De Novo Synthesis of Anticholinergic Hyoscyamine and Scopolamine in <i>Nicotiana benthamiana</i> Based on Elucidating Tropane Alkaloid Biosynthetic Pathway of <i>Anisodus luridus</... by Mengling Wen, Junlan Zeng, Fei Qiu, Fangyuan Zhang, Zhihua Liao

“…Its high yield of hyoscyamine makes <i>A. luridus</i> a valuable plant source for commercially producing TAs. In this study, we conduct homologous gene research across transcriptome data of different tissues together with functionally tested sequences in <i>Atropa belladonna</i> as a reference and identify 13 candidate genes for TAs biosynthesis in <i>A. luridus</i>. …”
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Improving the understanding and interpretation of myeloma screening among resident doctors and physician associates: a quality improvement project by Mahmoud Gouda, Hannah Hunter

“…Introduction: Myeloma is the second most common blood cancer in the UK, with a median age at diagnosis of 72.6 years.1 Patients with myeloma can initially present with vague and non-specific symptoms, making early diagnosis challenging. To improve early detection, a myeloma screen is commonly requested on medical wards. …”
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Protocol Biopsies in Kidney Transplant Recipients: Current Practice After Much Discussion by Christina Lazarou, Eleni Moysidou, Michalis Christodoulou, Stamatia Stai, Georgios Lioulios, Efstratios Kasimatis, Asimina Fylaktou, Maria Stangou

“…Expert opinion and consensus acknowledge the benefits of protocol biopsies for early detection and tailored management but also highlight ongoing debates regarding their routine use in low-risk patients due to risks, costs, and resource considerations. …”
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PhenoVision: A framework for automating and delivering research‐ready plant phenology data from field images by Russell Dinnage, Erin Grady, Nevyn Neal, Jonn Deck, Ellen Denny, Ramona Walls, Carrie Seltzer, Robert Guralnick, Daijiang Li

“…We close by discussing next steps, including automating phenology annotations, adding new phenology targets, for example leaf phenology, and further integration with other resources to form a global central database integrating all in situ plant phenology resources.…”
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eDNA Metabarcoding Reveals the Depth-Structured Variation of Coral Reef Fish by Jinfa Zhao, Lin Lin, Yong Liu, Teng Wang, Yu Liu, Yayuan Xiao, Jianzhong Shen, Hongyu Xie, Hai Huang, Qiuying Han

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Analysis of variant interactions in families with autism points to genes involved in the development of the central nervous system. by Jacek Kaczyński, Marta Pasenkiewicz-Gierula

“…The variants were used to build an ASD predictor based on an open-source machine learning library. The predictor correctly classifies over 78% of samples from a test set with an average significance level of 8.9· 10-158. …”
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Bioinformatics analysis of potential pathogenesis and risk genes of neuroinflammation-promoted brain injury in intracerebral hemorrhage by Ilgiz Gareev, Ozal Beylerli, Elmar Musaev, Chunlei Wang, Valentin Pavlov

“…TargetScan, miRDB, and RNA22 were used to investigate the miRNAs regulating the DEGs. The functional annotation of DEGs was performed using Gene Ontology (GO) resources, and the cell signaling pathway analysis of DEGs was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG). …”
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Cloning and expression of a C3H-type zinc finger protein gene BoCCCH2 from Brassica oleracea var. italica by JIANG Ming, LIU Qing’e, ZHANG Yanru, ZHU Qi, GONG Xiu, YU Keke, ZHOU Xiuqian

“…Cloning and expression analysis of BoCCCH2 provide evidence for further studies on gene function.…”
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INTERACTION BETWEEN DENTO-MAXILLOFACIAL ANOMALIES AND GENERAL-SOMATIC HUMAN CONDITION (LITERATURE REVIEW) by L.V. Smaglyuk, H.V. Voronkova, A.Ye. Karasiunok, A.V. Liakhovska, V.I. Smaglyuk

“…Materials and methods. Literary sources were reviewed on the relationship of malocclusion with the general diseases and the obtained data were analysed. …”
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Ecological security driving mechanisms and optimization of zoning in Chinese urban agglomerations: A case study of the central plains urban agglomeration by Jinyuan Zhang, Xuning Qiao, Yongju Yang, Liang Liu, Yalong Li, Shengnan Zhao

“…Additionally, it combines the ’Three-dimensional Rubik’s Cube model with primary functional zoning to enhance the optimization of ecological security delineation. …”
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Evaluation of Self-Regulating Doped Ferrite Nanoparticles with Glucose, Chitosan, and Poly-Ethylene Glycol Coatings for Hyperthermia and Dual Imaging by Negri A, Conti A, Milan E, Forlin E, Gherlinzoni F, Morana G, Gottardi M, Matteazzi P, Speghini A, Bongers A, Marzola P

“…Following intravenous administration, MRI and MPI functionalities were analyzed through phantom studies and in vivo murine models.Results: Coated M55 NPs displayed high colloidal stability in water and effective functionalization. …”
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Sensitivity and Specificity of Three Measures of Intrinsic Capacity in Older People Aged 80 and Over in Nursing Homes by Ma L, Zheng E, Fang Y, Chen H, Zhou C, Cai S, Luo F, Jiang W, Wang J, Ning X, Tu H, Yin Z

“…IC spans five function domains: Locomotor, psychological, cognitive, vitality, and sensory (including vision and hearing). …”
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Quality evaluation of Polygonatum sibiricum slices from different regions based on appearance traits and multi-index metabolites combined with TOPSIS and gray relation analysis by Cheng Wang, Cheng Wang, Ju Ye, Sisi Jiang, Sisi Jiang, Xuguang He, Xuguang He, Min Ma, Min Ma, Li Yin

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Spatial and Temporal Variation of Annual Precipitation in a River of the Loess Plateau in China by Cui Shen, Huang Qiang

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Who Leads Trends on Q&A Platforms? Identifying and Analyzing Trend Discoverers by Yongning Li, Lun Zhang, Ye Wu, Tianlan Wei

“…Q&A platforms are vital sources of information but often face challenges related to their high ratios of passive to active contributors, which can impede knowledge construction and information exchange on the platforms. …”
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Investigation of high fecundity genes by nanopore sequencing in sheep (Ovis aries) pituitary by Xue Xiao, Zhibin Ji, Tong Wang, Dejie Zhu, Zhonghui Li, Xinming Xu, Fen Li

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Adipose tissue oxylipin profile changes with subclinical ketosis and depot in postpartum dairy cows by Bridger B. Sparks, Hunter Ford, Tainara C. Michelotti, Clarissa Strieder-Barboza

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Predicting the Likelihood of Operational Risk Occurrence in the Banking Industry Using Machine Learning Algorithms by Hamed Naderi, Mohammad Ali Rastegar Sorkhe, Bakhtiar Ostadi, Mehrdad Kargari

“…Machine learning models can process complex datasets, identify hidden patterns, and facilitate early risk detection, enabling banks to implement preventive measures before risks materialize. …”
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VULVAR AND VAGINAL GRAFT VERSUS HOST DISEASE IN A PATIENT WITH CHRONIC PHASE CHRONIC MYELOID LEUKEMIA AFTER ALLOGENEIC STEM CELL TRANSPLANTATION by Esra Pirinççi, M. Orhan Ayyıldız, Abdullah Karakuş, Reyhan Gündüz

“…The main risk factor for the development of chronic genital GVHD issuing of peripheral blood as a source of progenitor cells; It represents a risk of three times higher than that obtained from bone marrow cells (9-11). …”
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3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay by Di Wu, Xiaoqi Guan, Tao Yang, Jiashuai Yan, Biwen Zhu, Junchao Zhou, Yibing Guo, Yuhua Lu

“…Cancer stem cells (CSCs), the primary source of therapy resistance in pancreatic ductal adenocarcinoma (PDAC), exist in a dynamic equilibrium through tumor microenvironment (TME)-driven plasticity. …”
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