Genomics and integrative clinical data machine learning scoring model to ascertain likely Lynch syndrome patients by Ramadhani Chambuso, Takudzwa Nyasha Musarurwa, Alessandro Pietro Aldera, Armin Deffur, Hayli Geffen, Douglas Perkins, Raj Ramesar

“…Annovar, Intervar, Variant Effect Predictor (VEP), and OncoKB software tools were used to functionally annotate and interpret somatic variants detected. …”
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Sodium formate induces development-dependent intestinal epithelial injury via necroptosis and apoptosis by Jingjing Wei, Yuan Tian, Meiqi Guan, Jinshu Wei, Yong Ji, Guozhong Tao, Karl G. Sylvester

“…Mice were sacrificed after 24 h of feces collection, and the blood and small intestinal tissues were collected to detect the pathological damage of intestinal tissue, intestinal permeability, oxidative stress indicators including SOD, HO-1, MDA, and 4-HNE, inflammatory cytokines including IL-1β, TNF-α and IL-6, mitochondrial function such as ATP and PGC-1α in mice intestinal tissue, indicators of the cell death modes including necroptosis-related protein RIPK1 and p-MLKL, and apoptosis- related protein cleaved-caspase-3 and p-AKT (S473).Results NaF treatment significantly damaged intestinal epithelial tissue and barrier function, caused mitochondrial dysfunction, manifesting as decreased ATP and PGC-1α levels, increased lipid peroxidation products MDA and 4-HNE, depleted antioxidant enzyme SOD, and upregulated the expression of HO-1. …”
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Responses of field-grown maize to different soil types, water regimes, and contrasting vapor pressure deficit by T. H. Nguyen, T. Gaiser, J. Vanderborght, A. Schnepf, F. Bauer, A. Klotzsche, L. Lärm, H. Hüging, F. Ewert, F. Ewert

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Agarwood leaf ethanol extract provides neuroprotective properties and promotes cholinergic differentiation of HT22 hippocampal neurons by Kishoree K. Kumaree, James M. Brimson, Kanika Verma, Siriporn Chuchawankul, Tewin Tencomnao, Anchalee Prasansuklab

“…Abstract Neurodegenerative diseases, characterized by the loss or damage of neurons, represent a growing global health concern. Plants are a rich source of naturally occurring compounds with immense therapeutic potential. …”
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Multimodal imaging of dark without pressure in high myopia reveals evidence that photoreceptor microscopic lesions may be reversible by Qingge Guo, Xiuxiu Jin, Xiaoyu Xin, Xiaohong Guo, Shuai Ming, Yuxiang Li, Bo Lei

“…Previous studies have concluded that DWP alone has no impact visual acuity, visual field, or other visual functions. This study aims to reveal the multimodal imaging manifestations of DWP in high myopia and to explore its impact on retinal function. …”
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One more way to address the seasonal water shortage of the largest freshwater lake in China? A nature-based solution through lake bathymetry restoration by Bing Li, Guishan Yang, Rongrong Wan, David P. Hamilton, Jing Yao

“…The simulations evaluated the hydrodynamic impacts of restoration, focusing on its implications for water resource management and ecological functions. New hydrological insights for the region: Results revealed significant impacts of bathymetry restoration, particularly during low-water-level periods. …”
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Genome‐wide association study identifies QTL and candidate genes for grain size and weight in a Triticum turgidum collection by G. Mangini, D. Nigro, P. L. Curci, R. Simeone, A. Blanco

“…Identifying loci controlling grain‐related traits will provide information on the genetic resources available to breeders to improve grain yield, as well as the opportunity to develop close gene markers to be used in marker‐assisted selection programs.…”
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Antioxidant Activity and Potential Bioactive Peptides from Skin Protein Hydrolysate of Yellowfin Tuna (<I>Thunnus albacares</I>) by Sitti Hardiyanti Rachman, Joko Santoso, Sugeng Heri Suseno

“…FPH possesses a molecular weight of 10.15-48.50 kDa. Functional groups detected were amides A, B, I, II, and III. …”
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OGLE-2011-BLG-0462: An Isolated Stellar-mass Black Hole Confirmed Using New HST Astrometry and Updated Photometry by Kailash C. Sahu, Jay Anderson, Stefano Casertano, Howard E. Bond, Martin Dominik, Annalisa Calamida, Andrea Bellini, Thomas M. Brown, Henry C. Ferguson, Marina Rejkuba

“…We have reanalyzed the data, including the new HST astrometry, and photometry obtained with 16 different telescopes. The source lies only $0\mathop{.}\limits^{^{\prime\prime} }4$ from a bright neighbor, making it crucial to perform precise subtraction of its point-spread function (PSF) in the astrometric measurements of the source. …”
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Evaluation of meningitis surveillance system in rural area, Rwanda by Solange Nyinawabeza, Jean Claude Niyoyita, Emmanuel Nshimiyimana, Jerome Ndayisenga, Angela Umutoni, Caroline Stamatakis

“…The study was cross-sectional, using purposive sampling to select healthcare providers participating in the meningitis surveillance. …”
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Cell fate analysis of embryonic ventral mesencephalic grafts in the 6-OHDA model of Parkinson's disease. by Sonya Carvalho Neto, Ahmad Salti, Zoe Puschban, Nadia Stefanova, Roxana Nat, Georg Dechant, Gregor K Wenning

“…To investigate this further, we used a GFP reporter mouse as source of VM tissue that enabled the detection and dissection of the grafts 6 weeks post implantation. …”
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Multi‐locus genome‐wide association study for grain yield and drought tolerance indices in sorghum accessions by Yirgalem Tsehaye, Temesgen M. Menamo, Fetien Abay, Taye Tadesse, Kassahun Bantte

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Reconstructing real-space geometries of polyatomic molecules undergoing strong field laser-induced Coulomb explosion by Aydin Ashrafi-Belgabad, Reza Karimi, Mohammad Monfared, Kaili Tian, Parviz Parvin, Benji Wales, Éric Bisson, Samuel Beaulieu, Mathieu Giguère, Jean-Claude Kieffer, Philippe Lassonde, François Légaré, Heide Ibrahim, Joseph H. Sanderson

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Organics in the stratosphere: new insights from weather balloon flights conducted in France by Roland Benoit, Hazel Vernier, Jean-Paul Vernier, Lilian Joly, Nicolas Dumelié, Gisèle Krysztofiak, Loïc Vieille, Sandrine Delpeux, Cyril Crevoisier, Philippe Dagaut, Gwenaël Berthet

“…Abstract Atmospheric aerosols significantly influence the Earth’s climate, yet they remain a major source of uncertainty in climate projections. Here, we present a set of unique offline analysis of organics collected from the ground to the stratosphere with ultimate sensitivity using a new balloon-borne sampling technique deployed on simple weather balloons. …”
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High throughput screening and evaluation of salt-tolerant mutants from an EMS collection of Cucurbita pepo by Sonsoles Alonso, Keshav Gautam, Jessica Iglesias-Moya, María Segura, María del Mar Rebolloso, María del Carmen Salas-Sanjuán, Cecilia Martínez, Manuel Jamilena

“…This enhanced salt tolerance was found to be associated with increased production of proline, soluble sugars, and anthocyanins, which are known to exert osmoprotective and ROS scavenging functions. The mutant lines TS-1378 and TS-2075 were selected to be tested as rootstocks and showed a positive effect on the vegetative growth of scions under standard and saline conditions. …”
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CircRALGPS2 modulates chicken follicle development through promotion of granulosa cell apoptosis and autophagy via the miR-200a-3p/TGFβ2/SMAD pathway by Haorong He, Xinghong Yu, Can Cui, Yao Zhang, Zhuanjian Li, Shunshun Han, Huadong Yin

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Urban Hierarchy Migration Model and Impact Mechanism of Graduates Admitted to the Guangdong Provincial Civil Service Examination by Wu Jinghao, Liu Ye, Tang Honglin

“…The decision-making and selection process in the selection mechanism for the migration mode of newly recruited graduates in the civil service examination is complex and dynamic, involving the interaction of multiple factors, such as government policy guidance, job characteristics, personal factors, and urban conditions, with objective limitations, personal abilities and resources, and subjective willingness. …”
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Association of Trace Elements with Polycystic Ovary Syndrome in Women—A Case-Control Study by Tinkara Srnovršnik, Bojana Pinter, Milena Horvat, Janja Snoj Tratnik, Ingrid Falnoga, Darja Mazej, Ivan Verdenik, Irma Virant-Klun

“…This case–control study aimed to determine levels of essential TEs (manganese (Mn), copper (Cu), zinc (Zn), selenium (Se), molybdenum (Mo)) and non-essential TEs (arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb)) in urine, whole blood, and serum to investigate a possible association with kidney and liver function, endocrine and metabolic parameters, and environmental and lifestyle sources of potential exposure and provide possible recommendations. …”
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Fluxgate Magnetometers Based on New Physical Principles by Ivan V. Bryakin, Igor V. Bochkarev, Vadim R. Khramshin, Vadim R. Gasiyarov, Ivan N. Erdakov

“…The authors considered a generalized flow of the physical processes in the FM to obtain a detailed representation of the operating functions of the FM. The presented experimental results for the proposed FM in the field meter mode confirm its operating parameters (±40 μT—measurement range, 0.5 nT—detection threshold). …”
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An Optimization Algorithm for Forward-Scatter Radar Network Node Deployment Based on BFGS and Improved NSGA-II by Yuqing Zheng, Xiaofeng Ai, Zhiming Xu, Jing Wu, Feng Zhao

“…A multi-objective optimization model was subsequently established with the objective functions of minimizing node cost and maximizing spatial detection area. …”
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