Structure-Guided design of Cas12a variants improves detection of nucleic acids by Xiaohan Tong, Tianle Li, Kun Zhang, Dongming Zhao, Ying Zhang, Hao Yin

“…Compared to wild-type Cas12a, the K595A mutant exhibited a 2–3 times faster reaction speed and a 1,000–10,000 times increase in sensitivity in a one-pot reaction. …”
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Multi-camera spatiotemporal deep learning framework for real-time abnormal behavior detection in dense urban environments by Sai Babu Veesam, B. Tarakeswara Rao, Zarina Begum, R. S. M. Lakshmi Patibandla, Arvin Arun Dcosta, Shonak Bansal, Krishna Prakash, Mohammad Rashed Iqbal Faruque, K. S. Al-mugren

“…Neuromorphic event-based encoding captures speed action analysis through spiking neural networks, lowering detection latency by 60%. …”
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The Dialectic of the Nature-Society-System by Christian Fuchs

“…Organized nature that is part of the production process in the form of technology increases the productivity of labour and hence reduces the costs of variable capital (total amount of wages) and increases the speed of the production of surplus value. …”
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Kinetics Study of the Hydrogen Reduction of Limonite Ore Using an Unreacted Core Model for Flat-Plate Particles by Jindi Huang, Tao Yi, Jing Li, Mingzhou Li, Fupeng Liu, Jinliang Wang

“…The research results show that the hydrogen reduction process of limonite ore is influenced by multiple factors, including temperature, hydrogen partial pressure, and particle size. Increasing the reduction temperature and hydrogen partial pressure can significantly speed up the reduction reaction rate and enhance the degree of reduction. …”
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Oxygenated VOC Detection Using SnO₂ Nanoparticles with Uniformly Dispersed Bi₂O₃ by Haoyue Yang, Koichi Suematsu, Felipe Hiroshi Mashiba, Ken Watanabe, Kengo Shimanoe

“…As a result, the gas sensor based on 1 mol% Bi₂O₃-loaded SnO₂ (1Bi-L-SnO₂) composites shows significantly higher sensitivity and a faster response speed toward various oxygenated VOCs compared with SnO₂, especially at 200 °C and 250 °C. …”
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Association of genetic risk of Alzheimer’s disease and cognitive function in two European populations by Biqi Wang, Lori B. Chibnik, Seung Hoan Choi, Deborah Blacker, Anita L. DeStefano, Honghuang Lin

“…Although not all of the cognitive measures were significantly associated with AD PRS, non-verbal fluid reasoning (matrix pattern completion, β = − 0.022, P = 0.003), processing speed (such as symbol digit substitution, β = − 0.017, P = 1.08E−05), short-term memory and attention (such as pairs matching, β = − 0.014, P = 1.66E−10), and reaction time (β = − 0.010, P = 1.19E−06) were inversely associated with increasing AD PRS in the UK Biobank. …”
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Neuroprotective effects of Kapikachhu (Mucuna pruriens) in a paraquat-induced zebrafish model of neurotoxicity relevant to Parkinson's disease by Akshatha Manjunath, Rashmi Kanugodu Vasappa, Manjunatha Bangeppagari

“…Behavioural assessments revealed that Kapikachhu-treated zebrafish exhibited a 30% improvement in mean swimming speed and a 40% increase in dopamine levels compared to PQ-exposed zebrafish. …”
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Highly sensitive multiplex PCR for convenient quantification and differentiation of canine Oomycota pathogens: Pythium insidiosum, Lagenidium giganteum f. caninum, and Paralagenidi... by Asfiha Tarannum, Subarna Barua, Leonel Mendoza, Raquel Vilela, Priscilla Barger, Terri Hathcock, Amelia White, Kelly Chenoweth, Chengming Wang

“…Here, we developed a multiplex PCR assay with remarkable sensitivity, detecting as few as one DNA copy per reaction for P. insidiosum and Para. karlingii and 10 copies per reaction for L. giganteum. …”
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Study on the Compatibility of C₆F₁₂O Gas Mixture with EPDM by Shuangshuang TIAN, Benli LIU, Guangyu DENG, Xiaoxing ZHANG, Huihui LI, Weihao LIU, Hui CHEN

“…Meanwhile, the reaction rate of the C₆F₁₂O gas mixture with EPDM and the concentration of C₃F₆ and C₃F₇H were increased by both the increasing temperature and O₂ introduction. …”
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Enhanced Pool Boiling via Binder-Jetting 3D-Printed Porous Copper Structures: CHF and HTC Investigation by Lilian Aketch Okwiri, Takeshi Mochizuki, Kairi Koito, Noriaki Fukui, Koji Enoki

“…Subsequently, a gradual decline in heat flux was observed with an increasing wall superheat, demonstrating an outstanding resistance to the boiling crisis. …”
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Technologic Considerations of Creation Dosage Form of Original Substance 3,7-diazabicyclo[3.3.1]nonane by G. E. Brkich, N. V. Pyatigorskaya, O. A. Zyryanov, N. B. Demina, E. O. Bakhrushina, I. I. Krasnyuk

“…The study of the «Dissolution» test of gelatinous and hypromellose capsules was carried out on an ERWEKA DT 720 «Paddle stirrer» apparatus at a stirrer rotation speed of 50 rpm in three media: pH 1.2, pH 4.5 and pH 6.8. …”
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Biphasic effects of Callicarpa nudiflora water extract on rumen fermentation in vitro and microbial communities in sheep by Wanqin Yang, Wanqin Yang, Runhang Li, Wenxi Wang, Kunna Li, Yiying Huang, Ying Ying, Yuning Liu, Hongxin Wu

“…The flasks were incubated at 39°C for 24 hours in water with a rotation speed of 80 r/min.ResultsIt showed that adding CW significantly affected in vitro rumen fermentation in sheep and displayed a biphasic action: The supplementation levels of 4 g/kg and 6 g/kg showed an improvement in the fermentation status and nitrogen utilization efficiency with the enhanced microbial protein concentration from 1.98 mg/mL (Con) to 2.84 mg/mL (P < 0.001) and the relative abundance of total bacteria from 4.05 (Con) to 5.27 (P < 0.001); When the dose surpassed 14g/kg, the decline in the hemicellulose degradation rate from 63.00% (Con) to 40.24% (P < 0.001), accompanied by an increase in ammonia-nitrogen (NH3−N) concentration from 173.37 mg/L (Con) to 177.46 mg/L (P = 0.020) and total gas production from 154.87 mL/g (Con) to 161.47 mL/g (P =0.007), signaled abnormal alterations in the fermentation process.Conclusions The optimal supplementation range in feed formulations was established as 4−6g/kg, showing that CW could serve as a natural rumen modulator for sheep. …”
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Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled s... by Geyan Surendran, Jake Saye, Syahira Binti Mohd Jalil, Jack Spreadborough, Kyle Duong, Israa M. Shatwan, Dash Lilley, Michael Heinrich, Michael Heinrich, Georgina F. Dodd, Shelini Surendran

“…Additionally, future research should aim to further elucidate potential mechanisms of action to explain potential brain region and cognitive domain specific effects, such as possible regional increases in cerebral blood flow following consumption of H. erinaceus fruiting bodies. …”
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UAV spatiotemporal crowdsourcing resource allocation based on deep reinforcement learning by Yaxi LIU, Xulong LI, Jiahao HUO, Wei HUANGFU

“…The SAC algorithm is adept at handling the continuous action spaces typical of UAV flight paths and power control problems, making it particularly well-suited for our application. …”
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3D graphene paper-based tandem metal-free thin-film supercapacitors with integrated 200 V output by Huilong Liu, Litian Gan, Renji Chen, Zhiwen Xiao, Yun Chen, Hongzuo Yang, Yahang Liu, Baisheng Wu, Ching-Ping Wong, Xin Chen

“…The formation process and mechanism of PI to graphene were clarified by microstructure and chemical characterizations and reaction molecular dynamics. The influences of laser scan density, power, defocus, and scan speed on the sheet resistance, longitudinal resistance, Raman spectra, and electrochemical performance of graphene papers were systematically investigated. …”
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The effect of bioimpedance analysis on residual renal functionsin patients receiving α-ketoacid-supplementedlow-protein diet by guiding hemodialysis combined with ultrafiltration by CHAI Lu, HU Hong, ZHANG Ying-zi, DING Yue-mei

“…RRF values（6.0±0.6）in group Chad the best protective action in the 4 groups, with significant difference（P<0.05）, at a slow decreasing speed than those in other 3 groups; while RRF values in group A（4.6±0.5 mL/min）, group B（4.8±0.6 mL/min） and group C（6.0±0.6 mL/min） had better protective action than group D（3.7±0.6 mL/min）, with significant differences（P<0.05）.The 24-hour urine volumes in group A（922.4±85.1 mL）, group B（901.9±97.9 mL） and group C（1187.1±211.4 mL） were all higher than that in group D（653.2±74.2 mL）,with statistically significant difference（P<0.05）. …”
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Effect of Hypothyroidism on Cognitive Status: Evidence from Stroop Task by Shilpi Goyal, Abhinav Dixit, Neelam Vaney, S. V. Madhu

“…Processing of color identification was suppressed than reading words in hypothyroid patients as evidenced by increased reaction time of Stroop task. This increase in reaction time can be reversed by earlier identification of drug-naïve hypothyroid cases so that they can get timely treatment to restore their cognitive status. …”
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Enhanced fire hazard detection in solar power plants: an integrated UAV, AI, and SCADA-based approach by Andrii Lysyi, Anatoliy Sachenko, Pavlo Radiuk, Mykola Lysyi, Oleksandr Melnychenko, Oleksii Ishchuk, Oleg Savenko

“…It addresses the critical shortcomings of conventional monitoring methods, which often lack the necessary integration, speed, and diagnostic depth to reliably prevent catastrophic failures resulting from photovoltaic (PV) module defects. …”
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Data Checking of Asymmetric Catalysis Literature Using a Graph Neural Network Approach by Eduardo Aguilar-Bejarano, Viraj Deorukhkar, Simon Woodward

“…The range of chemical databases available has dramatically increased in recent years, but the reliability and quality of their data are often negatively affected by human-error fidelity. …”
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Affective Responses and Behavioral Strategies to Social Fusion Events in Zoo-Housed Bonobos by Daan W. Laméris, Jonas Verspeek, Marina Salas, Clara Garcia-Co, Marcel Eens, Jeroen M.G. Stevens

“…Eight bonobos completed a response slowing task on touchscreens, in which individuals with negative affect show longer reaction times to targets when a mildly threatening stimulus is displayed. …”
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