The neuropeptide sulfakinin is a peripheral regulator of insect behavioral switch between mating and foraging by Hong-Fei Li, Bao Dong, Yuan-Yuan Peng, Hao-Yue Luo, Xiao-Lan Ou, Zheng-Lin Ren, Yoonseong Park, Jin-Jun Wang, Hong-Bo Jiang

“…Further analysis of the mutant flies revealed that sets of odorant receptor (OR) genes were differentially expressed. Functional characterization of the differentially expressed ORs suggested that sulfakinin directly suppresses the expression of ORs that respond to opposite-sex hormones while enhancing the expression of ORs that detect food volatiles. …”
Get full text

Genotype × environment interaction analysis and climatic factors impacts on grain yield in rainfed durum wheat trials in Iran by Reza Mohammadi, Moslem Abdipour, Mahnaz Rahmati, Mohammad Armion, Nastaran Mehri, Asghar Mehraban

Get full text

A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro by Paolo Petazzi, Telma Ventura, Francesca Paola Luongo, Heather McClafferty, Alisha May, Helen Alice Taylor, Michael J Shipston, Nicola Romanò, Lesley M Forrester, Pablo Menendez, Antonella Fidanza

“…A major challenge in the stem cell biology field is the ability to produce fully functional cells from induced pluripotent stem cells (iPSCs) that are a valuable resource for cell therapy, drug screening, and disease modelling. …”
Get full text

Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…Total number of major adverse cardiovascular events. Lung function (NB, during the COVID-19 pandemic, lung function could not be assessed in participants). …”
Get full text

Genomic signal selection analysis reveals genes related to the lambing trait of Hotan sheep by XinKun Wang, Wei Li, QiaoYan Huang, HuiPing Sun, LeXiao Zhu, RuoHuai Gu, Feng Xing

“…We identified 290 selected regions and 332 genes across the Hotan sheep genome by using two widely adopted selective scanning detection methods (FST statistics and Piratio). Functional annotation and enrichment analysis of these genes identified 13 genes associated with the lambing rate, which were enriched in pathways such as the transforming growth factor-β signaling pathway (BMPR2, ID2, SMAD7, THBS1, and RBX1), renal cell carcinoma (PAK1, ELOC), inositol phosphate metabolism (PLCZ), non-homologous terminal junction (RAD50), ABC transporters (ABCC4), and the NET pathway (H2B, H4, and H2A). …”
Get full text

Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Key outcomes that determine overall resource use are medical management (treatments and consultation time) and referral rates. …”
Get full text

IT: An interpretable transformer model for Alzheimer's disease prediction based on PET/MR images by Zhaomin Yao, Weiming Xie, Jiaming Chen, Ying Zhan, Xiaodan Wu, Yingxin Dai, Yusong Pei, Zhiguo Wang, Guoxu Zhang

“…These insights significantly bolster the arsenal of tools available for AD diagnostics and contribute to the broader narrative of deciphering brain functionality through state-of-the-art imaging modalities.…”
Get full text

Validation of a 60K SNP chip for caribou (Rangifer tarandus) for use in wildlife forensics, conservation, and management by Trottier-Lavoie Mallorie, Prunier Julien, Poisson William, Carrier Alexandra, Gilbert Isabelle, Mastromonaco Gabriela, Albert Vicky, Cecilia Hernandez, Bourret Vincent, Taillon Joëlle, Droit Arnaud, Côté Steeve D., Robert Claude

“…The SNP chip was shown to be robust, highly sensitive, reliable, and accurate at more than 10-fold below the recommended DNA input. Biological source of DNA had minor impact, even with fecal pellets given sufficient amount of host DNA. …”
Get full text

Transcriptome analysis reveals the mechanism of Rhodiola polysaccharide affecting the proliferation of porcine Leydig cells under hypoxia by Jinting Luo, Lei Wang, Youli Yao, Xuan Luo, Jianbo Zhang, Dandan Luo, Tian Tian, Guofang Wu

Get full text

A novel multi-timescale comprehensive drought index for drought monitoring in the Xijiang River Basin by Liping Wang, Shufang Wang, Jing Li, Xingnan Zhang

Get full text

Assessing the impact of a rare synonymous variant in the <i>KNG1</i> gene on the development of hereditary angioedema by N. A. Pechnikova, Yu. V. Ostankova, M. A. Saitgalina, A. M. Bebyakov, A. A. Totolian

“…The material was a whole blood sample obtained from a woman with clinical manifestations of hereditary angioedema without a decrease in the levels and function of the C1 inhibitor. The research methods included whole exome sequencing, bioinformatic analysis of the KNG1 gene mutation using a number of databases and web resources. …”
Get full text

BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults by Claire J. Cadwallader, Anna M. VandeBunte, D. Luke Fischer, Coty Chen, Valentina E. Diaz, Shannon Y. Lee, Brandon Chan, Argentina Lario‐Lago, Julio C. Rojas, Eliana Marisa Ramos, Jessica E. Rexach, Jennifer S. Yokoyama, Joel H. Kramer, Emily W. Paolillo, Rowan Saloner, Kaitlin B. Casaletto

“…In moderated mediation analyses examining cognitive outcomes, plasma p‐tau181 selectively mediated the relationship between PA and executive function in Val/Val participants. …”
Get full text

Spatial Pattern and Evolutionary Characteristics of Settlements in Dianchi River Basin from the Perspective of Toponymy by Ying’ao WANG, Weijian HU, Wen PENG, Yuliang YANG

“…By constructing a coupling analysis framework of toponym semantics and spatial attributes, this research confirms the “spatio-temporal code” function of toponym in the process reconstruction of human settlements, and the capability to analyze multi-source heterogeneous data based on the aforesaid function provides a new analytical methodology for the research on watershed human settlements. …”
Get full text

High prevalence of fecal carriage of extended-spectrum beta-lactamase producing Enterobacterales among patients with urinary tract infections in rural Tanzania by Magreth Erick Macha, Magreth Erick Macha, Magreth Erick Macha, Weihong Qi, Salome N. Seiffert, Anja Bösch, Philipp Kohler, Honorathy Msami Urassa, Sabine Haller, Erin West, Maja Weisser Rohacek, Maja Weisser Rohacek, Maja Weisser Rohacek, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury, Baharak Babouee Flury

Get full text

MaPep1 and MbPep1, as plant elicitor peptides in banana, confer resistance to banana blood disease caused by Ralstonia syzygii subsp. celebesensis by Praphat Kawicha, Ladawan Rattanapolsan, Ratri Boonruangrod, Yube Yamaguchi, Kusavadee Sangdee, Aphidech Sangdee, Thanwanit Thanyasiriwat

Get full text

Evaluation of hypoxia-inducible factor-1α and urine non-transferrin-bound iron concentrations in cats with chronic kidney disease by Chien-Hui Chen, Chien-Hui Chen, Wei-Li Hsu, Pei-Shiue Jason Tsai, Chun-Fu Lai, Meng-Ting Wu, Ya-Jane Lee, Ya-Jane Lee

Get full text

Research on Pedestrians’ Visual Perception Characteristics Based on USGGS: A Case Study of the Six Inner-City Districts of Tianjin by Hanwen YANG, Shang’en TSOU, Yike HU

“…The core objective of the research is to propose strategies to optimize the greening structure of urban streets by analyzing the correlation between USGGS and visual perception of pedestrians, so as to enhance the quality of the visual environment of street pedestrians, improve the urban human settlement environment and promote the organic integration of the urban ecological and humanistic environments, thus providing a new way of thinking for urban planning and construction, and promoting the high-quality and sustainable development of urban street space.MethodsThe research selects the six inner-city districts of Tianjin City as the research area, utilizes Baidu street view image (SVI) as data source, and collect SVIs and their coordinates in the six districts in 2019 by calling Baidu API, with a total of 17,326 points selected and 13,281 valid samples obtained after screening. …”
Get full text

WHSC1/NSD2 regulates immune infiltration in prostate cancer by Kunle Odunsi, Junko Matsuzaki, Takemasa Tsuji, Sebastiano Battaglia, Richard C. Koya, Prashant K Singh, Muzamil Y Want, James L Thorne, Ellen Karasik, Bryan Gillard, Eduardo Cortes Gomez, Amit Lugade

Get full text

PhenoVision: A framework for automating and delivering research‐ready plant phenology data from field images by Russell Dinnage, Erin Grady, Nevyn Neal, Jonn Deck, Ellen Denny, Ramona Walls, Carrie Seltzer, Robert Guralnick, Daijiang Li

“…We close by discussing next steps, including automating phenology annotations, adding new phenology targets, for example leaf phenology, and further integration with other resources to form a global central database integrating all in situ plant phenology resources.…”
Get full text

Diverse ancestral representation improves genetic intolerance metrics by Alexander L. Han, Chloe F. Sands, Dorota Matelska, Jessica C. Butts, Vida Ravanmehr, Fengyuan Hu, Esmeralda Villavicencio Gonzalez, Nicholas Katsanis, Carlos D. Bustamante, Quanli Wang, Slavé Petrovski, Dimitrios Vitsios, Ryan S. Dhindsa

“…These findings highlight the need for enhanced population representation in genomic resources to fully realize the potential of precision medicine and drug discovery. …”
Get full text