TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion by Xuhao Zhang, Yu Gao, Huiping Liao, Wenyan Wang, Zaili Yang, Weian Cao, Ge Li, Jing Wen, Gencheng Han, Yang-Xin Fu

“…Progressive loss of IL2-secretion is an early sign of diminished effector function in TILs, which raises the possibility of IL2 loss driving exhaustion of TILs. …”
Get full text

Differential efficacy of olfactory neurospheres from deviated nasal septum and chronic rhinosinusitis patients in regenerating olfactory epithelium by Rong-San Jiang, Chiang-Wen Lee, Yu-Hsuan Lin, Jing-Jie Wang, Jia-Bin Liao, Kuo-Ti Peng, Yao-Chang chiang, Pei-Ling Chi

“…Conclusions These findings highlight the importance of selecting the appropriate ONS source for therapeutic applications, with DNS-ONS showing greater promise for olfactory epithelium repair and olfactory function restoration.…”
Get full text

Multi-Omics Analysis Provides Insights into Green Soybean in Response to Cold Stress by Yanhui Lin, Guangping Cao, Jing Xu, Honglin Zhu, Liqiong Tang

“…The DEGs and DEMs were further subjected to KEGG functional analysis. Finally, 11 metabolites (such as sucrose, lactose, melibiose, and dehydroascorbate) and 17 genes (such as <i>GOLS</i>, <i>GLA</i>, <i>UGDH</i>, and <i>ALDH</i>) were selected as candidates associated with cold tolerance. …”
Get full text

Microfluidic Sensors Integrated with Smartphones for Applications in Forensics, Agriculture, and Environmental Monitoring by Tadsakamon Loima, Jeong-Yeol Yoon, Kattika Kaarj

“…In environmental monitoring, these sensors allow the timely detection of pollutants in air, water, and soil, enabling quicker responses to hazards. …”
Get full text

Biomarkers associated with cell-in-cell structure in kidney renal clear cell carcinoma based on transcriptome sequencing by Zehua Wang, Zhongxiao Zhang

“…Methods Data for this study were sourced from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and Gene Expression Omnibus (GEO) databases. …”
Get full text

Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically... by Nessrin Alomran, Jaffer Alsolaiss, Laura-Oana Albulescu, Edouard Crittenden, Robert A Harrison, Stuart Ainsworth, Nicholas R Casewell

“…Two different immunogen mixtures, consisting of seven and twelve haemotoxic venoms sourced from geographically diverse and/or medically important snakes, were used to raise ovine polyclonal antibodies, prior to characterisation of their immunological binding characteristics and in vitro neutralisation profiles against each of the venoms. …”
Get full text

Bioactive Compounds and Antioxidant Activity of <i>Boletus edulis</i>, <i>Imleria badia</i>, <i>Leccinum scabrum</i> in the Context of Environmental Conditions and Heavy Metals Bio... by Zofia Sotek, Katarzyna Malinowska, Małgorzata Stasińska, Ireneusz Ochmian

“…From a practical perspective, the results highlight the importance of species selection and sourcing location when considering wild mushrooms for consumption or processing, particularly in the context of nutritional value and contaminant load. …”
Get full text

Application of Artificial Intelligence in Acute Ischemic Stroke: A Scoping Review by JoonNyung Heo

“…Outcome prediction, the most explored category, includes studies predicting functional outcomes, mortality, and recurrence, often achieving high accuracy and outperforming traditional methods. …”
Get full text

Feature engineering for fault detection and diagnosis in Power Transmission Lines using a tree-based approach by Hassan N. Noura, Zaid Allal, Ola Salman, Khaled Chahine

“…The Power Transmission Line (PTL) is a pivotal infrastructure in the efficient distribution of electrical power, connecting the source generating stations to end-point consumers. …”
Get full text

Computational exploration of global venoms for antimicrobial discovery with Venomics artificial intelligence by Changge Guan, Marcelo D. T. Torres, Sufen Li, Cesar de la Fuente-Nunez

“…From these, we identified 386 candidates that are structurally and functionally distinct from known antimicrobial peptides. …”
Get full text

Vitamin D and Osteoporosis in HIV/HCV Coinfected Patients: A Literature Review by Paola Di Carlo, Lucia Siracusa, Giovanni Mazzola, Piero Colletti, Maurizio Soresi, Lydia Giannitrapani, Valentina Li Vecchi, Giuseppe Montalto

“…The final 12 articles selected are homogeneous in terms of age but heterogeneous in terms of sample size, participant recruitment, and data source. …”
Get full text

Harnessing Hemp (<i>Cannabis sativa</i> L.) Seed Cake Proteins: From Concentrate Production to Enhanced Choux Pastry Quality by Tatiana Capcanari, Eugenia Covaliov, Cătălina Negoița

“…This study explores the production and valorization of hemp seed cake protein concentrate (HPC) as a functional ingredient to enhance the nutritional quality and sensory attributes of choux pastry products, specifically éclairs. …”
Get full text

Development of grain drink technology based on unsteamed buckwheat by G. M. Kerimova, I. A. Fomenko, A. R. Pivchenko, I. R. Sokolov

“…The finished product is also a source  of soluble dietary fiber, which has a positive effect on the human microbiome.…”
Get full text

Application of artificial intelligence in echocardiography from 2009 to 2024: a bibliometric analysis by Yangli Liu, Lei Zhao, Bin Tu, Jie Wang, Yaqun He, Rufang Jiang, Xiaofeng Wu, Wen Wen, Jian Liu

“…The objective of this study is to explore the current status and prevailing research trends in this field from 2009 to 2024 through bibliometric analysis and to forecast future developmental trajectories.MethodsWe selected the Science Citation Index Expanded (SCI-Expanded) from the Web of Science Core Collection (WOSCC) as our primary data source and conducted a comprehensive search encompassing all articles and reviews published between 2009 and 2024 and used the online analysis platform of bibliometrics, CiteSpace and VOSviewer software to analyze countries/regions, institutions, authors, keywords, and references, used Microsoft Excel 2021 to visualize the trends of the number of articles published by year.ResultsBetween 2009 and 2024, a total of 3,411 publications on AI applications in echocardiography were identified, including 3,000 articles (87.9%) and 411 reviews (12.1%), contributed by researchers from 100 countries/regions. …”
Get full text

The evolution and competitive strategies of Akkermansia muciniphila in gut by Ji-Sun Kim, Se Won Kang, Ju Huck Lee, Seung-Hwan Park, Jung-Sook Lee

“…In addition, WapA and anSME, which function in competition and post-translational modification of sulfatase, respectively, have been a particularly important selective pressure in the evolution of group A. …”
Get full text

Influence of suturing material on wound healing: Experimental study in dogs by Gazivoda Dragan, Pelemiš Dejan, Vujašković Goran, Đurđević Slaviša

“…When using resorbable materials it is of great importance to determine whether its absorbability and tensile strength help wound healing in function of time. Sutures themselves can become a source of inflammation, that may reduce or compromise the potential of reparation and regeneration. …”
Get full text

Enhancing the socio-cultural valuation of ecosystem services in Mountain animal production: a case study from piedmont’s alpine valley (North-west Italy) by Chiara Costamagna, Valentina Maria Merlino, Danielle Borra, Lorenzo Baima, Paolo Cornale, Luca Maria Battaglini

“…These findings could have concrete implications on the definition of social and economic development strategies for the alpine mountain valleys, representing an important source of production for national mountain pasture livestock farming.…”
Get full text

Staged approach to bilateral severe carotid stenosis: a case report and literature review by Heitor Cabral Frade, Manmeet Kaur, Julia Aigbogun, Muhammad Zeeshan Memon, Arun Chhabra, Akm Muktadir, Hashem Shaltoni

“…Hyperperfusion syndrome (HPS), with or without associated intracerebral hemorrhage, although rare, is a major source of morbidity and mortality after carotid interventions, especially in the setting of bilateral CAD. …”
Get full text

Efficacy of Anti-VEGF/VEGFR Agents on Animal Models of Endometriosis: A Systematic Review and Meta-Analysis. by Shuangge Liu, Xiaoyan Xin, Teng Hua, Rui Shi, Shuqi Chi, Zhishan Jin, Hongbo Wang

“…Subgroup analyses were performed to determine the source of heterogeneity in endometriosis scores and follicle numbers.…”
Get full text

Mapping and Spatial Analysis of the Development of the Administrative Borders of Stavropol Region in 1785–2021 by Igor Yurievich Katorgin, Alexander Nikolaevich Roman

“…Geoinformation technologies allow processing, spatial coordination of digitized old maps with optimal accuracy, creation of thematic layers necessary for spatial analysis and visualization of the results of work in the form of a series of maps displaying the ATD of the Stavropol region for different periods of development history.Materials and research methods. As the main source of spatial data, old maps were used, selected according to 12 stages of the development of the Stavropol region ATD system over a 237-year period. …”
Get full text