Human cancer-targeted immunity via transgenic hematopoietic stem cell progeny by Theodore S. Nowicki, Nataly Naser Al Deen, Cole W. Peters, Begoña Comin-Anduix, Egmidio Medina, Cristina Puig-Saus, Ignacio Baselga Carretero, Paula Kaplan-Lefko, Mignonette H. Macabali, Ivan Perez Garcilazo, Daniel Chen, Jia Pang, Beata Berent-Maoz, Salem Haile, Jonathan Rodriguez, Moe Kawakami, Conner K. Kidd, Ameya Champhekar, Giuseppe Carlucci, Agustin Vega-Crespo, Bartosz Chmielowski, Arun Singh, Noah Federman, Gary M. Schiller, Sarah J. Larson, Martin Allen-Auerbach, Alexandra M. Klomhaus, Jerome Zack, David Baltimore, Lili Yang, Donald B. Kohn, Owen N. Witte, Antoni Ribas

“…These results demonstrate the utility of transgenic HSCs to generate a self-renewing source of tumor-specific cellular immunotherapy in human participants. …”
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Ultrasonic-assisted extraction of polysaccharides from Albizia julibrissin Durazz. leaf and pod: process optimization, physicochemical properties and anticomplementary activity by Yuanqi Duan, Yuxin Jiang, Jiayu Gu, Chenxi Sun, Boshi Sun, Yue Xu, Long Jin, Mei Jin, Mei Jin, Jinfeng Sun, Wei Zhou, Zhengyu Hu, Gao Li

“…This study established a foundation for developing and utilizing polysaccharide resources from A. julibrissin agro-byproducts, while providing a theoretical basis for their application in complement system overactivation.…”
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Enhancing hepatopathy clinical trial efficiency: a secure, large language model-powered pre-screening pipeline by Xiongbin Gui, Hanlin Lv, Xiao Wang, Longting Lv, Yi Xiao, Lei Wang

“…And its capability to function in resource-constrained environments further enhances its utility in clinical settings.…”
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Integrated multi-omics identify key signalling pathways for notochord lumenogenesis in ascidian Ciona savignyi by Jin Zhang, Zicheng Tan, Qishu Qin, Hongzhe Peng, Wenjie Shi, Haiyan Yu, Bo Dong

“…Meanwhile, we identified that CDC42 was a potential downstream target factor of the Ras-Rap1-MAPK signalling axis, playing crucial functions in notochord lumenogenesis. Overall, we systematically revealed the key regulatory signalling pathways for notochord lumen formation and verified a lumenogenesis-related signalling axis, providing a foundational data resource for exploring the mechanisms of lumenogenesis.…”
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(Cost-)effectiveness of lower extremity nerve decompression surgery in subjects with diabetes: the DeCompression (DECO) trial—study protocol for a randomised controlled trial by Manuel Castro Cabezas, Erwin Birnie, Willem D Rinkel, Tirzah M Fakkel, J Henk Coert

“…Surgical treatment of compression neuropathies in the lower extremities (lower extremity nerve decompression (LEND)) results in relief of symptoms and gain in peripheral nerve function, which may lead to less sensory loss (short term) and less associated detrimental effects including foot ulceration and amputations, and lower costs (long term). …”
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The role of the contralesional primary motor cortex in upper limb recovery after stroke: a scoping review following PRISMA-ScR guidelines by Peerapat Suputtitada, Valton Costa, Felipe Fregni

“…Animal studies provided evidence of structural and functional plasticity, including dendritic remodeling and enhanced neuronal connectivity, which paralleled improvements in motor function. …”
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The role of CD47 in immune escape of colon cancer and its correlation with heterogeneity of tumor immune microenvironment by Qiu-Si Tian, ChunMei Zhang, Zhi-Jun Bao, ZhiGang Pei

“…The Tumor Immune Estimation Resource and Kaplan-Meier plotter were utilized to assess the relationship between CD47 expression, patient prognosis, and immune infiltration. …”
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Rapid Prediction of Multi-physics Coupling in Heat Pipe ReactorBased on Neural Network by ZHANG Junda, LIU Xiaojing, XIONG Jinbiao, CHAI Xiang, ZHANG Tengfei

“…Concurrently, the neural network models utilized in rapid predictions have less stringent computational resource requirements and offer greater adaptability to varied environments. …”

Current practices in physiotherapy management of COPD in Pakistan by Sajjan Iqbal Memon, Fahad Tanveer, Gulzar Usman, Misbah Shakeel

“…Various studies have demonstrated that breathing exercises are efficacious in enhancing the strength of the muscles involved in inhalation and increasing the ability to engage in physical activity for those diagnosed with COPD.2 Physiotherapists routinely utilize the active cycle of breathing approach as a non-pharmacological method for airway clearance.3 Furthermore, the effects of oscillatory positive expiratory pressure therapy on the quality of life and objective signs of cough and sleep disturbance in COPD patients with regular sputum production have been investigated.4 The combination of postural drainage techniques and chest mobilization has been proven to effectively manage pneumonia and enhance postural alignment in patients with COPD.5 Several investigations are conducted to compare the postural alignment of COPD patients with that of healthy individuals and to establish a correlation between pulmonary function and postural alignment in the COPD group that has accounted for favorable results.6 In addition, the existing evidence suggests that active breathing strategies, such as the active cycle of breathing techniques, autogenic drainage, and forceful expiration, can be effective in managing COPD.7 At present, COPD management in Pakistan faces practical challenges such as resource limitations and training access for physiotherapists. …”
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Biological crusts increase soil microbial biomass and alter bacterial and fungal community compositions under pine restored over ten years in a Pisha sandstone soil by Qi Le, Qi Le, Meng Ru, Meng Ru, Ren Weibo, Ren Weibo, Zhang Min, Zhang Min, Mi Wentao, Mi Wentao, Yuan Ting, Yuan Ting, Liu Yaling, Yuan Feng

“…These pine forests have been utilized for soil and water conservation over a ten-year period of ecological restoration in the Pisha sandstone area. …”
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YOLO-SRMX: A Lightweight Model for Real-Time Object Detection on Unmanned Aerial Vehicles by Shimin Weng, Han Wang, Jiashu Wang, Changming Xu, Ende Zhang

“…Finally, the Wise-IoU loss function is adopted to replace the traditional bounding box loss. …”
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Pathway for Renewable Energy Application in Urban Green Space under the Low Carbon Perspective by Kailun WANG, Tonggang NIU, Lian LIU, Zhongjie WANG

“…The research provides a detailed analysis of energy application types and methods, as well as energy consumption models for each of the aforesaid three types of green spaces.ResultsThe research identifies three core challenges in the application of renewable energy in urban green spaces: 1) How to scientifically select the most appropriate renewable energy types and optimize spatial layouts in accordance with natural resource constraints and the functional requirements of green spaces in order to improve energy efficiency; 2) how to effectively integrate the technical functions of energy facilities with landscape and ecological values, so as to achieve a seamless integration of energy infrastructure with landscape, thereby enhancing both environmental adaptability and public acceptance; and 3) how to develop flexible energy utilization and management strategies tailored to the energy consumption characteristics of different green space types, thus ensuring long-term, stable, and sustainable energy supply. …”
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GINS1 is a prognostic biomarker and correlated with methylation and immune escape in liver hepatocellular carcinoma by Mingchao Liang, Tianqi Lai, Tianqi Lai, Zhen Li, Wei Yu, Mingrong Cao, Nan Yao, Youzhu Hu, Youzhu Hu, Tongzheng Liu, Junjie Liang

“…Enrichment analyses were conducted to investigate the functions of GINS1. To assess the genetic alterations, methylation, and prognostic value, cBioPortal, and MethSurv databases were utilized. …”
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Integrated analysis of single-cell and bulk transcriptomics reveals cellular subtypes and molecular features associated with osteosarcoma prognosis by Feng Liu, Tingting Zhang, Yongqiang Yang, Kailun Wang, Jinlan Wei, Ji-Hua Shi, Dong Zhang, Xia Sheng, Yi Zhang, Jing Zhou, Faming Zhao

“…Moreover, the study investigated the impact of ATF6α in OS aggressiveness through genetic and pharmacological loss of function analyses. Lastly, the CellChat algorithm was employed to investigate cell-cell communications. …”
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Characterization of a GH43 Bifunctional Glycosidase from Endophytic <i>Chaetomium globosum</i> and Its Potential Application in the Biotransformation of Ginsenosides by Yao Lu, Qiang Jiang, Yamin Dong, Runzhen Ji, Yiwen Xiao, Du Zhu, Boliang Gao

“…The GH43 family of glycosidases represents an important class of industrial enzymes that are widely utilized across the food, pharmaceutical, and various other sectors. …”
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A new fluorescent probe based on BODIPY for testing NO2 released from propellants by Ying-cui Cui, De-bin Xia, Zhong-yu Cui, Yu-jing Li, Jian Zhang, Ping Wang, Ting Guo, Kai-feng Lin, Yu-lin Yang

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Fast detection method for radionuclides based on Sequential Bayesian approach by WAN Linjian, ZHANG Xuan, ZHANG Chunlei, HUANG Jianwei, LIU Jiacheng, ZHANG Xiaole, LI Dehong, YANG Zhijun

“…Based on the principle that the time interval between adjacent two rays was exponential distributed, the decision was caculated by collecting a series of ray time samples in chronological sequence, and decisions were made by comparing the decision function with the preset upper and lower thresholds. …”
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Application of Anionic Hydrogels from Date Palm Waste for Dye Adsorption in Wastewater Treatment by Farid Fadhillah, Abdulrahman G. Alhamzani, Khaled Bin Bandar, Abdullah Alshamari, Saad Aljlil, Abdelrahman G. Gadallah, M. A. Habib, Mortaga M. Abou-Krisha, Mona A. Abdel-Fatah

“…Biogel formation of the CNF suspension was promoted by sonication, where its removal efficiency of methylene blue dye was studied as a function of dye concentration, temperature, contact time, and pH value. …”
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BASE: a web service for providing compound-protein binding affinity prediction datasets with reduced similarity bias by Hyojin Son, Sechan Lee, Jaeuk Kim, Haangik Park, Myeong-Ha Hwang, Gwan-Su Yi

“…We developed the BASE web service to allow researchers to download and utilize these datasets. Feature importance analysis revealed that previous models heavily relied on protein features. …”
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Gaussian pulse shaping algorithm based on finite impulse response filters by HUANG Haixi, HONG Xu, LIU Junlong, SONG Xinru, LI Lin, ZHOU Chengzhuo

“…The truncated GPS algorithm has better energy resolution and saves more hardware resources, whilest the normal GPS algorithm owns better pulse pile-up rejection capability for the same peaking time.…”
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