Should healthcare professionals include aspects of environmental sustainability in clinical decision-making? A systematic review of reasons by Sarah Gabriela Kuiter, Alina Herrmann, Marcel Mertz, Claudia Quitmann, Sabine Salloch

“…However, the extent to which considerations of environmental sustainability should be incorporated into clinical decision-making at the individual level is unclear. Methods We conducted a systematic review of the reasons stated for and against including aspects of environmental sustainability in the clinical decision-making of healthcare professionals. …”
Get full text

Neonatal nurses’ experiences with generative AI in clinical decision-making: a qualitative exploration in high-risk nicus by Abeer Nuwayfi Alruwaili, Afrah Madyan Alshammari, Ali Alhaiti, Nadia Bassuoni Elsharkawy, Sayed Ibrahim Ali, Osama Mohamed Elsayed Ramadan

“…Thematic analysis was used to code and interpret data, supported by an inter-rater reliability of 0.88. …”
Get full text

A comprehensive review on novel opportunities for Alzheimer therapy by targeting BIN1 by Trina Saha, Dipanjan Karati

“…Such isoform imbalance can interfere with neuronal function and play a role in AD pathogenesis, making it essential to target BIN1 splicing regulation as a therapeutic modality. …”
Get full text

HIV chromatin is a preferred target for drugs that bind in the DNA minor groove. by Clayton K Collings, Donald W Little, Samuel J Schafer, John N Anderson

“…A comparison of these results to the density of A-tracts in the HIV genome indicates that a large fraction of the nucleosomes that make up HIV chromatin should be preferred in vitro targets for the MGBDs. …”
Get full text

Editorial: Specific targeting of MHC antigens for T-cells and immune cells in human disease by Ali Afzal, Ali Afzal, Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Babar Khawar, Weijuan Gong, Weijuan Gong, Weijuan Gong, Brian M. Baker, Brian M. Baker, Haibo Sun, Haibo Sun

Get full text

Role of risk perceptions and vaccine hesitancy on decision-making among low-income mothers in Kenya: a qualitative study by Stephen Gichuhi Kimotho

“…Additionally, enhancing vaccine knowledge through targeted health education programmes would be crucial for empowering mothers to make informed decisions about their children’s health.…”
Get full text

Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer by Dechun Zhang, Shaoxuan Pei, Zixuan Feng, Guangfeng Xia

“…Abstract Recent studies have progressively clarified the critical role of long non-coding RNA (lncRNA) in cancer, especially concerning its involvement in immune processes, which holds significant therapeutic promise. …”
Get full text

LEADR, a p63 target, dampens interferon signalling in bladder cancer by Damiano Barnaba, Mariacristina Franzese Canonico, Manuela Helmer-Citterich, Paolo Gandellini, Gerry Melino, Artem Smirnov, Eleonora Candi

“…Therefore, understanding of key molecular pathways involved in cancer progression is critical for developing of new personalised targeted therapies. Recently, non-coding RNAs (ncRNAs) have emerged as key regulators orchestrating complex biological processes in cancer, yet their function is not fully understood. …”
Get full text

Small target detection in coal mine underground based on improved RTDETR algorithm by Feng Tian, Cong Song, Xiaopei Liu

“…In order to increase the accuracy of tiny object detection and concentrate on the detail information in the shallow feature map, the small object detection layer P2 is simultaneously added to the Head of the coding section. Based on the improvement of the above three parts, the improved PDP-RTDETR working model in this paper achieves a Mean Average Precision (mAP) of 56.6% for detecting small targets on the self-constructed dataset, which is 11.2, 12.1, 9.9, and 5.2% better than that of the traditional models Yolov5s, Yolov7-Tiny, Yolov8n, and RTDETR, respectively. …”
Get full text

Curcumin and neuroplasticity: epigenetic mechanisms underlying cognitive enhancement in aging and neurodegenerative disorders by Hao Jiao, Xiuying Wang, Dahui Zhang, Shengxue Zhou, Feng Gao

“…By targeting neuroinflammatory and oxidative stress pathways, curcumin further supports cognitive resilience and neuronal survival. …”
Get full text

Combined analysis of embryonic gonadal development differences of mulard duck and muscovy duck using long non-coding RNAs and mRNAs by LI Li, ZHANG Linli, XIN Qingwu, MIAO Zhongwei, ZHU Zhiming, QIU Junzhi, HAO Xiaona, HUANG Qinlou, ZHENG Nenzhu

“…The purpose of this study was to screen key mRNAs and long non-coding RNAs (lncRNAs) that affect gonadal development in duck embryos and to explain scientifically gonadal development defects in the mulard duck. …”
Get full text

Information Support of Statistic Research of Budget Investments’ Impact on Socio-Ecological and Economic Development of the Russian Federation regions by N. N. Kovalenko

Get full text

The DMD locus harbours multiple long non-coding RNAs which orchestrate and control transcription of muscle dystrophin mRNA isoforms. by Matteo Bovolenta, Daniela Erriquez, Emanuele Valli, Simona Brioschi, Chiara Scotton, Marcella Neri, Maria Sofia Falzarano, Samuele Gherardi, Marina Fabris, Paola Rimessi, Francesca Gualandi, Giovanni Perini, Alessandra Ferlini

“…Using a custom-made tiling array, specifically designed for the DMD locus, we identified a variety of novel long non-coding RNAs (lncRNAs), both sense and antisense oriented, whose expression profiles mirror that of DMD gene. …”
Get full text

Ferroptosis and recurrent miscarriage: a critical review of pathophysiology and emerging therapeutic targets by Mohammad Masoud Khodaei, Zahra Noori, Fateme Zare, Ahmad Meshkin

“…Further, new strategies targeting non-coding RNAs, and epigenetic regulators emphasize ferroptosis as a viable therapeutic target. …”
Get full text

Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemi... by Valeria Pecci, Melissa Borsa, Aurora Aiello, Sara De Martino, Luca Cis, Cristian Ripoli, Dante Rotili, Francesco Pierconti, Francesco Pinto, Claudio Grassi, Carlo Gaetano, Antonella Farsetti, Simona Nanni

“…Background/Objectives: Metastatic prostate cancer (PCa) remains a major clinical challenge with limited therapeutic options. The long non-coding RNA <i>H19</i> has been implicated in regulating cell adhesion molecules and collective migration, key features of metastatic dissemination. …”
Get full text

Targeting miRNA with flavonoids: unlocking novel pathways in cardiovascular disease management by Arya Tjipta Prananda, Princella Halim, Rony Abdi Syahputra

“…MicroRNAs (miRNAs), a class of non-coding RNAs, have emerged as key regulators of gene expression involved in these processes, positioning them as potential biomarkers and therapeutic targets in CVD management. …”
Get full text

Targeting TSPEAR-AS2 suppresses tumor growth and interferon signaling in esophageal cancer by Chunyan Zhang, Yuanbo Cui

Get full text

circFOXP1: a potential diagnostic and therapeutic target in human diseases by Qiang Yi, Xinting Ouyang, Kui Zhong, Zheng Chen, Weijian Zhu, Gangfeng Zhu, Jinghua Zhong

“…Circular RNA (circRNA) are a unique class of non-coding RNAs characterized by their covalently closed loop structures, which grant them properties such as stability and conservation. …”
Get full text

Sparse Reconstruction-Based Target Localization with Distributed Waveform-Diverse Array Radars by Runlong Ma, Lan Lan, Guisheng Liao, Jingwei Xu, Fa Wei, Ximin Li

“…At the configuration stage, the distributed radar system consists of two individual Frequency Diverse Array Multiple-Input Multiple-Output (FDA-MIMO) radars and one single Element-Pulse Coding MIMO (EPC-MIMO) radar. To obtain the angle and incremental range (i.e., the range offset between the sampling point and actual position within the range bin) of the targets in each local radar, two sparse reconstruction-based algorithms, including the grid-based Iterative Adaptive Approach (IAA) and gridless Atomic Norm Minimization (ANM) algorithms, are implemented. …”
Get full text

The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression by Kai Guo, Jie Yao, Qiang Yu, Zijian Li, Hu Huang, Jianguo Cheng, Zhigang Wang, Yunfeng Zhu

“…The plasmacytoma variant translocation 1 gene (PVT1) is a large non-coding locus at adjacent of c-Myc, and long non-coding RNA PVT1 is now recognized as a cancerous gene co-amplified with c-Myc in various cancers. …”
Get full text