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1861
Modulation of miRNAs by protein intake: A novel approach to mitigating stunting in children
Published 2025-06-01“…MicroRNAs (miRNAs) are small, non-coding RNA sequences that have a pivotal role in regulating gene expression, thereby influencing a range of biological processes, including growth and development. …”
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1862
Type II secretory phospholipase A2 and prognosis in patients with stable coronary heart disease: mendelian randomization study.
Published 2011-01-01“…<h4>Background</h4>Serum type II secretory phospholipase A(2) (sPLA(2)-IIa) has been found to be predictive of adverse outcomes in patients with stable coronary heart disease. Compounds targeting sPLA(2)-IIa are already under development. …”
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1863
Research Progress on the Functional Regulation Mechanisms of ZKSCAN3
Published 2025-07-01“…Furthermore, epigenetic mechanisms, including promoter methylation and non-coding RNA regulation, fine-tune ZKSCAN3 expression, contributing to tissue-specific outcomes. …”
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1864
The Role and Mechanism of Protein Post&#x2011;Translational Modification in Rheumatoid Arthritis
Published 2025-07-01“…This review systematically summarizes current knowledge on the roles and mechanisms of major PTMs in RA, with a special focus on the cross-talk between PTMs, their interaction with non-coding RNAs, and the emerging therapeutic potential of traditional Chinese medicine (TCM) targeting PTMs. …”
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1865
The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review
Published 2025-04-01“…Abstract MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. …”
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1866
Circular RNAs in non-alcoholic fatty liver disease: Functions and clinical significance
Published 2024-12-01“…Finally, we extensively discuss the potential application of targeting disease-related circRNAs and competing endogenous RNA networks through gain-of-function and loss-of-function approaches in targeted therapy of NAFLD.…”
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1867
A novel fragile X syndrome mutation reveals a conserved role for the carboxy‐terminus in FMRP localization and function
Published 2015-02-01“…We find that this novel peptide encodes a functional nuclear localization signal (NLS) targeting the patient FMRP to the nucleolus in human cells. …”
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1868
Exosomes in hypoxia: generation, secretion, and physiological roles in cancer progression
Published 2025-06-01“…Acting as nanoscale molecular envoys, exosomes transport oncogenic cargoes (including non-coding RNAs, mutated proteins, and metabolites) to reprogram stromal cells, prime pre-metastatic niches, and establish tumor-host metabolic symbiosis. …”
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1869
Beyond Theory: Leveraging Business Intelligence Tools to Uncover Actionable Pathways for Mapping the Intention–Behavior Gap in Behavioral Sciences
Published 2025-01-01“…., health and consumer behavior) and employ manual coding schemes, overlooking essential thematic relationships. …”
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1870
Drosophila Piwi distinguishes transposons from mRNAs by piRNA complementarity and abundance
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1871
The Role of NF-κB/MIR155HG in Regulating the Stemness and Radioresistance in Breast Cancer Stem Cells
Published 2025-01-01“…These findings underscore MIR155HG as a promising therapeutic target for breast cancer.…”
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1872
Recent Advances in Aptamer-Based Point-of-Care Testing
Published 2025-06-01“…Aptamers refer to a class of oligonucleotide probes that have demonstrated remarkable capabilities beyond mere genetic coding, including the unique ability to recognize and selectively bind to specific molecular targets. …”
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1873
Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.
Published 2016-07-01“…Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. …”
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1874
Protein Kinases as Mediators for miRNA Modulation of Neuropathic Pain
Published 2025-04-01“…By exploring how protein kinases mediate miRNA modulation of neuropathic pain, valuable insight may be gained into the pathophysiology of neuropathic pain, offering potential therapeutic targets for developing more effective strategies for pain management.…”
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1875
Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases
Published 2025-01-01“…We also explore their role in the occurrence and development of CVDs, as well as their potential as diagnostic biomarkers and therapeutic targets. Currently, therapies targeting seRNAs are a research hotspot. …”
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1876
Age and Sex-Related Characteristics of Obesity-Associated Adult Mortality
Published 2024-12-01“…Therefore, it is necessary to expand the preventive measures targeting these at-risk groups.…”
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1877
Left Behind in Lockdown: How COVID-19 Deepened the Crisis in K-12 Physical Education
Published 2025-05-01“…Participants were selected using criterion sampling, targeting educators experienced in teaching before, during, and after the pandemic. …”
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1878
Understanding challenges and enhancing the competency of healthcare providers for disability inclusive sexual and reproductive health services in rural Nepal.
Published 2024-01-01“…Additionally, improving interpersonal communication skills and decision-making autonomy of health care providers is important for disability inclusive SRH services.…”
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1879
Qualitative study exploring the key determinants of information gathering to inform the management of over-the-counter (OTC) consultations in community pharmacies
Published 2019-08-01“…Theory-based content analysis was undertaken using the TDF as an initial coding framework to identify key determinants and map them to salient domains. …”
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1880
Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1
Published 2024-09-01“…Specific antisense oligonucleotides (ASOs) targeting the junction site of circPIAS1 were developed to reduce its intracellular levels. …”
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