (long term). …”
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The role of the contralesional primary motor cortex in upper limb recovery after stroke: a scoping review following PRISMA-ScR guidelines by Peerapat Suputtitada, Valton Costa, Felipe Fregni

“…Animal studies provided evidence of structural and functional plasticity, including dendritic remodeling and enhanced neuronal connectivity, which paralleled improvements in motor function. …”
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The role of CD47 in immune escape of colon cancer and its correlation with heterogeneity of tumor immune microenvironment by Qiu-Si Tian, ChunMei Zhang, Zhi-Jun Bao, ZhiGang Pei

“…The Tumor Immune Estimation Resource and Kaplan-Meier plotter were utilized to assess the relationship between CD47 expression, patient prognosis, and immune infiltration. …”
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Rapid Prediction of Multi-physics Coupling in Heat Pipe ReactorBased on Neural Network by ZHANG Junda, LIU Xiaojing, XIONG Jinbiao, CHAI Xiang, ZHANG Tengfei

“…Concurrently, the neural network models utilized in rapid predictions have less stringent computational resource requirements and offer greater adaptability to varied environments. …”

Current practices in physiotherapy management of COPD in Pakistan by Sajjan Iqbal Memon, Fahad Tanveer, Gulzar Usman, Misbah Shakeel

“…Various studies have demonstrated that breathing exercises are efficacious in enhancing the strength of the muscles involved in inhalation and increasing the ability to engage in physical activity for those diagnosed with COPD.2 Physiotherapists routinely utilize the active cycle of breathing approach as a non-pharmacological method for airway clearance.3 Furthermore, the effects of oscillatory positive expiratory pressure therapy on the quality of life and objective signs of cough and sleep disturbance in COPD patients with regular sputum production have been investigated.4 The combination of postural drainage techniques and chest mobilization has been proven to effectively manage pneumonia and enhance postural alignment in patients with COPD.5 Several investigations are conducted to compare the postural alignment of COPD patients with that of healthy individuals and to establish a correlation between pulmonary function and postural alignment in the COPD group that has accounted for favorable results.6 In addition, the existing evidence suggests that active breathing strategies, such as the active cycle of breathing techniques, autogenic drainage, and forceful expiration, can be effective in managing COPD.7 At present, COPD management in Pakistan faces practical challenges such as resource limitations and training access for physiotherapists. …”
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Jacobian-Free Newton Krylov Methods for Steady and Transient Neutron Transport Models by ZHANG Yangyi, ZHANG Tiancheng, ZHOU Xiafeng

“…To rapidly construct the unified JFNK residuals, the parallel KBA transport sweep methods and physics-based preconditioning techniques were utilized to improve the computational efficiency. To rapidly construct the unified JFNK residuals, the parallel KBA transport sweep methods and physics-based preconditioning techniques were utilized. …”

Wild ActionFormer: Enhancing wildlife action recognition for 11 endangered species in Wolong by Dan Liu, Qianqian Sun, Jin Hou, Bochuan Zheng, Jindong Zhang, Desheng Li, Tomas Norton, Jifeng Ning

“…We constructed a differential dispersion regularization loss function to maintain the alignment of self-supervised learning features and improve the network’s robustness against interference. …”
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YOLO-SRMX: A Lightweight Model for Real-Time Object Detection on Unmanned Aerial Vehicles by Shimin Weng, Han Wang, Jiashu Wang, Changming Xu, Ende Zhang

“…Finally, the Wise-IoU loss function is adopted to replace the traditional bounding box loss. …”
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Pathway for Renewable Energy Application in Urban Green Space under the Low Carbon Perspective by Kailun WANG, Tonggang NIU, Lian LIU, Zhongjie WANG

“…The research provides a detailed analysis of energy application types and methods, as well as energy consumption models for each of the aforesaid three types of green spaces.ResultsThe research identifies three core challenges in the application of renewable energy in urban green spaces: 1) How to scientifically select the most appropriate renewable energy types and optimize spatial layouts in accordance with natural resource constraints and the functional requirements of green spaces in order to improve energy efficiency; 2) how to effectively integrate the technical functions of energy facilities with landscape and ecological values, so as to achieve a seamless integration of energy infrastructure with landscape, thereby enhancing both environmental adaptability and public acceptance; and 3) how to develop flexible energy utilization and management strategies tailored to the energy consumption characteristics of different green space types, thus ensuring long-term, stable, and sustainable energy supply. …”
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GINS1 is a prognostic biomarker and correlated with methylation and immune escape in liver hepatocellular carcinoma by Mingchao Liang, Tianqi Lai, Tianqi Lai, Zhen Li, Wei Yu, Mingrong Cao, Nan Yao, Youzhu Hu, Youzhu Hu, Tongzheng Liu, Junjie Liang

“…Enrichment analyses were conducted to investigate the functions of GINS1. To assess the genetic alterations, methylation, and prognostic value, cBioPortal, and MethSurv databases were utilized. …”
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