Challenges of integrating HIV prevention and treatment in China's border mountain regions: a grounded theory study by Sixian Du, Haoran Niu, Feng Jiang, Liwen Gong, Shan Zheng, Qi Cui, Xu Yang, Jiayan He, Rongcai Dai, Qilian Luo, Yiqing Yang

“…The qualitative data were analyzed through a rigorous three-stage coding process—comprising open coding, axial coding, and selective coding—consistent with grounded theory methodology, to systematically construct and refine conceptual categories underpinning the integration challenges. …”
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Application of RNA interference technology in pest control and its safety by WANG Fang, DANG Cong, JIN Hongxia, XIAO Shan, ZHONG Fujun, FANG Qi, YAO Hongwei, YE Gongyin

“…RNA interference (RNAi) is a highly conserved gene-silencing phenomenon, induced by 20-30 nucleotide (nt) small molecules of non-coding RNA in vivo. Three non-coding RNAs, such as small interfering RNA (siRNA), microRNA (miRNA) and PIWI-interacting RNA (piRNA), play important roles in RNAi of eukaryotes including insects. …”
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Why do healthcare workers refuse tuberculosis preventive treatment (TPT)? a qualitative study from Puducherry, South India by Palanivel Chinnakali, Sonali Sarkar, Sadhana Subramanian, Jilisha Gnanadhas, Manju Rajaram, Senbagavalli Prakashbabu

“…Two researchers performed manual thematic analysis using the mixed approach for coding. Codes were grouped into categories and themes. …”
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Functional Analysis of <i>Penicillium expansum</i> Glucose Oxidase-Encoding Gene, <i>GOX2</i>, and Its Expression Responses to Multiple Environmental Factors by Yongcheng Yuan, Yutong Ru, Xiaohe Yuan, Shuqi Huang, Dan Yuan, Maorun Fu, Wenxiao Jiao

“…In addition, a comprehensive assessment was conducted on the <i>P. expansum</i> GOX coding gene <i>GOX2</i>, and the expression response rules of <i>GOX2</i> under different external stress environments were explored. …”
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Supporting consumer engagement in health research about chronic conditions: a scoping review of evidence-based resources by Mingming Zhou, Anne Parkinson, Mengyu Andy Lyu, Hanna Suominen, Leanne Watts, Jane Desborough

“…Analysis We conducted a qualitative thematic analysis by coding the results sections of each included study line by line. …”
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Values and preferences of medication use in patients for primary and secondary prevention of cardiovascular diseases: a mixed-methods exploratory study by Shenghan LI, Heyue DU, Kang AN, Longtao HE, Jing LI, Sheyu LI

“…Timely identification and intervention targeting the individual-level misconceptions and improper practices are critical to improve the adherence.…”
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Dendritic cell-associated miRNAs are modulated via chromatin remodeling in response to different environments. by Shiyue Mei, Yuanhang Liu, Yue Bao, Yuan Zhang, Siping Min, Yifei Liu, Yun Huang, Xidi Yuan, Yue Feng, Jiandang Shi, Rongcun Yang

“…However, LPS-mediated miRNAs were often associated with H3K4me3 redistribution from the transcription start site (TSS) to the miRNA-coding region. Silencing LPS-associated NF-κB p65 and CBP/p300 not only inhibited H3K4m3 redistribution but also reduced miRNA expression. …”
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The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. by Tokameh Mahmoudi, Sylvia F Boj, Pantelis Hatzis, Vivian S W Li, Nadia Taouatas, Robert G J Vries, Hans Teunissen, Harry Begthel, Jeroen Korving, Shabaz Mohammed, Albert J R Heck, Hans Clevers

“…Mllt10/Af10-Dot1l, essential for transcription elongation, are recruited to Wnt target genes in a β-catenin-dependent manner, resulting in H3K79 methylation over their coding regions in vivo in proliferative crypts of mouse small intestine in colorectal cancer and Wnt-inducible HEK293T cells. …”
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Role of extracellular vesicles in immune modulation, angiogenesis, progression and therapeutic resistance of glioblastoma by Muhammad Izhar, Ahed H. Kattaa, Amirhossein Akhavan-Sigari, Elaheh Shaghaghian, Yusuke S. Hori, Fred C. Lam, Deyaaldeen AbuReesh, Sara C. Emrich, Louisa Ustrzynski, Armine Tayag, Steven D. Chang, David J. Park

“…The RNA cargo of EVs, which includes microRNAs and long non-coding RNAs, plays a crucial role in modulating gene expression and cellular responses to treatment. …”
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Hsa_circ_0072732 enhances sunitinib resistance of renal cell carcinoma by inhibiting ferroptosis by Xiaorui Tian, Jun Liu, Cheng Yi, Xiangyun You, Chunli Yuan

“…Our research suggests that ferroptosis is involved in sunitinib resistance, and targeting ferroptosis is a promising way for RCC treatment. …”
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Using verbal and social autopsy approaches to understand why neonates die in rural settings: a case study of a remote rural district in Uganda by Peter Waiswa, Rornald Muhumuza Kananura, Dinah Amongin, Joseph Akuze, Jacquellyn Nambi Ssanyu, Felix Kizito

“…VASA-coded data analysis of the causes of death was done in STATA V.14.0. …”
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Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression by Nikola Pavlović, Marinela Križanac, Marko Kumrić, Katarina Vukojević, Joško Božić

“…Future research should address the gaps in understanding the role of mitophagy in CAKUT and optimize targeted delivery systems for precision therapies.…”
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Serum LINC01278 serves as a negative biomarker for sepsis and its up-regulation inhibits LPS-induced inflammatory response in THP-1 cells by Ying Gu, Honggang Jia, Xinyu Lin, Ling Wang

“…Background: Sepsis represents a potentially fatal condition characterized by organ failure. Long non-coding RNAs (lncRNAs) have provided new insights into the treatment of inflammation caused by sepsis. …”
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LncRNA FLG-AS1 inhibits esophageal squamous cell carcinoma by regulating the miR-23a-3p/HOXD10 axis by Zhigao Zhang, Fucheng Zhang, Chuan Xue, Xiaoling Song, Yaojun Wang

“…This is a new mechanism affecting ESCC and will provide new ideas for the targeted therapy of ESCC.…”
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An Insight into Differentially Expressed Genes and MicroRNAs in the Pituitary Glands of the Two Estrous Phases of Sheep with Different <i>FecB</i> Genotypes by Yue Zhang, Xiaoyun He, Ran Di, Xiangyu Wang, Mingxing Chu

“…As an important class of non-coding RNAs, miRNAs participate in a variety of biological processes, including cell proliferation, differentiation, apoptosis, and hormone secretion. …”
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Distinct Lung Adenocarcinoma-Associated Microbiota Are Associated with Inflammatory Immune Landscapes and Tumor Cell Proliferation via LCIIAR&amp;ndash;ISG15 Regulatory Networks by Liu S, Zhang Z

“…These observations underscore the value of targeting microbiome-influenced mechanisms, such as the LCIIAR–ISG15 axis, as a promising approach to enhance treatment outcomes in lung adenocarcinoma.Keywords: lung adenocarcinoma, microbiota, tumor microenvironment, ceRNA network…”
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Effect of lncRNA XIST on acute myeloid leukemia cells via miR-142-5p-PFKP axis by Zhaozhi Jiang, Tingting Liu, Youhong Wang, Jiao Li, Lusheng Guo

“…Further analysis revealed that lncRNA XIST targeted and bound to miR-142-5p, and PFKP was a target gene of miR-142-5p. …”
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Success factors and measures for scaling patient-facing digital health technologies from leaders’ insights by Estelle Pfitzer, Odile Giger, Christoph Kausch, Tobias Kowatsch

“…Thematic analysis was performed, with two researchers independently coding the data to ensure reliability. Success factors were categorized as internal (e.g., employees) or external (e.g., partnerships). …”
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Spike substitutions E484D, P812R and Q954H mediate ACE2-independent entry of SARS-CoV-2 across different cell lines. by Greta Vizgirda, Alexander P Underwood, Ulrik Fahnøe, Nina Weis, Santseharay Ramirez, Jens Bukh

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has evolved into variants with multiple spike protein coding mutations that affect its transmissibility, infectivity, and immune evasion, in particular from neutralizing antibodies. …”
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SPINT1-AS1 promotes oxidative damage and apoptosis of gastric cancer cells via the miR-656-3p/PLCXD3 axis by Duo Xu, Tong Wu, Xin Zhao, ShaoHai Li, XiaoHui Wei

“…Abstract Background and objectives In the study of gastric cancer (GC), long non-coding RNAs (lncRNAs) have been identified and their functions have been partly characterized; however, the specific function of SPINT1 antisense RNA 1 (SPINT1-AS1) in GC remains unclear. …”
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